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Drug–target interactions prediction based on similarity graph features extraction and deep learning

Neural Computing and Applications 2025年第6期37卷 4303-4322页

作者： Torkey, Hanaa El-Behery, Heba Attia, Abdel-Fattah El-Fishawy, Nawal Computer Science and Engineering Department Faculty of Electronic Engineering Menoufia University Menouf Egypt Department of Computer Science and Engineering Faculty of Engineering Kafrelsheikh University Kafrelsheikh Egypt Department of Computer Science College of Computer Engineering and Sciences Prince Sattam Bin Abdulaziz University Al-Kharj Saudi Arabia

Identifying drug–target interactions (DTIs) is a critical step in both drug repositioning. The labor-intensive, time-consuming, and costly nature of classic DTI laboratory studies makes it imperative to create efficient computer algorithms to forecast possible DTIs. However, current computational approaches that predict potential drug–target interactions (DTIs) suffer from some limitations, like finding the best similarity measures or negative samples, and thus require substantial performance improvement. This study proposes an integrated approach based on feature representation and deep learning to predict DTIs. We extract the relevant features of drugs and proteins from heterogeneous networks using graph mining techniques. The proposed approach constructs a heterogeneous graph from the known drug–protein interactions, protein–protein, and drug–drug similarities. Then applying two feature extraction techniques to extract the features, then utilizing these features in training a deep learning model to predict the potential DTIs. Also, a novel algorithm is proposed to find the negative samples based on the drug and protein similarity matrices. Four Benchmark datasets are used to evaluate the proposed approach. Our approach achieves the highest AUC (area under the ROC curve) across all datasets (0.98) with around 2% increases over the existing methods. Experimental results demonstrate that our proposed approach outperforms the baseline methods in predicting DTI, and our negative sample-identifying algorithm could be established as a competitive solution. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2024.

关键词： Contrastive Learning

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Care4U: Integrated healthcare systems based on blockchain

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Blockchain(Research and Applications) 2023年第4期4卷 2-13页

作者： Randa Kamal Ezz El-Din Hemdan Nawal El-Fishway Department of Computer Science and Engineering Faculty of Electronic EngineeringMenoufia UniversityEgypt

During the COVID-19 crisis, the need to stay at home has increased dramatically. In addition, the number of sickpeople, especially elderly persons, has increased exponentially. In such a scenario, home monitoring of patientscan ensure remote healthcare at home using advanced technologies such as the Internet of Medical Things (IoMT).The IoMT can monitor and transmit sensitive health data;however, it may be vulnerable to various attacks. In thispaper, an efficient healthcare security system is proposed for IoMT applications. In the proposed system, themedical sensors can transmit sensed encrypted health data via a mobile application to the doctor for ***, three consortium blockchains are constructed for load balancing of transactions and reducing transactionlatency. They store the credentials of system entities, doctors' prescriptions and recommendations according to thedata transmitted via mobile applications, and the medical treatment process. Besides, cancelable biometrics areused for providing authentication and increasing the security of the proposed medical system. The investigationalresults show that the proposed system outperforms existing work where the proposed model consumed lessprocessing time by values of 18%, 22%, and 40%, and less energy for processing a 200 KB file by values of 9%,13%, and 17%. Finally, the proposed model consumed less memory usage by values of 7%, 7%, and 18.75%. Fromthese results, it is clear that the proposed system gives a very reliable and secure performance for efficientlysecuring medical applications.

