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Predicting Transitions from Mild Cognitive Impairment to Dementia within 5-years

Alzheimer's & Dementia 2023年第S18期19卷

作者： Samad Amini Boran Hao Jingmei Yang Cody Karjadi Vijaya B. Kolachalama Rhoda Au Ioannis Paschalidis Division of Systems Engineering Boston University Boston MA USA Department of Electrical & Computer Engineering Boston University Boston MA USA Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston MA USA College of Arts & Sciences Boston University Boston MA USA Boston University School of Medicine Boston MA USA Faculty of Computing & Data Sciences Boston University Boston MA USA The Framingham Heart Study Boston University School of Medicine Boston University School of Public Health Boston MA USA Department of Biomedical Engineering Boston University Boston MA USA

Background Early detection of individuals at high risk of future progression toward dementia is in great need, particularly in the era of emerging treatments for Alzheimer’s disease. Given the easier administration of neuropsychological (NP) tests over invasive and expensive biomarker acquisition, we seek to predict the future cognitive status of an individual based on digital voice recordings of NP exams. Method We utilized automatic speech recognition and natural language processing techniques to create an automated tool that predicts if an individual with mild cognitive impairment (MCI) will develop dementia in a fixed follow-up window (5 years). We characterize the predictive accuracy of this approach using data from the Framingham Heart Study. First, the automated transcription of the digital voice recordings were classified into 8 main NP sub-tests including memory assessment, naming and language skill, verbal fluency, general questions, etc. Using a large language model, only the participants’ sentences were encoded into quantitative data. These data and the participants’ characteristics, such as age, sex, ApoE4 (+/-) genotype, and education were employed to train and test a binary classifier, predicting dementia withing 5 years after a positive MCI diagnosis. We also provide a comparison between our approach and alternative models using demographics and ApoE genotype or the Mini-Mental State Examination (MMSE) score. Result We evaluated the performance of the classification task on the data containing 111 stable MCI and 103 progressive MCI subjects. Our method achieved an average accuracy of 75.5% on the held-out test data while a baseline model using age, sex, education, and ApoE has an average accuracy of 71.8%. The sensitivity and specificity of the proposed method versus the baseline model are 78.2% vs. 81.8% and 72.7% vs. 61.8%, respectively. Our approach also significantly outperforms the model based on the MMSE score by a margin of 14% in accuracy. Co

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A kinetic model with analysis for the oxidation of sugars by permanganate in simple aqueous media with sustainable fractional approach

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Computational Biology and Chemistry 2025年 119卷

作者： Muhammad Farman Aamir Shehzad Faisal Sultan Kottakkaran Sooppy Nisar Mustafa Bayrium Aceng Sambas Faculty of Arts and Sciences Department of Mathematics Near East University Turkey Faculty of Informatics and Computing Universiti Sultan Zainal Abidin Campus Besut 22200 Terengganu Malaysia Research Center of Applied Mathematics Khazar University Baku Azerbaijan Institute of Mathematics Khwaja Fareed University of Engineering and Information Technology Rahim Yar Khan Pakistan Department of Mathematics College of Science and Humanities in Al Kharj Prince Sattam Bin Abdulaziz University Al Kharj 11942 Saudi Arabia Hourani Center for Applied Scientific Research Al-Ahliyya Amman University Amman Jordan Department of Computer Engineering Biruni University 34010 Topkapi Istanbul Turkey Department of Mechanical Engineering Universitas Muhammadiyah Tasikmalaya Tasikmalaya 46196 Indonesia Artificial Intelligence Research Centre for Islamic and Sustainalbility Universiti Sultan Zainal Abidin Gongbadak Terengganu 21300 Terengganu Malaysia

