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Author Correction: Why rankings of biomedical image analysis competitions should be interpreted with care

Nature communications 2019年第1期10卷 588页

作者： Lena Maier-Hein Matthias Eisenmann Annika Reinke Sinan Onogur Marko Stankovic Patrick Scholz Tal Arbel Hrvoje Bogunovic Andrew P Bradley Aaron Carass Carolin Feldmann Alejandro F Frangi Peter M Full Bram van Ginneken Allan Hanbury Katrin Honauer Michal Kozubek Bennett A Landman Keno März Oskar Maier Klaus Maier-Hein Bjoern H Menze Henning Müller Peter F Neher Wiro Niessen Nasir Rajpoot Gregory C Sharp Korsuk Sirinukunwattana Stefanie Speidel Christian Stock Danail Stoyanov Abdel Aziz Taha Fons van der Sommen Ching-Wei Wang Marc-André Weber Guoyan Zheng Pierre Jannin Annette Kopp-Schneider Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. l.maier-hein@dkfz.de. Division of Computer Assisted Medical Interventions (CAMI) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Centre for Intelligent Machines McGill University Montreal QC H3A0G4 Canada. Christian Doppler Laboratory for Ophthalmic Image Analysis Department of Ophthalmology Medical University Vienna 1090 Vienna Austria. Science and Engineering Faculty Queensland University of Technology Brisbane QLD 4001 Australia. Department of Electrical and Computer Engineering Department of Computer Science Johns Hopkins University Baltimore MD 21218 USA. CISTIB - Center for Computational Imaging & Simulation Technologies in Biomedicine The University of Leeds Leeds Yorkshire LS2 9JT UK. Department of Radiology and Nuclear Medicine Medical Image Analysis Radboud University Center 6525 GA Nijmegen The Netherlands. Institute of Information Systems Engineering TU Wien 1040 Vienna Austria. Complexity Science Hub Vienna 1080 Vienna Austria. Heidelberg Collaboratory for Image Processing (HCI Heidelberg University 69120 Heidelberg Germany. Centre for Biomedical Image Analysis Masaryk University 60200 Brno Czech Republic. Electrical Engineering Vanderbilt University Nashville TN 37235-1679 USA. Institute of Medical Informatics Universität zu Lübeck 23562 Lübeck Germany. Division of Medical Image Computing (MIC) German Cancer Research Center (DKFZ) 69120 Heidelberg Germany. Institute for Advanced Studies Department of Informatics Technical University of Munich 80333 Munich Germany. Information System Institute HES-SO Sierre 3960 Switzerland. Departments of Radiology Nuclear Medicine and Medical Informatics Erasmus MC 3015 GD Rotterdam The Netherlands. Department of Computer Science University of Warwick Coventry CV4 7AL UK. Department of Radiation Oncology Massachusetts General Hospital Boston MA

In the original version of this Article the values in the rightmost column of Table 1 were inadvertently shifted relative to the other columns. This has now been corrected in the PDF and HTML versions of the Article.

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Correction: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

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Journal of neuroengineering and rehabilitation 2024年第1期21卷 71页

