检索结果-内蒙古大学图书馆

Supercomputing Frontiers and Innovations 2022年第2期9卷 79-83页

作者： Nilov, Dmitry K. Schmidtke, Michaela Makarov, Vadim A. Svedas, Vytas K. Lomonosov Moscow State University Belozersky Institute of Physicochemical Biology Moscow Russia Lomonosov Moscow State University Research Computing Center Moscow Russia Department of Virology and Antiviral Therapy Jena University Hospital Jena Germany Research Center of Biotechnology of the Russian Academy of Sciences Moscow Russia Lomonosov Moscow State University Faculty of Bioengineering and Bioinformatics Moscow Russia

An anthrapyrazole derivative STK663786 has been identified as a selective ligand of the socalled 430-cavity of influenza virus neuraminidase at virtual screening of a library of low-molecularweight compounds. It is able to form favorable contacts with hydrophobic residues as well as cation-interaction and hydrogen bonds with the polar Arg371 residue. The experimentally determined EC50 values have been found to be 19 and 30 μM for viruses H1N1 and H3N2, respectively. Complementarity of STK663786 to the 430-cavity adjacent to the sialic acid binding subsite in the active center of neuraminidase makes this compound a valuable structural fragment at construction of bifunctional inhibitors of the enzyme. © The Authors 2022. This paper is published with open access at ***

关键词： Viruses

来源：评论

学校读者我要写书评

暂无评论

Fluorescence color diversity of great barrier reef corals

引用

Journal of Innovative Optical Health Sciences 2015年第4期8卷 58-68页

作者： Grigory Lapshin Anya Salih Peter Kolosov Maria Golovkina Yuri Zavorotnyi Tatyana Ivashina Leonid Vinokurov Victor Bagratashvili Alexander Savitsky Physical Biochemistry Lab INBI RASLeninsky Prospekt 33Build.2 Moscow 119071Russia Faculty of Bioengineering and Bioinformatics Moscow State University Leninskiye Gory 1-73 MSU GSP-1 Moscow 119991Russia Confocal Bio-Imaging Facility(CBIF) Division Deputy Vice-Chancellor(Research&Development)University of Western SydneyLocked Bag 1797 Penrith South DCNSW 1797Australia Institute of Higher Nervous Activity and Neurophysiology The Russian Academy of Sciences 5A Butlerova St.Moscow 117485Russia Skobeltsyn Institute of Nuclear Physics Moscow State University 1(2)Leninskie Gory GSP-1Moscow 119991Russia Molecular Microbiology Lab Skryabin Institute of Biochemistry and Physiology of Micro-organisms RAS Prospect Nauki 5 Pushchino142290 Moscow RegionRussia Group of Bioengineering of Reporter Proteins Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Prospekt Nauki 65 Pushchino 142290 Moscow RegionRussia Institute of Laser and Information Technologies RAS 2 Pionerskaya TroitskMoscow 142190Russia

A group of variously colored proteins belonging to the green fAuorescent protein(GFP)family are responsible for coloring coral *** of the Great Barrier Reef were studied with the custom-built fiber laser fluorescence *** analysis showed that most of the excarmined corals contained multiple fuorescent peaks ranging from 470 to *** obser-vation was attributed to the presence of multiple genes of GFP-like proteins in a single coral,as well as by the photo-induced post-translational modifcations of certain GFP-like *** isolated a novel photo-convertible fuorescent protein(FP)from one of the tested ***:propose that two processes may explain the observed diversity of the fuorescent spectra in corals:(1)dark post-translational modifcation(maturation),and(2)color photo-conversion of certain maturated proteins in response to sunlight.

关键词： Coral fuorescence GFP like proteins fuorophores Kaede

来源：评论

学校读者我要写书评

暂无评论

Particle-Based Segmentation Of Extended Objects On Curved Biological Membranes

Particle-Based Segmentation Of Extended Objects On Curved Bi...

引用

IEEE International Symposium on Biomedical Imaging

作者： A. Solomatina Y. Kalaidzidis A. Cezanne K. Soans C. Norden M. Zerial I. F. Sbalzarini Faculty of Computer Science Technische Universität Dresden Dresden Germany Max Planck Institute of Molecular Cell Biology and Genetics Dresden Germany Center for Systems Biology Dresden Dresden Germany Faculty of Bioengineering and Bioinformatics Moscow State University Moscow Russia Cluster of Excellence Physics of Life TU Dresden Dresden Germany Instituto Gulbenkian de Ciência (IGC) Oeiras Portugal

We present a novel method for model-based segmentation of extended, blob-like objects on curved surfaces. Our method addresses several challenges arising when imaging curved biological membrane, such as out-of-membrane signal and geometry-induced background variations. We use a particle-based reconstruction of the membrane geometry, moment-conserving intensity interpolation from pixels to surface particles, and model-based in-surface segmentation. Our method denoises and deconvolves images, corrects for background variations, and quantifies the number, size, and intensity of segmented objects. We benchmark the accuracy of the method and present two applications to (1) neuroepithelial focal adhesion sites during optic cup morphogenesis in zebrafish and (2) reconstituted membrane domains bearing the small GTPase Rab5 on spherical beads.

