Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
The Gannet Optimization Algorithm (GOA) and the Whale Optimization Algorithm (WOA) demonstrate strong performance;however, there remains room for improvement in convergence and practical applications. This study intro...
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The Gannet Optimization Algorithm (GOA) and the Whale Optimization Algorithm (WOA) demonstrate strong performance;however, there remains room for improvement in convergence and practical applications. This study introduces a hybrid optimization algorithm, named the adaptive inertia weight whale optimization algorithm and gannet optimization algorithm (AIWGOA), which addresses challenges in enhancing handwritten documents. The hybrid strategy integrates the strengths of both algorithms, significantly enhancing their capabilities, whereas the adaptive parameter strategy mitigates the need for manual parameter setting. By amalgamating the hybrid strategy and parameter-adaptive approach, the Gannet Optimization Algorithm was refined to yield the AIWGOA. Through a performance analysis of the CEC2013 benchmark, the AIWGOA demonstrates notable advantages across various metrics. Subsequently, an evaluation index was employed to assess the enhanced handwritten documents and images, affirming the superior practical application of the AIWGOA compared with other algorithms.
Aspect-based sentiment analysis(ABSA)is a fine-grained *** fundamental subtasks are aspect termextraction(ATE)and aspect polarity classification(APC),and these subtasks are dependent and closely ***,most existing work...
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Aspect-based sentiment analysis(ABSA)is a fine-grained *** fundamental subtasks are aspect termextraction(ATE)and aspect polarity classification(APC),and these subtasks are dependent and closely ***,most existing works on Arabic ABSA content separately address them,assume that aspect terms are preidentified,or use a pipeline *** solutions design different models for each task,and the output from the ATE model is used as the input to the APC model,which may result in error propagation among different steps because APC is affected by ATE *** methods are impractical for real-world scenarios where the ATE task is the base task for APC,and its result impacts the accuracy of ***,in this study,we focused on a multi-task learning model for Arabic ATE and APC in which the model is jointly trained on two subtasks simultaneously in a *** paper integrates themulti-task model,namely Local Cotext Foucse-Aspect Term Extraction and Polarity classification(LCF-ATEPC)and Arabic Bidirectional Encoder Representation from Transformers(AraBERT)as a shred layer for Arabic contextual text *** LCF-ATEPC model is based on a multi-head selfattention and local context focus mechanism(LCF)to capture the interactive information between an aspect and its ***,data augmentation techniques are proposed based on state-of-the-art augmentation techniques(word embedding substitution with constraints and contextual embedding(AraBERT))to increase the diversity of the training *** paper examined the effect of data augmentation on the multi-task model for Arabic *** experiments were conducted on the original and combined datasets(merging the original and augmented datasets).Experimental results demonstrate that the proposed Multi-task model outperformed existing APC *** results were obtained by AraBERT and LCF-ATEPC with fusion layer(AR-LCF-ATEPC-Fusion)and the proposed data augmentation
Random pixel selection is one of the image steganography methods that has achieved significant success in enhancing the robustness of hidden *** property makes it difficult for steganalysts’powerful data extraction t...
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Random pixel selection is one of the image steganography methods that has achieved significant success in enhancing the robustness of hidden *** property makes it difficult for steganalysts’powerful data extraction tools to detect the hidden data and ensures high-quality stego image ***,using a seed key to generate non-repeated sequential numbers takes a long time because it requires specific mathematical *** addition,these numbers may cluster in certain *** hidden data in these clustered pixels will reduce the image quality,which steganalysis tools can ***,this paper proposes a data structure that safeguards the steganographic model data and maintains the quality of the stego *** paper employs the AdelsonVelsky and Landis(AVL)tree data structure algorithm to implement the randomization pixel selection technique for data *** AVL tree algorithm provides several advantages for image ***,it ensures balanced tree structures,which leads to efficient data retrieval and insertion ***,the self-balancing nature of AVL trees minimizes clustering by maintaining an even distribution of pixels,thereby preserving the stego image *** data structure employs the pixel indicator technique for Red,Green,and Blue(RGB)channel *** green channel serves as the foundation for building a balanced binary ***,the sender identifies the colored cover image and secret *** sender will use the two least significant bits(2-LSB)of RGB channels to conceal the data’s size and associated *** next step is to create a balanced binary tree based on the green *** the channel pixel indicator on the LSB of the green channel,we can conceal bits in the 2-LSB of the red or blue *** first four levels of the data structure tree will mask the data size,while subsequent levels will conceal the remaining digits of secret *** embedding the bits i
Diabetic retinopathy (DR) is an infection that bases eternal visualization loss in patients with diabetes mellitus. With DR, the glucose level in the blood increases, as well as its viscosity, this results in fluid le...
