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Artificial intelligence in cancer target identification and drug discovery

Signal Transduction and Targeted Therapy 2022年第6期7卷 1951-1974页

作者： Yujie You Xin Lai Yi Pan Huiru Zheng Julio Vera Suran Liu Senyi Deng Le Zhang College of Computer Science Sichuan UniversityChengdu 610065China Laboratory of Systems Tumor Immunology Friedrich-Alexander-Universität Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenErlangen 91052Germany Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesRoom D5131068 Xueyuan AvenueShenzhen University TownShenzhen 518055China School of Computing Ulster UniversityBelfast BT151EDUK Institute of Thoracic Oncology Department of Thoracic SurgeryWest China HospitalSichuan UniversityChengdu 610065China Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as ***,we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover ***,we describe the scope of artificial intelligence biology analysis for novel anticancer target ***,we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence ***,we showcase the applications of artificial intelligence approaches in cancer target identification and drug *** together,the artificial intelligence models have provided us with a quantitative framework to study the relationship between network characteristics and cancer,thereby leading to the identification of potential anticancer targets and the discovery of novel drug candidates.

关键词： drugs cancer drug

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MR2CPPIS: Accurate prediction of protein–protein interaction sites based on multi-scale Res2Net with coordinate attention mechanism

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computers in Biology and Medicine 2024年 176卷 108543-108543页

作者： Gong, Yinyin Li, Rui Liu, Yan Wang, Jilong Cao, Buwen Fu, Xiangzheng Li, Renfa Chen, Danny Z. College of Computer Science and Electronic Engineering Hunan University Changsha410082 China Hunan Engineering Research Center of Advanced Embedded Computing and Intelligent Medical Systems Hunan University Changsha410082 China Peng Cheng Laboratory Shenzhen518066 China College of Information and Electronic Engineering Hunan City University Yiyang413002 China Department of Computer Science and Engineering University of Notre Dame Notre DameIN46556 United States

Proteins play a vital role in various biological processes and achieve their functions through protein–protein interactions (PPIs). Thus, accurate identification of PPI sites is essential. Traditional biological methods for identifying PPIs are costly, labor-intensive, and time-consuming. The development of computational prediction methods for PPI sites offers promising alternatives. Most known deep learning (DL) methods employ layer-wise multi-scale CNNs to extract features from protein sequences. But, these methods usually neglect the spatial positions and hierarchical information embedded within protein sequences, which are actually crucial for PPI site prediction. In this paper, we propose MR2CPPIS, a novel sequence-based DL model that utilizes the multi-scale Res2Net with coordinate attention mechanism to exploit multi-scale features and enhance PPI site prediction capability. We leverage the multi-scale Res2Net to expand the receptive field for each network layer, thus capturing multi-scale information of protein sequences at a granular level. To further explore the local contextual features of each target residue, we employ a coordinate attention block to characterize the precise spatial position information, enabling the network to effectively extract long-range dependencies. We evaluate our MR2CPPIS on three public benchmark datasets (Dset 72, Dset 186, and PDBset 164), achieving state-of-the-art performance. The source codes are available at https://***/YyinGong/MR2CPPIS. © 2024 Elsevier Ltd

关键词： Forecasting

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Uncertainty Quantification and Quality Control for Heatmap-based Landmark Detection Models

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IEEE Transactions on Medical Imaging 2025年

作者： Feng, Yong Yang, Jinzhu Tang, Lingzhi Sun, Song Wang, Yonghuai Northeastern University Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Shenyang China Northeastern University School of Computer Science and Engineering Shenyang China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Shenyang China The First Hospital of China Medical University Department of Cardiovascular Ultrasound Shenyang China