作者： M Encarna Micó-Amigo Tecla Bonci Anisoara Paraschiv-Ionescu Martin Ullrich Cameron Kirk Abolfazl Soltani Arne Küderle Eran Gazit Francesca Salis Lisa Alcock Kamiar Aminian Clemens Becker Stefano Bertuletti Philip Brown Ellen Buckley Alma Cantu Anne-Elie Carsin Marco Caruso Brian Caulfield Andrea Cereatti Lorenzo Chiari Ilaria D'Ascanio Bjoern Eskofier Sara Fernstad Marcel Froehlich Judith Garcia-Aymerich Clint Hansen Jeffrey M Hausdorff Hugo Hiden Emily Hume Alison Keogh Felix Kluge Sarah Koch Walter Maetzler Dimitrios Megaritis Arne Mueller Martijn Niessen Luca Palmerini Lars Schwickert Kirsty Scott Basil Sharrack Henrik Sillén David Singleton Beatrix Vereijken Ioannis Vogiatzis Alison J Yarnall Lynn Rochester Claudia Mazzà Silvia Del Din Translational and Clinical Research Institute Faculty of Medical Sciences Newcastle University Newcastle Upon Tyne UK. Department of Mechanical Engineering and Insigneo Institute for in Silico Medicine The University of Sheffield Sheffield UK. Laboratory of Movement Analysis and Measurement Ecole Polytechnique Federale de Lausanne Lausanne Switzerland. Machine Learning and Data Analytics Lab Department of Artificial Intelligence in Biomedical Engineering Friedrich-Alexander-Universität Erlangen Nürnberg Erlangen Germany. Center for the Study of Movement Cognition and Mobility Neurological Institute Tel Aviv Sourasky Medical Center Tel Aviv Israel. Department of Biomedical Sciences University of Sassari Sassari Italy. Department of Electronics and Telecommunications Politecnico di Torino Turin Italy. National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC) Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK. Robert Bosch Gesellschaft für Medizinische Forschung Stuttgart Germany. The Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK. School of Computing Newcastle University Newcastle Upon Tyne UK. Barcelona Institute for Global Health (ISGlobal) Barcelona Spain. Universitat Pompeu Fabra Barcelona Catalonia Spain. CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain. Insight Centre for Data Analytics University College Dublin Dublin Ireland. School of Public Health Physiotherapy and Sports Science University College Dublin Dublin Ireland. Department of Electrical Electronic and Information Engineering «Guglielmo Marconi» University of Bologna Bologna Italy. Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV) University of Bologna Bologna Italy. Grünenthal GmbH Aachen Germany. Department of Neurology University Medical Center Schleswig-Holstein Campus Kiel Kiel Germany. Sagol School of Neuroscien

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Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries

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Cell 2024年第5期187卷 1296-1311.e26页

作者： Yu-Xi Tsai Ning-En Chang Klaus Reuter Hao-Ting Chang Tzu-Jing Yang Sören von Bülow Vidhi Sehrawat Noémie Zerrouki Matthieu Tuffery Michael Gecht Isabell Louise Grothaus Lucio Colombi Ciacchi Yong-Sheng Wang Min-Feng Hsu Kay-Hooi Khoo Gerhard Hummer Shang-Te Danny Hsu Cyril Hanus Mateusz Sikora Institute of Biological Chemistry Academia Sinica Taipei 11529 Taiwan Institute of Biochemical Sciences National Taiwan University Taipei 10617 Taiwan. Max Planck Computing and Data Facility 85748 Garching Germany. Department of Theoretical Biophysics Max Planck Institute for Biophysics 60438 Frankfurt Germany. Department of Theoretical Biophysics Max Planck Institute for Biophysics 60438 Frankfurt Germany Malopolska Centre of Biotechnology Jagiellonian University 31-007 Kraków Poland. Institute of Psychiatry and Neurosciences of Paris Inserm UMR1266 Université Paris-Cité 75014 Paris France. Hybrid Materials Interfaces Group Faculty of Production Engineering Bremen Center for Computational Materials Science and MAPEX Center for Materials and Processes University of Bremen 28359 Bremen Germany. Institute of Biological Chemistry Academia Sinica Taipei 11529 Taiwan. Institute of Biophysics Goethe University 60438 Frankfurt Germany. Institute of Biochemical Sciences National Taiwan University Taipei 10617 Taiwan International Institute for Sustainability with Knotted Chiral Meta Matter (WPI-SKCM(2)) Hiroshima University Hiroshima 739-8526 Japan. Electronic address: sthsu@gate.sinica.edu.tw. Institute of Psychiatry and Neurosciences of Paris Inserm UMR1266 Université Paris-Cité 75014 Paris France GHU Psychiatrie et Neurosciences de Paris 75014 Paris France. Electronic address: cyril.hanus@inserm.fr. Malopolska Centre of Biotechnology Jagiellonian University 31-007 Kraków Poland. Electronic address: mateusz.sikora@uj.edu.pl.