The development of a recycling method for manganese dioxide, a byproduct of reactions, has made permanganate, a persistent oxidant in organic chemistry, more environmentally benign. This makes permanganate developments in technology more cost-effective and less hazardous to the environment. Understanding the rate and mechanisms of chemical reactions is important in a variety of fields, including chemistry and biology. Sugars, as organic substrates, are sensitive to oxidation by the potent oxidant permanganate. We utilized the commonly used oxidants in permanganate oxidation, D-glucose, D-fructose, and D-sucrose. This study investigates the importance of efficient oxidation processes by creating extended fractal fractional models for computer analysis. It looks at possible ways permanganate can be oxidized by analyzing these equations both qualitatively and quantitatively with the Mittag-Leffler kernel, which is not commonly studied. Using advanced fixed-point theory results, the kinetic system’s solutions are analyzed and found to be unique. A Lyapunov function is offered for the proposed kinetic system, which necessitates consideration of the oxidation process kinetics as well as a thorough stability analysis of chemical parameters. In addition, we stabilize the kinetic system utilizing the proposed linear feedback regulate technique for chaos control and system sensitivity analysis. We use the Spectral Quasi Equilibrium Manifold (SQEM) approach, an advanced modeling simplification tool, to study the complex behavior of multi-step reaction processes. A strong numerical technique based on the Newton polynomial is used in computational simulations to examine the influence of the fractal-fractional operator on surface and contour graphs. Graphs with differing fractal and fractional orders have a substantial effect on the correlations of kinetic system compartments at different parameter values. The findings aim to increase perception and process representation in orde

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Constraining inflation with nonminimal derivative coupling with the Parkes Pulsar Timing Array third data release

arXiv

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arXiv 2024年

作者： Han, Chang Chen, Li-Yang Chen, Zu-Cheng Fu, Chengjie Wu, Puxun Yu, Hongwei Bhat, N.D. Ramesh Liu, Xiaojin Di Marco, Valentina Mishra, Saurav Reardon, Daniel J. Russell, Christopher J. Shannon, Ryan M. Zhang, Lei Zhu, Xingjiang Zic, Andrew Department of Physics Synergetic Innovation Center for Quantum Effects and Applications Hunan Normal University Hunan Changsha410081 China Institute of Interdisciplinary Studies Hunan Normal University Hunan Changsha410081 China College of Physics and Engineering Technology Chengdu Normal University Sichuan Chengdu611130 China Department of Physics Anhui Normal University Anhui Wuhu241002 China International Centre for Radio Astronomy Research Curtin University BentleyWA6102 Australia Department of Physics Faculty of Arts and Sciences Beijing Normal University Zhuhai519087 China School of Physics and Astronomy Monash University ClaytonVIC3800 Australia OzGrav: The ARC Center of Excellence for Gravitational Wave Discovery ClaytonVIC3800 Australia Australia Telescope National Facility CSIRO PO Box 76 EppingNSW1710 Australia Centre for Astrophysics and Supercomputing Swinburne University of Technology P.O. Box 218 HawthornVIC3122 Australia OzGrav: The ARC Centre of Excellence for Gravitational Wave Discovery HawthornVIC3122 Australia CSIRO Scientific Computing Australian Technology Park Locked Bag 9013 AlexandriaNSW1435 Australia National Astronomical Observatories Chinese Academy of Sciences A20 Datun Road Chaoyang District Beijing100101 China Institute for Frontier in Astronomy and Astrophysics Beijing Normal University Beijing102206 China

We study an inflation model with nonminimal derivative coupling that features a coupling between the derivative of the inflaton field and the Einstein tensor. This model naturally amplifies curvature perturbations at small scales via gravitationally enhanced friction, a mechanism critical for the formation of primordial black holes and the associated production of potentially detectable scalar-induced gravitational waves. We derive analytical expressions for the primordial power spectrum, enabling efficient exploration of the model parameter space without requiring computationally intensive numerical solutions of the Mukhanov-Sasaki equation. Using the third data release of the Parkes Pulsar Timing Array (PPTA DR3), we constrain the model parameters characterizing the coupling function: c = 3.7+0−035MP, log10 ωL = 7.1+0−063, and log10 σ = −8.3+0−036 at 90% confidence level. Our results demonstrate the growing capability of pulsar timing arrays to probe early Universe physics, complementing traditional cosmic microwave background observations by providing unique constraints on inflationary dynamics at small scales. © 2024, CC BY.