关键词： Geometry Image segmentation Interpolation Surface reconstruction Biomedical optical imaging Biological system modeling Benchmark testing

来源：评论

学校读者我要写书评

暂无评论

The evolution of Homo sapiens denisova and Homo sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain

引用

BMC GENOMICS 2015年第Sup13期16卷 S4-S4页

作者： Gunbin, Konstantin V. Afonnikov, Dmitry A. Kolchanov, Nikolay A. Derevianko, Anatoly P. Rogaev, Eugeny I. Center of Brain Neurobiology and Neurogenetics Federal State Research Center Institute of Cytology and Genetics Siberian Branch Russian Academy of Sciences Akademika Lavrenti'eva Ave. 10 Novosibirsk 630090 Russia Novosibirsk State University Pirogova St. 2 Novosibirsk 630090 Russia National Research Centre Kurchatov Institute Akademika Kurchatova pl. 1 Moscow 123182 Russia Institute of Archaeology and Ethnography Siberian Branch Russian Academy of Sciences Akademika Lavrent'eva Ave. 17 Novosibirsk 630090 Russia Lomonosov Moscow State University Faculty of Bioengineering and Bioinformatics Moscow Russia Vavilov Institute of General Genetics Gubkina 3 Moscow Russia BNRI Department of Psychiatry University of Massachusetts Medical School 303 Belmont Street Worcester MA 15604 USA

Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo sapiens neanderthalensis and Homo sapiens denisova, and elucidated the expression of their target mRNAs in bain. Results A comparative analysis of the genomes of primates, including species in the genus Homo, identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo sapiens neanderthalensis and Homo sapiens denisova. The mRNAs targeted by miRNAs with mutations specific for Homo sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Conclusions Our results highlight the importance of changes in miRNA gene sequences in the course of Homo sapiens denisova and Homo sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo sapiens denisova and Homo sapiens neanderthalensis, potentially contributing to the cultural differences between these two archaic hominines.

关键词： miRNA functionally important substitutions Homo sapiens neanderthalensis Homo sapiens denisova

来源：评论

学校读者我要写书评

暂无评论

Nuclear lamina maintains global spatial organization of chromatin in Drosophila cultured cells

Nuclear lamina maintains global spatial organization of chro...

引用

IEEE International Conference on bioinformatics and Biomedicine

作者： Sergey V. Ulianov Semen A. Doronin Ekaterina E. Khrameeva Pavel I. Kos Sergey S. Starikov Aleksandra A. Galitsyna Artem Luzhin Mikhail S. Gelfand Alexander V. Chertovich Sergey V. Razin Yuri Y. Shevelyov Russian Academy of Sciences Institute of Gene Biology Moscow Russia Russian Academy of Sciences Institute of Molecular Genetics Moscow Russia Russian Academy of Sciences Institute for Information Transmission Problems (the Kharkevich Institute) Moscow Russia Faculty of Physics M.V. Lomonosov Moscow State University Moscow Russia Faculty of Bioengineering and Bioinformatics M.V. Lomonosov Moscow State University Moscow Russia

ISBN: (纸本)9781538654897;9781538654880

Interphase chromatin in animals is constrained by interactions with the nuclear lamina (NL) - a protein mesh lining nuclear envelope and composed from lamins and lamin-associated proteins. About 30% of chromatin is located near the NL in a living cell forming densely packed lamina-associated domains (LADs). LADs largely overlap with topologically-associating domains (TADs) build up from repressed chromatin, and contain predominately inactive genes, thus playing a role in transcription regulation. Here, we show that the NL disruption in Drosophila leads to en mass chromatin compactisation and redistribution towards the nuclear interior. This results in an increase of contact frequency between active and repressed fractions of the genome accompanied by the transcription upregulation in LADs. A subset of TADs characterized by high level of LADs become less compact, that could be driven by the loss of interactions with the nuclear envelope as revealed by polymer modelling. These results indicate that the NL in Drosophila cells plays a role in the specific spatial positioning of the chromatin inside the nucleus, its compartmentalization and at least partially controls the packaging density and low-level transcription in LADs.