Uncertainty quantification is a vital aspect of explainable artificial intelligence that fosters clinician trust in medical applications and facilitates timely interventions, leading to safer and more reliable outcomes. Although deep learning models have reached clinically acceptable accuracy in anatomical landmark detection, their predictions remain susceptible to contextual noise due to the small size of the target structures, making uncertainty quantification more challenging than in classification and segmentation tasks. This paper presents an end-to-end uncertainty quantification method tailored for heatmapbased anatomical landmark detection models, designed to improve both interpretability and controllability in clinical applications. Leveraging Dempster-Shafer Theory and Subjective Logic Theory, we implement probability assignment and uncertainty quantification through a single forward pass to ensure computational efficiency. We introduce an evidence map that captures the strength of landmark evidence, alongside an uncertainty map that calibrates predicted probabilities within the Subjective Logic framework. The interaction between these two components, facilitated by a cross-attention mechanism, further improves landmark detection accuracy and enhances the effectiveness of uncertainty quantification. Experimental results demonstrate that the proposed method maintains detection accuracy, even in noisy environments, while outperforming state-of-the-art methods in terms of uncertainty quantification and quality control. Furthermore, the model effectively identifies out-of-distribution data solely through calibrated probabilities when encountering inconsistencies in multi-center data and novel data, underscoring its potential for clinical applications. © 1982-2012 IEEE.

关键词： Model predictive control

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Reversible Data Hiding With Secret Encrypted Image Sharing and Adaptive Coding

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IEEE Internet of Things Journal 2025年

作者： Fang, Guangtian Wang, Feng Zhao, Chenbin Qin, Chuan Chang, Ching-Chun Chang, Chin-Chen Fujian University of Technology College of Computer Science and Mathematics Fuzhou350118 China Fujian University of Technology College of Computer Science and Mathematics Key Laboratory of Big Data Mining and Applications Fuzhou350118 China Monash University Faculty of IT Department of Software Systems and Cybersecurity VIC3800 Australia Ministry of Education School of Cyber Science and Engineering Key Laboratory of Aerospace Information Security and Trusted Computing Wuhan430072 China University of Shanghai for Science and Technology School of Optical-Electrical and Computer Engineering Shanghai200093 China Feng Chia University Information and Communication Security Research Center Taichuang 40724 Taiwan Feng Chia University Department of Information Engineering and Computer Science Taichung40724 Taiwan

To ensure the security of image information and facilitate efficient management in the cloud, the utilization of reversible data hiding in encrypted images (RDHEI) has emerged as pivotal. However, most existing RDHEI schemes suffer from lower security and limited embedding capacity. To tackle these challenges, we propose a reversible data hiding with secret encrypted image sharing and adaptive coding scheme. Specifically, in the encryption phase, we introduce an improved secret sharing (SS) encryption method based on the chinese remainder theorem for polynomials (CRTP). This method not only improves the security of encrypted images but also vacates a larger room for embedding. In the embedding phase, we introduce an adaptive coding embedding approach using XOR preservation (XORP) and huffman coding, which provides high embedding capacity. Experimental results and security analysis demonstrate that our proposed encryption method achieves optimal values in security indicators for encrypted images, such as information entropy, histograms, NPCR and UACI. The proposed embedding method is superior to some state-of-the-art schemes in terms of embedding capacity. Furthermore, in datasets BOSSBase and BOWS2, the average embedding rates of the proposed embedding approach can reach 2.1745 bpp and 2.0656 bpp, respectively. © 2025 IEEE.

关键词： adaptive coding chinese remainder theorem for polynomials encrypted images Reversible data hiding secret sharing

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A Survey of Integrating Generative Artificial Intelligence and 6G Mobile Services: Architectures, Solutions, Technologies and Outlooks

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IEEE Transactions on Cognitive Communications and Networking 2025年第3期11卷 1334-1356页

作者： Liu, Yi-Jing Du, Hongyang Xu, Xinyi Zhang, Ruichen Feng, Gang Cao, Bin Niyato, Dusit Kim, Dong In Jamalipour, Abbas Letaief, Khaled B. Tafazolli, Rahim University of Electronic Science and Technology of China National Key Lab on Wireless Communications Chengdu China University of Hong Kong Department of Electrical and Electronic Engineering Pok Fu Lam Hong Kong Nanyang Technological University College of Computing and Data Science Singapore Singapore Beijing University of Posts and Telecommunications State Key Laboratory of Networking and Switching Technology Beijing China Sungkyunkwan University Department of Electrical and Computer Engineering Suwon Korea Republic of University of Sydney School of Electrical and Computer Engineering Sydney Australia Hong Kong University of Science and Technology Department of Electronic and Computer Engineering Hong Kong Hong Kong University of Surrey Institute for Communication Systems School of Computer Science and Electronic Engineering United Kingdom

