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Drug–target interactions prediction based on similarity graph features extraction and deep learning

Neural Computing and Applications 2025年第6期37卷 4303-4322页

作者： Torkey, Hanaa El-Behery, Heba Attia, Abdel-Fattah El-Fishawy, Nawal Computer Science and Engineering Department Faculty of Electronic Engineering Menoufia University Menouf Egypt Department of Computer Science and Engineering Faculty of Engineering Kafrelsheikh University Kafrelsheikh Egypt Department of Computer Science College of Computer Engineering and Sciences Prince Sattam Bin Abdulaziz University Al-Kharj Saudi Arabia

Identifying drug–target interactions (DTIs) is a critical step in both drug repositioning. The labor-intensive, time-consuming, and costly nature of classic DTI laboratory studies makes it imperative to create efficient computer algorithms to forecast possible DTIs. However, current computational approaches that predict potential drug–target interactions (DTIs) suffer from some limitations, like finding the best similarity measures or negative samples, and thus require substantial performance improvement. This study proposes an integrated approach based on feature representation and deep learning to predict DTIs. We extract the relevant features of drugs and proteins from heterogeneous networks using graph mining techniques. The proposed approach constructs a heterogeneous graph from the known drug–protein interactions, protein–protein, and drug–drug similarities. Then applying two feature extraction techniques to extract the features, then utilizing these features in training a deep learning model to predict the potential DTIs. Also, a novel algorithm is proposed to find the negative samples based on the drug and protein similarity matrices. Four Benchmark datasets are used to evaluate the proposed approach. Our approach achieves the highest AUC (area under the ROC curve) across all datasets (0.98) with around 2% increases over the existing methods. Experimental results demonstrate that our proposed approach outperforms the baseline methods in predicting DTI, and our negative sample-identifying algorithm could be established as a competitive solution. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2024.

关键词： Contrastive Learning

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Secure speech coding using chaotic shift keying for encryption combined with error recovery

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Multimedia Tools and Applications 2025年第7期84卷 3893-3927页

作者： Boumaraf, Messaouda Merazka, Fatiha LISIC Laboratory Telecommunications Department Electronic and Computer Engineering Faculty USTHB University Algiers Algeria LISIC Laboratory Telecommunications Department Electrical Engineering Faculty USTHB University Algiers Algeria

This paper presents a speech encryption algorithm utilizing chaotic shift keying alongside error recovery techniques for the G.722.2 codec. The algorithm employs chaotic data interleaving on speech inter-frames to replace continuous packet loss with isolated losses, thus restoring missing data packets. Codec parameters undergo encryption through the combination of multiple chaotic maps applied to intra sub-frames of speech, facilitating confusion and diffusion processes. Enhanced security is achieved through the utilization of multiple chaotic maps, including chaotic shift keying generators applied to codec sub-frame parameters. Specifically, the chaotic shift keying mechanism is employed using four chaotic maps: a Henon map for xn and yn, a logistic map for zn, a tent map for wn, and a cubic map for un. The keys derived from these maps are utilized for chaotic data interleaving on both inter-frames and intra sub-frames of the speech file to shuffle frame parameters (confusion) and scramble sub-frame parameters (diffusion). Additionally, the proposed system enhances speech quality by mitigating degradation caused by packet loss through a waveform substitution-based recovery method, which replaces lost packets with previously received copies. A series of experiments, including waveform representation, spectrogram analysis, Enhanced Modified Bark Spectral Distortion (EMBSD) test, WideBand Perceptual Evaluation of Speech Quality (WB-PESQ) test, MUltiple Stimuli with Hidden Reference and Anchor (MUSHRA) score, Mean Opinion Score (MOS) score, correlation test, entropy test, Number of Samples Change Rate (NSCR) test, Unified Average Modified Intensity (UACI) test, key space analysis, and sensitivity test, are conducted to evaluate the security and speech quality of the proposed system. The results validate the system’s security and confirm its ability to maintain good audio quality even under packet loss rates ranging from 5% to 20%. © The Author(s), under exclusive licen

关键词： Cryptography

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Evolutionary recurrent neural network based on equilibrium optimization method for cloud-edge resource management in internet of things

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Neural Computing and Applications 2025年第6期37卷 4957-4969页

作者： Ebrahimi Mood, Sepehr Rouhbakhsh, Adel Souri, Alireza Department of Computer Science Yazd University Yazd Iran Department of Computer Engineering Faculty of Engineering Haliç University Istanbul34060 Turkey School of Electrical and Electronic Engineering Shandong University of Technology Zibo255000 China

