Background:Japanese encephalitis(JE)is a leading cause of childhood viral encephalitis both at global level and in *** is recommended as a key strategy to control *** China most JE cases have been reported in southwes...
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Background:Japanese encephalitis(JE)is a leading cause of childhood viral encephalitis both at global level and in *** is recommended as a key strategy to control *** China most JE cases have been reported in southwest provinces,which include *** this study,we quantify the epidemiological shift of JE in Yunnan Province from 2005 to 2017,covering before and after the introduction of JE vaccination into routine expandedprogram on immunization(EPI)in ***:We used routinely collected data in the case-based JE surveillance system from 2005 through 2017 in *** were reported from hospital and county-level Centers for Disease Control in line with the National JE Surveillance *** data were extracted,analysed and presented in appropriate *** coverage was estimated from actual JE doses administered and new births for each ***:A total 4780 JE cases(3077 laboratory-confirmed,1266 clinical and 437 suspected)were reported in the study *** of JE(per 100000 population)increased from 0.95 in 2005 to 1.69 in *** increase in vaccination coverage,incidence rates decreased steadily from 1.16 in 2009 to 0.17 in ***,seasonality remained similar across the years,peaking in ***(bordering Myanmar and Laos),Dehong(bordering Myanmar),and Zhaotong(an inland prefecture)had the highest incidence rates of 2.3,1.9,and 1.6,respectively.97%of all cases were among local *** vaccination coverage increased(and incidence decreased),proportion of JE cases among children<10 years old decreased from 70%in 2005 to 32%in 2017,while that among adults>20 years old increased from 12 to 48%.There were a large number of JE cases with unknown treatment outcomes,especially in the earlier years of the surveillance ***:The 13-year JE surveillance data in Yunnan Province showed dramatic decrease of total incidence and a shift from children to *** vaccinati
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