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Artificial intelligence in cancer target identification and drug discovery

Signal Transduction and Targeted Therapy 2022年第6期7卷 1951-1974页

作者： Yujie You Xin Lai Yi Pan Huiru Zheng Julio Vera Suran Liu Senyi Deng Le Zhang College of Computer Science Sichuan UniversityChengdu 610065China Laboratory of Systems Tumor Immunology Friedrich-Alexander-Universität Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenErlangen 91052Germany Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesRoom D5131068 Xueyuan AvenueShenzhen University TownShenzhen 518055China School of Computing Ulster UniversityBelfast BT151EDUK Institute of Thoracic Oncology Department of Thoracic SurgeryWest China HospitalSichuan UniversityChengdu 610065China Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China Key Laboratory of Systems Health Science of Zhejiang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Artificial intelligence is an advanced method to identify novel anticancer targets and discover novel drugs from biology networks because the networks can effectively preserve and quantify the interaction between components of cell systems underlying human diseases such as ***,we review and discuss how to employ artificial intelligence approaches to identify novel anticancer targets and discover ***,we describe the scope of artificial intelligence biology analysis for novel anticancer target ***,we review and discuss the basic principles and theory of commonly used network-based and machine learning-based artificial intelligence ***,we showcase the applications of artificial intelligence approaches in cancer target identification and drug *** together,the artificial intelligence models have provided us with a quantitative framework to study the relationship between network characteristics and cancer,thereby leading to the identification of potential anticancer targets and the discovery of novel drug candidates.

关键词： drugs cancer drug

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Cybersecurity Threat Detection in the Behavior of IoT Devices: Analysis of Data Mining Competition Results 18

Cybersecurity Threat Detection in the Behavior of IoT Device...

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18th Conference on computer science and Intelligence systems, FedCSIS 2023

作者： Czerwinski, Michal Michalak, Marcin Biczyk, Piotr Adamczyk, Blazej Iwanicki, Daniel Kostorz, Iwona Brzeczek, Maksym Janusz, Andrzej Hermansa, Marek Wawrowski, Lukasz Kozlowski, Artur Qed Software Mazowiecka 11/49 Warsaw0-052 Poland Ukasiewicz Research Network - Institute of Innovative Technologies Emag Leopolda 31 Katowice40-189 Poland Efigo Sp. Z O.o. M.Kopernika 8/6 Katowice40-064 Poland Faculty of Mathematics University of Warsaw Banacha 2 Warsaw02-097 Poland Department of Computer Networks and Systems Faculty of Automatic Control University of Technology Electronics and Computer Science Akademicka 16 Gliwice44-100 Poland

ISBN: (纸本)9788396744784

The paper discusses a data science competition centered around the development of an anomaly detection system for IoT devices. The competition utilized a unique environment that allowed for the operation and monitoring of real IoT devices, including scheduling of attacks on these devices. The environment was used to collect the data, which included both normal and attack-induced behavior of IoT devices. The paper presents the background of the competition, the top models submitted, and the competition results. The paper also includes a discussion about restrictions related to the use of synthetic attack data as input for constructing anomaly detection systems. © 2023 Polish Information Processing Society.

关键词： Quality control

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EQUILIBRIA AND STABILITY OF ONE MESSENGER RNA AND TWO MICRO RNA DYNAMICS

UPB Scientific Bulletin, Series C: Electrical Engineering an...

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UPB Scientific Bulletin, Series C: Electrical Engineering and computer science 2022年第4期84卷 3-8页

作者： Olteanu, Mircea Ştefan, Radu Department of Mathematical Methods and Models Faculty of Applied Sciences University "Politehnica" of Bucharest Romania Department of Automatic Control and Systems Engineering Faculty of Automatic Control and Computer Science University "Politehnica" of Bucharest Romania

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A Parallel and Asynchronous Blob Shape Descriptor Implemented in CMOS Technology

A Parallel and Asynchronous Blob Shape Descriptor Implemente...

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International Conference on Microelectronics, MIEL

作者： P. Bogacki M. Długosz T. Talaśka R. Długosz Aptiv Services Poland Kraków Poland Institute of Telecommunications Faculty of Computer Science Electronics and Telecommunications AGH University of Science and Technology Kraków Poland Faculty of Control Robotics and Electrical Engineering Institute of Automation and Robotics Division of Signal Processing and Electronic Systems Poznan University of Technology Poznan Poland Faculty of Telecommunication Computer Science and Electrical Engineering Bydgoszcz University of Science and Technology Bydgoszcz Poland

The paper presents a family of novel light blob shape descriptors for use in selected active safety algorithms used in Advanced Driver Assistance systems (ADAS). One of the motivations was to obtain a descriptor that would ensure low computational complexity. This makes it easy to implement both in software and hardware. One assumption is that the location of the center of a given light spot is approximately known. The principle of its operation is then to count white pixels in selected directions, starting from this central point. A key issue here is an efficient way of determining indexes of particular pixels belonging to the image patch, as well as the location of points representing places where the white area turns into black. In the case of a hardware implementation, this can be done using a parallel circuit operating in asynchronous mode, without the need for a control clock.

