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Ten decadal advances in fungal biology leading towards human well‑being

Fungal Diversity 2022年第5期116卷 547-614页

作者： Ausana Mapook·Kevin DHyde Kevin D.Hyde Khadija Hassan Blondelle Matio Kemkuignou Adela Cmokova Frank Surup Eric Kuhnert Pathompong Paomephan Tian Cheng Sybren de Hoog Yinggai Song Ruvishika S.Jayawardena Abdullah M.S.Al‑Hatmi Tokameh Mahmoudi Nadia Ponts Lena Studt‑Reinhold Florence Richard‑Forget K.W.Thilini Chethana Dulanjalee L.Harishchandra Peter E.Mortimer Huili Li Saisamorm Lumyong Worawoot Aiduang Jaturong Kumla Nakarin Suwannarach Chitrabhanu S.Bhunjun Feng‑Ming Yu Qi Zhao Doug Schaefer Marc Stadler Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department Microbial Drugs Helmholtz Centre for Infection Research(HZI)and German Centre for Infection Research(DZIF)Partner Site Hannover‑BraunschweigInhoffenstrasse 738124 BrunswickGermany Institute of Microbiology Technische Universitat BraunschweigSpielmannstrase 738106 BrunswickGermany Laboratory of Fungal Genetics and Metabolism Institute of MicrobiologyCzech Academy of SciencesPragueCzech Republic Centre of Biomolecular Drug Research(BMWZ) Institute for Organic ChemistryLeibniz University HannoverSchneiderberg 3830167 HannoverGermany Department of Biotechnology Faculty of ScienceMahidol University272 Rama VI RoadRatchathewiBangkok 10400Thailand Center of Expertise in Mycology Radboud University Medical Center/Canisius Wilhelmina HospitalNijmegenThe Netherlands Key Laboratory of Environmental Pollution Monitoring and Disease Control Guizhou Medical UniversityGuiyangChina Microbiology Parasitology and Pathology Graduate ProgramFederal University of ParanaCuritibaBrazil Department of Dermatology Peking University First HospitalPeking UniversityBeijingChina Natural and Medical Sciences Research Center University of NizwaNizwaOman Department of Biochemistry Erasmus University Medical CenterRotterdamThe Netherlands INRAE UR1264 Mycology and Food Safety(MycSA)33882 Villenave d’OrnonFrance Department of Applied Genetics and Cell Biology Institute of Microbial GeneticsUniversity of Natural Resources and Life SciencesVienna(BOKU)Tulln an der DonauAustria Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Centre for Mountai

Fungi are an understudied resource possessing huge potential for developing products that can greatly improve human *** the current paper,we highlight some important discoveries and developments in applied mycology and interdisciplinary Life science *** examples concern recently introduced drugs for the treatment of infections and neurological diseases;application of–OMICS techniques and genetic tools in medical mycology and the regulation of mycotoxin production;as well as some highlights of mushroom cultivaton in *** for new diagnostic tools in medical mycology and the exploitation of new candidates for therapeutic drugs,are also *** addition,two entries illustrating the latest developments in the use of fungi for biodegradation and fungal biomaterial production are *** other areas where there have been and/or will be significant developments are also *** is our hope that this paper will help realise the importance of fungi as a potential industrial resource and see the next two decades bring forward many new fungal and fungus-derived products.

关键词： Biomaterial CRISPR Drug development Morel cultivation Mushroom cultivation Mycotoxin biosynthesis Plastic degradation

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Embracing systems toxicology at single-cell resolution

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Current Opinion in Toxicology 2019年 16卷 49-57页

作者： Zhang, Qiang Caudle, W. Michael Pi, Jingbo Bhattacharya, Sudin Andersen, Melvin E. Kaminski, Norbert E. Conolly, Rory B. Department of Environmental Health Rollins School of Public Health Emory University Atlanta GA United States Program of Environmental Toxicology School of Public Health China Medical University Shenyang China Department of Biomedical Engineering Department of Pharmacology and Toxicology Center for Research on Ingredient Safety Institute for Quantitative Health Science and Engineering and Institute for Integrative Toxicology Michigan State University East Lansing MI United States ScitoVation LLC Research Triangle Park NC United States Departments of Pharmacology and Toxicology and Institute for Integrative Toxicology Michigan State University East Lansing MI United States Integrated Systems Toxicology Division National Health and Environmental Effects Research Laboratory United States Environmental Protection Agency Durham NC United States

As systems biology expands its multi-omic spectrum to increasing resolutions, distinguishing cells based on single-cell profiles becomes feasible. Unlike traditional bulk assays that average cellular responses and blur the distinct identities of responsive cells, single-cell technologies enable sensitive detection of small cellular changes and precise identification of those cells perturbed by toxicants. Among the suite of omic technologies that continue to expand and become affordable, single-cell RNA sequencing is at the cutting edge and leading the way to transform systems toxicology. Single-cell systems toxicology can provide a wealth of information to elucidate cell-specific alterations and response trajectories, detect points of departure, and map and develop dynamical models of toxicity pathways. © 2019 Elsevier B.V.

