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Fuzzy Predictions Regarding In Vitro Behavior of Cells Line Under Cytostatic Treatment

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Fuzzy Predictions Regarding In Vitro Behavior of Cells Line ...

E-Health and Bioengineering Conference (EHB)

作者： M. Caramihai N. Radu M. Bostan G. Ion A. A. Chirvase M. Constantin M. Doni N. Babeanu Faculty of Automatic Control and Computer Science University POLITEHNICA of Bucharest Romania Biotechnology Department University of Agronomic Sciences and Veterinary Medicine of Bucharest Romania Immunology Center of IVN S. Nicolau Bucharest Romania Biotechnology Department National Institute of Chemistry and PetrochemistryR&D of Bucharest Romania

Behavior evaluation of tumor and normal cell lines, under the influence of mixture between cytostatic and immunomodulatory compounds represents a challenge in oncologic research, because it is expected that in the presence of immunomodulatory compound, the normal cells will be less affected and the tumor cells will be destroyed much more. The aim of this paper is to predict the behavior of tumor cell line (FaDu) and normal cell line (HUVEC) under the influence of cytostatic compound named Cisplatin (CisPt) and under the influence of immunomodulatory compound named Curcumin (CR), in order to obtain an optimal mixing ratio between these two compounds. Based on the results obtained in Lab regarding the response of the two cell lines evolution vs. the treatment with each reagent in the concentration range of (0-100μM/mL), it was tried to model the behavior of the system in presence of these two compounds, using a fuzzy prediction. The obtained results were compared with predictions resulted from fuzzy simulation. Analyzing the numeric values, the best results were obtained in the case of prediction regarding HUVEC behavior with a fuzzy simulation.

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control of discrete-time nonlinear systems via finite-step control Lyapunov functions

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arXiv 2019年

作者： Noroozi, Navid Geiselhart, Roman Grüne, Lars Wirth, Fabian R. Otto-von-Guericke University of Magdeburg Laboratory for Systems Theory and Automatic Control Magdeburg39106 Germany University of Ulm Institute of Measurement Control and Microtechnology Albert-Einstein-Allee 41 Ulm89081 Germany University of Bayreuth Mathematical Institute Universitätsstraße 30 Bayreuth95440 Germany University of Passau Faculty of Computer Science and Mathematics Innstraße 33 Passau94032 Germany

In this work, we establish different control design approaches for discrete-time systems, which build upon the notion of finite-step control Lyapunov functions (fs-CLFs). The design approaches are formulated as optimization problems and solved in a model predictive control (MPC) fashion. In particular, we establish contractive multi-step MPC with and without reoptimization and compare it to classic MPC. The idea behind these approaches is to use the fs-CLF as running cost. These new design approaches are particularly relevant in situations where information exchange between plant and controller cannot be ensured at all time instants. An example shows the different behavior of the proposed controller design approaches. Copyright © 2019, The Authors. All rights reserved.

关键词： Model predictive control

On the influence of small perturbations on the senior Lyapunov exponent of the discrete time-varying system

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IFAC-PapersOnLine 2017年第1期50卷 7462-7466页

作者： Babiarz A. Barabanov E. Czornik A. Niezabitowski M. Vaidzelevich A. Silesian University of Technology Faculty of Automatic Control Electronics and Computer Science Institute of Automatic Control Akademicka 16 Street Gliwice 44-100 Poland Institute of Mathematics of National Academy of Sciences of Belarus Surganova 11 Minsk Belarus

In this paper we consider the influence of parametric perturbations on the maximal Lyapunov exponent of the discrete time-varying system. The main result states that the exact upper movability boundaries of the greate... 详细信息

关键词： central exponent discrete linear time-varying systems Lyapunov exponents rotation method

Considerations regarding security issues impact on systems availability

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arXiv 2018年

作者： Pricop, Emil Mihalache, Sanda Florentina Paraschiv, Nicolae Fattahi, Jaouhar Zamfir, Florin Automatic Control Computers and Electronics Department Petroleum-Gas University of Ploiesti Ploiesti Romania Dept. of Computer Science and Software Engineering Université Laval QC Canada Automatic Control Computers and Electronics Dept. Petroleum-Gas University of Ploiesti Ploiesti Romania

control systems behavior can be analyzed taking into account a large number of parameters: Performances, reliability, availability, security. Each control system presents various security vulnerabilities that affect in lower or higher measure its functioning. In this paper the authors present a method to assess the impact of security issues on the systems availability. A fuzzy model for estimating the availability of the system based on the security level and achieved availability coefficient (depending on MTBF and MTR) is developed and described. The results of the fuzzy inference system (FIS) are presented in the last section of the paper. Copyright © 2018, The Authors. All rights reserved.