Cloud computing is an emerging field in information technology, enabling users to access a shared pool of computing resources. Despite its potential, cloud technology presents various challenges, with one of the most significant being resource management within the cloud environment. Specifically, the allocation of physical machines (PMs) to virtual machines (VMs) in the Infrastructure as a service (IaaS) layer aims to achieve optimal efficiency. To address this challenge, we propose an evolutionary recurrent neural network (RNN) for resource allocation, enhanced by the equilibrium optimization (EO) algorithm. This method improves the generalization performance and reduces the architecture complexity of RNNs, while ensuring better adaptability to various demand patterns in cloud environments. Additionally, the effectiveness of RNNs heavily relies on the quality of training data;hence, we generate appropriate training data to facilitate the development of an efficient resource management model. Through extensive simulations, our method demonstrates superior performance compared to traditional algorithms. However, it is worth noting that this study is primarily based on simulation results, highlighting the need for real-world validation to confirm its practical applicability. The proposed method's applicability to different cloud computing environments and scenarios, including various service models (IaaS, PaaS, and SaaS) and deployment models (public, private, and hybrid), is also briefly discussed. Future studies should explore the computational efficiency and potential optimization techniques of the EO-RNN approach and consider real-world implementations to validate its effectiveness and uncover practical challenges. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2024.

关键词： Cloud platforms

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Neuroadaptive Containment Control for Nonlinear Multiagent Systems With Input Saturation: An Event-Triggered Communication Approach

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IEEE Transactions on Systems, Man, and Cybernetics: Systems 2025年第5期55卷 3163-3173页

作者： Wang, Xin Zhang, Sen Li, Huaqing Zhang, Wei Li, Hongyi Huang, Tingwen Southwest University College of Electronic and Information Engineering Chongqing400715 China Shenzhen University of Advanced Technology Faculty of Computer Science and Control Engineering Shenzhen518055 China

In this article, a neuroadaptive event-triggered containment control strategy combined with the dynamic surface control (DSC) approach is proposed for nonlinear multiagent systems (MASs) with input saturation. Based on the event-triggered communication mechanisms, the updates of neural network weight and controllers are implemented solely under triggering conditions of violation, which markedly reduces unnecessary communication resources and minimizes inefficient control costs compared with the traditional control method. Radial basis function neural networks (RBF NNs) are employed to handle the nonlinear uncertainties of MASs. Simultaneously, an adaptive compensatory mechanism is incorporated within the backstepping process to address the nonlinear effect posed by input saturation. Additionally, we demonstrate the system stability by extending the Lyapunov theorem to jump and continuous scenarios while excluding Zeno behavior, realizing that all followers can enter the convex hull constructed by leaders. Finally, the effectiveness of the proposed methodology is verified through application simulations. © 2013 IEEE.

关键词： Radial basis function networks

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A comprehensive analysis of real-time video anomaly detection methods for human and vehicular movement

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Multimedia Tools and Applications 2025年第10期84卷 7519-7564页

作者： Pathirannahalage, Iroshan Jayasooriya, Vidura Samarabandu, Jagath Subasinghe, Akila Department of Electrical and Electronic Engineering Faculty of Engineering University of Sri Jayewardenepura Gangodawila Nugegoda10250 Sri Lanka Department of Electrical and Computer Engineering Faculty of Engineering Western University LondonONN6A 3K7 Canada

The ubiquitous integration of computer vision technologies has revolutionised various application domains, ranging from agriculture and transportation to healthcare and the military. In this context, real-time anomaly detection in video streams has emerged as a critical facet, particularly concerning the movement of vehicles and humans. Despite the increasing adoption of these technologies in real-life applications, a conspicuous research gap exists, the necessity for robust validation of benchmarked datasets and state-of-the-art methods before deployment in real-time settings. This paper addresses this gap through a holistic approach to extensively review the real-time video anomaly detection literature in Human and Vehicular Movement applications. Specifically, we examine the various architectures used for real-time video anomaly detection and provide a detailed analysis of their performance on benchmarked datasets. Furthermore, we delve into the multifaceted challenges encountered when identifying anomalies across different categories, encompassing issues related to computational resources, noise interference, frame complexity, data sparsity, diversity, ethical considerations and their combinations. We address these challenges by proposing potential future trends in anomaly detection, including the development of more sophisticated datasets, exploration of hybrid architectural models, integration of multi-camera systems, advancement in open-set action recognition algorithms, model development for cutting-edge process automation systems, harnessing the potential of IoT, leveraging edge computing, and incorporating drone technologies into anomaly detection strategies. This paper aims to illuminate the direction of real-time anomaly detection for future research in vehicular and human movement. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