Generative artificial intelligence (GenAI) is rapidly driving a new phase of artificial intelligence revolution, marked by various applications such as ChatGPT, Sora and DeepSeek. With powerful capabilities in content generation, personalization and user interaction, GenAI can drive significant enhancements in various mobile services to satisfy individual user preferences. Meanwhile, mobile services offer substantial support for accessibility, functionality and intelligence of GenAI applications. However, current research on integrating GenAI and mobile services remains nascent, lacking necessary theoretical and technical support. In this survey, we break down a new vision to guide research on integrating GenAI and mobile services, aiming to improve 6G intelligence levels and enable 6G mobile networks to support the integration of GenAI and mobile services effectively. We begin by examining the necessity of integrating GenAI with 6G mobile services and exploring potential learning architectures of GenAI models within mobile networks. Next, we analyze potential solutions from two perspectives: how 6G mobile networks empower GenAI and how GenAI enables mobile services. We subsequently explore a promising use case, along with essential features and techniques, to facilitate the integration of GenAI and mobile services. Finally, we discuss future research directions, aiming at realizing intelligent 6G networks. © 2015 IEEE.

关键词： Generative adversarial networks

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FireXnet: an explainable AI-based tailored deep learning model for wildfire detection on resource-constrained devices

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Fire Ecology 2023年第1期19卷 1-19页

作者： Ahmad, Khubab Khan, Muhammad Shahbaz Ahmed, Fawad Driss, Maha Boulila, Wadii Alazeb, Abdulwahab Alsulami, Mohammad Alshehri, Mohammed S. Ghadi, Yazeed Yasin Ahmad, Jawad Faculty of Engineering and Technology Multimedia University Melaka Malaysia School of Computing Engineering and the Built Environment Edinburgh Napier University Edinburgh UK Department of Cyber Security Pakistan Navy Engineering College NUST Karachi Pakistan Robotics and Internet of Things Laboratory Prince Sultan University Riyadh Saudi Arabia RIADI Laboratory National School of Computer Sciences University of Manouba Manouba Tunisia Department of Computer Science College of Computer Science and Information Systems Najran University Najran Saudi Arabia Department of Software Engineering Computer Science Al Ain University Abu Dhabi United Arab Emirates

Forests cover nearly one-third of the Earth’s land and are some of our most biodiverse ecosystems. Due to climate change, these essential habitats are endangered by increasing wildfires. Wildfires are not just a risk to the environment, but they also pose public health risks. Given these issues, there is an indispensable need for efficient and early detection methods. Conventional detection approaches fall short due to spatial limitations and manual feature engineering, which calls for the exploration and development of data-driven deep learning solutions. This paper, in this regard, proposes 'FireXnet', a tailored deep learning model designed for improved efficiency and accuracy in wildfire detection. FireXnet is tailored to have a lightweight architecture that exhibits high accuracy with significantly less training and testing time. It contains considerably reduced trainable and non-trainable parameters, which makes it suitable for resource-constrained devices. To make the FireXnet model visually explainable and trustable, a powerful explainable artificial intelligence (AI) tool, SHAP (SHapley Additive exPlanations) has been incorporated. It interprets FireXnet’s decisions by computing the contribution of each feature to the prediction. Furthermore, the performance of FireXnet is compared against five pre-trained models — VGG16, InceptionResNetV2, InceptionV3, DenseNet201, and MobileNetV2 — to benchmark its efficiency. For a fair comparison, transfer learning and fine-tuning have been applied to the aforementioned models to retrain the models on our dataset. The test accuracy of the proposed FireXnet model is 98.42%, which is greater than all other models used for comparison. Furthermore, results of reliability parameters confirm the model’s reliability, i.e., a confidence interval of [0.97, 1.00] validates the certainty of the proposed model’s estimates and a Cohen’s kappa coefficient of 0.98 proves that decisions of FireXnet are in considerable accordance with t

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Efficient Hybrid Multi-Population Genetic Algorithm for Multi-UAV Task Assignment in Consumer Electronics Applications

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IEEE Transactions on Consumer Electronics 2025年