关键词： Availability

Constraining Lens Masses in Moderately to Highly Magnified Microlensing Events from Gaia

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arXiv 2025年

作者： Pylypenko, U. Wyrzykowski, L. Mikolajczyk, P.J. Kotysz, K. Zieliński, P. Ihanec, N. Wicker, M. Ratajczak, M. Sitek, M. Howil, K. Jablońska, M. Kaczmarek, Z. Kruszyńska, K. Udalski, A. Damljanovic, G. Stojanovic, M. Jovanovic, M.D. Kvernadze, T. Kvaratskhelia, O. Zejmo, M. Brincat, S.M. Qvam, J.K.T. Güver, T. Bachelet, E. Rybicki, K.A. Garofalo, A. Hardy, L. Zdanavicius, J. Pakstiene, E. Zola, S. Kurowski, S. Reichart, D.E. Davidson, J.W. Burgaz, U. Rivet, J.P. Jelinek, M. Popowicz, A. Esenoglu, H.H. Sonbas, E. Carrasco, J.M. Awiphan, S. Tasuya, O. Godunova, V. Simon, A. Fukui, A. Galdies, C. Bakowska, K. Hofbauer, P. Gurgul, A. Joachimczyk, B. Dominik, M. Tsapras, Y. Street, R.A. Hundertmark, M. Bozza, V. Rota, P. Cassan, A. Wambsganss, J. Figuera Jaimes, R. Astronomical Observatory University of Warsaw Al. Ujazdowskie 4 Warsaw00-478 Poland Astrophysics Division National Centre for Nuclear Research Pasteura 7 Warsaw02-093 Poland Astronomical Institute University of Wroclaw ul. Mikolaja Kopernika 11 Wroclaw51-622 Poland Institute of Astronomy Faculty of Physics Astronomy and Informatics Nicolaus Copernicus University in Toruń Grudziadzka 5 Toruń87-100 Poland Faculty of Mathematics and Computer Science Jagiellonian University Lojasiewicza 6 Kraków30-348 Poland Research School of Astronomy and Astrophysics Australian National University Mount Stromlo Observatory Cotter Road Weston CreekACT2611 Australia Zentrum für Astronomie der Universität Heidelberg Astronomisches Rechen-Institut Mönchhofstr. 12-14 Heidelberg69120 Germany Las Cumbres Observatory Global Telescope Network 6740 Cortona Drive suite 102 GoletaCA93117 United States Astronomical Observatory Volgina 7 Belgrade11060 Serbia E.Kharadze Georgian National Astrophysical Observatory Abastumani0301 Georgia Janusz Gil Institute of Astronomy University of Zielona Góra Lubuska 2 Zielona GóraPL-65-265 Poland Flarestar Obsevatory Fl.5 Ent.B Silver Jubilee Apt George Tayar Street San GwannSGN 3160 Malta Horten Videregaende Skole Strandpromenaden 33 Horten3183 Norway Istanbul University Faculty of Science Department of Astronomy and Spaces Sciences Istanbul34119 Turkey Istanbul University Observatory Research and Application Center Istanbul University Istanbul34119 Turkey Department of Physics Adıyaman University Adıyaman02040 Turkey Department of Physics The George Washington University WashingtonDC20052 United States IPAC Mail Code 100-22 Caltech 1200 E. California Blvd. PasadenaCA91125 United States Department of Particle Physics and Astrophysics Weizmann Institute of Science Rehovot76100 Israel INAF-Osservatorio di Astrofisica e Scienza dello Spazio Via Gobetti 93/3 BolognaI-40129 Italy Department of Physics and Astronom

Context. Microlensing events provide a unique way to detect and measure the masses of isolated, non-luminous objects, particularly dark stellar remnants. Under certain conditions, it is possible to measure the mass of these objects using photometry alone, specifically when a microlensing light curve displays a finite-source (FS) effect. This effect generally occurs in highly magnified light curves, i.e. when the source and the lens are very well aligned. Aims. In this study, we analyse Gaia Alerts and Gaia Data Release 3 datasets, identifying four moderate-to-high-magnification microlensing events without a discernible FS effect. The absence of this effect suggests a large Einstein radius, implying substantial lens masses. Methods. In each event, we constrain the FS effect and therefore establish lower limits for angular Einstein radius and lens mass. Additionally, we use the DarkLensCode software to obtain mass, distance, and brightness distribution for the lens based on the Galactic model. Results. Our analysis established lower mass limits of ∼ 0.2 M☉ for one lens and ∼ 0.3 − 0.5 M☉ for two others. DarkLensCode analysis supports these findings, estimating lens masses in the range of∼ 0.42 − 1.66 M☉ and dark lens probabilities exceeding 60%. These results strongly indicate that the lenses are stellar remnants, such as white dwarfs or neutron stars. Conclusions. While further investigations are required to confirm the nature of these lenses, we demonstrate a straightforward yet effective approach to identifying stellar remnant candidates. © 2025, CC BY.