Most membrane proteins are modified by covalent addition of complex sugars through N- and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary structures and remain very mobile, shielding potentially large fractions of protein surface. High glycan conformational freedom hinders complete structural elucidation of glycoproteins. Computer simulations may be used to model glycosylated proteins but require hundreds of thousands of computing hours on supercomputers, thus limiting routine use. Here, we describe GlycoSHIELD, a reductionist method that can be implemented on personal computers to graft realistic ensembles of glycan conformers onto static protein structures in minutes. Using molecular dynamics simulation, small-angle X-ray scattering, cryoelectron microscopy, and mass spectrometry, we show that this open-access toolkit provides enhanced models of glycoprotein structures. Focusing on N-cadherin, human coronavirus spike proteins, and gamma-aminobutyric acid receptors, we show that GlycoSHIELD can shed light on the impact of glycans on the conformation and activity of complex glycoproteins.

关键词： GABAA receptor N-cadherin SAXS coronavirus S protein cryo-EM glycans glycoproteins mass spectrometry molecular dynamics

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The Fermi galactic center GeV excess and implications for dark matter

arXiv

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arXiv 2017年

作者： Ackermann, M. Ajello, M. Albert, A. Atwood, W.B. Baldini, L. Ballet, J. Barbiellini, G. Bastieri, D. Bellazzini, R. Bissaldi, E. Blandford, R.D. Bloom, E.D. Bonino, R. Bottacini, E. Brandt, T.J. Bregeon, J. Bruel, P. Buehler, R. Burnett, T.H. Cameron, R.A. Caputo, R. Caragiulo, M. Caraveo, P.A. Cavazzuti, E. Cecchi, C. Charles, E. Chekhtman, A. Chiang, J. Chiappo, A. Chiaro, G. Ciprini, S. Conrad, J. Costanza, F. Cuoco, A. Cutini, S. D’Ammando, F. de Palma, F. Desiante, R. Digel, S.W. Lalla, N. Di Mauro, M. Di Venere, L. Di Drell, P.S. Favuzzi, C. Fegan, S.J. Ferrara, E.C. Focke, W.B. Franckowiak, A. Fukazawa, Y. Funk, S. Fusco, P. Gargano, F. Gasparrini, D. Giglietto, N. Giordano, F. Giroletti, M. Glanzman, T. Gomez-Vargas, G.A. Green, D. Grenier, I.A. Grove, J.E. Guillemot, L. Guiriec, S. Gustafsson, M. Harding, A.K. Hays, E. Hewitt, J.W. Horan, D. Jogler, T. Johnson, A.S. Kamae, T. Kocevski, D. Kuss, M. Mura, G. La Larsson, S. Latronico, L. Li, J. Longo, F. Loparco, F. Lovellette, M.N. Lubrano, P. Magill, J.D. Maldera, S. Malyshev, D. Manfreda, A. Martin, P. Mazziotta, M.N. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Moiseev, A.A. Monzani, M.E. Morselli, A. Negro, M. Nuss, E. Ohsugi, T. Orienti, M. Orlando, E. Ormes, J.F. Paneque, D. Perkins, J.S. Persic, M. Pesce-Rollins, M. Piron, F. Principe, G. Rainò, S. Rando, R. Razzano, M. Razzaque, S. Reimer, A. Reimer, O. Sánchez-Conde, M. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Suson, D.J. Tajima, H. Tanaka, K. Thayer, J.B. Tibaldo, L. Torres, D.F. Troja, E. Uchiyama, Y. Vianello, G. Wood, K.S. Wood, M. Zaharijas, G. Zimmer, S. Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Los Alamos National Laboratory Los AlamosNM87545 United States Santa Cruz Institute for Particle Physics Department of Physics Department of Astronomy and Astrophysics University of California at Santa Cruz Santa CruzCA95064 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Laboratoire AIM CEA-IRFU CNRS Université Paris Diderot Service d’Astrophysique CEA Saclay Gif sur YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy NASA Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Department of Physics University of Washington SeattleWA98195-1560 United States Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 M