关键词： Gravitational effects

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Optimization of laser-driven quantum beam generation and the applications with artificial intelligence

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Physics of Plasmas 2024年第5期31卷

作者： Kuramitsu, Y. Taguchi, T. Nikaido, F. Minami, T. Hihara, T. Suzuki, S. Oda, K. Kuramoto, K. Yasui, T. Abe, Y. Ibano, K. Takabe, H. Chu, C.M. Wu, K.T. Woon, W.Y. Chen, S.H. Jao, C.S. Chen, Y.C. Liu, Y.L. Morace, A. Yogo, A. Arikawa, Y. Kohri, H. Tokiyasu, A. Kodaira, S. Kusumoto, T. Kanasaki, M. Asai, T. Fukuda, Y. Kondo, K. Kiriyama, H. Hayakawa, T. Tanaka, S.J. Isayama, S. Watamura, N. Suzuki, H. Kumar, H.S. Ohnishi, N. Pikuz, T. Filippov, E. Sakai, K. Yasuhara, R. Nakata, M. Ishikawa, R. Hoshi, T. Mizuta, A. Bolouki, N. Saura, N. Benkadda, S. Koenig, M. Hamaguchi, S. Graduate School of Engineering Osaka University 2-1 Yamadaoka Osaka Suita565-0871 Japan Institute of Laser Engineering Osaka University 2-6 Yamadaoka Osaka Suita565-0871 Japan 8-1-7 Umemidai Kyoto Kizugawa619-0215 Japan Department of Physics National Central University No. 300 Jhongda Rd. Taoyuan Jhongli320 Taiwan Department of Physics National Cheng Kung University Tainan701 Taiwan National Center for High-Performance Computing National Applied Research Laboratories Tainan City711010 Taiwan Institute of Space and Plasma Sciences National Cheng Kung University Tainan701 Taiwan Research Center for Nuclear Physics Osaka University 10-1 Mihogaoka Osaka Ibaraki567-0047 Japan Research Center for Accelerator and Radioisotope Science Tohoku University 1-2-1 Mikamine Taihaku-ku Miyagi Sendai982-0826 Japan Inage Chiba263-8555 Japan Graduate School of Maritime Sciences Kobe University Kobe658-0022 Japan Department of Physical Sciences Aoyama Gakuin University 5-10-1 Fuchinobe Kanagawa Sagamihara252-5258 Japan Department of Advanced Environmental Science and Engineering Kyushu University 6-1 Kasuga-Kohen Fukuoka Kasuga816-8580 Japan Graduate School of Information Science and Technology Osaka University 2-1 Yamadaoka Suita565-0871 Japan Department of Aerospace Engineering Tohoku University 6-6-01 Aramakiazaaoba Aoba-ku Sendai980-8579 Japan Institute for Open and Transdisciplinary Research Initiatives Osaka University 2-1 Yamadaoka Osaka Suita565-0871 Japan Villamayor Salamanca37185 Spain National Institute for Fusion Science 322-6 Oroshicho Gifu Toki509-5292 Japan Faculty of Arts and Sciences Komazawa University 1-23-1 Komazawa Setagaya-ku Tokyo154-8525 Japan Astrophysical Big Bang Laboratory RIKEN Saitama Wako351-0198 Japan Department of Plasma Physics and Technology Faculty of Science Masaryk University Kotlářská 2 Brno611 37 Czech Republic Aix-Marseille Université CNRS PIIM UMR 7345 Marseille France LULI CN

We have investigated space and astrophysical phenomena in nonrelativistic laboratory plasmas with long high-power lasers, such as collisionless shocks and magnetic reconnections, and have been exploring relativistic regimes with intense short pulse lasers, such as energetic ion acceleration using large-area suspended graphene. Increasing the intensity and repetition rate of the intense lasers, we have to handle large amounts of data from the experiments as well as the control parameters of laser beamlines. Artificial intelligence (AI) such as machine learning and neural networks may play essential roles in optimizing the laser and target conditions for efficient laser ion acceleration. Implementing AI into the laser system in mind, as the first step, we are introducing machine learning in ion etch pit analyses detected on plastic nuclear track detectors. Convolutional neural networks allow us to analyze big ion etch pit data with high precision and recall. We introduce one of the applications of laser-driven ion beams using AI to reconstruct vector electric and magnetic fields in laser-produced turbulent plasmas in three dimensions. © 2024 Author(s).

