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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Yang, Jingcheng Kulwa, Frank Liu, Xuanwei Lu, Yiqing Fu, Yufa Li, Guanglin Huai, Yaping Zhang, Xin Li, Yongcheng Shenzhen Dapeng New District Nanao People's Hospital Guangdong Shenzhen518000 China Shenzhen Longhua District Central Hospital Department of Rehabilitation Medicine Guangdong Shenzhen518000 China Kunming University of Science and Technology Faculty of Information Engineering and Automation Kunming650500 China Kunming University of Science and Technology Brain Cognition and Brain-Computer Intelligence Integration Group Kunming650500 China Cas Key Laboratory of Human-Machine Intelligence Synergy Systems Shenzhen518055 China University of Chinese Academy of Sciences Shenzhen College of Advanced Technology Shenzhen518055 China Shandong Zhongke Advanced Technology Co. Ltd. Jinan250014 China

ISBN: (纸本)9798350371499

The emerging neurorehabilitation technology, Brain-Computer Interface (BCI), provides a novel prospect for stroke recovery. However, decoding brain activity during the movement present substantial challenges, and feature extraction is crutial to build a better decoder. In this study the CEBRA method were employed to extract features first based on electroencephalogram(EEG) data during Motor Execution(ME) and Motor lmagery (Ml) tasks for 20 participants (including 10 stroke patients). The results revealed that, in MI tasks, CEBRA-RF (Random Forests) achieved an average classification accuracy of 91.33%, with an average F1-score of 91.19%, and CEBRA-SVM (Support Vector Machine) achieved an average classification accuracy of 91.32%, with an average F1-score of 90.83%. Compared to other conventional feature extraction methods, CEBRA shows significantly higher accuracy (t-test, p © 2024 IEEE.

关键词： Patient rehabilitation

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A self-motivated carrier free nanoplatform for synergistic photodynamic and ferroptosis-based therapy for targeted antitumor treatment

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Nano Research 2025年第5期18卷 463-474页

作者： Chutong Tian Wenjing Ma Jianbin Shi Jia Deng Zeping Gao Haowen Tian Ayumi Kikkawa Kaho Tanaka Ronggang Xi Cong Luo Xiaobo Wang Ken-ichiro Kamei Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Pharmacy Department the 967th Hospital of PLA Joint Logistics Support ForceDalian 116021China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang 110016China Graduate School and Faculty of Pharmaceutical Sciences Kyoto UniversityYoshida-Ushinomiya-choSakyo-kuKyoto 606-8501Japan Institute for Integrated Cell-Material Sciences(WPI-iCeMS) Institute for Advanced StudyKyoto UniversityYoshida-Ushinomiya-choSakyo-kuKyoto 606-8501Japan Programs of Biology and Bioengineering Divisions of Science and EngineeringNew York University Abu DhabiAbu Dhabi 129188United Arab Emirates Department of Biomedical Engineering Tandon School of EngineeringNew York UniversityMetroTechBrooklynNY 11201USA

Photodynamic therapy(PDT)has been extensively investigated as an alternative cancer treatment;however,its efficacy is limited by the low oxygen content and excess glutathione(GSH)in tumor *** the emergence of ferroptosis,which also impacts redox homeostasis,a combined PDT-ferroptosis approach holds promise for amplifying the efficacy of both ***,concerns persist regarding biocompatibility and tumor-specific ***,we report a self-motivated co-nanoassembly for combined PDT and ferroptosis-driven tumor *** first modify linoleic acid with protoporphyrin Ⅸ to form a lipidic derivative(denoted as PLA)and develop a light-boosted carrier-free nanoplatform(PLA@R NPs)by co-assembling the ferroptosis inducer RAS-selective lethal 3(RSL3)and *** light irradiation,reactive oxygen species produced by PDT trigger linoleic acid peroxidation,leading to the destruction of the nanoparticles and the release of *** rapid release of RSL3 enhances PDT sensitivity by depleting GSH and utilizing the Fenton reaction to supplement ***,PDT accelerates lipid peroxidation,further inducing *** self-motivated effect increases oxidative stress in tumor tissues,as confirmed by a tumor-on-a-chip ***,the in vivo therapeutic effect with the PLA@R NPs is significant,demonstrating the promising potential of combining PDT and ferroptosis using a light-boosted and self-motivated nanoplatform.