关键词： Anomaly detection

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Hybrid lightweight encryption for IoT: integrating chaotic key generators with Feistel and substitution-permutation networks for secure 3DV transmission

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Multimedia Tools and Applications 2025年 1-47页

作者： El-Shafai, Walid Mesrega, Ahmed K. Ahmed, Hossam Eldin H. Elbahnasawy, Nirmeen A. El-Samie, Fathi E. Abd Computer Science Department Prince Sultan University Riyadh11586 Saudi Arabia Deptartment of Electronics and Electrical Communications Engineering Faculty of Electronic Engineering Menoufia University Menouf32952 Egypt Department of Computer Science and Engineering Faculty of Electronic Engineering Menoufia University Menouf Egypt Department of Information Technology College of Computer and Information Sciences Princess Nourah Bint Abdulrahman University P.O. Box 84428 Riyadh11671 Saudi Arabia

The Internet of Things (IoT) stands as a revolutionary leap in digital connectivity, envisioning a future network connecting billions of devices, seamlessly. Amidst the myriad benefits, there arises an intricate web of challenges, prominently centered around potential threats and data security implications. Recent cryptography techniques, such as DNA-based cryptography, 3D chaos-based cryptography, and optical cryptography, face challenges including large encryption times, high energy consumption, and suboptimal rather than optimal performance. Particularly, the burden of long encryption cycles strains the energy resources of typical low-power and compact IoT devices. These challenges render the devices vulnerable to unauthorized breaches, despite large storage capacities. The hallmark of the IoT ecosystem, characterized by its low-power compact devices, is the burgeoning volume of data they generate. This escalating data influx, while necessitating expansive storage, remains vulnerable to unauthorized access and breaches. Historically, encryption algorithms, with their multifaceted architectures, have been the bulwark against such intrusions. However, their inherently-complex nature, entailing multiple encryption cycles, strains the limited energy reserves of typical IoT devices. In response to this intricate dilemma, we present a hybrid lightweight encryption strategy. Our algorithm innovatively leverages both one-dimensional (1D) and two-dimensional (2D) chaotic key generators. Furthermore, it amalgamates a classical encryption philosophy, harmonizing the strengths of Feistel and substitution-permutation networks. The centerpiece of our strategy is achieving effective encryption in merely three rounds, tailored expressly for compressed Three-Dimensional Video (3DV) frames, ensuring their unwavering integrity. Our workflow commences with the H.264/MVC compression algorithm, setting the stage for the subsequent encryption phase. Through rigorous MATLAB simulations,

关键词： Image coding

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A Fully LTPS-TFT-Based Bi-Directional Biomedical Interface Circuit for Large-Area Healthcare Applications

IEEE Journal on Flexible Electronics

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IEEE Journal on Flexible electronics 2025年第12期3卷 526-532页

作者： Zhang, Hanbo Lou, Yuqing Zhang, Zhihang Li, Yongfu Rokhan, Fakhrul Wang, Guoxing Zhao, Jian Shanghai Jiao Tong University School of Electronic Information and Electrical Engineering Shanghai200240 China Universiti Putra Malaysia Faculty of Engineering Department of Computer and Communication System Engineering Selangor Serdang43400 Malaysia

This paper proposed a fully LTPS-TFT-based bi-directional biomedical pixel interface with integrated a high linearity stimulator and a high-performance bio-potential sensing front-end circuit to amplify and digitize biological signals for high robustness data transmission. All circuits are designed and manufactured under a 3-μm LTPS process. We demonstrated the experiment in saline using the stimulator circuit to simulate stimulation inside the organism, achieving stimulation with different average currents under different duty cycles. The proposed front-end circuit has a gain of 40 dB. The referred input voltage noise of the entire signal chain is 86.2 μV/√Hz, and the ENOB is 9.13 bits at an input of 0.5 mVPP. Simultaneously conducting statistical testing on 20 chips has achieved a 1.05 dB SNDR standard deviation. Finally, we use a function signal generator to simulate the input signals of ECoG, ECG, and EOG, then use front-end circuits to read and reconstruct them to demonstrate that the proposed pixel interface can correctly read common biomedical signals for healthcare applications. © 2022 IEEE.