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Diabetic retinopathy (DR) is an infection that bases eternal visualization loss in patients with diabetes mellitus. With DR, the glucose level in the blood increases, as well as its viscosity, this results in fluid leakage into surrounding tissues in the retina. In other words, DR represents the pathology of capillaries and venules in the retina with leakage effects, being the main acute retinal disorder caused by diabetes. Many DR detection methods have been previously discussed by different researchers;however, accurate DR detection with a reduced execution time has not been achieved by existing methods. The proposed method, the Shape Adaptive box linear filtering-based Gradient Deep Belief network classifier (SAGDEB) Model, is performed to enhance the accuracy of DR detection. The objective of the SAGDEB Model is to perform an efficient DR identification with a higher accuracy and lower execution time. This model comprises three phases: pre-processing, feature extraction, and classification. The shape adaptive box linear filtering image pre-processing is carried out to reduce the image noise without removing significant parts of image content. Then, an isomap geometric feature extraction is performed to compute features of different natures, like shape, texture, and color, from the pre-processed images. After that, the Adaptive gradient Tversky Deep belief network classifier is to perform classification. The deep belief network is probabilistic and generative graphical model that consists of multiple layers such as one input unit, three hidden units, and one output unit. The extracted image featuresare considered in the input layer and these images are sent to hidden layers. Tversky similarity index is applied in hidden layer 1 to analyze the extracted features with testing features. Regarding the similarity value, the sigmoid activation function is determined in hidden layer 2 so different levels of DR can be identified. Finally, the adaptive gradient method is
The challenge of bankruptcy prediction, critical for averting financial sector losses, is amplified by the prevalence of imbalanced datasets, which often skew prediction models. Addressing this, our study introduces t...
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This systematic literature review delves into the dynamic realm of graphical passwords, focusing on the myriad security attacks they face and the diverse countermeasures devised to mitigate these threats. The core obj...
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Generative Artificial Intelligence (GAI) is fundamentally changing the ways of working and blurring the boundaries between human and machine-generated contents. While there is an increasing interest in the adoption of...
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Non-Orthogonal Multiple Access(NOMA)has already proven to be an effective multiple access scheme for5th Generation(5G)wireless *** provides improved performance in terms of system throughput,spectral efficiency,fairne...
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Non-Orthogonal Multiple Access(NOMA)has already proven to be an effective multiple access scheme for5th Generation(5G)wireless *** provides improved performance in terms of system throughput,spectral efficiency,fairness,and energy efficiency(EE).However,in conventional NOMA networks,performance degradation still exists because of the stochastic behavior of wireless *** combat this challenge,the concept of Intelligent Reflecting Surface(IRS)has risen to prominence as a low-cost intelligent solution for Beyond 5G(B5G)*** this paper,a modeling primer based on the integration of these two cutting-edge technologies,i.e.,IRS and NOMA,for B5G wireless networks is *** in-depth comparative analysis of IRS-assisted Power Domain(PD)-NOMA networks is provided through 3-fold ***,a primer is presented on the system architecture of IRS-enabled multiple-configuration PD-NOMA systems,and parallels are drawn with conventional network configurations,i.e.,conventional NOMA,Orthogonal Multiple Access(OMA),and IRS-assisted OMA *** by this,a comparative analysis of these network configurations is showcased in terms of significant performance metrics,namely,individual users'achievable rate,sum rate,ergodic rate,EE,and outage ***,for multi-antenna IRS-enabled NOMA networks,we exploit the active Beamforming(BF)technique by employing a greedy algorithm using a state-of-the-art branch-reduceand-bound(BRB)*** optimality of the BRB algorithm is presented by comparing it with benchmark BF techniques,i.e.,minimum-mean-square-error,zero-forcing-BF,and ***,we present an outlook on future envisioned NOMA networks,aided by IRSs,i.e.,with a variety of potential applications for 6G wireless *** work presents a generic performance assessment toolkit for wireless networks,focusing on IRS-assisted NOMA *** comparative analysis provides a solid foundation for the dev
In this article, a neuroadaptive event-triggered containment control strategy combined with the dynamic surface control (DSC) approach is proposed for nonlinear multiagent systems (MASs) with input saturation. Based o...
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