关键词： Bulk assay Computational toxicology Machine learning Single-cell RNA sequencing Systems toxicology Transcriptomics

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Author Correction: Compound dry-hot-fire events connecting Central and Southeastern South America: an unapparent and deadly ripple effect

npj Natural Hazards

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npj Natural Hazards 2024年第1期1卷 1页

作者： Djacinto Monteiro dos Santos Aline M. de Oliveira Julia A. Rodrigues Lucas S. Menezes Ronaldo Albuquerque Leonardo F. Peres Renata Libonati Ediclê S. F. Duarte Judith J. Hoelzemann Fabio de O. Roque Departamento de Meteorologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Dom Luiz (IDL) Faculdade de Ciências Universidade de Lisboa Lisboa Portugal Department of Atmospheric and Climate Sciences Graduate Program in Climate Sciences Federal University of Rio Grande do Norte Natal Brazil University of Évora - Institute of Earth Sciences Évora Portugal Universidade Federal de Mato Grosso do Sul Campo Grande Brazil Center for Tropical Environmental and Sustainability Science (TESS) and College of Science and Engineering James Cook University Cairns QLD Australia

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Compound dry-hot-fire events connecting Central and Southeastern South America: an unapparent and deadly ripple effect

npj Natural Hazards

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npj Natural Hazards 2024年第1期1卷 1-13页

South America has experienced severe compound drought-heatwaves (CDHW), exacerbating fires. Recently, the unprecedented Pantanal 2020 fire season (P20F), burning a third of the biome, resulted in well-reported local impacts on the ecosystem, economy, and health. Nevertheless, the long-range ripple effects of this event remain unknown. We investigated the P20F-related cascading hazards, integrating models, observational and satellite-based data. P20F-related smoke elevated PM2.5levels in the SA’s most populated area, exceeding WHO guidelines by up to 600%. Smoke-induced air pollution episodes coincided with widespread heatwaves, amplifying health risks. The mortality burden attributable to this multi-hazard short-term (14 days) exposure was estimated to be 2150 premature deaths (21% increase above expected levels). Our findings highlight that the impacts of CDHW-fires in SA are beyond the local level, implying growing challenges for risk management and public health and the need for governance based on telecoupled flows, linking different systems over multiple scales.

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The Application Potential of Eco-Efficiency for Greening Company 2

The Application Potential of Eco-Efficiency for Greening Com...

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2nd International Conference on Energy, environmental and Information System, ICENIS 2017

作者： Prasaja, Lukman Eka Hadiyanto Master Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Departement of Chemical Engineering Faculty of Engineering Diponegoro University Semarang Indonesia

Eco-Efficiency emerged in the 1990s as a measure of "the efficiency that ecological sources use to meet human needs." As a tool in economic and environmental integration, Eco-efficiency needs to be promoted further so that regulation in government and industrial management can include it as an important instrument. This paper provides several approaches that can help various industries to develop effective eco-efficiency principles. The approach used is to maximize the role of the Steering Committee of the company's internal environment. Utilization of natural resources such as water, forests, mines and energy needs need to be balanced with Eco-Efficiency so that natural exploitation can be well controlled so that sustainable development aspired by the world can be realized. © 2018 The Authors, published by EDP sciences.

关键词： environmental regulations

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Water Footprint Assessment in the Agro-industry: A Case Study of Soy Sauce Production 2

Water Footprint Assessment in the Agro-industry: A Case Stud...

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2nd International Conference on Energy, environmental and Information System, ICENIS 2017

作者： Firda, Alfiana Aulia Purwanto Master Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Semarang Indonesia

In terms of global water scarcity, the water footprint is an indicator of the use of water resources that given knowledge about the environmental impact of consuming a product. The sustainable use of water resources nowadays bring challenges related to the production and consumption phase of water intensive related goods such as in the agro-industry. The objective of the study was to assessment the total water footprint from soy sauce production in Grobogan Regency. The total water footprint is equal to the sum of the supply chain water footprint and the operational water footprint. The assessment is based on the production chain diagram of soy sauce production which presenting the relevant process stages from the source to the final product. The result of this research is the total water footprint of soy sauce production is 1.986,35 L/kg with fraction of green water 78,43%, blue water 21,4% and gray water 0,17%. © 2018 The Authors, published by EDP sciences.