关键词： Ions

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Blended learning and media centers: A bibliometric analysis

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Social sciences and Humanities Open 2024年 10卷

作者： Challco, Geiser Chalco Silva, Wesley Vieira da Setton Gonçalves, Bruno de Almeida Levino, Natallya Bittencourt, Ibsen Mateus Kaczam, Fabíola de Oliveira, Elaine Harada Teixeira Martins, Flavio Pinheiro de Lima Filho, Walter Araujo de Araújo, Ronaldo Ferreira Bittencourt, Ig Ibert Paiva, Ranilson Oscar Araújo Department of Engineering and Technology (DETEC) Federal Rural University of Semi-Árido (UFERSA) RN Pau dos Ferros 59900-000 Brazil Scholarship CNPq Research Productivity (D Level) and Professor Faculty of Economics Administration and Accounting Federal University of Alagoas (UFAL) Maceió 57072-900 Brazil Faculty of Economics Administration and Accounting Federal University of Alagoas (UFAL) Maceió 57072-900 Brazil Leader of the Laboratory of Applied Public Administration (LAPA) of the Public Administration Course Campus Arapirca Federal University of Alagoas Arapiraca 57309-005 Brazil Faculty of Economics Business and Accounting Federal University of Alagoas Maceio 57072-900 Brazil Postgraduate Program in Administration Federal University Santa Maria (UFSM) Building 74C 2nd floor Room 4209 97105-900 Brazil Institute of Computing Federal University of Amazonas Amazonas Manaus Brazil The Bartlett School of Sustainable Construction University College London—UCL London WC1E 6BT United Kingdom Visiting Researcher at Leiden University ou Pesquisador Visitante na Universidade de Leiden Institute of Human Sciences Communication and Arts Federal University of Alagoas Alagoas Maceio 57072-900 Brazil Harvard Graduate School of Education Harvard University Cambridge MA United States Center of Excellence for Social Technologies Federal University of Alagoas Brazil Universidade Federal de Alagoas - Instituto de Computação Brazil

Blended learning can be considered an approach that combines face-to-face and online periods in education through the integration of some technological resources, such as media centers. The present research sought to investigate the panorama of scientific production on blended learning and identify evidence of how media centers are used to support this type of teaching. This is a bibliometric study carried out based on the principles of the Systematic Literature Review (SLR). Although the results indicate an increase in production, a high rate of authors with only one published work was identified, which can be interpreted as an expanding topic. The United States stood out as the country that contributed the most with research and the areas of Computer Science and Education among the fields of research with the highest number of articles. © 2024 The Author(s)

关键词： Blended learning Hybrid education Media centers Systematic review

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Why is the winner the best?

