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Abstracts from the 3rd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects

Molecular Cytogenetics 2017年第2期10卷 77-94页

作者： Athel Cornish-Bowden David Rasnick Henry H. Heng Steven Horne Batoul Abdallah Guo Liu Christine J. Ye Mathew Bloomfield Mark D. Vincent C. Marcelo Aldaz Jenny Karlsson Anders Valind Caroline Jansson David Gisselsson Jennifer A. Marshall Graves Aleksei A. Stepanenko Svitlana V. Andreieva Kateryna V. Korets Dmytro O. Mykytenko Stanislav S. Avdieiev Nataliya L. Huleyuk Vladimir P. Baklaushev Oksana A. Kovaleva Vladimir P. Chekhonin Yegor S. Vassetzky Bjorn Bakker Aaron S. Taudt Mirjam E. Belderbos David Porubsky Diana C. J. Spierings Tristan V. de Jong Nancy Halsema Hinke G. Kazemier Karina Hoekstra-Wakker Victor Guryev Peter M. Lansdorp Maria Colomé Tatché Floris Foijer Allan Bradley Eveline S. J. M. de Bont Anke van den Berg Thomas Liehr Nicolaas C. Baudoin Joshua M. Nicholson Kimberly Soto Daniela Cimini Isabel Quintanilla Jordi Camps M. Dürrbaum N. Donnelly V. Passerini C. Kruse Z. Storchová B. Habermann Daniele Mandrioli Fiorella Belpoggi Ellen K Silbergeld Melissa J Perry Rolf I. Skotheim Marthe Løvf Bjarne Johannessen Andreas M. Hoff Sen Zhao Jonas M. SveeStrømme Anita Sveen Ragnhild A. Lothe R. Hehlmann A. Voskanyan A. Fabarius Alfred Böcking Stefan Biesterfeld Leonid Berynskyy Christof Börgermann Rainer Engers Josef Dietz A. Fritz N. Page C. Tye G. Stein J. Stein N. Sehgal R. Berezney J. Vecerova B. Stojkovicz H. Ding J. Xu S. Bhattacharya Xue Gong Sarah Grasedieck Julian Swoboda Jonathan R. Pollack Frank G. Rücker Lars Bullinger Fani-Marlen Roumelioti Maria Chiourea Christina Raftopoulou Sarantis Gagos Peter Duesberg Mat Bloomfield Sunyoung Hwang Hans Tobias Gustafsson Ciara O’Sullivan Aracelli Acevedo-Colina Eduardo M. Torres Xinhe Huang Robert C. Dickson Christian Klose Andrej Schevchenko Paola Cavaliere Noah Dephoure Martha R. Stampfer Mark A. LaBarge James C. Garbe Lukas Vrba Bernard Futscher Yi-Hong Zhou Andrew L. Trinh Michelle Digman Directeur de Recherche (Émérite) Centre National de la Recherche Scientifique (CNRS) Marseilles France 549 Fairbanks Ave. Oakland California 94610 USA Wayne State University School of Medicine Detroit MI USA University of Michigan School of Medicine Ann Arbor MI USA Department of Molecular and Cell Biology UC Berkeley Donner Lab Berkeley CA USA Department of Natural Sciences and Mathematics Dominican University of California San Rafael CA USA Department of Medical Oncology London Regional Cancer Program London Ontario N6A 4L6 Canada Department of Epigenetics and Molecular Carcinogenesis University of Texas M.D. Anderson Cancer Center Science Park Smithville TX 78957 USA Department of Laboratory Medicine Division of Clinical Genetics Lund University Lund SE221 84 Sweden Department of Clinical Sciences Division of Oncology and Pathology Lund University Lund SE221 85 Sweden Skåne Regional and Univeristy Laboratories Department of Pathology Lund SE221 85 Sweden School of Life Sciences La Trobe University Melbourne Vic 3168 Australia Department of Functional Genomics Institute of Molecular Biology and Genetics Kyiv 03680 Ukraine Institute of Hereditary Pathology National Academy of Medical Sciences of Ukraine Lviv 79008 Ukraine Federal Research and Clinical Center FMBA of Russia Moscow 115682 Russia R.E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology Kyiv 03022 Ukraine V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology Ministry of Health of the Russian Federation Moscow 119034 Russia Department of Medicinal Nanobiotechnology Pirogov Russian State Medical University Moscow 117997 Russia CNRS UMR8126 Université Paris-Sud 11 Institut de Cancérologie Gustave Roussy Villejuif 94805 France European Research Institute for the Biology of Ageing University of Groningen University Medical Center Groningen A. Deusinglaan 1 NL-9713 AV Groningen The Netherlands Department of Paediatrics University