作者： Bai, Xiaoshan Jiang, Haoyu Li, Chao Ullah, Inam Dabel, Maryam M. Al Bashir, Ali Kashif Wu, Zongze Sam, Shuzhi Shenzhen University College of Mechatronics and Control Engineering National Engineering Laboratory for Big Data System Computing Technology Shenzhen518060 China Shenzhen University College of Mechatronics and Control Engineering Shenzhen518060 China Shenzhen University Shenzhen City Joint Laboratory of Autonomous Unmanned Systems and Intelligent Manipulation Shenzhen518060 China Tashkent State University of Economics Department of Artificial Intelligence Tashkent100066 Uzbekistan University of Hafr Al Batin Department of Computer Science and Engineering College of Computer Science and Engineering Saudi Arabia Manchester Metropolitan University Manchester United Kingdom Shenzhen518060 China National University of Singapore Department of Electrical and Computer Engineering Singapore117576 Singapore

In recent years, as people’s living standards have improved and consumption concepts have been transformed, the demand for purchasing consumer electronics online has continued to grow, further stimulating the development of the logistics industry. Consequently, how to deliver consumer electronics to households at minimal cost has become a crucial factor that limits the development of the consumer technology industry. To tackle this problem, this paper studies the task assignment problem for multiple initially dispersed UAVs to deliver products to target locations while minimizing their total operation time. Each UAV can continuously provide delivery services to multiple target locations within its limited loading capacity and operation time. To solve this problem, we propose several hybrid multipopulation genetic algorithms. First, a novel crossover operator for the genetic algorithms is designed, through which a single parent chromosome can generate offspring individually. Second, two mutation mechanisms are performed to increase gene diversity. Third, multiple local search strategies are employed to enhance the populations’ fitness during each iteration of evolution. An improved 2-opt local search strategy is applied to optimize individual chromosomes when their similarity with the current best chromosome falls below a prescribed threshold. Alternatively, local search strategies are utilized for 1-opt, 2h-opt and interchange processes. Combining local search strategies, genetic operators, and the multi-population mechanism leads to several hybrid multi-population genetic algorithms. Numerical simulations and experimental tests demonstrate that the hybrid multi-population genetic algorithm, integrated with the improved 2-opt and 1-opt local search strategies, exhibits superior performance among the designed hybrid genetic algorithms, the minimum marginal cost algorithm (MMA), and the existing popular Co-evolutionary Multi-population Genetic Algorithm (CMGA). In exp

关键词： Genetic algorithms

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Data engineering and AI-Powered Skin Cancer Identification for Healthcare Applications

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Procedia computer science 2024年 246卷 179-188页

作者： Imran Ahmed Misbah Ahmad Abdellah Chehri Gwanggil Jeon School of Computing and Information Science Anglia Ruskin University Cambridge UK Animal and Agriculture Department Hartpury University Gloucester UK Centre for Machine Vision Bristol Robotics Laboratory University of the West of England Bristol UK Department of Mathematics and Computer Science at the Royal Military College of Canada (RMC) Canada Department of Embedded Systems Engineering Incheon National University Incheon Korea

Skin cancer diagnosis, a critical task in the medical domain, can be revolutionized through the application of advanced deep-learning techniques. This work investigates the efficacy of Convolutional Neural Networks (CNNs) in the automated classification of skin cancer. The process begins with a comprehensive explanation of key CNN layers: Conv2D, MaxPool2D, Dropout, and Dense. The Conv2D layers employ learnable filters that transform localized image segments, while MaxPool2D contributes to downsampling, effectively reducing computational cost and overfitting risk. Integrating these layers enables the network to capture local and global characteristics, which is crucial for accurate classification. Adding Dropout layers enhances generalization and mitigates overfitting by introducing randomness during training. ReLU activation functions infuse non-linearity, and the Flatten layer facilitates the transition to fully connected layers. The proposed CNN architecture is meticulously designed considering filter counts, kernel sizes, and pooling dimensions. The trained model demonstrates promising performance by utilizing the HAM10000 dataset, encompassing diverse skin lesion images across seven classes. The CNN model’s parameters and architecture are systematically presented, offering insights into its design rationale. The model undergoes optimization with the Adam optimizer and annealing techniques to facilitate convergence. The model’s effectiveness is evaluated on validation and test datasets, demonstrating an accuracy of 78.55% and 76.49%, respectively, for skin cancer classification. Data augmentation strategies are introduced to enhance model generalization further. The results underscore CNN’s potential as a robust tool for automating skin cancer diagnosis, aligning with the broader trend of leveraging deep learning for medical image analysis