The region around the Galactic center (GC) is now well established to be brighter at energies of a few GeV than expected from conventional models of diffuse gamma-ray emission and catalogs of known gamma-ray sources. We study the GeV excess using 6.5 years of data from the Fermi Large Area Telescope. We characterize the uncertainty of the GC excess spectrum and morphology due to uncertainties in cosmic-ray source distributions and propagation, uncertainties in the distribution of interstellar gas in the Milky Way, and uncertainties due to a potential contribution from the Fermi bubbles. We also evaluate uncertainties in the excess properties due to resolved point sources of gamma rays. The Galactic center is of particular interest as it would be expected to have the brightest signal from annihilation of weakly interacting massive dark matter particles. However, control regions along the Galactic plane, where a dark-matter signal is not expected, show excesses of similar amplitude relative to the local background. Based on the magnitude of the systematic uncertainties, we conservatively report upper limits for the annihilation cross section as function of particle mass and annihilation channel. Copyright © 2017, The Authors. All rights reserved.

关键词： Gamma rays

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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Updated search for spectral lines from Galactic dark matter interactions with pass 8 data from the Fermi Large Area Telescope

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Physical Review D 2015年第12期91卷 122002-122002页

作者： M. Ackermann M. Ajello A. Albert B. Anderson W. B. Atwood L. Baldini G. Barbiellini D. Bastieri R. Bellazzini E. Bissaldi R. D. Blandford E. D. Bloom R. Bonino E. Bottacini T. J. Brandt J. Bregeon P. Bruel R. Buehler S. Buson G. A. Caliandro R. A. Cameron R. Caputo M. Caragiulo P. A. Caraveo C. Cecchi E. Charles A. Chekhtman J. Chiang G. Chiaro S. Ciprini R. Claus J. Cohen-Tanugi J. Conrad A. Cuoco S. Cutini F. D’Ammando A. de Angelis F. de Palma R. Desiante S. W. Digel L. Di Venere P. S. Drell A. Drlica-Wagner C. Favuzzi S. J. Fegan A. Franckowiak Y. Fukazawa S. Funk P. Fusco F. Gargano D. Gasparrini N. Giglietto F. Giordano M. Giroletti G. Godfrey G. A. Gomez-Vargas I. A. Grenier J. E. Grove S. Guiriec M. Gustafsson J. W. Hewitt A. B. Hill D. Horan G. Jóhannesson R. P. Johnson M. Kuss S. Larsson L. Latronico J. Li L. Li F. Longo F. Loparco M. N. Lovellette P. Lubrano D. Malyshev M. Mayer M. N. Mazziotta J. E. McEnery P. F. Michelson T. Mizuno A. A. Moiseev M. E. Monzani A. Morselli S. Murgia E. Nuss T. Ohsugi M. Orienti E. Orlando J. F. Ormes D. Paneque M. Pesce-Rollins F. Piron G. Pivato S. Rainò R. Rando M. Razzano A. Reimer T. Reposeur S. Ritz M. Sánchez-Conde A. Schulz C. Sgrò E. J. Siskind F. Spada G. Spandre P. Spinelli H. Tajima H. Takahashi J. B. Thayer L. Tibaldo D. F. Torres G. Tosti E. Troja G. Vianello M. Werner B. L. Winer K. S. Wood M. Wood G. Zaharijas S. Zimmer Deutsches Elektronen Synchrotron DESY D-15738 Zeuthen Germany Department of Physics and Astronomy Kinard Lab of Physics Clemson University Clemson South Carolina 29634-0978 USA W.W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics and SLAC National Accelerator Laboratory Stanford University Stanford California 94305 USA Department of Physics Stockholm University AlbaNova SE-106 91 Stockholm Sweden The Oskar Klein Centre for Cosmoparticle Physics AlbaNova SE-106 91 Stockholm Sweden Department of Physics and Department of Astronomy and Astrophysics Santa Cruz Institute for Particle Physics University of California at Santa Cruz Santa Cruz California 95064 USA Università di Pisa and Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste I-34127 Trieste Italy Dipartimento di Fisica Università di Trieste I-34127 Trieste Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova I-35131 Padova Italy Dipartimento di Fisica e Astronomia “G. Galilei ” Università di Padova I-35131 Padova Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa I-56127 Pisa Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari 70126 Bari Italy Istituto Nazionale di Fisica Nucleare Sezione di Torino I-10125 Torino Italy Dipartimento di Fisica Generale “Amadeo Avogadro ” Università degli Studi di Torino I-10125 Torino Italy NASA Goddard Space Flight Center Greenbelt Maryland 20771 USA Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 Montpellier France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 Route de Saclay F91128 Palaiseau France Consorzio Interuniversitario per la Fisica Spaziale (CIFS) I-10133 Torino Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica I-20133 Milano Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia I-06123 Perugia Italy Dipartime