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Basal repertoire of toxin-related transcripts in the zoanthid Protopalythoa variabilis(Cnidaria,Anthozoa)

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中国药理学与毒理学杂志 2015年第S1期29卷 104-104页

作者： ChenHUANG Jean-EtienneRLMORLIGHEM HefengZHOU EricaPatríciaLIMA PaulaBragaGOMES CarlosDanielPEREZ InchioLOU SimonMingYuenLEE GRadis-BAPTISTA State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences University of Macao Northeast Biotechnology Network Post-graduation program in Biotechnology Federal University of Ceara Laboratory of Biochemistry and Biotechnology Institute for Marine Sciences Federal University of Ceara Centro Acadêmico de Vitoria Universidade Federal de Pernambuco Departamento de Biologia Universidade Federal Rural de Pernambuco Faculty of Science and Technology Department of Civil and Environmental Engineering University of Macao Macao China

OBJECTIVE To analyze the whole transcriptome of zoanthid Protopalythoa variabilis(***),a cnidarian,and discover the potential toxic substances in *** The *** RNA deep sequencing was performed using the HiSeq 2500 automatic sequencing *** the unigenes generated from the assembly process were functionally annotated based on the similarity with *** multiple alignments of translated toxin-related sequences were performed with Clustalw2,and amino acid identity and similarity highlighted by using BoxShade *** different methods including ITASSER,PEP-FOLD and MODELLER were applied to predict tri-dimensional models of toxin-related polypeptides from translated transcript sequences of *** toxicity of one of the putative toxins,namely ShK/Aurelin-like peptide,was evaluated using zebrafish *** A total of 67,549,914 pairs of quality-filtered,90-base-pair Illumina reads from an mRNA sample were *** de novo assemblies yielded 276,526 *** sequence comparison of 130,121 unigenes with entries in Toxin database showed that 1542 unigenes were potential peptide toxins at which 11 unigenes were related to Stichodactyla toxin(ShK)domain(Pfam ID:PF01549).ShK is a 35 residues peptide sequence that was firstly discovered from the sea anemone Stichodactyla ***,we found out one ShK-like peptide that processed a relatively higher sequence similarity with known ShK(Uniprot ID:P29186)of Bunodosoma granuliferum(red warty sea anemone).The Protopalythoa Shk-like peptide was submitted to Probis server to detect probable binding site and found to match with a protein AURELIN(PDB id:2lg4,UniProt id:Q0MWV8)which possesses structural homology with previously identified antimicrobial peptides and K+-channel-blocking *** results showed that the ShK/Aurelin-like peptide was lethal to zebrafish embryos at concentrations above 30-μmol·L1,and could induce zebrafish locomotor deficit at 10μmol

关键词： zoanthidea transcriptome peptide toxin Protopalyth

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Effects of Recent Invasive Species Events on Nearshore Methylmercury Dynamics in Lake Michigan

Effects of Recent Invasive Species Events on Nearshore Methy...

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The 17th International Conference on Heavy Metals in the Environment (ICHMET2014)(第十七届国际环境重金属会议)

作者： James Hurley Ryan Lepak David Krabbenhoft Department of Civil and Environmental Engineering Environmental Chemistry and Technology ProgramUniversity of Wisconsin-MadisonMadisonWI 53706 United States Geological SurveyWisconsin Water Science CenterMiddletonWisconsin 53562

