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Publisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

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Nature communications 2019年第1期10卷 2459页

作者： Peer Aramillo Irizar Sascha Schäuble Daniela Esser Marco Groth Christiane Frahm Steffen Priebe Mario Baumgart Nils Hartmann Shiva Marthandan Uwe Menzel Jule Müller Silvio Schmidt Volker Ast Amke Caliebe Rainer König Michael Krawczak Michael Ristow Stefan Schuster Alessandro Cellerino Stephan Diekmann Christoph Englert Peter Hemmerich Jürgen Sühnel Reinhard Guthke Otto W Witte Matthias Platzer Eytan Ruppin Christoph Kaleta Research Group Medical Systems Biology Institute of Experimental Medicine Christian-Albrechts-University Kiel D-24105 Kiel Germany. Jena University Language and Information Engineering Lab Friedrich-Schiller-University Jena D-07743 Jena Germany. GerontoSys JenAge Consortium D-07745 Jena Germany. Genome Analysis Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Hans Berger Department of Neurology Jena University Hospital D-07747 Jena Germany. Systems Biology and Bioinformatics Group Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute D-07745 Jena Germany. Biology of Ageing Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Molecular Genetics Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Imageing Facility Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Integrated Research and Treatment Center Center for Sepsis Control and Care (CSCC) Jena University Hospital D-07747 Jena Germany. Network Modeling Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute D-07745 Jena Germany. Institute for Medical Informatics and Statistics Christian-Albrechts-University Kiel D-24105 Kiel Germany. Energy Metabolism Laboratory Swiss Federal Institute of Technology (ETH) Zurich Schwerzenbach/Zürich CH-8603 Switzerland. Department of Bioinformatics Friedrich-Schiller-University Jena D-07743 Jena Germany. Laboratory of Neurobiology Scuola Normale Superiore University of Pisa I-56100 Pisa Italy. Molecular Biology Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Faculty of Biology and Pharmacy Friedrich-Schiller-University Jena D-07743 Jena Germany. Biocomputing Lab Leibniz Institute on Aging-Fritz-Lipmann-Institute D-07745 Jena Germany. Department of Computer Science and Center for Bioinformatics and Computational Biology University of Maryland College Park M

The original version of this Article contained an error in the spelling of the author Jule Müller, which was incorrectly given as Julia Müller. Additionally, in Fig. 4a, the blue-red colour scale for fold change in ageing/disease regulation included a blue stripe in place of a red stripe at the right-hand end of the scale. These errors have been corrected in both the PDF and HTML versions of the Article.

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Data-driven Property Verification of Grey-box systems by Bayesian Experiment Design

Data-driven Property Verification of Grey-box Systems by Bay...

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American control Conference

作者： S. Haesaert P.M.J. Van den Hof A. Abate Control Systems group in the Faculty of Electrical Engineering Eindhoven University of Technology The Netherlands Department of Computer Science Oxford University UK

ISBN: (纸本)9781479917730

A measurement-based statistical verification approach is developed for systems with partly unknown dynamics. These grey-box systems are subject to identification experiments which, new in this contribution, enable accepting or rejecting system properties expressed in a linear-time logic. We employ a Bayesian framework for the computation of a confidence level on the properties and for the design of optimal experiments. Applied to dynamical systems, this work enables data-driven verification of partly-known system dynamics with controllable non-determinism (inputs) and noisy output observations. A numerical case study concerning the safety of a dynamical system is used to elucidate this data-driven and model-based verification technique.

关键词： data driven Verification DYNAMICAL systems Bayesian inference System dynamics box system

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Platform for extending home automation gateway's functionality with plugin mechanism

Platform for extending home automation gateway's functionali...

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IEEE International Conference on Consumer Electronics - Berlin (ICCE-Berlin)

作者： Milan Pandurov Boris Petelj Roman Pavlović Nikola Teslić Control and Computing Department Faculty of Technical Sciences Novi Sad Serbia RT-RK Computer Based Systems Novi Sad Serbia

This paper presents design and implementation of a platform for easy extension and customization of home automation systems. The platform is intended to be a host for user-created extension plugin modules and to be deployed on home automation gateways. Platform allows those extension modules to be independent from target platform and execute them concurrently in secure and isolated environments. Developing plugin modules relies on common concept of web application development: it consists of server side part which is written in JavaScript and client side part which is written in common HTML5 manner.

