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To establish a pharmacological experimental platform for the study of cardiac hypoxia using the microelectrode array

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Journal of Pharmacological and Toxicological Methods 2009年第3期59卷 146-152页

作者： Yeung, Chi-Kong Sommerhage, Frank Wrobel, Günter Law, Jessica Ka-Yan Offenhäusser, Andreas Rudd, John Anthony Ingebrandt, Sven Chan, Mansun Department of Pharmacology Faculty of Medicine The Chinese University of Hong Kong (CUHK) Shatin Hong Kong Institute of Bio- and Nanosystems - Bioelectronics (IBN-2) Centre of Nanoelectronic Systems for Information Technology (CNI) Leo-Brandt-Str. D-52425 Jülich Germany Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology (HKUST) Hong Kong

Introduction: Simultaneous recording of electrical potentials from multiple cells may be useful for physiological and pharmacological research. The present study aimed to establish an in vitro cardiac hypoxia experimental platform on the microelectrode array (MEA). Methods: Embryonic rat cardiac myocytes were cultured on the MEAs. Following ≥ 90 min of hypoxia, changes in lactate production (mM), pH, beat frequency (beats per min, bpm), extracellular action potential (exAP) amplitude, and propagation velocity between the normoxic and hypoxic cells were compared. Results: Under hypoxia, the beat frequency of cells increased and peaked at around 42.5 min (08.1 ± 3.2 bpm). The exAP amplitude reduced as soon as the cells were exposed to the hypoxic medium, and this reduction increased significantly after approximately 20 min of hypoxia. The propagation velocity of the hypoxic cells was significantly lower than that of the control throughout the entire 90+ min of hypoxia. The rate of depolarisation and Na⁺ signal gradually reduced over time, and these changes had a direct effect on the exAP duration. Discussion: The extracellular electrophysiological measurements allow a partial reconstruction of the signal shape and time course of the underlying hypoxia-associated physiological changes. The present study showed that the cardiac myocyte-integrated MEA may be used as an experimental platform for the pharmacological studies of cardiovascular diseases in the future. © 2009 Elsevier Inc. All rights reserved.

关键词： Cardiac myocytes Disease model Extracellular action potential Functional studies Hypoxia Microelectrode array

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Capturing Digital Ink as Retrieving Fragments of Document Images

Capturing Digital Ink as Retrieving Fragments of Document Im...

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International Conference on Document Analysis and Recognition

作者： Kazumasa Iwata Koichi Kise Tomohiro Nakai Masakazu Iwamura Seiichi Uchida Shinichiro Omachi Department of Computer and Systems Sciences Graduate School of Engineering Osaka Prefecture University Japan Faculty of Information Science and Electrical Engineering Kyushu University Japan Graduate School of Engineering University of Tohoku Japan

ISBN: (纸本)9781424445004

This paper presents a new method of capturing digital ink for pen-based computing. Current technologies such as tablets, ultrasonic and the Anoto pens rely on special mechanisms for locating the pen tip,which result in limiting the *** proposal is to ease this problem-a camera pen that allows us to write on ordinary paper for capturing digital ink. A document image retrieval method called LLAH is tuned to locate the pen tip efficiently and accurately on the coordinates of a document only by capturing its tiny *** this paper, we report some results on captured digital ink as well as to evaluate their quality.

关键词： Ink Image retrieval Text analysis

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Design and Object-oriented Implementation of an Intelligence Entity Sharing Pool

Design and Object-oriented Implementation of an Intelligence...

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GCIS, WRI Global Congress on Intelligent systems

作者： Runhe Huang Jianhua Ma Kenichi Takahashi Kouichi Sakurai Faculty of Computer and Information Sciences Hosei University Tokyo Japan Institute of Systems and Information Technologies and Nanotechnologies Fukuoka Japan Department of Computer Science and Communication Engineering Kyushu University Fukuoka Japan

One of the challenges for ubiquitous intelligence computing is how to enable ubiquitous devices (u-devices) certain levels of intelligent/smart/autonomic/ processing capabilities. Due to their limited capacity and processing power, it is difficult to embed such capabilities into u-devices. The idea is to design an intelligence entity sharing pool in which an intelligence entity can be dynamically composed from a number of atomic intelligence entities and/or complex intelligence entities. This research has two phases: (1) how to design the intelligence entity sharing pool; and (2) how to share an intelligence entity in the sharing pool. The second phase is completely upon the first phase as the premise. This paper is mainly focused on presenting our design ideas of the intelligence entity sharing pool in the following aspects: (1) defining atomic intelligence entity and complex intelligence entity; (2) designing an appropriate structure for storing atomic/complex intelligence entities; and (3) designing mechanisms for composition and decomposition of intelligence entity/entities.

关键词： Competitive intelligence Intelligent structures Intelligent agent Intelligent systems Intelligent sensors Pervasive computing Multiagent systems Wireless sensor networks Information technology Nanoscale devices

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Autonomously normalized horizontal differentials as features for HMM-based Omni font-written OCR systems for cursively scripted languages

Autonomously normalized horizontal differentials as features...