The recent invasion of Dreissenid mussels in there North American Great Lakes,especially quagga mussels(Dreissena bugensis)in Lake Michigan,has resulted in a profound shift in nutrient and carbon dynamics of the nearshore *** enhanced nearshore nutrient cycling,proliferation of the filamentous green alga Cladophora is evident in many areas,especially nearshore zones on the western and northeastern regions of the *** turbulent conditions and during senescence,Cladophora detach,and in many cases,accumulate and decay both on the shore and in nearshore depositional *** shift in carbon flow in the nearshore zone has significant impacts on mercury(Hg)cycling,most notably in production of methyl mercury(MeHg).Two study sites were investigated--a nearshore beach and shallow water site,and a nearshore depression that serves as a Cladophora deposition *** phase deposits of decaying plant material on beaches were elevated in MeHg and were seasonally dynamic,with 10-50%of total Hg(HgT)as *** water(which most likely is transported advectively to Lake Michigan)collected under the decaying Cladophora mats ranged from 1.9 to 5.3 ng/L MeHg(64-76%of HgT as MeHg).A transect parallel to the shore showed increased aqueous MeHg levels near cladophora-rich zones,exceeding offshore zones by a factor of 2 to 10,with highest concentrations in the beach wash *** the second site,the Cladophora deposition zone,solid phase surface sediments were enriched with MeHg(10-20%of HgT as MeHg),with pore water and overlying water suggesting strong diffusive gradients from the deposited *** the quagga mussel as a biosentinel,we also observed about a twofold enrichment of MeHg content in nearshore organisms over their offshore *** work on Lake Michigan had identified deep sediment fluxes and riverine inputs as major drivers of MeHg *** we have identified a new source of nearshore MeHg production in Lake Michigan,driven by invasive

关键词： mercury Great Lakes coastal methylation bioaccumulation

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The gas centrifuge and nuclear weapons proliferation

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AIP Conference Proceedings 2014年第1期1596卷 210-218页

作者： Houston G. Wood Alexander Glaser R. Scott Kemp Mechanical and Aerospace Engineering Department University of Virginia Charlottesville Virginia USA Woodrow Wilson School of Public and International Affairs Program on Science Technology and Environmental Policy Princeton University Princeton New Jersey USA Nuclear Science and Engineering Department Massachusetts Institute of Technology Cambridge Massachusetts USA

Uranium enrichment by centrifugation is the basis for the quick and efficient production of nuclear fuel-or nuclear weapons.

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Density-dependent enhancement of methane oxidation activity and growth of Methylocystis sp. by a non-methanotrophic bacterium Sphingopyxis sp.

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Biotechnology Reports 2014年第1期4卷 128-133页

作者： Jeong, So-Yeon Cho, Kyung-Suk Kim, Tae Gwan Global Top 5 Program Department of Environmental Science and Engineering Ewha Womans University 52 Ewhayeodae-gil Seodaemun-gu Seoul 120-750 South Korea Department of Ecosystem Function Bureau of Basic Ecological Research National Institute of Ecology 1210 Geumgang-ro Maseo-myeon Seocheon-gun Chungcheongnam-do 325-813 South Korea

Methanotrophs are a biological resource as they degrade the greenhouse gas methane and various organic contaminants. Several non-methanotrophic bacteria have shown potential to stimulate growth of methanotrophs when co-cultured, and however, the ecology is largely unknown. Effects of Sphingopyxis sp. NM1 on methanotrophic activity and growth of Methylocystis sp. M6 were investigated in this study. M6 and NM1 were mixed at mixing ratios of 9:1,1:1, and 1:9 (v/v), using cell suspensions of 7.5 7times;10¹¹ cells L¹. Methane oxidation of M6 was monitored, and M6 population was estimated using fluorescence in situ hybridization (FISH). Real-time PCR was applied to quantify rRNA and expression of transcripts for three enzymes involved in the methane oxidation pathway. NM1 had a positive effect on M6 growth at a 1:9 ratio (p<0.05), while no significant effects were observed at 9:1 and 1:1 ratios. NM1 enhanced the methane oxidation 1.34-fold at the 1:9 ratio. NM1 increased the population density and relative rRNA level of M6 by 2.4-fold and 5.4-fold at the 1:9 ratio, indicating that NM1 stimulated the population growth of M6. NM1 increased the relative transcriptional expression of all mRNA targets only at the 1:9 ratio. These results demonstrated that NM1 enhanced the methanotrophic activity and growth of M6, which was dependent on the proportion of NM1 present in the culture. This stimulation can be used as management and enhancement strategies for methanotrophic biotechnological processes. © 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/3.0/).