arXiv

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arXiv 2023年

作者： Eisenmann, M. Reinke, A. Weru, V. Tizabi, M.D. Isensee, F. Adler, T.J. Ali, S. Andrearczyk, V. Aubreville, M. Baid, U. Bakas, S. Balu, N. Bano, S. Bernal, J. Bodenstedt, S. Casella, A. Cheplygina, V. Daum, M. de Bruijne, M. Depeursinge, A. Dorent, R. Egger, J. Ellis, D.G. Engelhardt, S. Ganz, M. Ghatwary, N. Girard, G. Godau, P. Gupta, A. Hansen, L. Harada, K. Heinrich, M. Heller, N. Hering, A. Huaulmé, A. Jannin, P. Kavur, A.E. Kodym, O. Kozubek, M. Li, J. Li, H. Ma, J. Martín-Isla, C. Menze, B. Noble, A. Oreiller, V. Padoy, N. Pati, S. Payette, K. Rädsch, T. Rafael-Patiño, J. Bawa, V. Singh Speidel, S. Sudre, C.H. van Wijnen, K. Wagner, M. Wei, D. Yamlahi, A. Yap, M.H. Yuan, C. Zenk, M. Zia, A. Zimmerer, D. Aydogan, D. Bhattarai, B. Bloch, L. Brüngel, R. Cho, J. Choi, C. Dou, Q. Ezhov, I. Friedrich, C.M. Fuller, C. Gaire, R.R. Galdran, A. Faura, Á. García Grammatikopoulou, M. Hong, S. Jahanifar, M. Jang, I. Kadkhodamohammadi, A. Kang, I. Kofler, F. Kondo, S. Kuijf, H. Li, M. Luu, M. Martinčič, T. Morais, P. Naser, M.A. Oliveira, B. Owen, D. Pang, S. Park, J. Park, S. Plotka, S. Puybareau, E. Rajpoot, N. Ryu, K. Saeed, N. Shephard, A. Shi, P. Štepec, D. Subedi, R. Tochon, G. Torres, H.R. Urien, H. Vilaça, J.L. Wahid, K.A. Wang, H. Wang, J. Wang, L. Wang, X. Wiestler, B. Wodzinski, M. Xia, F. Xie, J. Xiong, Z. Yang, S. Yang, Y. Zhao, Z. Maier-Hein, K. Jäger, P.F. Kopp-Schneider, A. Maier-Hein, L. Heidelberg Germany Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Heidelberg Germany Heidelberg Germany School of Computing Faculty of Engineering and Physical Sciences University of Leeds Leeds United Kingdom Institute of Informatics School of Management HES-SO Valais-Wallis University of Applied Sciences and Arts Western Switzerland Sierre Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University Hospital Lausanne Switzerland Technische Hochschule Ingolstadt Ingolstadt Germany University of Pennsylvania PhiladelphiaPA United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Radiology University of Washington SeattleWA United States Department of Computer Science University College London London United Kingdom Universitat Autònoma de Barcelona & Computer Vision Center Barcelona Spain Dresden Dresden Germany Department of Advanced Robotics Istituto Italiano di Tecnologia Italy IT University of Copenhagen Copenhagen Denmark Department of General Visceral and Transplantation Surgery Heidelberg University Hospital Heidelberg Germany Biomedical Imaging Group Rotterdam Department of Radiology and Nuclear Medicine Erasmus MC Rotterdam Netherlands Department of Computer Science University of Copenhagen Copenhagen Denmark Sierre Switzerland Harvard Medical School Brigham and Women’s Hospital BostonMA United States School of Biomedical Engineering and Imaging Sciences King’s College London London United Kingdom Essen Germany University of Nebraska Medical Center OmahaNE United States Department of Internal Medicine III Heidelberg University Hospital Heidelberg Germany Neurobiology Research Unit Copenhagen University Hospital Rigshospitalet C

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and postprocessing (66%). The "typical" lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work. © 2023, CC BY.

关键词： Benchmarking

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Eye tracking: empirical foundations for a minimal reporting guideline

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Behavior research methods 2023年第1期55卷 364-416页

