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Suppression of pair-pulse depression of the population spike in the dentate gyrus during carbachol-induced theta-like activity in guinea pig hippocampal slices

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NEUROscience RESEARCH 1997年第2期29卷 113-120页

作者： Natsume, K Kometani, K Department of Biochemical Engineering and Science Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology Iizuka Fukuoka 820 Japan

In pair-pulse stimulation experiments, pair-pulse depression (PPD) of the population spike (PS) occurred at intervals shorter than 20 ms in the dentate gyrus in guinea pig hippocampal slices. Application of 50 mu M carbachol resulted in an increase in the test PS amplitude and caused suppression of PPD. This suppression was antagonized by atropine sulfate, a muscarinic receptor antagonist. Carbachol at 50 mu M induced intermittent bursts of theta-like activity (TLA). We compared the pair-pulse index (PPI) during TLA with that in a rest period between bursts of TLA. The PPI was defined as the ratio of the amplitude of the test PS to that of the conditioning PS. The PPI during TLA were significantly larger than that during the rest period, although there were no significant differences in the conditioning PS amplitude and the test pEPSP slope. When TLA was induced, the PPI during the rest period was increased by bicuculline. The PPI during TLA did not change significantly with the drug. The increase by bicuculline in the PPI during the rest period was caused by increase in the test PS amplitude. PPD can occur due to inhibition of granule cell activity by inhibitory neurons. Our findings suggest that the action of inhibitory neurons on granule cell activity is suppressed by activation of muscarinic receptors, with stronger suppression during TLA than during the rest period between bursts of TLA. (C) 1997 Elsevier science Ireland Ltd.

关键词： guinea pig carbachol rhythmic wave pair-pulse depression disinhibition theta-like activity memory process

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3D surface estimation and model construction from specular motion in image sequences

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IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE 1997年第5期19卷 513-520页

作者： Zheng, JY Fukagawa, Y Abe, N Faculty of computer Science and Systems Engineering Kyushu Institute of Technology Fukagawa Japan Kyushu Institute of Technology Japan

This work reconstructs a 3D graphics model of an object with specular surfaces by its rotation. Continuous images are taken to measure highlights on the smooth surfaces and their motion. Coplanar extended lights determine a plane of rays to produce a highlight stripe on the object. 3D surfaces are then recovered from the moving stripe. We investigate global motion characteristics of the highlights in the Epipolar-plane images so as to qualitatively identify surface types and control the modeling process. Under single and multiple plane-of-rays illuminations, we give two quantitative approaches for surface and normal recovery which use highlight orientation in the image and highlight motion in the Epipolar-Plane images. The computations employ a first-order differential equation and linear equations, respectively.

关键词： specular motion highlight shape estimation model recovery epipolar-plane images qualitative shape identification

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A CDNA-ENCODING THE HUMAN TRANSFORMING GROWTH-FACTOR-BETA RECEPTOR SUPPRESSES THE GROWTH DEFECT OF A YEAST MUTANT

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GENE 1994年第2期149卷 367-372页

作者： NIKAWA, J Department of Biochemical Engineering and Science Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology Iizuka Fukuoka 820 Japan

Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular processes. TGF-beta signals through a heteromeric complex of type-I and type-II receptors, which both belong to the transmembrane (TM) receptor serine/threonine kinase family. Reported here is the isolation of a subtype of the human TGF-beta receptor type II from a cDNA library using a Saccharomyces cerevisiae mutant. This yeast mutant has a defect in the expression of the gene encoding inositol-1-phosphate synthase and requires myo-inositol for its growth. The cloned subtype of the TGF-beta receptor type II has a 25-amino-acid insertion relative to the reported receptor type-II sequence. In addition to that encoding the TGF-beta receptor, two more human genes were obtained using the same yeast mutant. They encode the protein phosphatase type 2A regulatory subunit A and a 14-3-3 protein which is known as a regulatory protein for protein kinases. These results clearly indicate that these human genes function in yeast cells. It is also suggested that yeast possesses a signal transduction mechanism resembling the human TGF-beta-mediated signaling pathway.

