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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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Corrigendum to “Forest Hydrology in Chile;paste, present, and future” [J. Hydrol. 616 (2023)]

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Journal of Hydrology 2023年 617卷

作者： Francisco Balocchi Mauricio Galleguillos Diego Rivera Alejandra Stehr Jose Luis Arumi Roberto Pizarro Pablo Garcia-Chevesich Andrés Iroumé Juan J. Armesto Pedro Hervé-Fernández Carlos Oyarzún Pilar Barria Christian Little Gabriel Mancilla Santiago Yépez Rolando Rodriguez Don A. White Richard P. Silberstein Daniel G. Neary Pablo Ramírez de Arellano Bioforest SA camino a Coronel s/n km 15 Coronel Chile Water Resources and Energy for Agriculture PhD Program Water Resources Department Universidad de Concepción Chillán Chile Facultad de Ingeniería y Ciencias Universidad Adolfo Ibañez Santiago Chile Center for Climate and Resilience Research (CR2) University of Chile Santiago Chile Centro de Sustentabilidad y Gestión Estratégica de Recursos (CiSGER) Facultad de Ingeniería Universidad del Desarrollo Las Condes Chile Water Research Center for Agriculture and Mining (ANID/FONDAP/15130015) Victoria 1295 4070411 Concepción Chile Departamento Ingeniería Civil Facultad de Ingeniería Universidad de Concepción Concepción Chile Departamento de Recursos Hídricos Facultad de Ingeniería Agrícola Universidad de Concepción Chillan Chillan Chile Cátedra Unesco en Hidrología de Superficie U. de Talca Chile. Avda. Lircay s/n Talca Chile Centro Nacional de Excelencia para la Industria de la Madera (CENAMAD) Pontificia Universidad Católica de Chile Av. Vicuña Mackenna 4860 Santiago de Chile Chile Colorado School of Mines Department of Civil and Environmental Engineering 1500 Illinois St. Golden CO 80401 USA Universidad Austral de Chile Facultad de Ciencias Forestales y Recursos Naturales Valdivia Chile Departamento de Ecología Pontificia Universidad Católica de Chile Alameda 340 Santiago Chile Institute of Ecology and Biodiversity (IEB) Santiago Chile Cary Institute of Ecosystem Studies Millbrook NY 12545 USA Global Institute for Water Security School of Environment and Sustainability University of Saskatchewan 11 Innovation Boulevard Saskatoon SK S7N 3H5 Canada Laboratorio de Monitoreo de Pastizales Departamento de Ciencias Agropecuarias y Acuícolas Facultad de Ciencias Universidad de Magallanes Punta Arenas 6210005 Chile Instituto Ciencias de la Tierra Universidad Austral de Chile Valdivia Chile Facultad de Ciencias Forestales y de la Conservación de la Naturaleza Universidad de Chile Santiago Chile Instituto

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Author Correction: Ongoing declines for the world's amphibians in the face of emerging threats