Dark matter in the Milky Way may annihilate directly into γ rays, producing a monoenergetic spectral line. Therefore, detecting such a signature would be strong evidence for dark matter annihilation or decay. We search for spectral lines in the Fermi Large Area Telescope observations of the Milky Way halo in the energy range 200 MeV–500 GeV using analysis methods from our most recent line searches. The main improvements relative to previous works are our use of 5.8 years of data reprocessed with the Pass 8 event-level analysis and the additional data resulting from the modified observing strategy designed to increase exposure of the Galactic center region. We search in five sky regions selected to optimize sensitivity to different theoretically motivated dark matter scenarios and find no significant detections. In addition to presenting the results from our search for lines, we also investigate the previously reported tentative detection of a line at 133 GeV using the new Pass 8 data.

关键词： SPECTRAL lines DARK matter (Astronomy) ATOMIC spectra FERMI energy ELECTRONIC structure MILKY Way

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A Search for Cosmic-ray Proton Anisotropy with the Fermi Large Area Telescope

arXiv

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arXiv 2019年

作者： Ajello, M. Baldini, L. Barbiellini, G. Bastieri, D. Bechtol, K. Bellazzini, R. Bissaldi, E. Blandford, R.D. Bonino, R. Bottacini, E. Brandt, T.J. Bruel, P. Buson, S. Cameron, R.A. Caputo, R. Cavazzuti, E. Chen, S. Chiaro, G. Ciprini, S. Cohen-Tanugi, J. Costantin, D. Cuoco, A. Cutini, S. D’Ammando, F. de la Torre Luque, P. de Palma, F. Desai, A. Digel, S.W. Lalla, N. Di Venere, L. Di Domínguez, A. Fegan, S.J. Fukazawa, Y. Funk, S. Fusco, P. Gargano, F. Gasparrini, D. Giglietto, N. Giordano, F. Giroletti, M. Green, D. Grenier, I.A. Guiriec, S. Hayashi, K. Hays, E. Hewitt, J.W. Horan, D. Jóhannesson, G. Kuss, M. Latronico, L. Li, J. Liodakis, I. Longo, F. Loparco, F. Lubrano, P. Maldera, S. Manfreda, A. Martí-Devesa, G. Mazziotta, M.N. Meehan, M. Mereu, I. Meyer, M. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Morselli, A. Negro, M. Nuss, E. Omodei, N. Orienti, M. Orlando, E. Paliya, V.S. Paneque, D. Persic, M. Pesce-Rollins, M. Piron, F. Porter, T.A. Principe, G. Rainò, S. Rando, R. Razzano, M. Razzaque, S. Reimer, A. Reimer, O. Serini, D. Sgrò, C. Siskind, E.J. Spandre, G. Spinelli, P. Suson, D.J. Tajima, H. Thayer, J.B. Torres, D.F. Troja, E. Vandenbroucke, J. Yassine, M. Zimmer, S. Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Department of Physics University of Wisconsin-Madison MadisonWI53706 United States Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy Department of Physics and Astronomy University of Padova Vicolo Osservatorio 3 PadovaI-35122 Italy NASA Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Institut für Theoretische Physik and Astrophysik Universität Würzburg WürzburgD-97074 Germany NASA Goddard Space Flight Center GreenbeltMD20771 United States Italian Space Agency Via del Politecnico snc Roma00133 Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Istituto Nazionale di Fisica Nucleare Sezione di Roma "Tor Vergata" RomaI-00133 Italy Space Science Data Center - Agenzia Spaziale Italiana Via del Politecnico snc RomaI-00133 Italy Labo