关键词： PROTEIN PHOSPHATASE TYPE 2A 14-3-3 PROTEIN TGF-BETA RECEPTOR SACCHAROMYCES CEREVISIAE

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BIOCHEMICAL SWITCHING DEVICE - BIOMIMETIC APPROACH AND APPLICATION TO NEURAL NETWORK STUDY

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JOURNAL OF BIOTECHNOLOGY 1992年第1期24卷 109-127页

作者： OKAMOTO, M Department of Biochemical Engineering and Science Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology Iizuka-city Japan.

There are many examples of enzymes that share substrates or cofactors in a cyclic manner. Techniques have been developed that use cyclic enzyme systems to assay quantitatively small amounts of biochemical substances (cofactor, substrate), however, only a few studies of the control of these systems have been published. The author previously showed with computer simulations that cyclic enzyme systems have the reliability of ON-OFF types of operation (McCulloch-Pitts' neuronic equation) capable of storing short-memory, and the applicability for a switching circuit in a biocomputer. This paper introduces a unique switching mechanism of cyclic enzyme system (basic switching element), and next, building the integrated biochemical switching system being composed of the basic switching element, shows the physiological phenomenon termed 'selective elimination of synapses' generally produced as a result of low-frequency train of electrical stimuli to the synapses.

关键词： BIOMIMETICS CYCLIC ENZYME SYSTEM INFORMATION PROCESSING MEMORY-STORAGE NEURAL NETWORKS THRESHOLD-LOGIC FUNCTION

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Distributed learning particle swarm optimizer for global optimization of multimodal problems

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Frontiers of computer science 2018年第1期12卷 122-134页

作者： Geng ZHANG Yangmin LI Yuhui SHI Department of Electromechanical Engineering Faculty of Science and Technology University of Macao Macao China Industrial and Systems Engineering Faculty of Engineering The Hong Kong Polytechnic University Hong Kong China Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen 518055 China

Particle swarm optimizer （PSO） is an effective tool for solving many optimization problems. However, it may easily get trapped into local optimum when solving com- plex multimodal nonseparable problems. This paper presents a novel algorithm called distributed learning particle swarm optimizer （DLPSO） to solve multimodal nonseparable prob- lems. The strategy for DLPSO is to extract good vector infor- mation from local vectors which are distributed around the search space and then to form a new vector which can jump out of local optima and will be optimized further. Experimen- tal studies on a set of test functions show that DLPSO ex- hibits better performance in solving optimization problems with few interactions between variables than several other peer algorithms.

关键词： particle swarm optimizer （PSO） orthogonal ex-perimental design （OED） swarm intelligence

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Screening cognitive impairment in patients with atrial fibrillation: A deep learning model based on retinal fundus photographs

Heart Rhythm O2

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Heart Rhythm O2 2025年第5期6卷 678.0-686.0页

作者： Wang, Zhen Li, Mingxiao Xia, Peng Jiang, Chao Shen, Ting Ma, Jiaming Bai, Yu Zhang, Suhui Lai, Yiwei Li, Sitong Xu, Hui Xu, Yang Ma, Tong Ju, Lie He, Liu Dong, Li Sang, Caihua Long, Deyong Chen, Yuzhong Du, Xin Ge, Zongyuan Dong, Jianzeng Wei, Wen-Bin Ma, Changsheng Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China Engineering Research Center of Medical Devices for Cardiovascular Diseases Ministry of Education Capital Medical University Beijing China National Clinical Research Center for Cardiovascular Diseases Beijing China Beijing Airdoc Technology Co. Ltd. Beijing China Department of Electrical and Computer Systems Engineering Faculty of Engineering Monash University Clayton Australia Yale School of Medicine New Haven Connecticut United States School of Clinical Medicine Peking Union Medical College and Chinese Academy of Medical Science Beijing China Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology & Visual Sciences Key Lab Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology Beijing Tongren Hospital Capital Medical University Beijing China Monash e-Research Center Monash University Clayton Australia