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Nature 2024年第7993期625卷 E2页

作者： Jennifer A Luedtke Janice Chanson Kelsey Neam Louise Hobin Adriano O Maciel Alessandro Catenazzi Amaël Borzée Amir Hamidy Anchalee Aowphol Anderson Jean Ángel Sosa-Bartuano Ansel Fong G Anslem de Silva Antoine Fouquet Ariadne Angulo Artem A Kidov Arturo Muñoz Saravia Arvin C Diesmos Atsushi Tominaga Biraj Shrestha Brian Gratwicke Burhan Tjaturadi Carlos C Martínez Rivera Carlos R Vásquez Almazán Celsa Señaris S R Chandramouli Christine Strüssmann Claudia Fabiola Cortez Fernández Claudio Azat Conrad J Hoskin Craig Hilton-Taylor Damion L Whyte David J Gower Deanna H Olson Diego F Cisneros-Heredia Diego José Santana Elizah Nagombi Elnaz Najafi-Majd Evan S H Quah Federico Bolaños Feng Xie Francisco Brusquetti Francisco S Álvarez Franco Andreone Frank Glaw Franklin Enrique Castañeda Fred Kraus Gabriela Parra-Olea Gerardo Chaves Guido F Medina-Rangel Gustavo González-Durán H Mauricio Ortega-Andrade Iberê F Machado Indraneil Das Iuri Ribeiro Dias J Nicolas Urbina-Cardona Jelka Crnobrnja-Isailović Jian-Huan Yang Jiang Jianping Jigme Tshelthrim Wangyal Jodi J L Rowley John Measey Karthikeyan Vasudevan Kin Onn Chan Kotambylu Vasudeva Gururaja Kristiina Ovaska Lauren C Warr Luis Canseco-Márquez Luís Felipe Toledo Luis M Díaz M Monirul H Khan Madhava Meegaskumbura Manuel E Acevedo Marcelo Felgueiras Napoli Marcos A Ponce Marcos Vaira Margarita Lampo Mario H Yánez-Muñoz Mark D Scherz Mark-Oliver Rödel Masafumi Matsui Maxon Fildor Mirza D Kusrini Mohammad Firoz Ahmed Muhammad Rais N'Goran G Kouamé Nieves García Nono Legrand Gonwouo Patricia A Burrowes Paul Y Imbun Philipp Wagner Philippe J R Kok Rafael L Joglar Renoir J Auguste Reuber Albuquerque Brandão Roberto Ibáñez Rudolf von May S Blair Hedges S D Biju S R Ganesh Sally Wren Sandeep Das Sandra V Flechas Sara L Ashpole Silvia J Robleto-Hernández Simon P Loader Sixto J Incháustegui Sonali Garg Somphouthone Phimmachak Stephen J Richards Tahar Slimani Tamara Osborne-Naikatini Tatianne P F Abreu-Jardim Thais H Condez Thiago R De Carvalho Timothy P Cutajar Todd W Pierson Truong Re:wild Austin TX USA. jluedtke@***. IUCN SSC Amphibian Specialist Group Toronto Ontario Canada. jluedtke@***. Re:wild Austin TX USA. IUCN SSC Amphibian Specialist Group Toronto Ontario Canada. Museu Paraense Emílio Goeldi CZO/Herpetologia Belém Brazil. Florida International University Miami FL USA. Centro de Ornitologia y Biodiversidad (CORBIDI) Lima Peru. Laboratory of Animal Behaviour and Conservation College of Life Sciences Nanjing Forestry University Nanjing People's Republic of China. Laboratory of Herpetology Museum Zoologicum Bogoriense Research Center for Biosystematics and Evolution National Research and Innovation Agency (BRIN) Cibinong Indonesia. Department of Zoology Faculty of Science Kasetsart University Bangkok Thailand. Action Pour la Sauvegarde de l'Ecologie en Haïti (ACSEH) Les Cayes Haiti. Environmental Protection In the Caribbean (EPIC) Maho Sint Maarten. Museo de Vertebrados de la Universidad de Panamá Ciudad de Panama Panama. Centro Oriental de Ecosistemas y Biodiversidad (BIOECO) Museo de Historia Natural "Tomás Romay" Santiago de Cuba Cuba. IUCN SSC Amphibian Specialist Group Sri Lanka Gampola Sri Lanka. Laboratoire Évolution & Diversité Biologique UMR 5174 Université Toulouse III Paul Sabatier Toulouse France. Russian State Agrarian University-MTAA Moscow Russia. IUCN SSC Amphibian Specialist Group Bolivia La Paz Bolivia. Animal Nutrition Unit Department of Veterinary and Biosciences Ghent University Ghent Belgium. ASEAN Centre for Biodiversity University of the Philippines Los Baños Laguna Philippines. HerpWatch Pilipinas Manila Philippines. Faculty of Education University of the Ryukyus Okinawa Japan. Graduate School of Engineering and Science University of the Ryukyus Okinawa Japan. SAVE THE FROGS! Laguna Beach CA USA. The University of Texas at Arlington Arlington TX USA. Smithsonian Conservation Biology Institute Front Royal VA USA. Center for Environmental Studies Sanata Dharma University (CESSDU) Yogya

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Plant-based green synthesis of metallic nanoparticles: scientific curiosity or a realistic alternative to chemical synthesis?