关键词： Home automation Logic gates Web servers Libraries Sockets Protocols

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Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the BRATS challenge

arXiv

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arXiv 2018年

作者： Bakas, Spyridon Reyes, Mauricio Jakab, Andras Bauer, Stefan Rempfler, Markus Crimi, Alessandro Shinohara, Russell Takeshi Berger, Christoph Ha, Sung Min Rozycki, Martin Prastawa, Marcel Alberts, Esther Lipkova, Jana Freymann, John Kirby, Justin Bilello, Michel Fathallah-Shaykh, Hassan M. Wiest, Roland Kirschke, Jan Wiestler, Benedikt Colen, Rivka Kotrotsou, Aikaterini Lamontagne, Pamela Marcus, Daniel Milchenko, Mikhail Nazeri, Arash Weber, Marc-Andr Mahajan, Abhishek Baid, Ujjwal Gerstner, Elizabeth Kwon, Dongjin Acharya, Gagan Agarwal, Manu Alam, Mahbubul Albiol, Alberto Albiol, Antonio Albiol, Francisco J. Alex, Varghese Allinson, Nigel Amorim, Pedro H.A. Amrutkar, Abhijit Anand, Ganesh Andermatt, Simon Arbel, Tal Arbelaez, Pablo Avery, Aaron Azmat, Muneeza Pranjal, B. Bai, Wenjia Banerjee, Subhashis Barth, Bill Batchelder, Thomas Batmanghelich, Kayhan Battistella, Enzo Beers, Andrew Belyaev, Mikhail Bendszus, Martin Benson, Eze Bernal, Jose Bharath, Halandur Nagaraja Biros, George Bisdas, Sotirios Brown, James Cabezas, Mariano Cao, Shilei Cardoso, Jorge M. Carver, Eric N. Casamitjana, Adri Castillo, Laura Silvana Cat, Marcel Cattin, Philippe Cérigues, Albert Chagas, Vinicius S. Chandra, Siddhartha Chang, Yi-Ju Chang, Shiyu Chang, Ken Chazalon, Joseph Chen, Shengcong Chen, Wei Chen, Jefferson W. Chen, Zhaolin Cheng, Kun Choudhury, Ahana Roy Chylla, Roger Clrigues, Albert Colleman, Steven Colmeiro, Ramiro German Rodriguez Combalia, Marc Costa, Anthony Cui, Xiaomeng Dai, Zhenzhen Dai, Lutao Daza, Laura Alexandra Deutsch, Eric Ding, Changxing Dong, Chao Dong, Shidu Dudzik, Wojciech Eaton-Rosen, Zach Egan, Gary Escudero, Guilherme Estienne, Tho Everson, Richard Fabrizio, Jonathan Fan, Yong Fang, Longwei Feng, Xue Ferrante, Enzo Fidon, Lucas Fischer, Martin French, Andrew P. Fridman, Naomi Fu, Huan Fuentes, David Gao, Yaozong Gates, Evan Gering, David Gholami, Amir Gierke, Willi Glocker, Ben Gong, Mingming Gonzlez-Vill, Sandra Grosges, T. Guan, Yuanfang Guo, Sheng Gupta, Sudeep Han, Woo-Sup Han, Il Song Harmuth, Ko Center for Biomedical Image Computing and Analytics University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Institute for Surgical Technology and Biomechanics University of Bern Bern Switzerland Center for MR-Research University Children's Hospital Zurich Zurich Switzerland Support Centre for Advanced Neuroimaging Inselspital Institute for Diagnostic and Interventional Neuroradiology Bern University Hospital Bern Switzerland University Hospital of Zurich Zurich Switzerland Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia United States Image-Based Biomedical Modeling Group Technical University of Munich Munich Germany Icahn School of Medicine Mount Sinai Health System New YorkNY United States Leidos Biomedical Research Inc. Frederick National Laboratory for Cancer Research FrederickMD21701 United States Cancer Imaging Program National Cancer Institute National Institutes of Health BethesdaMD20814 United States Department of Neurology University of Alabama at Birmingham BirminghamAL United States Department of Diagnostic Radiology University of Texas MD Anderson Cancer Center HoustonTX United States Department of Psychology Washington University St. LouisMO United States Neuroimaging Informatics and Analysis Center Washington University St. LouisMO United States Department of Radiology Washington University St. LouisMO United States Institute of Diagnostic and Interventional Radiology Pediatric Radiology and Neuroradiology University Medical Center Rostock Ernst-Heydemann-Str. 6 Rostock18057 Germany Tata Memorial Centre Homi Bhabha National Institute Mumbai India Shri Guru Gobind Singhji Institute of Engineering and Technology Nanded India NVIDIA Santa Clara

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset. Copyright © 2018, The Authors. All rights reserved.