关键词： White dwarfs

Partial Parallel Encoding and Algorithmic Construction of Non-Binary Structured IRA Codes

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China Communications 2016年第8期13卷 103-116页

作者： Wojciech Sulek Marcin Kucharczyk Faculty of Automatic Control Electronics and Computer Science Silesian University of Technology

The non-binary(NB) Irregular Repeat Accumulate(IRA) codes, as a subclass of NB LDPC codes, potentially have an excellent error-correcting performance. They are also known to provide linear complexity of encoding, but the basic encoding method with the serial rate-1 accumulator significantly limits the encoder throughput. Then the objective of the research presented in this paper is to develop an encoding method pro- viding significantly increased throughput of an NB-IRA encoder altogether with a flexible code construction methods for the structured(S-NB-IRA) codes eligible for the proposed encoding method. For this purpose, we reformulate the classic encoding algorithm to fit into the partial parallel encoder architecture. We propose the S-NB-IRA encoder block diagram and show that its estimated throughput is proportional to the submatrix size of the parity check matrix, which guarantees a wide complexity- throughput tradeoff. Then, in order to facilitate the S-NB-IRA coding systems design, we present a computer search algorithm for the construction of good S-NB-IRA codes. The algorithm aims at optimizing the code graph topology along with selecting an appropriate non-binary elements in the parity check matrix. Numerical results show that the constructed S-NB-IRA codes significantly outperform the binary IRA and S-IRA codes, while their performance is similar to the best unstructured NB-LDPC codes.

关键词： channel coding LDPC codes non-binary LDPC IRA codes LDPC encoding LDPC encoder design

Spray-on glass solution for fabrication silicon solar cell emitter layer

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Spray-on glass solution for fabrication silicon solar cell e...

作者： Filipowski, Wojciech Wrobel, Edyta Drabczyk, Kazimierz Waczynski, Krzysztof Kulesza-Matlak, Grazyna Lipinski, Marek Faculty of Automatic Control Electronics and Computer Science Silesian University of Technology Gliwice Poland Institute of Electronics Silesian University of Technology Gliwice Poland Institute of Metallurgy and Materials Science Polish Academy of Science Krakow Poland

Purpose - The main aim of this study was a preparation development of dopant solution (DS) which can be deposited by a spray-on method and subsequently allows obtaining the no emitter layer with surface resistance in the range of 65-80 ω1. The intention of chosen spray-on method was to gain a cheaper way of dopant source deposition, compared to the commonly used methods, which is of particular importance for the new low-cost production processes. Design/methodology/approach - This paper presents the sequence in producing a spray-on glass solution (DS) with very high concentration of phosphorus, which allows to perform diffusion doping at relatively low temperatures. DS contained deionized water, ethyl alcohol, tetraethoxysilane and othophosphoric acid. Findings - The sequence in producing a DS was performed with respect to enabling the application to silicon wafers by spray-on method. Furthermore, the equations defined density and viscosity of DS in term of storage time were referred to determine the possibility of applying this solution by spray-on method. Besides, the dependence of the emitter surface resistance on the doping (diffusion) time was determined. Accordingly, optimal process conditions were specified. Originality/value - The paper presents a new, so far unpublished composition of DS with very high concentration of phosphorus, which can be applied using a spray-on method. Moreover, original are also investigations respecting some properties of obtained DS relative to storage time. © 2017 Emerald Publishing Limited.

关键词： Silicon solar cells

Tank based unified torque/impedance control for a pneumatically actuated antagonistic robot joint

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Tank based unified torque/impedance control for a pneumatica...

2017 IEEE International Conference on Robotics and Automation, ICRA 2017

作者： Toedtheide, Alexander Shahriari, Erfan Haddadin, Sami Institute of Automatic Control Faculty of Electrical Engineering and Computer Science Institute of Automatic Control Leibniz Universität Hannover Appelstr. 11 HannoverD-30167 Germany

ISBN: (纸本)9781509046331

In this paper the concept of a unified torque/impedance controller is applied to a pneumatically actuated, antagonistic robot joint. The investigated control algorithm consists of a cascaded structure in which the outer torque/impedance controller commands a desired torque to two cylinder-based force controllers. The torque-/impedance controller is equipped with a virtual tank that ensures passivity of the control loops above force level. Additionally, a shaping function provides a continuous transition to impedance control in case of sudden contact loss during a torque control operation. External torques used in the feedback loop for contact force regulation are estimated by a momentum observer. Experimental and simulation results show a maximum deflection of 9.7° over 130 ms in case of contact loss until a resting position is reached. Additionally, step and sinusoidal torque tracking up to 5 Hz was successfully tested at good performance. © 2017 IEEE.