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Nanotechnology for environmental engineering 2016年第1期1卷 1-29页

作者： Peralta-Videa, Jose R. Huang, Yuxiong Parsons, Jason G. Zhao, Lijuan Lopez-Moreno, Laura Hernandez-Viezcas, Jose A. Gardea-Torresdey, Jorge L. Chemistry Department University of Texas at El Paso 500 West University Ave. El PasoTX79968 United States Environmental Science and Engineering PhD Program University of Texas at El Paso 500 West University Ave. El PasoTX79968 United States University of Texas at El Paso 500 West University Ave. El PasoTX79968 United States Bren School of Environmental Science and Management University of California Santa Barbara Santa BarbaraCA United States Department of Chemistry The University of Texas Rio Grande Valley 1201 W University Dr EdinburgTX78539 United States Department of Chemistry University of Puerto Rico at Mayagüez Mayagüez PR00680 United States

Currently, thousands of tons of metallic nanoparticles (MNPs) are produced and utilized in nano-enabled devises, personal care, medicinal, food and agricultural products. It is generally accepted that the reaction compounds and the techniques used in industrial production of MNPs are not environmentally friendly. The green synthesis has been proposed as an alternative to reduce the use of hazardous compounds and harsh reaction conditions in the production of MNPs. In this endeavor, investigators have used organic compounds, microbes, plants and plant-derived materials as reducing agents. Research papers are published every year, and each one of them stresses the benefits of the green approach and the advantages over the traditional syntheses. However, after almost two decades since the explosion of the reports about the new approach, the commercial production of green-synthesized nanoparticles does not seem to find a way to scale up commercial production. This review includes descriptions of the traditional and green synthesis and applications of MNPs and highlights the factors limiting the use of plant-based synthesis as a real alternative to the traditional synthesis of MNPs. © 2016, Springer International Publishing Switzerland.

关键词： Synthesis (chemical)

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Corrigendum to “Kinetic analysis for thermal cracking of HDPE: A new isoconversional approach” Polymer Degradation and Stability 2016;129: 306–318

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Polymer Degradation and Stability 2016年 133卷 349-349页

作者： Sahar Khedri Siamak Elyasi Biotechnology PhD Program Faculty of Science and Environmental Studies Lakehead University 955 Oliver Rd Thunder Bay Ontario P7B 5E1 Canada Chemical Engineering Department Lakehead University 955 Oliver Rd Thunder Bay Ontario P7B 5E1 Canada

Converting waste plastic into marketable hydrocarbons is a promising way to protect the environment and earn financial gain. While several kinetic studies have examined the cracking of waste plastic, they are often oversimplified or inappropriate for designing an industrial reactor. This work proves the necessity of using isoconversional methods by using Differential Scanning Calorimetry (DSC). DSC verified that cracking of waste plastic involves the production of several intermediates, indicating that the kinetics is more complex and requires further studies. Several isoconversional methods such as Friedman, Ozawa, Flynn-Wall-Ozawa (FWO), Kissinger-Akahira-Sunose (KAS) and model-free were applied to estimate the apparent activation energy and frequency factor of thermal cracking of high-density polyethylene (HDPE) using non-isothermal and isothermal Thermogravimetric Analysis (TGA). The determined kinetic parameters from each method were evaluated against the experimental data. In order to overcome the failures and shortages engaged with the employed methods, a new isothermal isoconversional model was proposed and good matching results were observed.

关键词： Thermal cracking Kinetic parameters HDPE Isothermal TGAs Non-isothermal TGAs Isoconversional methods

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Alginate modifies the physiological impact of CeO2nanoparticles in corn seedlings cultivated in soil

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Journal of environmental sciences 2014年第2期26卷 382-389页

作者： Lijuan Zhao Jose R.Peralta-Videa Bo Peng Susmita Bandyopadhyay Baltazar Corral-Diaz Pedro Osuna-Avila Milka O.Montes Arturo A.Keller Jorge L.Gardea-Torresdey Chemistry Department The University of Texas at El Paso 500 West University Avenue University of California Center for Environmental Implications of Nanotechnology The University of Texas at El Paso 500 West University Avenue Environmental Science and Engineering PhD program The University of Texas at El Paso 500 West University Avenue Department of Biological Sciences The University of Texas at El Paso 500 West University Avenue Universidad Aut'onoma De Ciudad Ju'arez Plutarco Elias Calles # 1210 Fovissste Chamizal. Ciudad Juarez Chihuahua 32310 Mexico Chemistry Department University of Texas of the Permian Basin Odessa Bren School of Environmental Sciences and Management 3420 Bren Hall University of California