关键词： Methanotrophic activity Methylocystis Microbial interaction Population growth Sphingopyxis

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Heating value prediction for combustible fraction of municipal solid waste in Semarang using backpropagation neural network

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AIP Conference Proceedings 2015年第1期1699卷

作者： Ainie Khuriati Wahyu Setiabudi Muhammad Nur Istadi Istadi 1Doctorate Program of Environmental Science Diponegoro University Semarang 50241 Indonesia 2Department of Physics Diponegoro University Semarang 50275 Indonesia 3Department of Chemical Engineering Diponegoro University 50275 Semarang Indonesia

Backpropgation neural network was trained to predict of combustible fraction heating value of MSW from the physical composition. Waste-to-Energy (WtE) is a viable option for municipal solid waste (MSW) management. The influence of the heating value of municipal solid waste (MSW) is very important on the implementation of WtE systems. As MSW is heterogeneous material, direct heating value measurements are often not feasible. In this study an empirical model was developed to describe the heating value of the combustible fraction of municipal solid waste as a function of its physical composition of MSW using backpropagation neural network. Sampling process was carried out at Jatibarang landfill. The weight of each sorting sample taken from each discharged MSW vehicle load is 100 kg. The MSW physical components were grouped into paper wastes, absorbent hygiene product waste, styrofoam waste, HD plastic waste, plastic waste, rubber waste, textile waste, wood waste, yard wastes, kitchen waste, coco waste, and miscellaneous combustible waste. Network was trained by 24 datasets with 1200, 769, and 210 epochs. The results of this analysis showed that the correlation from the physical composition is better than multiple regression method .

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Food Waste to Bioenergy via Anaerobic Processes

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Energy Procedia 2014年 61卷 307-312页

作者： Thi Ngoc Bao Dung Biswarup Sen Chin-Chao Chen Gopalakrishnan Kumar Chiu-Yue Lin Department of Environmental Engineering and Science Feng Chia University Taichung 40724 Taiwan Green Energy Development Centre Feng Chia University Taichung 40724 Taiwan Master's Program of Green Energy Science and Technology Feng Chia University Taichung 40724 Taiwan Department of Landscape Architecture ChungChou University of Science and Technology Changhua County 510 Taiwan Department of Environmental Engineering Daegu University Gyeongsan Gyeongbuk 712-714 Republic of Korea

The value of food waste has not been paid much attention due to the lack of application policies and suitable management laws. In this paper the food waste management in the prospect of bioenergy production and the future directions has been reviewed. The official data in relation to food waste generation and current status of food waste management were collected from 21 countries. The bioenergy production potential of food wastes from these countries has been calculated by applying five different innovative methods of bioenergy production. The bioenergy potential based on anaerobic digestion for bio-methane (Method I), two-phase process for bio-hythane (Method II), three-stage fermentation for bio-methane (Method III), two-step process of dark-fermentation and photo-fermentation for bio-hydrogen (Method IV), and three-stage fermentation for bio-hythane (Method V) were about 379,796 KWh/year, 102,137 KWh/year, 76,743 KWh/year, 833,555 KWh/year and 141,739 KWh/year, respectively. By evaluating the bioenergy potential of these anaerobic processes, the appropriate strategy and related management policy were suggested. Besides, this study provides a hierarchical vision for food waste management which would lead towards the sustainable development.

关键词： Bioenergy Bio-hythane Bio-hydrogen Bio-methane Anaerobic process Food waste management

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Model Predictions for New Iron Ore Sintering Process Technology Based on Biomass and Gaseous Fuels

Model Predictions for New Iron Ore Sintering Process Technol...

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2014 3rd International Conference on Micro Nano Devices,Structure and Computing Systems(MNDSCS 2014)

作者： Jose Adilson de Castro Federal Fluminense University-Graduate Program on Mechanical Engineering-Volta Redonda Environmental Metallurgy Laboratory (IML) Graduate Institute of Ferrous Technology (GIFT)-Pohang University of Science and Technology