作者： Kenneth Holmqvist Saga Lee Örbom Ignace T C Hooge Diederick C Niehorster Robert G Alexander Richard Andersson Jeroen S Benjamins Pieter Blignaut Anne-Marie Brouwer Lewis L Chuang Kirsten A Dalrymple Denis Drieghe Matt J Dunn Ulrich Ettinger Susann Fiedler Tom Foulsham Jos N van der Geest Dan Witzner Hansen Samuel B Hutton Enkelejda Kasneci Alan Kingstone Paul C Knox Ellen M Kok Helena Lee Joy Yeonjoo Lee Jukka M Leppänen Stephen Macknik Päivi Majaranta Susana Martinez-Conde Antje Nuthmann Marcus Nyström Jacob L Orquin Jorge Otero-Millan Soon Young Park Stanislav Popelka Frank Proudlock Frank Renkewitz Austin Roorda Michael Schulte-Mecklenbeck Bonita Sharif Frederick Shic Mark Shovman Mervyn G Thomas Ward Venrooij Raimondas Zemblys Roy S Hessels Department of Psychology Nicolaus Copernicus University Torun Poland. kenneth.holmqvist@ur.de. Department of Computer Science and Informatics University of the Free State Bloemfontein South Africa. kenneth.holmqvist@ur.de. Department of Psychology Regensburg University Regensburg Germany. kenneth.holmqvist@ur.de. Department of Psychology Regensburg University Regensburg Germany. Experimental Psychology Helmholtz Institute Utrecht University Utrecht The Netherlands. Lund University Humanities Lab and Department of Psychology Lund University Lund Sweden. Department of Ophthalmology SUNY Downstate Health Sciences University Brooklyn NY USA. Tobii Pro AB Danderyd Sweden. Social Health and Organizational Psychology Utrecht University Utrecht The Netherlands. Department of Computer Science and Informatics University of the Free State Bloemfontein South Africa. TNO Soesterberg The Netherlands. Department of Ergonomics Leibniz Institute for Working Environments and Human Factors Dortmund Germany. Institute of Informatics LMU Munich Munich Germany. Institute of Child Development University of Minnesota Minneapolis USA. School of Psychology University of Southampton Southampton UK. School of Optometry and Vision Sciences Cardiff University Cardiff UK. Department of Psychology University of Bonn Bonn Germany. Vienna University of Economics and Business Vienna Austria. Department of Psychology University of Essex Essex UK. Department of Neuroscience Erasmus MC Rotterdam The Netherlands. Machine Learning Group Department of Computer Science IT University of Copenhagen Copenhagen Denmark. SR Research Ltd Ottawa Canada. Human-Computer Interaction University of Tübingen Tübingen Germany. University of British Columbia Columbia Canada. Department of Eye and Vision Science Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK. Department of Education and Pedagogy Division Education Faculty of Social and Behavioral Sciences Ut

In this paper, we present a review of how the various aspects of any study using an eye tracker (such as the instrument, methodology, environment, participant, etc.) affect the quality of the recorded eye-tracking data and the obtained eye-movement and gaze measures. We take this review to represent the empirical foundation for reporting guidelines of any study involving an eye tracker. We compare this empirical foundation to five existing reporting guidelines and to a database of 207 published eye-tracking studies. We find that reporting guidelines vary substantially and do not match with actual reporting practices. We end by deriving a minimal, flexible reporting guideline based on empirical research (Section "An empirically based minimal reporting guideline").

关键词： Data quality Eye movements Eye tracking Replicability Reporting guidelines Reporting practices Reporting standards Reproducibility

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Music, computing, and Health: A Roadmap for the Current and Future Roles of Music Technology for Health Care and Well-Being

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Music and Science 2021年 4卷

作者： Agres, Kat R. Schaefer, Rebecca S. Volk, Anja van Hooren, Susan Holzapfel, Andre Dalla Bella, Simone Müller, Meinard de Witte, Martina Herremans, Dorien Ramirez Melendez, Rafael Neerincx, Mark Ruiz, Sebastian Meredith, David Dimitriadis, Theo Magee, Wendy L. Yong Siew Toh Conservatory of Music National University of Singapore Singapore Social and Cognitive Computing Department Institute of High Performance Computing A*STAR Singapore Institute for Psychology Health Medical Neuropsychology Unit Leiden University Leiden Netherlands Leiden Institute for Brain and Cognition Leiden University Leiden Netherlands Academy of Creative and Performing Arts Leiden University Leiden Netherlands Department of Information and Computing Sciences Utrecht University Utrecht Netherlands Faculty of Health care Department of Arts Therapies Zuyd University of Applied Sciences Heerlen Netherlands KenVaK Research Centre for the Arts Therapies and Psychomotricity Heerlen Netherlands Faculty of Psychology Open University of The Netherlands Heerlen Netherlands Division of Media Technology and Interaction Design KTH Royal Institute of Technology Stockholm Sweden International Laboratory for Brain Music and Sound Research (BRAMS) Outremont QC Canada Department of Psychology University of Montreal Montreal QC Canada Centre for Research on Brain Language and Music (CRBLM) Montreal QC Canada University of Economics and Human Sciences in Warsaw Warsaw Poland International Audio Laboratories Erlangen Friedrich-Alexander Universität Erlangen-Nürnberg Erlangen Germany HAN University of Applied Sciences Department of Arts Therapies and Psychological Studies Nijmegen Netherlands University of Amsterdam Research Institute of Child Development and Education Amsterdam Netherlands Treatment Centre for People with Mild Intellectual Disabilities and Psychiatric and Behavioral Disorders Gennep Netherlands Information Systems Technology and Design Singapore University of Technology and Design Singapore Music and Machine Learning Lab Music Technology Group Universitat Pompeu Fabra Barcelona Spain Faculty of EEMCS Interactive Intelligence Group Delft University of Technology Delft Netherlands Centre for Digital Music School of Electronic Engineerin