The Fermi Large Area Telescope (LAT) has amassed a large data set of primary cosmic-ray protons throughout its mission. The LAT’s wide field of view and full-sky survey capabilities make it an excellent instrument for studying cosmic-ray anisotropy. As a space-based survey instrument, the LAT is sensitive to anisotropy in both right ascension and declination, while ground-based observations only measure the anisotropy in right ascension. We present the results of the first ever proton anisotropy search using Fermi LAT. The data set uses eight years of data and consists of approximately 179 million protons above 78 GeV, enabling it to probe dipole anisotropy below an amplitude of 10−3, resulting in the most stringent limits on the declination dependence of the dipole to date. We measure a dipole amplitude δ = 3.9 ±1.5 ×10−4 with a p-value of 0.01 (pre-trials) for protons with a minimum energy of 78 GeV. We discuss various systematic effects that could give rise to a dipole excess and calculate upper limits on the dipole amplitude as a function of minimum energy. The 95% CL upper limit on the dipole amplitude is δUL = 1.3 × 10−3 for protons with a minimum energy of 78 GeV and δUL = 1.2 × 10−3 for protons with a minimum energy of 251 GeV. Copyright © 2019, The Authors. All rights reserved.

关键词： Anisotropy

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Fermi-lat observations of high-energy behind-the-limb solar flares

arXiv

引用

arXiv 2017年

作者： Ackermann, M. Allafort, A. Baldini, L. Barbiellini, G. Bastieri, D. Bellazzini, R. Bissaldi, E. Bonino, R. Bottacini, E. Bregeon, J. Bruel, P. Buehler, R. Cameron, R.A. Caragiulo, M. Caraveo, P.A. Cavazzuti, E. Cecchi, C. Charles, E. Ciprini, S. Costanza, F. Cutini, S. D'Ammando, F. de Palma, F. Desiante, R. Digel, S.W. Di Lalla, N. Di Mauro, M. Di Venere, L. Drell, P.S. Favuzzi, C. Fukazawa, Y. Fusco, P. Gargano, F. Giglietto, N. Giordano, F. Giroletti, M. Grenier, I.A. Guillemot, L. Guiriec, S. Jogler, T. Jóhannesson, G. Kashapova, L. Krucker, S. Kuss, M. la Mura, G. Larsson, S. Latronico, L. Li, J. Liu, W. Longo, F. Loparco, F. Lubrano, P. Magill, J.D. Maldera, S. Manfreda, A. Mazziotta, M.N. Mitthumsiri, W. Mizuno, T. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Ohsugi, T. Omodei, N. Orlando, E. Pal'shin, V. Paneque, D. Perkins, J.S. Pesce-Rollins, M. Petrosian, V. Piron, F. Principe, G. Rainò, S. Rando, R. Razzano, M. Reimer, O. Rubio da Costa, F. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Tajima, H. Thayer, J.B. Torres, D.F. Troja, E. Vianello, G. Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS IN2P3 PalaiseauF-91128 France Dipartimento di Fisica "M. Merlin" dell'Università e del Politecnico di Bari BariI-70126 Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Science Data Center RomaI-00133 Italy Istituto Nazionale di Fisica Nucleare Sezione di Perugia PerugiaI-06123 Italy Dipartimento di Fisica Università degli Studi di Perugia PerugiaI-06123 Italy INAF Istituto di Radioastronomia BolognaI-40129 Italy Dipartimento di Astronomia Università di Bologna BolognaI-40127 Italy Università Telematica Pegaso Piazza Trieste e Trento 48 NapoliI-80132 Italy Università di Udine UdineI-33100 Italy Department of Physical Sciences Hiroshima University Higashi-Hiroshima Hiroshima739-8526 Japan Laboratoire AIM CEA IRFU CNRS Université Paris Diderot Servic