关键词： ferroptosis photodynamic therapy carrier-free nanoparticle cancer treatment

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Time-Sensor Domain Data Decomposition and Analysis for Fault Diagnosis of Cutting Tools

Time-Sensor Domain Data Decomposition and Analysis for Fault...

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International Conference on control, Automation, Robotics and Vision (ICARCV)

作者： Yufei Gui Zi-Qiang Lang Zepeng Liu Yunpeng Zhu Hatim Laalej Department of Automatic Control and Systems Engineering The University of Sheffield Sheffield UK School of Engineering and Materials Science Queen Mary University of London London UK Advanced Manufacturing Research Centre The University of Sheffield Sheffield UK

ISBN: (纸本)9781665476881

In the present study, a novel time and sensor domain data decomposition and analysis framework is proposed to perform fault diagnosis of cutting tools. The problem of excessive computation burden existing in multi-sensor data-driven tool condition monitoring (TCM) system is resolved at the data level by compressing raw signals into a significantly smaller set of time and sensor domain data. The utilisation of the time domain components eliminates the influence of environmental noise on raw signals. Meanwhile, the introduction of the sensor domain components reveals the correlation relationship within multiple sensors. Experimental studies are conducted to verify the effectiveness of the proposed approach and illustrate the advantages of the time and sensor domain features compared with raw signal features.

关键词： Fault diagnosis Cutting tools Correlation Working environment noise Milling Robot sensing systems Robustness

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ROSIE: A ROS Adapter for a Modular Digital Twinning Framework

ROSIE: A ROS Adapter for a Modular Digital Twinning Framewor...

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IEEE International Workshop on Robot and Human Communication (ROMAN)

作者： Gianmarco Pisanelli Mariusz Tymczuk James A Douthwaite Jonathan M. Aitken James Law Advanced Manufacturing Research Centre The University of Sheffield Sheffield UK Department of Automatic Control and Systems Engineering The University of Sheffield Sheffield UK Department of Computer Science Advanced Manufacturing Research Centre The University of Sheffield Sheffield UK

ISBN: (数字)9781728188591

ISBN: (纸本)9781665406802

As robotic systems become more interactive and complex, there is a need to standardise interfaces and simplify development processes. This is particularly pertinent in the field of manufacturing, where human-robot collaboration is on the increase, but where standards and proprietary software are key barriers to deployment and *** this article we present the ROSIE Adapter, a general-purpose, modular adapter developed in ROS designed to support the creation and connection of industry-ready digital twins. Together with our previous work on the modular CSI digital-twin framework, we demonstrate how the ROSIE Adapter creates a versatile "plug-and-play" interface that simplifies the development of new robotic processes, and improves accessibility to novice users. Furthermore, the adaptor supports integration of intuitive interface devices, such as speech and augmented reality interfaces, which enable more natural collaboration. We describe the adaptor and its use in two real-world applications, demonstrate the ease of use via a three-day hackathon event, and provide results showing the faithfulness of the arising digital twins to their connected physical systems.

关键词： Adaptation models Collaboration Process control Data models Digital twins Safety Speech processing

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Port-Hamiltonian Modeling of Hydraulics in 4th Generation District Heating Networks

Port-Hamiltonian Modeling of Hydraulics in 4th Generation Di...