关键词： Tumors

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Web based solution for smart home functionality extension and control

Web based solution for smart home functionality extension an...

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IEEE International Conference on Consumer Electronics - Berlin (ICCE-Berlin)

作者： Boris Petelj Milan Pandurov Dejan Stefanović Ištvan Papp Control and Computing Department Faculty of Technical Sciences Novi Sad Serbia RT-RK Institute for Computer Based Systems Novi Sad Serbia

Some of the home automation solutions support user manageable extensions, although with numerous constraints: e.g. requirement for specific controller devices, operating system dependency, or platform specific programming knowledge for development. This approach results in closed policy of home automation systems and excludes independent developers from anticipating in their expansion. This paper provides a concept and implementation that overcomes these constraints by developing extensions using common Web technologies. It offers mechanism for users to configure their system with new functionality, by installing or removing extension modules from system in run-time. Extensions can be accessed and controlled from various personal devices independent from operating system through Web interface. The solution was validated through development and installation of application for smart devices control, based on modern Web technologies. Still, only basic programming knowledge is required for extension development, making it facile to novice developers.

关键词： Home automation Logic gates Standards Protocols Conferences

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Radiative Cooling of the Thermally Isolated System in KAGRA Gravitational Wave Telescope

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Journal of Physics: Conference Series 2021年第1期1857卷

作者： T. Akutsu M. Ando K. Arai Y. Arai S. Araki A. Araya N. Aritomi Y. Aso S.-W. Bae Y.-B. Bae L. Baiotti R. Bajpai M. A. Barton K. Cannon E. Capocasa M.-L. Chan C.-S. Chen K.-H. Chen Y.-R. Chen H.-Y. Chu Y.-K. Chu S. Eguchi Y. Enomoto R. Flaminio Y. Fujii M. Fukunaga M. Fukushima G.-G. Ge A. Hagiwara S. Haino K. Hasegawa H. Hayakawa K. Hayama Y. Himemoto Y. Hiranuma N. Hirata E. Hirose Z. Hong B.-H. Hsieh G.-Z. Huang P.-W. Huang Y.-J. Huang B. Ikenoue S. Imam K. Inayoshi Y. Inoue K. Ioka Y. Itoh K. Izumi K. Jung P. Jung T. Kajita M. Kamiizumi N. Kanda G.-W. Kang K. Kawaguchi N. Kawai T. Kawasaki C. Kim J. Kim W. Kim Y.-M. Kim N. Kimura N. Kita H. Kitazawa Y. Kojima K. Kokeyama K. Komori A. K. H. Kong K. Kotake C. Kozakai R. Kozu R. Kumar J. Kume C.-M. Kuo H.-S. Kuo S. Kuroyanagi K. Kusayanagi K. Kwak H.-K. Lee H.-W. Lee R.-K. Lee M. Leonardi C.-Y. Lin F.-L. Lin L. C.-C. Lin G.-C. Liu L.-W. Luo M. Marchio Y. Michimura N. Mio O. Miyakawa A. Miyamoto Y. Miyazaki K. Miyo S. Miyoki S. Morisaki Y. Moriwaki K. Nagano S. Nagano K. Nakamura H. Nakano M. Nakano R. Nakashima T. Narikawa R. Negishi W.-T. Ni A. Nishizawa Y. Obuchi W. Ogaki J. J. Oh S.-H. Oh M. Ohashi N. Ohishi M. Ohkawa K. Okutomi K. Oohara C.-P. Ooi S. Oshino K.-C. Pan H.-F. Pang J. Park F. E. Peiia Arellano I. Pinto N. Sago S. Saito Y. Saito K. Sakai Y. Sakai Y. Sakuno S. Sato T. Sato T. Sawada T. Sekiguchi Y. Sekiguchi S. Shibagaki R. Shimizu T. Shimoda K. Shimode H. Shinkai T. Shishido A. Shoda K. Somiya E. J. Son H. Sotani R. Sugimoto T. Suzuki H. Tagoshi H. Takahashi R. Takahashi A. Takamori S. Takano H. Takeda M. Takeda H. Tanaka K. Tanaka T. Tanaka S. Tanioka E. N. Tapia San Martin S. Telada T. Tomaru Y. Tomigami T. Tomura F. Travasso L. Trozzo T. T. L. Tsang K. Tsubono S. Tsuchida T. Tsuzuki D. Tuyenbayev N. Uchikata T. Uchiyama A. Ueda T. Uehara K. Ueno G. Ueshima F. Uraguchi T. Ushiba M. H. P. M. van Putten H. Vocca J. Wang C.-M. Wu H.-C. Wu S.-R. Wu W.-R. Xu T. Yamada K. Yamamoto T. Yamamoto K. Yokogawa J. Yokoyama T. Yokozawa T. Yoshioka H. Yuzurihar National Astronomical Observatory of Japan (NAOJ) 2-21-1 Osawa Mitaka-City Tokyo 181-8588 Japan Research Center for the Early Universe (RESCEU) The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Department of Physics The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Institute for Cosmic Ray Research (ICRR) The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa-City Chiba 277-8582Japan Accelerator Laboratory High Energy Accelerator Research Organization (KEK) 1-1 OhoTsukuba-City Ibaraki 305-0801 Japan Earthquake Research Institute The University of Tokyo 1-1-1Yayoi Bunkyo-ku Tokyo 113-0032Japan Kamioka Branch National Astronomical Observatory of Japan (NAOJ) 238 Higashi-Mozumi Kamioka-cho Hida-City Gifu Pref. Japan The Graduate University for Advanced Studies (SOKENDAI) 2-21-1 Osawa Mitaka-City Tokyo 181-8588 Japan Korea Institute of Science and Technology Information (KISTI) 245 Daehak-ro Yuseong-gu Daejeon 34141 South Korea National Institute for Mathematical Sciences 70 Yuseong-daero 1689 beon-gil Yuseong-gu Daejeon 34047 South Korea Graduate School of Science Osaka University 1-1 Machikaneyama-cho Toyonaka-City Osaka560-0043 Japan School of High Energy Accelerator Science The Graduate University for Advanced Studies (SOKENDAI) 1-1 Oho Tsukuba-City Ibaraki 305-0801 Japan Institute for Gravitational Research University of Glasgow Kelvin Building G12 8QQ UK Department of Applied Physics Fukuoka University Fukuoka Jonan Nanakuma 814-0180 Japan Department of Physics Tamkang university No.151 Yingzhuan Rd. Danshui Dist. New Taipei-City 25137 Taiwan Department of Physics the Center for High Energy and High Field Physics National Central University No. 300 Zhongda Road Zhongyi District Taiyuan-City 320 Taiwan Institute of Astronomy National Tsing Hua University No. 101 Section 2 Kuang-Fu Road Hsinchu 30013 Taiwan Department of Physics National Tsing Hua University No. 101 Section 2