The fields of music, health, and technology have seen significant interactions in recent years in developing music technology for health care and well-being. In an effort to strengthen the collaboration between the involved disciplines, the workshop “Music, computing, and Health” was held to discuss best practices and state-of-the-art at the intersection of these areas with researchers from music psychology and neuroscience, music therapy, music information retrieval, music technology, medical technology (medtech), and robotics. Following the discussions at the workshop, this article provides an overview of the different methods of the involved disciplines and their potential contributions to developing music technology for health and well-being. Furthermore, the article summarizes the state of the art in music technology that can be applied in various health scenarios and provides a perspective on challenges and opportunities for developing music technology that (1) supports person-centered care and evidence-based treatments, and (2) contributes to developing standardized, large-scale research on music-based interventions in an interdisciplinary manner. The article provides a resource for those seeking to engage in interdisciplinary research using music-based computational methods to develop technology for health care, and aims to inspire future research directions by evaluating the state of the art with respect to the challenges facing each field. © The Author(s) 2021.

关键词： health care interdisciplinarity MedTech music information retrieval (MIR) music neuroscience Music psychology music technology music therapy well-being

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Why is the Winner the Best?

Why is the Winner the Best?

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Conference on Computer Vision and Pattern Recognition (CVPR)

作者： M. Eisenmann A. Reinke V. Weru M. D. Tizabi F. Isensee T. J. Adler S. Ali V. Andrearczyk M. Aubreville U. Baid S. Bakas N. Balu S. Bano J. Bernal S. Bodenstedt A. Casella V. Cheplygina M. Daum M. De Bruijne A. Depeursinge R. Dorent J. Egger D. G. Ellis S. Engelhardt M. Ganz N. Ghatwary G. Girard P. Godau A. Gupta L. Hansen K. Harada M. Heinrich N. Heller A. Hering A. Huaulmé P. Jannin A. E. Kavur O. Kodym M. Kozubek J. Li H. Li J. Ma C. Martín-Isla B. Menze A. Noble V. Oreiller N. Padoy S. Pati K. Payette T. Rädsch J. Rafael-Patiño V. Singh Bawa S. Speidel C. H. Sudre K. Van Wijnen M. Wagner D. Wei A. Yamlahi M. H. Yap C. Yuan M. Zenk A. Zia D. Zimmerer D. Aydogan B. Bhattarai L. Bloch R. Brüngel J. Cho C. Choi Q. Dou I. Ezhov C. M. Friedrich C. Fuller R. R. Gaire A. Galdran Á. García Faura M. Grammatikopoulou S. Hong M. Jahanifar I. Jang A. Kadkhodamohammadi I. Kang F. Kofler S. Kondo H. Kuijf M. Li M. Luu T. Martinčič P. Morais M. A. Naser B. Oliveira D. Owen S. Pang J. Park S. Park S. Płotka E. Puybareau N. Rajpoot K. Ryu N. Saeed A. Shephard P. Shi D. Štepec R. Subedi G. Tochon H. R. Torres H. Urien J. L. Vilaça K. A. Wahid H. Wang J. Wang L. Wang X. Wang B. Wiestler M. Wodzinski F. Xia J. Xie Z. Xiong S. Yang Y. Yang Z. Zhao K. Maier-Hein P. F. Jäger A. Kopp-Schneider L. Maier-Hein Division of Intelligent Medical Systems German Cancer Research Center (DKFZ) Heidelberg Germany Helmholtz Imaging German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Division of Biostatistics German Cancer Research Center (DKFZ) Heidelberg Germany Division of Medical Image Computing German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Engineering and Physical Sciences School of Computing University of Leeds Leeds UK Institute of Informatics School of Management HES-SO Valais-Wallis University of Applied Sciences and Arts Western Switzerland Sierre Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University Hospital Lausanne Switzerland Technische Hochschule Ingolstadt Ingolstadt Germany Center for Artificial Intelligence and Data Science for Integrated Diagnostics (AI2D) and Center for Biomedical Image Computing and Analytics (CBICA) University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology University of Washington Seattle WA USA Department of Computer Science Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) University College London London UK Universitat Autònoma de Barcelona & Computer Vision Center Barcelona Spain Division of Translational Surgical Oncology National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany Department of Advanced Robotics Istituto Italiano di Tecnologia Italy Department of Electronics Information and Bioengineering Politecnico di Milano Milan Italy IT University of Copenhagen Copenhagen Denmark Department of General Visceral and Transplantation Surgery Heidelberg University Hospital Heidelberg Germany Department of Radiology and Nuc