关键词： Supply chains

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Optimization of biogas production in Indonesian region by liquid anaerobic digestion (L-AD) method from rice husk using response surface methodology (RSM)

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IOP Conference Series: Materials science and engineering 2020年第1期845卷

作者： W D Nugraha Syafrudin V N Kusumastuti H H A Matin Budiyono Environmental Engineering Department Engineering Faculty Diponegoro University Semarang Indonesia Environmental Science Study Program Faculty of Science and Mathematic Sebelas Maret University Surakarta Indonesia Chemical Engineering Department Engineering Faculty Diponegoro University Semarang Indonesia

Rice husk is one of agricultural waste that is potentially converted to biogas. In this research, rice husk is used as the material to produce biogas by liquid anaerobic digestion (L-AD) with TS concentration below 15/5. The purposes of this research are finding the optimum value of total solid (TS), C/N ratio, and microbial consortium (MC) for biogas production and then analyzing the optimum biogas production rate from rice husk. Because of the high lignin content, rice husk must be through the pretreatment stage using NaOH 3%. The variations of the observed factor are 5%, 10%, 15% for TS concentration; 20, 35, 50 for C/N ratio; and 3%, 6%, 9% for MC concentration. There are 16 reactors in which the variation for each reactor was determined by Central Composite Design. Data obtained from the research will be optimized using Response Surface Methodology (RSM) in Statistica 10. The result shows that the optimum condition of biogas production from rice husk is TS in between 1%-2.5%, C/N ration 33.45, and MC in between 5.5%-7%. Reactor having a combination of value factors that close to the optimum value will be analyzed using Polymath 6.0, which is reactor 10. The kinetics constant of biogas production rate (u) is 3.625 ml/***, the maximum biogas production (A) is 277.374 ml/gr TS, and the minimum time needed to produce biogas (λ) is 3.878 days.

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Good Housekeeping Implementation for Improving Efficiency in Cassava Starch Industry (Case Study: Margoyoso District, Pati Regency) 2

Good Housekeeping Implementation for Improving Efficiency in...

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2nd International Conference on Energy, environmental and Information System, ICENIS 2017

作者： Aji, Wijayanto Setyo Purwanto Suherman Master Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Semarang Indonesia

Cassava starch industry is one of the leading small-medium enterprises (SMEs) in Pati Regency. Cassava starch industry released waste that reduces the quantity of final product and potentially contamined the environment. This study was conducted to observe the feasibility of good housekeeping implementation to reduce waste and at the same time improve efficiency of production process. Good housekeeping opportunities are consideration by three aspect, technical, economy and environmental. Good housekeeping opportunities involved water conservation and waste reduction. These included reuse of water in washing process, improving workers awareness in drying section and packaging section. Implementation of these opportunities can reduce water consumption, reduce wastewater and solid waste generation also increased quantity of final product. © 2018 The Authors, published by EDP sciences.

关键词： Water conservation

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Understanding safety data sheets as a strategy to protect humans and the environment at the laboratory 2

Understanding safety data sheets as a strategy to protect hu...

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2nd International Conference on Energy, environmental and Information System, ICENIS 2017

作者： Elza, Rizkiawalia Suherman, Suherman Master Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Semarang Indonesia

Safety Data Sheet (SDS) gave important information for safe chemicals handling and widely used in communicating chemical hazards. Laboratory as one of the places associated with the consumption of a number of chemicals, then the worker in laboratory have to know the information chemicals used. The purpose of this research is to know the perception and understanding of workers in a laboratory toward SDS. The quantitative research was used and the collect data by questionnaire using Likert scale, then analyzed descriptively. The total sample of data was twenty-seven of laboratory worker people. The finding from this study showed that a great majority of people agree SDS has benefits for workers in the laboratory, agree the SDS should be available in the workplace, feel the need to know the contents of the SDS, but not so many people agree 'I access SDS while working using chemicals' and great majority of people feel 'I obtained chemical information other than SDS'. © 2018 The Authors, published by EDP sciences.

关键词： Laboratories

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Utilization of Information Technology for Non Domestic Waste Management in Semarang City 2

Utilization of Information Technology for Non Domestic Waste...

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2nd International Conference on Energy, environmental and Information System, ICENIS 2017

作者： Ali, Muhammad Hadi, Sudharto P. Soemantri, Maman Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Department of Electricall Engineering Faculty of Engineering Diponegoro University Semarang Indonesia

Garbage problem is often very complex in urban areas. The handling pattern of collecting, transporting and disposing that has been applied up to this day has not yet produced an appropriate solution. This is evident from the data of statistic centre institution in 2015 that 76.31% of the existing waste in the community has not been sorted, while 10.28% sorted to be used and 13.41% sorted to be discarded, showing the community amount of unsorted garbage large enough to necessitate managerial efforts at the waste sources. In designing a systematic and structured waste management system, the generations, compositions, and characteristics of the waste are indispensable. Therefore, a research is conducted on these three dimensions to the non-domestic waste in Semarang City, which involves commercial waste (from the markets, restaurants, and hotels), institutional waste (from the offices and schools). From the research result the average of 0,24kgs/person/day in weight unit of the City's non-domestical waste generation is derived. The waste composition is dominated by organic waste of around 61.95%, while the rest percentage is inorganic. The management policy is directed with the application of Management Information System model based on Information Technology because of the system's abilities to effectuate the waste management. © 2018 The Authors, published by EDP sciences.

关键词： Waste management

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