Radiative cooling of the thermally isolated system is investigated in KAGRA gravitational wave telescope. KAGRA is a laser interferometer-based detector and main mirrors constituting optical cavities are cool down to 20K to reduce noises caused by the thermal fluctuation. The mirror is suspended with the multi-stage pendulum to isolate any vibration. Therefore, this mirror suspension system has few heat links to reduce vibration injection. Thus, this system is mainly cooled down with thermal radiation. In order to understand the process of radiative cooling of the mirror, we analyzed cooling curve based on mass and specific heat. As a result, it was newly found that a cryogenic part called 'cryogenic duct-shield' seems to have large contribution in the beginning of the mirror cooling. This finding will help to design new cooling system for the next generation cryogenic gravitational wave detector.

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A robust dynamic controller with observer for the tracking of a ZMP reference trajectory: A biped robot's walking under constraints

A robust dynamic controller with observer for the tracking o...

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World Symposium on Mechatronics Engineering & Applied Physics (WSMEAP)

作者： Mohamed Adel Sellami Imen Dakhli Elyes Maherzi Mongi Besbes Laboratory of Analysis Conception and Control of Systems Faculty of sciences of Tunis University of EI Manar Tunisia Unity of Mechatronic systems and signals High School of Technology and Computer Science University of Carthage Tunisia

In this work, we propose a novel robust dynamic controller in order to stabilize a walking biped robot with input and output constraints. Firstly, the trajectory of the robot is generated via the Zero Moment Point method based on the resolution of a convex optimization problem with Linear Matrix Inequalities. Then, the tracking of a referential trajectory is insured by the design of an optimal dynamic controller with predictive control theory. The synthesized dynamic controller allows the Lyapunov stability of the robot's walk. Moreover, it ensures the reducing of the overshoot and undershoot of the output signal, difficult to be adjusted by classical methods. This work is validated by a simulation via Matlab of some illustrative examples and results highlight the efficiency of the proposed study.