We report on the Fermi-LAT detection of high-energy emission from the behind-the-limb solar flares that occurred on 2013 October 11, 2014 January 6 and 2014 September 1. The Fermi-LAT observations are associated with flares from active regions originating behind both the eastern and western limbs, as determined by STEREO. All three flares are associated with very fast Coronal Mass Ejections (CMEs) and strong Solar Energetic Particle events. We present updated localizations of the > 100 MeV photon emission, hard X-ray (HXR) and EUV images and broad-band spectra from 10 keV to 10 GeV as well as microwave spectra. We also provide a comparison of the behind-the-limb flares detected by the Fermi-LAT with three on-disk flares and present a study of some of the significant quantities of these flares as an attempt to better understand the acceleration mechanisms at work during these occulted flares. We interpret the HXR emission to be due to electron bremsstrahlung from a coronal thin-target loop-top with the accelerated electron spectra steepening at semirelativistic energies. The > 100 MeV gamma-rays are best described by a pion decay model resulting from interaction of protons (and other ions) in a thick target photospheric source. The protons are believed to have been accelerated (to energies > 10 GeV) in the CME environment and precipitate down to the photosphere from the down-stream side of the CME shock and landed on the front side of the Sun, away from the original flare site and the HXR emission. Copyright © 2017, The Authors. All rights reserved.

关键词： Gamma rays

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OBSERVATIONS OF M31 AND M33 WITH THE FERMI LARGE AREA TELESCOPE: A GALACTIC CENTER EXCESS IN ANDROMEDA?