关键词： Healthcare Blockchain Cyber security Internet of things Internet of Medical Things Cancelable biometrics

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Hybrid two-level protection system for preserving pre-trained DNN models ownership

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Neural Computing and Applications 2024年第34期36卷 21415-21449页

作者： Fkirin, Alaa Moursi, Ahmed Samy Attiya, Gamal El-Sayed, Ayman Shouman, Marwa A. Department of Electrical Engineering Faculty of Engineering Fayoum University Fayoum Egypt Computer Science and Engineering Department Faculty of Electronic Engineering Menoufia Governorate Menouf32952 Egypt

Recent advancements in deep neural networks (DNNs) have made them indispensable for numerous commercial applications. These include healthcare systems and self-driving cars. Training DNN models typically demands substantial time, vast datasets and high computational costs. However, these valuable models face significant risks. Attackers can steal and sell pre-trained DNN models for profit. Unauthorised sharing of these models poses a serious threat. Once sold, they can be easily copied and redistributed. Therefore, a well-built pre-trained DNN model is a valuable asset that requires protection. This paper introduces a robust hybrid two-level protection system for safeguarding the ownership of pre-trained DNN models. The first-level employs zero-bit watermarking. The second-level incorporates an adversarial attack as a watermark by using a perturbation technique to embed the watermark. The robustness of the proposed system is evaluated against seven types of attacks. These are Fast Gradient Method Attack, Auto Projected Gradient Descent Attack, Auto Conjugate Gradient Attack, Basic Iterative Method Attack, Momentum Iterative Method Attack, Square Attack and Auto Attack. The proposed two-level protection system withstands all seven attack types. It maintains accuracy and surpasses current state-of-the-art methods. © The Author(s) 2024.

关键词： Deep neural networks

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Food ingredient recognition model via image and textual feature extraction and hybrid classification strategy

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International Journal of Reasoning-based Intelligent Systems 2024年第1期16卷 74-90页

作者： Madival, Sharanabasappa A. Jawaligi, Shivkumar S. Department of Computer Science and Engineering Faculty of Engineering and Technology Sharnbasva University India Department of Electronic and Communication Engineering Faculty of Engineering and Technology Sharnbasva University Karanataka Kalburgi India

This research work focuses on food recognition, especially, the identification of the ingredients from food images. Here, the developed model includes two stages namely: 1) feature extraction;2) classification. Initially, the image features and textual features will be extracted, where image features like SIFT and improved CNN-based deep features, textural features are extracted. Then, the hybrid classifier is used for the identification of food ingredients that combines the models like neural network (NN) as well as long short-term memory (LSTM). In order to make the accurate results, the weights of NN and LSTM are fine-tuned via the Chebyshev map evaluated teamwork optimisation (CME-TWO) algorithm. At the final stage, the primacy of the offered scheme is proven concerning varied metrics. Copyright © 2024 Inderscience Enterprises Ltd.

关键词： Feature extraction

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Efficient Saliency Map Detection for Low-Light Images Based on Image Gradient

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IEEE Transactions on Circuits and Systems for Video Technology 2024年第2期34卷 852-865页

作者： Lin, Chun-Yi Haq, Muhamad Amirul Chen, Jiun-Han Ruan, Shanq-Jang Naroska, Edwin National Taiwan University of Science and Technology Department of Electronic and Computer Engineering Taipei10607 Taiwan Hochschule Niederrhein University of Applied Science Faculty of Electrical Engineering and Computer Science Krefeld47805 Germany

Recently, deep learning has been widely employed across various domains. The Convolution Neural Network (CNN), a popular deep learning algorithm, has been successfully utilized in object recognition tasks, such as face recognition, vehicle recognition, and license plate recognition. However, conventional methods for object recognition may not be appropriate for low-light image recognition due to information loss in the dark regions and unexpected noise that can impair object quality. Therefore, the development of specialized techniques for low-light image enhancement has become a major research focus for object detection. This paper proposed a gradient-based saliency map detection method with an improved ResNet architecture that outperforms previous works in detecting multiple or large objects. Additionally, the proposed method enhances images with the object as the center and emphasizes foreground-background differences. Compared with previous works, this paper achieves1.28× improvements in the parameters and 1.32× faster inference speed than the original ResNet architecture. © 1991-2012 IEEE.

关键词： Neural networks

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The Integration of Explainable AI Methods for the Classification of Medical Image Data 11

The Integration of Explainable AI Methods for the Classifica...