关键词： Torque

A Robust Ensemble Algorithm for Ischemic Stroke Lesion Segmentation: Generalizability and Clinical Utility Beyond the ISLES Challenge

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arXiv 2024年

作者： de la Rosa, Ezequiel Reyes, Mauricio Liew, Sook-Lei Hutton, Alexandre Wiest, Roland Kaesmacher, Johannes Hanning, Uta Hakim, Arsany Zubal, Richard Valenzuela, Waldo Robben, David Sima, Diana M. Anania, Vincenzo Brys, Arne Meakin, James A. Mickan, Anne Broocks, Gabriel Heitkamp, Christian Gao, Shengbo Liang, Kongming Zhang, Ziji Siddiquee, Md Mahfuzur Rahman Myronenko, Andriy Ashtari, Pooya Van Huffel, Sabine Jeong, Hyun-Su Yoon, Chi-Ho Kim, Chulhong Huo, Jiayu Ourselin, Sebastien Sparks, Rachel Clèrigues, Albert Oliver, Arnau Lladó, Xavier Chalcroft, Liam Pappas, Ioannis Bertels, Jeroen Heylen, Ewout Moreau, Juliette Hatami, Nima Frindel, Carole Qayyum, Abdul Mazher, Moona Puig, Domenec Lin, Shao-Chieh Juan, Chun-Jung Hu, Tianxi Boone, Lyndon Goubran, Maged Liu, Yi-Jui Wegener, Susanne Kofler, Florian Ezhov, Ivan Shit, Suprosanna Hernandez Petzsche, Moritz R. Menze, Bjoern Kirschke, Jan S. Wiestler, Benedikt Department of Quantitative Biomedicine University of Zurich Zurich Switzerland Department of Informatics Technical University Munich Germany Icometrix Leuven Belgium ARTORG Center for Biomedical Research University of Bern Bern Switzerland Department of Radiation Oncology University Hospital Bern University of Bern Switzerland University of Bern Bern Switzerland Chan Division of Occupational Science and Occupational Therapy University of Southern California Los AngelesCA United States Stevens Neuroimaging and Informatics Institute Department of Neurology Keck School of Medicine University of Southern California United States University Institute of Diagnostic and Interventional Neuroradiology Inselspital Bern Switzerland University Institute of Diagnostic and Interventional Neuroradiology University Hospital Bern Inselspital University of Bern Bern Switzerland Department of Diagnostic and Interventional neuroradiology University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Medical Imaging Radboud University Medical Center Institute for Health Sciences Nijmegen Netherlands Deepwise AI Lab Beijing China Beijing University of Posts and Telecommunications Bejing China School of Computing and Augmented Intelligence Arizona State University TempeAZ United States NVIDIA Santa ClaraCA United States STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium Pohang Korea Republic of School of Biomedical Engineering & Imaging Sciences King’s College London United Kingdom Institute of Computer Vision and Robotics University of Girona Spain Wellcome Centre for Human Neuroimaging University College London London United Kingdom Laboratory of Neuro Imaging Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California Los Angeles United States KU Leuven Leuven Belgium CREATIS Université Lyon1 CNRS UMR5220 INSERM U1206 INSA-Lyon Villeurbanne696

Diffusion-weighted MRI (DWI) is essential for stroke diagnosis, treatment decisions, and prognosis. However, image and disease variability hinder the development of generalizable AI algorithms with clinical value. We address this gap by presenting a novel ensemble algorithm derived from the 2022 Ischemic Stroke Lesion Segmentation (ISLES) challenge. ISLES’22 provided 400 patient scans with ischemic stroke from various medical centers, facilitating the development of a wide range of cutting-edge segmentation algorithms by the research community. By assessing them against a hidden test set, we identified strengths, weaknesses, and potential biases. Through collaboration with leading teams, we combined top-performing algorithms into an ensemble model that overcomes the limitations of individual solutions. Our ensemble model combines the individual algorithms’ strengths and achieved superior ischemic lesion detection and segmentation accuracy (median Dice score: 0.82, median lesion-wise F1 score: 0.86) on our internal test set compared to individual algorithms. This accuracy generalized well across diverse image and disease variables. Furthermore, the model excelled in extracting clinical biomarkers like lesion types and affected vascular territories. Notably, in a Turing-like test, neuroradiologists consistently preferred the algorithm’s segmentations over manual expert efforts, highlighting increased comprehensiveness and precision. Validation using a real-world external dataset (N=1686) confirmed the model’s generalizability (median Dice score: 0.82, median lesion-wise F1 score: 0.86). The algorithm’s outputs also demonstrated strong correlations with clinical scores (admission NIHSS and 90-day mRS) on par with or exceeding expert-derived results, underlining its clinical relevance. This study offers two key findings. First, we present an ensemble algorithm that detects and segments ischemic stroke lesions on DWI across diverse scenarios on par with expert (neuro)rad

关键词： Diagnosis