关键词： Robustness Legged locomotion Trajectory Observers Predictive control

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Hamiltonian Feedback Design for Mass Action Law Chemical Reaction Networks

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IFAC-PapersOnLine 2015年第13期48卷 158-163页

作者： György Lipták Gábor Szederkényi Katalin M. Hangos Process Control Research Group Systems and Control Laboratory Computer and Automation Research Institute Hungarian Academy of Sciences P.O. Box 63 H-1518 Budapest Hungary Faculty of Information Technology Peter Pazmany Catholic University Budapest Hungary

A special polynomial state feedback structure is proposed for open chemical reaction networks obeying the mass action law (MAL-CRNs) that stabilizes them for any of their admissible positive set of parameters. The proposed feedback makes the closed-loop system a reversible CRN that enables a generalized Hamiltonian description assuming that their number of reversible reactions is less or equal that the number of species. The design is based on solving a mixed integer linear optimization problem (MILP). A simple example is used to illustrate the basic concepts and the design method.

关键词： Process control Hamiltonian control Modelling Chemical Reaction Networks

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The fuzzy-controller for WiMAX networks

The fuzzy-controller for WiMAX networks

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Siberian Conference on control and Communications (SIBCON)

作者： Olena Semenova Andriy Semenov Oleksandr Voznyak Dmytro Mostoviy Igor Dudatyev Faculty of Radio Engineering Telecommunication and Instrument Engineering Vinnytsia National Technical University Vinnytsia Ukraine Faculty of Automatics Electronics and Computer Control Systems Vinnytsia National Technical University Vinnytsia Ukraine

ISBN: (纸本)9781479971046

WiMAX is a broadband wireless last mile technology providing high speeds for long distances and offering great flexibility. Scheduling in WiMAX became one of the most important tasks, because it is responsible for distributing available resources among users. A high level of quality of service and scheduling support is one of the most interesting features of the WiMAX standard. In modern telecommunication networks the access control techniques are widely used. That is because using such devices instead of traditional ones permits to increase accuracy and reliability of control. Fuzzy systems have replaced conventional techniques in many engineering applications, especially in control systems. In the article it is suggested to use a fuzzy controller for access control in WiMAX networks that allows avoiding congestion in networks. The main objective of this work is providing an implementation of the WiMAX standard using the dynamic fuzzy logic based priority scheduler. We propose to use a fuzzy controller having three input and one output linguistic variables. Input linguistic variables of the controller are waiting time, queue length and packet size, its output variable is priority. A block diagram of the fuzzy controller was developed. Linguistic variables, terms and membership functions for input and output values have been defined. The Waiting time linguistic variable has three terms: low, medium, high. The Queue length linguistic variable has three terms: short, medium, long. The Packet size linguistic variable has three terms: small, medium, large. The rules base consisting of twenty-seven rules has been developed. The fuzzy controller has been simulated using Matlab 6.5. Results of the simulation prove the accuracy and reliability of the fuzzy-controller's model.

关键词： Broadband communication Telecommunication network reliability

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Optimal Placement of the Distribution Substations to Improve Reliability Under Load Growth

Optimal Placement of the Distribution Substations to Improve...

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IEEE Power and Energy Society General Meeting

作者： M. R. Haghifam M. Esmaeeli A. Kazemi H. Shayanfar Faculty of Electrical and Computer Engineering Tarbiat Modares University Center of Excellence for Power Systems Control and Operation Department of Electrical Engineering Iran University of Science and Technology

ISBN: (纸本)9781467380416

In this paper, an approach is proposed for planning distribution networks in which the placement of distribution transformer is optimally planned. The size, number, and placement of distribution transformers are optimally determined in order to improve system reliability and to minimize the losses under load growth. An objective function is constituted, composed of the investment cost, maintenance cost, loss cost, and reliability cost. The reliability worth is not usually considered in the optimization of the distribution substation placement. However, it may be effective on the planning problem. The proposed approach is applied to a test system consisting of 42 electric load points. It is observed that the considering reliability in the planning approach reduces the total cost of the distribution transformer placement. However, the associated investment cost is increased but the reliability cost is more decreased.

关键词： Distribution Planning Load Growth Mixed Integer Nonlinear Programming (MINLP) Reliability Transformer

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