Alginates are naturally occurring components of organic matter in natural soil whose effects on nanoparticle （NP） toxicity to plants is not well understood. In the present study, corn plants were grown for one month in soil spiked with 400 mg/kg CeO2 NPs with various alginate concentrations. After one month of growth in the NPs impacted soil, plants were harvested and analyzed for Ce and mineral element concentrations. Chlorophyll concentration and heat shock protein 70, used as biomarkers for oxidative stress, were also evaluated. Results showed that, compared to CeO2 NPs treatment, alginate at 10, 50, and 100 mg/kg increased Ce concentration in roots by approximately 46%, 38%, and 29% and by 115%, 45%, and 56% in shoots, respectively. CeO 2 NPs without alginate increased Mn accumulation in roots by 34% compared to control. CeO2 NPs with low and medium alginate increased Mn by ca. 92% respect to NPs without alginate and by ca. 155% respect to control. CeO2 NPs without/with alginate significantly increased accumulation of Fe and Al in roots. In addition, alginate at 50 mg/kg increased Zn accumulation in roots by 52% compared to control. In shoots, K increased at all NP treatments but the accumulation of other elements was not affected. Alginate enlarged the impact of CeO2 NPs to corn plants by reducing chlorophyll a content and triggering overexpression of heat shock protein 70.

关键词： CeO2 NPs alginate nutrient uptake chlorophyll heat shock protein

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随机扩增多态性DNA技术研究发现二氧化钛纳米颗粒对西葫芦具有基因毒性(英文)

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Journal of Zhejiang University-science A(Applied Physics & engineering) 2014年第8期15卷 618-623页

作者： Fabiola MORENO-OLIVAS Vincent U.GANT Jr. Kyle L.JOHNSON Jose R.PERALTA-VIDEA Jorge L.GARDEA-TORRESDEY Depertment of Chemistry The University of Texas at El Paso El Paso TX 79968 USA University of California Center for Environmental Implications of Nanotechnology (UC CEIN) The University of Texas at El Paso El Paso TX 79968 USA Department of Biological Sciences and Border Biomedical Research Center The University of Texas at El Paso El Paso TX 79968 USA Environmental Science and Engineering PhD Program The University of Texas at El Paso El Paso TX 79968 USA

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具... 详细信息

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具有毒性特别是是否会产生植物基因毒性至今尚不清楚。因此,本文使用随机扩增多态性DNA技术研究TiO2纳米颗粒是否对西葫芦具有基因毒性,为TiO2纳米颗粒排放进入环境后的潜在植物毒性风险评价提供依据。创新要点:首次发现了TiO2纳米颗粒对西葫芦具有基因毒性。重要结论:采用随机扩增多态性DNA技术,发现TiO2纳米颗粒污染处理的西葫芦样品与未处理样品的基因组DNA图谱相比,不仅在谱带强度有明显差异,而且存在谱带消失和新谱带产生现象,表明TiO2纳米颗粒对西葫芦具有基因毒性。

关键词：随机扩增多态性DNA技术 TiO2 纳米颗粒基因组DNA 西葫芦毒性

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Direct detection of adenovirus in environmental waste waters by portable optical fiber sensor platform

Direct detection of adenovirus in environmental waste waters...

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12th IEEE SENSORS 2013 Conference

作者： Yildirim, Nimet Li, Dan Long, Feng Gu, April Z. Bioengineering PhD Program Northeastern University Boston United States Department of Civil and Environmental Engineering Northeastern University Boston United States State Key Joint Laboratory of Environment Simulation and Pollution Control Environmental Science and Engineering Tsinghua University Beijing China Department of Environment Science and Engineering Tsinghua University Beijing China 360 Huntington Ave. Boston MA 02115 United States

ISBN: (纸本)9781467346405

Reusable and portable evanescent wave biosensor for rapid, sensitive and highly selective direct detection of adenoviruses was developed. Here, specific antibody for the hexon protein of the virus was used as a recognition element. Linear detection range was determined from 100PFU/ml to 2000PFU/ml. This direct detection system can be regenerated successfully with over 5 times without significant deterioration of the sensor performance. The developed biosensor system has high specificity towards adenovirus, and it was applied to environmental waste water samples for the detection of adenovirus with 95 to 117% recovery and 1.1 to 8.1% cv values (n=2). © 2013 IEEE.

关键词： Optical fibers

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