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Image and Kernel Representations for Variational systems*

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IFAC-PapersOnLine 2023年第2期56卷 797-802页

作者： Yu Kawano Arjan J. van der Schaft Jacquelien M.A. Scherpen Graduate School of Advanced Science and Engineering Hiroshima University Higashi-hiroshima 739-8527 Japan Bernoulli Institute for Mathematics Computer Science and AI University of Groningen 9700 AK Groningen The Netherlands Faculty of Science and Engineering University of Groningen 9747 AG Groningen The Netherlands Jan C. Willems Center for Systems and Control

The Youla-Kucera parametrization, a method to parametrize all stabilizing controllers, is developed for linear and nonlinear systems based on their stable image and kernel representations. As a stepping stone of parametrizing nonlinear controllers for contraction, we investigate in this paper stable image and kernel representations for variational systems. In particular, we construct stable inner image (resp. co-inner kernel) representations having stable left (resp. right) inverses based on differential Riccati equations for contraction analysis.

关键词： nonlinear systems variational systems image representations kernel representations contraction

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Energy-Based control Approaches for Weakly Coupled Electromechanical systems

arXiv

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arXiv 2024年

作者： Javanmardi, Najmeh Borja, P. Yazdanpanah, M.J. Scherpen, J.M.A. Jan C. Willems Center for Systems and Control ENTEG Faculty of Science and Engineering University of Groningen Groningen Netherlands School of Engineering Computing and Mathematics University of Plymouth Plymouth United Kingdom Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran

This paper addresses the regulation and trajectory-tracking problems for two classes of weakly coupled electromechanical systems. To this end, we formulate an energy-based model for these systems within the port-Hamiltonian framework. Then, we employ Lyapunov theory and the notion of contractive systems to develop control approaches in the port-Hamiltonian framework. Remarkably, these control methods eliminate the need for solving partial differential equations or implementing any change of coordinates, and are endowed with a physical interpretation. We also investigate the effect of coupled damping on the transient performance and convergence rate of the closed-loop system. Finally, the applicability of the proposed approaches is illustrated in two applications of electromechanical systems via simulations. © 2024, CC BY.

关键词： Damping

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Ranking of attributes—comparative study based on data from stylometric domain

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Procedia computer science 2022年 207卷 2737-2746页

作者： Beata Zielosko Urszula Stańczyk Krzysztof Żabiński Institute of Computer Science University of Silesia in Katowice Będzińska 39 41-200 Sosnowiec Poland Department of Graphics Computer Vision and Digital Systems Faculty of Automatic Control Electronics and Computer Science Silesian University of Technology Akademicka 2A 44-100 Gliwice Poland

The area of feature selection methods constantly expands along with the development of artificial intelligence domain, and has great impact on almost every field, whenever data is processed and explored. The paper presents research where a ranking method was proposed, inspired by an approach which comes from an algorithm for induction of decision rules. The ranking procedure was based on calculation of standard deviation for attributes, taking into account assigned class labels. This method was compared with another ranking mechanism, a modified version of popular Relief algorithm, with incorporating characteristics of variables by supervised discretisation. Comparison of obtained results included the aspect of knowledge representation as well as the perspective of the accuracy for constructed rule-based classifiers. The experiments were performed on datasets from stylometry domain, where authorship attribution was considered as a classification task, and stylometric descriptors as characteristic features defining writing styles of authors.

关键词： Feature selection Ranking of attributes Relief Standard deviation Decision rules Stylometry Supervised discretisation Authorship attribution

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TEMPORAL LOGIC control FOR NONLINEAR STOCHASTIC systems UNDER UNKNOWN DISTURBANCES

arXiv

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arXiv 2024年

作者： Gracia, Ibon Laurenti, Luca Mazo, Manuel Abate, Alessandro Lahijanian, Morteza Smead Department of Aerospace Engineering Sciences CU Boulder BoulderCO United States Delft Center for Systems and Control Faculty of Mechanical Maritime and Materials Engineering Delft University of Technology Netherlands Department of Computer Science University of Oxford United Kingdom