关键词： Conferences bioinformatics

来源：评论

学校读者我要写书评

暂无评论

A Novel Approach Based on Voronoï Cells to Classify Spectrogram Zeros of Multicomponent Signals

A Novel Approach Based on Voronoï Cells to Classify Spectro...

引用

International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： N. Laurent S. Meignen M. A. Colominas J. M. Miramont F. Auger LJK University of Grenoble-Alpes and CNRS UMR 5224 Grenoble France Faculty of Engineering (UNER) Oro Verde Institute for Research and Development in Bioengineering and Bioinformatics (IBB UNER - CONICET) Entre Rios Argentina Institut de Recherche en Énergie Électrique de Nantes Atlantique (IREENA UR 4642) Nantes Université Saint-Nazaire France

In this paper, we propose a novel approach to classify the spectrogram zeros (SZs) of multicomponent signals based on the analysis of the Voronoï cells associated with these zeros. More precisely, the characterization of the distribution of the spectrogram maxima of a complex white Gaussian noise along the edges of the Voronoï cells associated with SZs enables us to derive an algorithm to classify the different types of zeros present in the spectrogram of a multicomponent signal. Numerical applications on simulated signals confirm the relevance of the proposed classification algorithm, and an illustration on a real signal concludes the paper.

关键词： Time-frequency analysis Gaussian noise Signal processing algorithms Interference Acoustics Classification algorithms Noise measurement

来源：评论

学校读者我要写书评

暂无评论

Mitochondria-targeted Quinones Can Inhibit Peroxidase Activity of Cytochrome c /Cardiolipin Complex by Dissociation of the Protein from Liposomes

引用

Biochimica et Biophysica Acta (BBA) - Bioenergetics 2016年 1857卷 e48-e48页

作者： Alexander M. Firsov Elena A. Kotova Yuri N. Antonenko Belozersky Institute of Physico-Chemical Biology Russia Faculty of Bioengineering and Bioinformatics Lomonosov Moscow State University Moscow 119991 Russia

来源：评论

学校读者我要写书评

暂无评论

Interaction of antibodies with aromatic ligands: the role of pi-stacking

引用

Journal of bioinformatics and computational biology 2010年第3期8卷 471-83页

作者： Vladimir Arzhanik Darja Svistunova Oleg Koliasnikov Alexey M Egorov Lomonosov Moscow State University Faculty of Bioengineering and Bioinformatics LenGory 1 b.73 Moscow Russia 119992 Russia.

Antibodies are responsible for antigen recognition in vertebrate organisms. Practically any molecule can be bound by antibodies. In this work structures of 73 complexes of antibodies with small antigens were taken from PDB database and compared. The main epitope of studied ligands was an aromatic ring. Antibodies bound it with a deep cavity, lying between complementary determining regions (CDR) H3 and L3 and formed by aromatic residues. In most cases the aromatic ring of ligand was placed parallel to one or two aromatic sidechains of binding site at 3.5-4 Angstrom distance. This disposition of aromatic rings is a sign of the presence of pi-stacking. It was found that small ligands with aromatics area percentage > 36% predominantly form pi-stacking interaction with antibodies. Most often this interaction was observed for residues in positions H33, H95, L32 and L93.

关键词： Antibody small aromatic antigens π-stacking

来源：评论

学校读者我要写书评

暂无评论

The role of residue beta249 in MgADP inhibition of Escherichia coli ATP synthase

引用

Biochimica et Biophysica Acta (BBA) - Bioenergetics 2014年 1837卷 e15-e15页

作者： Boris Feniouk Anastasia Prikhodko Anna Lapashina Maria Vitushkina Roman Zinovkin Faculty of Bioengineering and Bioinformatics Lomonosov Moscow State University Russia Lomonosov Moscow State University Moscow Russia Faculty of Biology Lomonosov Moscow State University Russia

来源：评论

学校读者我要写书评

暂无评论

The effect of betaq259l mutation on MgADP-inhibition of B. subtilis H + -F O F 1 -ATP-synthase

引用

Biochimica et Biophysica Acta (BBA) - Bioenergetics 2014年 1837卷 e16-e16页

作者： Anna Lapashina Maria Vitushkina Roman Zinovkin Boris Feniouk Lomonosov Moscow State University Moscow Russia Faculty of Biology Lomonosov Moscow State University Russia Faculty of Bioengineering and Bioinformatics Lomonosov Moscow State University Russia

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：