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11th International Conference on Electrical, electronic and Computing engineering, IcETRAN 2024

作者： Nikolić, Mina Janković, Dragan Stanimirović, Aleksandar Stoimenov, Leonid Faculty of Electronic Engineering Computer Science Department Niš Serbia

ISBN: (纸本)9798350386998

Deep convolutional neural network architectures have in recent years been widely used for enhancing various computer vision tasks, such as Image classification, Semantic Segmentation and Object detection. With great advancements in terms of quality of the obtained results, the path was paved for using these kinds of neural networks in the medical domain. But, when working with sensitive matters involving human lives, there is a need to consider the interpretability and explainability of these models and not just the typical evaluation metrics for the given task. To do such a thing, tools such as LIME and PyTorch Grad-CAM can be used, among many others. The integration of Explainable AI (XAI) methods proposed in this paper aims to enable the paradigm of XAI to be used in medical image classification tasks with the standardized MedMNIST dataset. By doing such an integration, a deeper analysis regarding the quality of the model can be enabled. In that way, instances that were misclassified can be visually examined and used to paint a clearer picture of the complete model's decision-making process. © 2024 IEEE.

关键词： Convolutional neural networks

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Modified SPICE-Compatible Model Integrating NBTI and Self-Heating Effects for VDMOS Transistors 11

Modified SPICE-Compatible Model Integrating NBTI and Self-He...

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11th International Conference on Electrical, electronic and Computing engineering, IcETRAN 2024

作者： Marjanović, Milos Veljković, Sandra Mitrović, Nikola Živanović, Emilija Gavrić, Aleksandar Danković, Danijel Faculty of Electronic Engineering Department of Microelectronics Niš Serbia Faculty of Electronic Engineering Department of Computer Science Niš Serbia

ISBN: (纸本)9798350386998

This paper describes a modified SPICE-compatible VDMOS transistor model that includes NBT and self-heating effects. A complete circuit diagram of the transistor is given, which includes the electrical part of the circuit that models the NBT effect and the equivalent thermal part of the circuit that models the self-heating effect. The parameters of the model were determined based on the technical documentation and the fitting method based on the performed experiments. Fresh transistors and NBT-stressed transistors, with and without a heatsink in the load-driving circuit, were considered. The results of experiments and simulations correspond to each other with a maximum deviation of up to 10%. The proposed model can be used in the design and analysis of transistor reliability parameters. © 2024 IEEE.

关键词： SPICE

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Arrhythmia Detection by Using Chaos Theory with Machine Learning Algorithms

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computers, Materials & Continua 2024年第6期79卷 3855-3875页

作者： Maie Aboghazalah Passent El-kafrawy Abdelmoty M.Ahmed Rasha Elnemr Belgacem Bouallegue Ayman El-sayed Math and Computer Science Department Faculty of ScienceMenoufia UniversityShebin El-komEgypt College of Engineering Computer Science DepartmentEffat UniversityJeddahKingdom of Saudi Arabia Department of Computer Engineering College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia Computer Science and Engineering Department Faculty of Electronic EngineeringMenoufia UniversityShebin El-komEgypt Climate Change Information Center and Expert Systems Agriculture Research CenterGizaEgypt

Heart monitoring improves life ***(ECGs or EKGs)detect heart *** learning algorithms can create a few ECG diagnosis processing *** first method uses raw ECG and time-series *** second method classifies the ECG by patient *** third technique translates ECG impulses into Q waves,R waves and S waves(QRS)features using richer *** ECG signals vary naturally between humans and activities,we will combine the three feature selection methods to improve classification accuracy and *** using all three approaches have not been examined till *** researchers found that Machine Learning(ML)techniques can improve ECG *** study will compare popular machine learning techniques to evaluate ECG *** algorithms—Support Vector Machine(SVM),Decision Tree,Naive Bayes,and Neural Network—compare categorization *** plus prior knowledge has the highest accuracy(99%)of the four ML *** characteristics failed to identify signals without chaos *** 99.8%classification accuracy,the Decision Tree technique outperformed all previous experiments.