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IEEE International Conference on Signal and Image Processing Applications (ICSIPA)

作者： Mohamed Attia Mohsen A. A. Rashwan Mohamed S. M. El-Mahallawy The Engineering Company of the Development of Computer Systems RDI Egypt Department of Electronics & Electrical Communication Faculty of Engineering Cairo University Egypt Arab Academy for Science Technology and Maritime Transport Egypt

Automatic font-written Optical Character Recognition (OCR) is highly desirable for numerous modern information technology (IT) applications. Reliable font-written OCR's for Latin scripts are readily in use since long. For cursively scripted languages, that are the mother tongues of over one fourth of the world population, such OCR's are however not available at a robust and reliable performance. In this regard, the main challenge is the mandatory connectivity of characters/ligatures (i.e. graphemes) that has to be resolved simultaneously upon the recognition of these graphemes. Among the various approaches tried over decades, Hidden Markov Models (HMM)-based OCR's seem to be the most promising as they capitalize on the ability of HMM decoders to achieve segmentation and recognition simultaneously similar to the widely used HMM-based automatic speech recognition (ASR). Unlike ASR's, what is missing in HMM-based OCR's is the definition of a rigorously founded features vector capable to robustly achieving minimal “font type/size-independent” (omnifont) word error rates comparable to those realized with Latin scripts. Here comes the contribution of this paper that introduces such a sound features vector design, and experimentally shows its superiority in this regard.

关键词： Optical character recognition software Hidden Markov models Automatic speech recognition Application software Character recognition Robustness Error analysis Writing Signal processing Image processing

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From state-of-the-art static fleet assignment to flexible stochastic planning of the future

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作者： Grothklags, Sven Lorenz, Ulf Monien, Burkhard Lufthansa Systems Berlin GmbH Airline Planning and Control Salzufer 8 D-10587 Berlin Germany Darmstadt University of Technology Institute of Mathematics Schlossgartenstr. 7 D-64289 Darmstadt Germany University of Paderborn Faculty of Computer Science Electrical Engineering and Mathematics Fürstenallee 11 D-33102 Paderborn Germany

ISBN: (纸本)3642020933

Given a flight schedule, which is a set of non-stop flights, called legs, with specified departure and arrival times, and a set of aircraft types, called subfleets, the fleet assignment problem is to determine which aircraft type should fly each leg. The objective is to maximize the overall profit. Usually, planners assume that precise input data are determininstically available at planning time. As a consequence, an important insufficiency of modern industrial plans, especially flight-plans, is their lack of robustness. Disruptions prevent from operating as planned before and induce high costs for trouble shooting. One reason for the uncertainties in the data for fleet assignment is that this problem is part of a long row of optimization problems of an airline. Therefore, important restrictions of later steps like connection dependent ground times should be considered in the fleet assignment problem. We show how connection dependent ground times can be added to the fleet assignment problem and presents three optimization methods, varying in run time and solution quality, that can solve real-world problem instances with more than 6000 legs within minutes. Moreover, real or believed non-determinism leads to inevitable uncertainties in input data. As a consequence, instead of a traditional plan, a flexible strategy which reacts on different relizations of the uncertain data is demanded. The Repair Game is a formalization of a planning task, and playing it performs disruption management and generates robust plans with the help of game tree search. We introduce the game and present experimental results of a feasibility study. © 2009 Springer Berlin Heidelberg.

关键词： Stochastic systems

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A CEP-based SOA for the management of WasteWater Treatment Plants

A CEP-based SOA for the management of WasteWater Treatment P...

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IEEE Workshop on Environmental, Energy, and Structural Monitoring systems, EESMS

作者： Davide Sottara Alberto Manservisi Paola Mello Gabriele Colombini Luca Luccarini Department of Computer Science Electronics and Systems Faculty of Engineering University of Bologna Bologna Italy Water Resource Management Section ENEA-ACS PROT IDR Bologna Italy

In the last years, integrated hardware/software architectures for the remote and/or automatic management of WasteWater Treatment Plants have been developed using different approaches and techniques. In this paper, we propose a different modular infrastructure which extends a Service-Oriented Architecture with the concept of Complex Event Processing. Our proposal is based on an Enterprise Service Bus, a distributed message-oriented middleware, extended with a Rule Service, embedding a rule engine in the system, an Event Router and an Event Scheduler. The infrastructure is then used to implement a modular and flexible management system for a Sequencing Batch Reactor treatment plant: this system includes a database facility, a user interface, a temporized manager to schedule the different phases of the treatment process and, finally, a signal-aware realtime DSS used for an adaptive process control.