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The “typical” lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work.

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Association of structural MRI with Braak staging using neural network-based risk scoring

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Alzheimer's & Dementia 2023年第S3期19卷

作者： Matthew I. Miller Shangran Qiu Prajakta S. Joshi Joyce Lee Rhoda Au Vijaya B. Kolachalama Boston University School of Medicine Boston MA USA College of Arts & Sciences Boston University Boston MA USA Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston MA USA Boston University Alzheimer’s Disease Center Boston University Boston MA USA Boston University School of Public Health Boston MA USA Department of Anatomy and Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston MA USA Hariri Institute for Computing and Computational Science & Engineering Boston University Boston MA USA Faculty of Computing & Data Sciences Boston University Boston MA USA Boston University Alzheimer’s Disease Center Boston University Chobanian & Avedisian School of Medicine Boston MA USA Whitaker Cardiovascular Institute Boston University Chobanian & Avedisian School of Medicine Boston MA USA

Background The gold standard of Alzheimer’s disease (AD) diagnosis remains histopathologic examination of neuropathologic changes. However, the dependence on post-mortem microscopic analysis limits the role of pathology in clinical care. Magnetic resonance imaging (MRI) is routinely used to diagnose suspected dementia (DE) due to AD, but correlating neuroimaging to underlying pathologic changes remains challenging. Herein, we report the development of two risk scores derived from convolutional neural network (CNN) processing of MRI scans, which we then validate against Braak staging of neurofibrillary tangles from autopsy reports. Method Using T1-weighted MRIs from the National Alzheimer’s Coordinating Center (NACC), we trained two CNNs (Figure 1) to predict continuous scores for overall cognitive status (“COG” score) and AD probability (“ALZ” score). The COG score, ranging from 0-2, graded a subject’s cognitive status on a spectrum from normal cognition (NC, 0), to mild cognitive impairment (MCI, 1), and DE due to any cause (2). The ALZ score then graded each DE individual’s probability of AD from 0 to 1. These CNNs were then applied to a subset of participants with autopsy reports available within 6 months of MRI. CNN performance was evaluated by area under receiver operating characteristic curve (AUC). Differences in risk scores were assessed by Kruskal-Wallis H testing with post hoc Dunn testing. Result The CNN models for COG and ALZ score estimation were trained on 4,822 NACC participants. Thresholding of COG scores distinguished individuals with DE from those with NC and MCI (AUC = 0.87). ALZ scores distinguished individuals with AD from those with non-AD causes of DE (AUC = 0.77). Among 74 persons with available neuropathology data, COG scores differed significantly among Braak staging groups (p<0.001), increasing from a mean of 0.99±0.36 in Stage 1 to 1.47±0.41 in Stage 6 (p = 0.010). Significant differences in ALZ scores were also observed (p = 0.039) betwe

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