Background: Patients with atrial fibrillation (AF) have a higher risk of cognitive impairment (CI). However, complexity of CI diagnosis and lack of simple screening approaches limited early screening and intervention of CI in AF patients. Objective: Our study aimed to develop deep learning models based on fundus photographs for easy screening of CI in AF patients. Methods: From May 2021 to April 2023, patients who completed fundus examination and cognitive function evaluation in the Chinese Atrial Fibrillation Registry Study were included. The training and validation sets were randomly split at an 8:2 ratio. Participants from the Beijing Eye Study served as the external validation set. Different deep learning models were trained, and their CI detection ability was validated. Results: A total of 899 patients in the Chinese Atrial Fibrillation Registry Study were included. In the validation set, the vision-ensemble model based on fundus images alone had an area under the receiver-operating characteristic curve (AUROC) of 0.855 (95% confidence interval 0.816–0.894) for CI screening. The multimodal model (AUROC 0.861, 95% confidence interval 0.823–0.898), based on fundus photographs and 4 clinical variables, performed comparably to the vision-ensemble model. The AUROC of the vision-ensemble model for CI screening achieved 0.773 (95% confidence interval 0.709–0.837) in the external test set. In the saliency map, the vision-ensemble model focused on areas around retinal vessels and the optic disc. Conclusion: A vision-ensemble model based on fundus images might be practical for preliminary screening of CI in AF patients. © 2025 Heart Rhythm Society

关键词： Artificial intelligence Atrial fibrillation Cognitive impairment Deep learning Fundus photography

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DPPAD-IE: Dynamic Polyhedra Permutating and Arnold Diffusing Medical Image Encryption Using 2D Cross Gaussian Hyperchaotic Map

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IEEE Transactions on Consumer Electronics 2025年

作者： Li, Quanjun Li, Qian Ling, Bingo Wing-Kuen Pun, Chi-Man Huang, Guoheng Yuan, Xiaochen Zhong, Guo Ayouni, Sarra Chen, Jianwu Guangdong University of Technology School of Advanced Manufacturing Jieyang522000 China Wuyi University School of Electronics and Information Engineering Jiangmen510006 China Guangdong University of Technology School of Information Engineering Guangzhou510006 China University of Macau Faculty of Science and Technology Macau China Guangdong University of Technology School of Computer Science and Technology Guangzhou510006 China Macau Polytechnic University Faculty of Applied Sciences Macau China Guangdong University of Foreign Studies School of Information Science and Technology Guangzhou510420 China Princess Nourah bint Abdulrahman University College of Computer and Information sciences Department of Information Systems Riyadh11671 Saudi Arabia Fujian Medical University Union Hospital Department of Radiation Oncology Fujian province Fuzhou China Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors Fujian Medical University Fujian province Fuzhou China Fujian province Fuzhou China

With the rapid improvement of medical consumer electronics (CE), the transmission of multiple images has become increasingly common in the medical field. During the transmission and storage of image data, sensitive information, including medical images, may be accessed by unauthorized parties, resulting in possible privacy violations. Consequently, several multi-image encryption (MIE) algorithms have been proposed to solve this real-world problem. Nevertheless, current MIE schemes exhibit several drawbacks, including insufficient security in permutation and diffusion algorithms, as well as the insensitivity of chaotic maps. This paper presents a new encryption algorithm called DPPAD-IE. The algorithm primarily consists of three components. First, we developed an innovative hyperchaotic map called the 2D Cross Gaussian Hyperchaotic Map (2D-CGHM), which has an expanded chaotic interval and is proficient in producing chaotic sequences with improved pseudorandomness. Second, we introduce a new Dynamic Polyhedra Permutation algorithm (DPP) that successfully alters pixel locations of the image, hence diminishing the connection between neighboring pixels. Third, we propose an Arnold Diffusion algorithm (AD), using chaotic sequences to further encrypt the permuted image. The DPPAD-IE is capable of encrypting images of any quantity and size concurrently. The experimental results confirm that this approach is both robust and effective, capable of defending against various security attacks. The code are available at:https://***/QuincyQAQ/DPPAD-IE. © 1975-2011 IEEE.