In this paper, we present a novel framework to synthesize robust strategies for discrete-time nonlinear systems with random disturbances that are unknown, against temporal logic specifications. The proposed framework is data-driven and abstraction-based: leveraging observations of the system, our approach learns a high-confidence abstraction of the system in the form of an uncertain Markov decision process (UMDP). The uncertainty in the resulting UMDP is used to formally account for both the error in abstracting the system and for the uncertainty coming from the data. Critically, we show that for any given state-action pair in the resulting UMDP, the uncertainty in the transition probabilities can be represented as a convex polytope obtained by a two-layer state discretization and concentration inequalities. This allows us to obtain tighter uncertainty estimates compared to existing approaches, and guarantees efficiency, as we tailor a synthesis algorithm exploiting the structure of this UMDP. We empirically validate our approach on several case studies, showing substantially improved performance compared to the state-of-the-art. © 2024, CC BY.

关键词： Temporal logic

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QoS-Coordinated Adaptive Spectrum Management Method for Coexistence 5G-U and Wi-Fi Networks with Short-Term Channel Failures

QoS-Coordinated Adaptive Spectrum Management Method for Coex...

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International Conference on CAD systems in Microelectronics (CADSM)

作者： Mykola Beshley Volodymyr Kochan Halyna Beshley Mykhailo Medvetskyi Ihor Kahalo Yuriy Shkoropad Department of telecommunications Lviv Polytechnic National University Lviv Ukraine Department of Information Systems Faculty of Management Comenius University in Bratislava Bratislava Slovakia School of Computer Science Hubei University of Technology Wuhan China Department of Information Computer Systems and Control West Ukrainian National University Ternopil Ukraine

5G on unlicensed band (5G-U) technology, which is a further long-term evolution on unlicensed band (LTE-U), is a promising solution to address spectrum deficits and increase data rates. The main task of 5G-U is to operate in the highly congested 5 GHz bands while ensuring harmonious coexistence with other wireless technologies such as Wi-Fi. For this reason, we propose a method of adaptive use of unlicensed spectrum by Wi-Fi and 5G-U networks to ensure the required quality of service (QoS) and fair coexistence. Based on the users' QoS requirements, this method centrally takes reasonable decisions concerning the part of unlicensed radio resource use by 5G-U mobile operators, which allows increasing spectral efficiency in the integrated 5G-U networks with the avoidance of inter-system interference. Simulation results show that the proposed approach, unlike the traditional CSAT (Carrier Sensing Adaptive Transmission) for LTE-U, allocates throughput according to the QoS requirements of users for both Wi-Fi and 5G-U networks. A modified packet queue management algorithm at the data link layer is developed to overcome the consequences of short-term channel failures (interference, low signal strength). This algorithm can occur in Wi-Fi networks under conditions of mass 5G-U deployment. As a result of the simulation, it is proved that the proposed algorithm improved the quality of the video image from 5% to 45% according to the MSE (Mean Squared Error) criterion in the integrated 5G-U/Wi-Fi network.

关键词： Degradation Adaptive systems 5G mobile communication Heuristic algorithms Quality of service Interference Streaming media

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Infrastructure-dependent ramp-metering control for METANET-s

Infrastructure-dependent ramp-metering control for METANET-s

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IEEE Conference on Decision and control

作者： Ayda Kamalifar Carlo Cenedese Michele Cucuzzella Antonella Ferrara Department of Electrical Computer Science and Biomedical Engineering University of Pavia Pavia Italy Department of Information Technology and Electrical Engineering ETH Zürich Zürich Switzerland Center for Systems and Control ENTEG Faculty of Science and Engineering (FSE) University of Groningen (UG) Nijenborgh 4 Groningen the Netherlands

ISBN: (数字)9798350316339

ISBN: (纸本)9798350316346

In this paper, we propose a novel infrastructure-dependent ramp-metering control for the recently proposed METANET with service station (METANET-s) model, i.e., a second-order macroscopic traffic model that, compared to the classical METANET, incorporates the dynamics of service stations on highways. We study the effect of a ramp-metering control scheme on a highway stretch with a service station and show that it is capable of actively regulate internal traffic demand attempting to exit the service station via its on-ramp, on top of contributing to decrease the traffic congestion on the mainstream. In fact, the proposed control scheme effectively prevents the backlog of vehicles attempting to merge back onto the mainstream. This dynamic control mechanism is further endowed by a route guidance control strategy increasing the share of vehicles stopping at the service station during main-stream congestion periods, e.g. via incentives. The combined effect of our control schemes allows to take full advantage of the presence of service stations, reducing the overall traffic congestion. Simulation results demonstrate the effectiveness of the proposed control strategies.

关键词： Simulation Merging Numerical models Vehicle dynamics Traffic congestion

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