arXiv

引用

arXiv 2017年

作者： Ackermann, M. Ajello, M. Albert, A. Baldini, L. Ballet, J. Barbiellini, G. Bastieri, D. Bellazzini, R. Bissaldi, E. Bloom, E.D. Bonino, R. Bottacini, E. Brandt, T.J. Bregeon, J. Bruel, P. Buehler, R. Cameron, R.A. Caputo, R. Caragiulo, M. Caraveo, P.A. Cavazzuti, E. Cecchi, C. Charles, E. Chekhtman, A. Chiaro, G. Ciprini, S. Costanza, F. Cutini, S. D’Ammando, F. de Palma, F. Desiante, R. Digel, S.W. Di Lalla, N. Di Mauro, M. Di Venere, L. Favuzzi, C. Funk, S. Fusco, P. Gargano, F. Giglietto, N. Giordano, F. Giroletti, M. Glanzman, T. Green, D. Grenier, I.A. Guillemot, L. Guiriec, S. Hayashi, K. Hou, X. Jóhannesson, G. Kamae, T. Knödlseder, J. Kong, A.K.H. Kuss, M. la Mura, G. Larsson, S. Latronico, L. Li, J. Longo, F. Loparco, F. Lubrano, P. Maldera, S. Malyshev, D. Manfreda, A. Martin, P. Mazziotta, M.N. Michelson, P.F. Mirabal, N. Mitthumsiri, W. Mizuno, T. Monzani, M.E. Morselli, A. Moskalenko, I.V. Negro, M. Nuss, E. Ohsugi, T. Omodei, N. Orlando, E. Ormes, J.F. Paneque, D. Persic, M. Pesce-Rollins, M. Piron, F. Porter, T.A. Principe, G. Rainò, S. Rando, R. Razzano, M. Reimer, O. Sánchez-Conde, M. Sgrò, C. Simone, D. Siskind, E.J. Spada, F. Spandre, G. Spinelli, P. Tanaka, K. Tibaldo, L. Torres, D.F. Troja, E. Uchiyama, Y. Wang, J.C. Wood, K.S. Wood, M. Zaharijas, G. Zhou, M. Deutsches Elektronen Synchrotron DESY ZeuthenD-15738 Germany Department of Physics and Astronomy Clemson University Kinard Lab of Physics ClemsonSC29634-0978 United States Los Alamos National Laboratory Los AlamosNM87545 United States Università di Pisa Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Laboratoire AIM CEA-IRFU CNRS Université Paris Diderot Service d’Astrophysique CEA Saclay Gif sur YvetteF-91191 France Istituto Nazionale di Fisica Nucleare Sezione di Trieste TriesteI-34127 Italy Dipartimento di Fisica Università di Trieste TriesteI-34127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Padova PadovaI-35131 Italy Dipartimento di Fisica e Astronomia "G. Galilei" Università di Padova PadovaI-35131 Italy Istituto Nazionale di Fisica Nucleare Sezione di Pisa PisaI-56127 Italy Istituto Nazionale di Fisica Nucleare Sezione di Bari BariI-70126 Italy W. W. Hansen Experimental Physics Laboratory Kavli Institute for Particle Astrophysics and Cosmology Department of Physics SLAC National Accelerator Laboratory Stanford University StanfordCA94305 United States Istituto Nazionale di Fisica Nucleare Sezione di Torino TorinoI-10125 Italy Dipartimento di Fisica Università degli Studi di Torino TorinoI-10125 Italy NASA Goddard Space Flight Center GreenbeltMD20771 United States Laboratoire Univers et Particules de Montpellier Université Montpellier CNRS/IN2P3 MontpellierF-34095 France Laboratoire Leprince-Ringuet École polytechnique CNRS/IN2P3 PalaiseauF-91128 France Santa Cruz Institute for Particle Physics Department of Physics Department of Astronomy and Astrophysics University of California at Santa Cruz Santa CruzCA95064 United States Dipartimento di Fisica "M. Merlin" dell’Università e del Politecnico di Bari BariI-70126 Italy INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica Milano via E. Bassini 15 MilanoI-20133 Italy Science Data Center RomaI-00133 Italy Istituto Nazionale di Fi

The Fermi Large Area Telescope (LAT) has opened the way for comparative studies of cosmic rays (CRs) and high-energy objects in the Milky Way (MW) and in other, external, star-forming galaxies. Using 2 yr of observations with the Fermi LAT, Local Group galaxy M31 was detected as a marginally extended gamma-ray source, while only an upper limit has been derived for the other nearby galaxy M33. We revisited the gamma-ray emission in the direction of M31 and M33 using more than 7 yr of LAT Pass 8 data in the energy range 0.1−100 GeV, presenting detailed morphological and spectral analyses. M33 remains undetected, and we computed an upper limit of 2.0×10−12 erg cm−2 s−1 on the 0.1−100 GeV energy flux (95% confidence level). This revised upper limit remains consistent with the observed correlation between gamma-ray luminosity and star-formation rate tracers and implies an average CR density in M33 that is at most half of that of the MW. M31 is detected with a significance of nearly 10σ. Its spectrum is consistent with a power law with photon index Γ = 2.4±0.1stat+syst and a 0.1−100 GeV energy flux of (5.6±0.6stat+syst)×10−12 erg cm−2 s−1. M31 is detected to be extended with a 4σ significance. The spatial distribution of the emission is consistent with a uniform-brightness disk with a radius of 0◦.4 and no offset from the center of the galaxy, but nonuniform intensity distributions cannot be excluded. The flux from M31 appears confined to the inner regions of the galaxy and does not fill the disk of the galaxy or extend far from it. The gamma-ray signal is not correlated with regions rich in gas or star-formation activity, which suggests that the emission is not interstellar in origin, unless the energetic particles radiating in gamma rays do not originate in recent star formation. Alternative and nonexclusive interpretations are that the emission results from a population of millisecond pulsars dispersed in the bulge and disk of M31 by disrupted globular clusters or from

关键词： Galaxies

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

引用

NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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