关键词： Medical imaging

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APPARENT KINETIC-PARAMETERS OF AN IMMOBILIZED ENZYME REACTION - WHAT IS EXPECTED FROM OVERSIMPLIFICATION

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ENZYME AND MICROBIAL TECHNOLOGY 1994年第4期16卷 349-350页

作者： SHIRAISHI, F Department of Biochemical Engineering and Science Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology Iizuka 820 Japan

A response to the comments by Lortie and Andre is given, and the usefulness of their methodology is considered. The need for simplification should be reconsidered in light of the remarkably improved ability of modern ... 详细信息

关键词： APPARENT KINETIC PARAMETERS IMMOBILIZED ENZYME

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Recasting Arrow’s Impossibility Theorem as Gödelian Incomputability

arXiv

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arXiv 2025年

作者： Livson, Ori Prokopenko, Mikhail The Centre for Complex Systems University of Sydney NSW2006 Australia School of Computer Science Faculty of Engineering University of Sydney NSW2006 Australia

Incomputability results in formal logic and the Theory of Computation (i.e., incompleteness and undecidability) have deep implications for the foundations of mathematics and computer science. Likewise, Social Choice Theory, a branch of Welfare Economics, contains several impossibility results that place limits on the potential fairness, rationality and consistency of social decision-making processes. A formal relationship between Gödel’s Incompleteness Theorems in formal logic, and Arrow’s Impossibility Theorem in Social Choice Theory has long been conjectured. In this paper, we address this gap by bringing these two theories closer by introducing a general mathematical object called a Self-Reference System. Impossibility in Social Choice Theory is demonstrated to correspond to the impossibility of a Self-Reference System to interpret its own internal consistency. We also provide a proof of Gödel’s First Incompleteness Theorem in the same terms. Together, this recasts Arrow’s Impossibility Theorem as incomputability in the Gödelian sense. The incomputability results in both fields are shown to arise out of self-referential paradoxes. This is exemplified by a new proof of Arrow’s Impossibility Theorem centred around Condorcet Paradoxes. Copyright © 2025, The Authors. All rights reserved.

关键词： Formal logic

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DIFFUSIONAL AND ELECTROSTATIC EFFECTS ON APPARENT KINETIC-PARAMETERS OF REACTIONS CATALYZED BY ENZYME IMMOBILIZED ON THE EXTERNAL SURFACE OF A SUPPORT

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JOURNAL OF FERMENTATION AND BIOengineering 1995年第4期79卷 373-377页

作者： SHIRAISHI, F Department of Biochemical Engineering and Science Faculty of Computer Science and Systems Engineering Kyushu Institute of Technology Iizuka 820 Japan

Diffusional and electrostatic effects on the apparent maximum reaction rate V-m(app) and the apparent Michaelis constant K-m(app) were investigated theoretically for a system in which an enzyme immobilized on the external surface of a solid support catalyzes a reaction according to Michaelis-Menten kinetics. In such a system, the dependence of V-m(app) and K-m(app) on the substrate concentration can be expressed analytically. When the support and substrate carry charges of the same sign, resulting in a repulsive force between them, both V-m(app) and K-m(app) decrease with increasing substrate concentration, but they never decrease below the respective intrinsic values. On the other hand, when the support and substrate carry charges of opposite sign and therefore an attractive force occurs, V-m(app) decreases towards its intrinsic value, while K-m(app) decreases to values below its intrinsic value in the region of high substrate concentration.

关键词： APPARENT KINETIC PARAMETERS IMMOBILIZED ENZYME REACTION DIFFUSIONAL EFFECT ELECTROSTATIC EFFECT

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