In this paper a new technology for a compact iron ore sintering machine is *** compact sintering process is based on the massive injection of gaseous fuels and the solid fuel is only agglomerated fine charcoal obtained by *** solid fuel used in this study is obtained by agglomeration of fine charcoal produced from elephant glass which has very short period for production and CO capture（less than 6 months in tropical climate）.To overcome the lower heat supply into the combustion front of the sintering process the simultaneous injection of oxygen and gaseous fuel is *** proposed methodology is to combine the solid fuel（agglomerated fines charcoal） and steelworks gases in a compact machine to enhance heat and mass transfer with high productivity（about 5 times the conventional large machine）.A multiphase mathematical model based on transport equations of momentum,energy and chemical species coupled with chemical reaction rates and phase transformations is used to analyze the inner process parameters.A base case representing a possible actual industrial operation of the sintering machine is used in order to compare different scenarios of practicable operations which represents advanced operations *** model was used to predict six cases of combined operation with biomass and fuel gas utilization:a)Scenario 01 and 02:Wind boxes inflow from N01-N10 of rich mixture of natural gas（NG） +Air+O,b) Scenario 03 and 04:Wind boxes inflow from N01-N10 of rich mixture of coke oven gas（COG）+Air +O,c) Scenario 05 and 06:Wind boxes inflow from N01-N10 of mixture of COG+BFG+Air+*** model predictions indicated that for all cases,the sintering zone is enlarged and the solid fuel consumption is *** order to maximize the steelworks gas utilization it is recommended the use of mixture of COG and BFG with optimum inner temperature distribution within a compact sintering machine（in this study was the scenario 05）,which enhance the productivity keep

关键词： Sintering process Multiphase modeling Gaseous fuels Biomass

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Investigation of stability of a tunnel in a deep coal mine in China

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International Journal of Mining science and Technology 2013年第4期23卷 567-577页

作者： Kulatilake P.H.S.W. Wu Qiong Yu Zhengxing Jiang Fuxing Geological Engineering Program Department of Materials Science & Engineering University of Arizona Faculty of Engineering China University of Geosciences China Academy of Safety Science and Technology School of Civil and Environmental Engineering University of Science and Technology Beijing

Stability level of tunnels that exist in an underground mine has a great influence on the safety,production and economic performance of *** of stability for soft-rock tunnels is an important task for deep coal mines located in high in situ stress *** the available information on stratigraphy,geological structures,in situ stress measurements and geo-mechanical properties of intact rock and discontinuity interfaces,a three-dimensional numerical model was built by using 3DEC software to simulate the stress conditions around a tunnel located under high in situ stress conditions in a coal rock mass in *** were conducted for several tunnel shapes and rock support *** obtained for the distribution of failure zones,and stress and displacement felds around the tunnel were compared to select the best tunnel shape and support pattern to achieve the optimum stability conditions.

关键词： Coal mine Tunnel stability High in situ stress Numerical modeling 3DEC

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随机扩增多态性DNA技术研究发现二氧化钛纳米颗粒对西葫芦具有基因毒性(英文)

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Journal of Zhejiang University-science A(Applied Physics & engineering) 2014年第8期15卷 618-623页

作者： Fabiola MORENO-OLIVAS Vincent U.GANT Jr. Kyle L.JOHNSON Jose R.PERALTA-VIDEA Jorge L.GARDEA-TORRESDEY Depertment of Chemistry The University of Texas at El Paso El Paso TX 79968 USA University of California Center for Environmental Implications of Nanotechnology (UC CEIN) The University of Texas at El Paso El Paso TX 79968 USA Department of Biological Sciences and Border Biomedical Research Center The University of Texas at El Paso El Paso TX 79968 USA Environmental Science and Engineering PhD Program The University of Texas at El Paso El Paso TX 79968 USA

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具... 详细信息

研究目的:二氧化钛(TiO2)纳米颗粒已经广泛应用于化妆品、防晒霜、涂料和牙膏等。这些纳米颗粒性质非常稳定,能在废水和生物固体中转移和分散。现有研究表明,TiO2纳米颗粒对动物正常生理活动具有毒性等负面作用。但是,它们对植物是否具有毒性特别是是否会产生植物基因毒性至今尚不清楚。因此,本文使用随机扩增多态性DNA技术研究TiO2纳米颗粒是否对西葫芦具有基因毒性,为TiO2纳米颗粒排放进入环境后的潜在植物毒性风险评价提供依据。创新要点:首次发现了TiO2纳米颗粒对西葫芦具有基因毒性。重要结论:采用随机扩增多态性DNA技术,发现TiO2纳米颗粒污染处理的西葫芦样品与未处理样品的基因组DNA图谱相比,不仅在谱带强度有明显差异,而且存在谱带消失和新谱带产生现象,表明TiO2纳米颗粒对西葫芦具有基因毒性。

关键词：随机扩增多态性DNA技术 TiO2 纳米颗粒基因组DNA 西葫芦毒性

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