关键词： Image segmentation

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Enabling Ultralow-Latency Services with Ubiquitous Mobility by Means of a Compact Network Architecture

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IEEE Transactions on Mobile Computing 2025年第6期24卷 4858-4873页

作者： Cai, Guiliang Wu, Qiang Wang, Ran Zhi, Lianyi Fu, Xiaoming Zhang, Hongke Computer Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing China Faculty of Mathematics and Computer Science University of G¨oettingen Germany School of Electronic and Information Engineering Beijing Jiaotong University Beijing100044 China

With the rapid development of emerging services such as cellular vehicle-to-everything and immersive video service, network connections have further evolved from tangible physical connections to intangible virtual connections such as content, services, and computing resources, and the application scenarios have become more abundant. The mobile ultra-service, which is characterized by ultra-low latency, ultra-high reliability, and ubiquitous mobility, is becoming one of the most representative traffic types. However, the existing mobile network architecture has not evolved sufficiently to meet the specific requirements of these mobile ultra-services, the mobility anchors introduce unnecessary node and link latency, leaving space for further optimization. A compact network architecture (ComArch) is proposed in this paper for ultralow-latency services with ubiquitous mobility. ComArch is designed with a mapping control plane and a generalized forwarding plane to collaboratively implement packet forwarding in mobile scenarios. The generalized forwarding plane handles packet forwarding, while the mapping control plane manages terminals’ identifier and locator mapping entries. The node latency introduced by mobility anchors is eliminated, and an efficient routing scheme is proposed to find the optimal mandatory nodes in the forwarding path, thereby reducing unnecessary link latency. Experimental results show that ComArch can effectively reduce end-to-end delay while saving resources. © 2002-2012 IEEE.

关键词： Vehicle to Everything

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Comparison of Classical and Deep Learning-Based Feature Representations for Age-Related Macular Degeneration 5th

Comparison of Classical and Deep Learning-Based Feature Re...

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5th International Conference on Medical Imaging and computer Aided Diagnosis, MICAD 2024

作者： Sinichi, Parsa Bernabeu, Miguel O. Javidi, Malihe Department of Computer Engineering Faculty of Electronic and Computer Engineering Quchan University of Technology Quchan Iran Centre for Medical Informatics University of Edinburgh Edinburgh United Kingdom

ISBN: (纸本)9789819638628

Age-related Macular Degeneration (AMD) is a leading cause of visual impairment among the elderly worldwide. This study compares deep learning-based and classical feature extraction methods for AMD classification using colour fundus images, a cost-effective imaging modality. This comparative approach aims to evaluate the performance of advanced deep learning methods against traditional computer vision approaches in generating effective feature representation. To achieve this, we compared various classical feature extraction methods alongside deep learning-based approaches, specifically VGG16 pre-trained on ImageNet, RETFound and RETFound-Green, which are foundation models pre-trained on a significant number of retinal images. The results demonstrate that combinations of classical features still obtained notable performance and even outperformed the VGG16 model pre-trained on ImageNet. These results also highlight the need for deep learning models to be trained on domain-specific data to surpass classical approaches. In this regard, the pre-trained RETFound and RETFound-Green models yielded promising outcomes for AMD classification, and the highest performance was achieved using a fine-tuned RETFound model. Furthermore, the best proposed method was compared with the state-of-the-art methods. This approach achieved competitive results on the ADAM dataset, demonstrating its robustness and effectiveness in AMD classification while utilising a significantly simpler architecture. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Contrastive Learning

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Exploiting Multi-Level Data Uncertainty for Japanese-Chinese Neural Machine Translation

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IEICE Transactions on Information and Systems 2025年第5期E108.D卷 440-443页

作者： Li, Zezhong Ma, Jianjun Ren, Fuji Faculty of Computer Science Zhejiang University of Water Resources and Electric Power China Faculty of Foreign Languages Dalian University of Technology China College of Computer Science and Engineering The Shenzhen Institute for Advanced Study University of Electronic Science and Technology of China China

The performance of Neural Machine Translation (NMT) heavily depends on the severity of data uncertainty existing in the training examples. In terms of its causes, data uncertainty can be categorized into intrinsic and extrinsic uncertainty, both of which can increase the learning difficulty in NMT, and lead to degradation in translation performance. To cope with this challenge, we propose a simple yet effective method to estimate the data uncertainty and incorporate it into the adaptive training of NMT, which can mitigate the hurt brought by the uncertain data. Our method consists of two modules: 1) we propose a mBERT based model for estimating token-level and sentence-level data uncertainties jointly, which is trained with multi-task learning;2) we propose heterogeneous ways of incorporating the derived multi-level uncertainties into the NMT training by using soft-masked embedding and weighted loss. Extensive experiments on Japanese↔Chinese translation show that our proposed methods substantially outperform the strong baselines in terms of BLEU scores, and verify the effectiveness of modeling data uncertainty in NMT. Copyright © 2025 The Institute of electronics, Information and Communication Engineers.

关键词： Neural machine translation

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