关键词： ECG extraction ECG leads time series prior knowledge and arrhythmia chaos theory QRS complex analysis machine learning ECG classification

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An Efficient Encryption and Compression of Sensed IoT Medical Images Using Auto-Encoder

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computer Modeling in engineering & sciences 2023年第2期134卷 909-926页

作者： Passent El-kafrawy Maie Aboghazalah Abdelmoty M.Ahmed Hanaa Torkey Ayman El-Sayed School of Information Technology and Computer Science Nile UniversityGiza12677Egypt Math and Computer Science Department Faculty of ScienceMenoufia UniversityMenoufia32511Egypt Department of Computer Engineering College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia Computer Science and Engineering Department Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

Healthcare systems nowadays depend on IoT sensors for sending data over the internet as a common *** ofmedical images is very important to secure patient *** these images consumes a lot of time onedge computing;therefore,theuse of anauto-encoder for compressionbefore encodingwill solve such a *** this paper,we use an auto-encoder to compress amedical image before encryption,and an encryption output(vector)is sent out over the *** the other hand,a decoder was used to reproduce the original image back after the vector was received and *** convolutional neural networks were conducted to evaluate our proposed approach:The first one is the auto-encoder,which is utilized to compress and encrypt the images,and the other assesses the classification accuracy of the image after decryption and *** hyperparameters of the encoder were tested,followed by the classification of the image to verify that no critical information was lost,to test the encryption and encoding *** this approach,sixteen hyperparameter permutations are utilized,but this research discusses three main cases in *** first case shows that the combination of Mean Square Logarithmic Error(MSLE),ADAgrad,two layers for the auto-encoder,and ReLU had the best auto-encoder results with a Mean Absolute Error(MAE)=0.221 after 50 epochs and 75%classification with the best result for the classification *** second case shows the reflection of auto-encoder results on the classification results which is a combination ofMean Square Error(MSE),RMSprop,three layers for the auto-encoder,and ReLU,which had the best classification accuracy of 65%,the auto-encoder gives MAE=0.31 after 50 *** third case is the worst,which is the combination of the hinge,RMSprop,three layers for the auto-encoder,and ReLU,providing accuracy of 20%and MAE=0.485.

关键词： Auto-encoder cloud image encryption IoT healthcare

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A privacy and compliance in regulated anonymous payment system based on blockchain

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Journal of Ambient Intelligence and Humanized Computing 2024年第8期15卷 3141-3157页

作者： Elfadul, Issameldeen Wu, Lijun Elhabob, Rashad Elkhalil, Ahmed School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu611731 China School of Information and Software Engineering University of Electronic Science and Technology of China Chengdu610054 China School of Computer and Information Engineering Qilu Institute of Technology Shandong Jinan250200 China Faculty of Computer Science and Information Technology Karary University Khartoum Sudan

Decentralized Anonymous Payment Systems (DAP), often known as cryptocurrencies, stand out as some of the most innovative and successful applications on the blockchain. These systems have garnered significant attention in the financial industry due to their highly secure and reliable features. Regrettably, the DAP system can be exploited to fund illegal activities such as drug dealing and terrorism. Therefore, governments are increasingly worried about the illicit use of DAP systems, which poses a critical threat to their security. This paper proposes Privacy and Compliance in Regulated Anonymous Payment System Based on Blockchain (PCRAP), which provides government supervision and enforces regulations over transactions without sacrificing the essential idea of the blockchain, that is, without surrendering transaction privacy or anonymity of the participants. The key characteristic of the proposed scheme is using a ring signature and stealth address to ensure the anonymity of both the sender and receiver of the transaction. Moreover, a Merkle Tree is used to guarantee government supervision and enforce regulations. Our proposed scheme satisfies most of the stringent security requirements and complies with the standards of secure payment systems. Additionally, while our work supports government regulations and supervision, it guarantees unconditional anonymity for users. Furthermore, the performance analysis demonstrates that our suggested scheme still remains applicable and effective even when achieving complete anonymity. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Blockchain

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