关键词： Semiconductor optical amplifiers Waste management Wastewater treatment Service oriented architecture Hardware Software architecture Software development management Proposals Message-oriented middleware Engines

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Algorithm for analyzing order of importance of persons in images

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Kyokai Joho Imeji Zasshi/Journal of the Institute of Image Information and Television Engineers 2009年第9期63卷 1314-1317页

作者： Kageyamat, Yoichi Toduka, Yasuhiro Sato, Mizuho Nishida, Makoto Shirasawa, Yoichi Ootakitt, Kenta Department of Computer Science and Engineering Faculty of Engineering and Resource Science Akita University 1-1 Tegata Gakuen Akita 010-8502 Japan Alpha Systems Inc. 6-6-1 Kamikodajiaka Nakahara-Ku Kawasaki-City Kanagawa 211-0053 Japan

To pinpoint a specific person from two or more individuals per image stored in a database, the order of importance of all individuals in the image must be analyzed. An algorithm is proposed that can be used to automatically analyze the order of importance on the basis of face size and the placement of a face within an image. The relative values among the major person and the others are also calculated. The proposed algorithm includes four steps: detection of faces, acquisition of composition information, selection of the major person, and judgment of order of importance. Tests on 100 images suggest that the proposed algorithm is suitable for analyzing the order of importance of individuals per image.

关键词： Image analysis

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Data communication crypto protocol for security systems sensor networks

Data communication crypto protocol for security systems sens...

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IEEE International Workshop on Intelligent Data Acquisition and Advanced Computing systems: Technology and Applications

作者： P. Bykovyy V. Kochan Y. Kinakh A. Sachenko O. Roshchupkin S. Aksoy G. Markowsky Ternopil National Economic University Research Institute of Intelligent Computer Systems Ternopil Ukraine Computer Science Faculty Chernivtsi National University Chernivtsi Ukraine Electronics Engineering Department Gebze Institute of Technology Gebze Kocaeli Turkey Department of Computer Science Orono ME USA

This paper describes hardware implementations of crypto protocol elements for secured data communication in two wired networks of security system detectors. Those elements are basic to crypto protocol development for that type of network. In addition, hardware tools for the network controller and the network server that support this protocol were developed. These tools will allow us to test and debug the proposed security elements and the crypto protocol.

关键词： Data communication Cryptography Protocols Communication system security Data security Sensor systems Hardware Detectors Communication system control Network servers

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Compact modelling of Through-Silicon Vias (TSVs) in three-dimensional (3-D) integrated circuits

Compact modelling of Through-Silicon Vias (TSVs) in three-di...

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IEEE International Conference on 3D System Integration, 3DIC

作者： Roshan Weerasekera Matt Grange Dinesh Pamunuwa Hannu Tenhunen Li-Rong Zheng Department of Electronics Computer and Software Systems KTH School of Information and Communication Technologies Kista Sweden Centre of Microsystems Engineering Faculty of Science & Technology Lancaster University Lancaster UK

Modeling parasitic parameters of Through-Silicon-Via (TSV) structures is essential in exploring electrical characteristics such as delay and signal integrity (SI) of circuits and interconnections in three-dimensional (3-D) integrated circuits (ICs). This paper presents a complete set of self-consistent equations including self and coupling terms for resistance, capacitance and inductance of various TSV structures. Further, a reduced-order electrical circuit model is proposed for isolated TSVs as well as bundled structures for delay and SI analysis, and extracted TSV parasitics are employed in Spectre simulations for performance evaluations. Critical issues in the performance modeling for design space exploration of 3-D ICs such as cross-talk induced switching pattern dependent delay variation and cross-talk on noise are discussed. The error in these metrics when using the proposed models as compared to a field solver is contained to a few percentage points.

关键词： Integrated circuit modeling Through-silicon vias Delay Electric variables Integrated circuit interconnections Equations Coupling circuits Electric resistance Parasitic capacitance Inductance

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Multi Channel EOG Signal Recognition for an Embedded Eye Movement Tracking Device

Multi Channel EOG Signal Recognition for an Embedded Eye Mov...

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International Conference on systems, Signals and Image Processing, IWSSIP

作者： Matej Kirbis Iztok Kramberger ASTRON d.o.o. RND Company Maribor Slovenia Faculty of Electrical Engineering and Computer Science Laboratory for Digital and Information Systems University of Maribor Maribor Slovenia

In this paper we describe a low cost embedded system for eye movement tracking that supports disabled persons with basic interaction with Bluetooth enabled electronic devices. The method is based on tracking the EOG potential. The device has a built-in 32-bit RISC processor that performs acquisition of multichannel differential EOG signals and signal recognition. Signal recognition is based on cross correlation principle where a simplified triangulated linear model for eye movement is used as a reference signal. The eye movement recognition is more or less user independent, but it takes some time and practice to become familiar with the system for efficient use. The embedded eye movement tracking device communicates with other devices via personal network, which is based on Bluetooth wireless technology. The communication protocol at the application level has been simplified in order to gain plain integration with other devices.

关键词： Electrooculography Tracking Skin Image segmentation Streaming media Reflectivity Image sensors Color Feature extraction computer vision

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