关键词： Image Processing Medical Imaging Deep learning Skin Cancer Data Analytics

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Co‑packaged optics(CPO):status,challenges,and solutions

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Frontiers of Optoelectronics 2023年第1期16卷 1-40页

作者： Min Tan Jiang Xu Siyang Liu Junbo Feng Hua Zhang Chaonan Yao Shixi Chen Hangyu Guo Gengshi Han Zhanhao Wen Bao Chen Yu He Xuqiang Zheng Da Ming Yaowen Tu Qiang Fu Nan Qi Dan Li Li Geng Song Wen Fenghe Yang Huimin He Fengman Liu Haiyun Xue Yuhang Wang Ciyuan Qiu Guangcan Mi Yanbo Li Tianhai Chang Mingche Lai Luo Zhang Qinfen Hao Mengyuan Qin School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina HKUST Fok Ying Tung Research Institute Guangzhou 511462China The Hong Kong University of Science and Technology(Guangzhou) Guangzhou 511462China Chongqing United Micro-Electronics Center(CUMEC) Chongqing 401332China Hisense Broadband Multimedia Technologies Co. Ltd.Qingdao 266000China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Microelectronics Xi’an Jiaotong UniversityXi’an 710049China Zhangjiang Laboratory Shanghai 201210China The State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China Huawei Technologies Co. Ltd.Shenzhen 440307China College of Computer National University of Defense TechnologyChangsha 410073China Institute of Computing Technology Chinese Academy of SciencesBeijing 100086China

Due to the rise of 5G,IoT,AI,and high-performance computing applications,datacenter trafc has grown at a compound annual growth rate of nearly 30%.Furthermore,nearly three-fourths of the datacenter trafc resides within *** conventional pluggable optics increases at a much slower rate than that of datacenter *** gap between application requirements and the capability of conventional pluggable optics keeps increasing,a trend that is *** optics(CPO)is a disruptive approach to increasing the interconnecting bandwidth density and energy efciency by dramatically shortening the electrical link length through advanced packaging and co-optimization of electronics and *** is widely regarded as a promising solution for future datacenter interconnections,and silicon platform is the most promising platform for large-scale *** international companies(e.g.,Intel,Broadcom and IBM)have heavily investigated in CPO technology,an inter-disciplinary research feld that involves photonic devices,integrated circuits design,packaging,photonic device modeling,electronic-photonic co-simulation,applications,and *** review aims to provide the readers a comprehensive overview of the state-of-the-art progress of CPO in silicon platform,identify the key challenges,and point out the potential solutions,hoping to encourage collaboration between diferent research felds to accelerate the development of CPO technology.

关键词： Co-packaged optics Silicon photonics High-performance computing Advanced packaging External laser Optical power delivery Co-simulation Standardization Transmitter Receiver

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Coordination of networking and computing: toward new information infrastructure and new services mode

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Frontiers of Information Technology & Electronic engineering 2024年第5期25卷 629-632页

作者： Xiaoyun WANG Tao SUN Yong CUI Rajkumar BUYYA Deke GUO Qun HUANG Hassnaa MOUSTAFA Chen TIAN Shangguang WANG China Mobile Communications Corporation Beijing 100032China China Mobile Research Institute Beijing 100053China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China CLOUDS Lab School of Computing and Information SystemsUniversity of MelbourneMelbourneVIC 3010Australia National Key Laboratory of Information Systems Engineering National University of Defense TechnologyChangsha 410073China School of Computer Science Peking UniversityBeijing 100871China Intel Corporation Santa ClaraCA 95054USA State Key Laboratory for Novel Sofiware Technology Nanjing UniversityNanjing 210023China State Key Laboratory of Networking and Switching Technology Bejing University of Posts and TelecommunicationsBeijing 100876China

computing,serving as the cornerstone of information processing,plays a pivotal role in the digital service ***"network"and"computing,"responsible for information transmission and processing respectively,traditionally belong to different stakeholders and have evolved ***,the recent trend toward the coordination and integration of computing and networks has garnered significant attention from both industry and *** such as"computility network"and"computing force network"have emerged,and the International Telecommunication Union-Telecommunication Standardization(ITU-T)has initiated efforts to develop standards for the coordination of networking and computing(CNC),focusing on the architecture and framework.

关键词： computing services network

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