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IEEE Conference on Decision and control

作者： Felix Strehle Juan E. Machado Michele Cucuzzella Albertus J. Malan Jacquelien M.A. Scherpen Sören Hohmann Institute of Control Systems Karlsruhe Institute of Technology (KIT) Karlsruhe Germany Jan C. Willems Center for Systems and Control ENTEG Faculty of Science and Engineering University of Groningen AG Groningen the Netherlands Department of Electrical Computer and Biomedical Engineering University of Pavia Pavia Italy

ISBN: (数字)9781665467612

ISBN: (纸本)9781665467629

In this paper, we use elements of graph theory and port-Hamiltonian systems to develop a modular dynamic model describing the hydraulic behavior of 4th generation district heating networks. In contrast with earlier generation networks with a single or few heat sources and pumps, newer installations will prominently feature distributed heat generation units, bringing about a number of challenges for the control and stable operation of these systems, e.g., flow reversals and interactions among pumps controllers, which may lead to severe oscillations. We focus thus on flexible system setups with an arbitrary number of distributed heat sources and end-users interconnected through a meshed, multi-layer distribution network of pipes. Moreover, differently from related works on the topic, we incorporate dynamic models for the pumps in the system and explicitly account for the presence of pressure holding units. By inferring suitable (power-preserving) interconnection ports, we provide a number of claims about the passivity properties of the overall, interconnected system, which proves to be highly beneficial in the design of decentralized control schemes and stability analyses.

关键词： Heating systems Heat pumps Decentralized control Hydraulic systems Interconnected systems Distribution networks Stability analysis

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A Unifying Passivity-Based Framework for Pressure and Volume Flow Rate control in District Heating Networks

arXiv

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arXiv 2023年

作者： Strehle, Felix Machado, Juan E. Cucuzzella, Michele Malan, Albertus J. Scherpen, Jacquelien M.A. Hohmann, Sören Karlsruhe76131 Germany The Jan C. Willems Center for Systems and Control ENTEG Faculty of Science and Engineering University of Groningen Nijenborgh 4 Groningen9747 AG Netherlands The Department of Electrical Computer and Biomedical Engineering University of Pavia via Ferrata 5 Pavia27100 Italy

A fundamental precondition for the secure and efficient operation of district heating networks (DHNs) is a stable hydraulic behavior. However, the ongoing transition towards a sustainable heat supply, especially the rising integration of distributed heat sources and the increasingly meshed topologies, introduce complex and potentially destabilizing hydraulic dynamics. In this work, we propose a unifying, passivity-based framework which guarantees asymptotic stability of any forced hydraulic DHN equilibrium while allowing for meshed, time-varying topologies and different, dynamically interacting distributed heat sources. To establish the desired hydraulic equilibria, we propose decentralized, passivity-based pressure and volume flow rate controllers for the pumps and valves in the actuated DHN subsystems. In particular, we leverage the equilibrium-independent passivity (EIP) properties of the DHN subsystems, the skew-symmetric nature of their interconnections, and LaSalle's Invariance principle to assess asymptotic stability in a modular manner. The obtained results hold for the state-of-the-art as well as future DHN generations featuring, for example, multiple distributed heat sources, asymmetric pipe networks, and multiple temperature layers. We verify our findings by means of simulations. Copyright © 2023, The Authors. All rights reserved.

关键词： Asymptotic stability

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Extended Observer Form for Nonlinear System with Disturbances: Algorithm and Application

Extended Observer Form for Nonlinear System with Disturbance...

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International Conference on control, Automation, Robotics and Vision (ICARCV)

作者： Vadim Kaparin Ashutosh Simha Nilanjan Roy Chowdhury Ülle Kotta Yoash Levron Juri Belikov Department of Software Science Tallinn University of Technology Tallinn Estonia Flight Dynamics and Control Kadet Defence Systems Bangalore India Tata Consultancy Services Research Pune India Andrew and Erna Viterbi Faculty of Electrical Engineering Technion—Israel Institute of Technology Haifa Israel

ISBN: (数字)9798331518493

ISBN: (纸本)9798331518509

The paper addresses the problem of transforming single-output nonlinear state equations affine in disturbance into an extended observer form whose nonlinear injection part depends additionally on the derivatives of the output up to a finite order. Moreover, the considered form is affine in disturbance. Based on the earlier results a detailed algorithm is given and applied to the model of a synchronous machine connected to an infinite bus. For the system in the extended observer form a reduced-order Kalman-filter based observer can be designed such that its error dynamics is exponentially attractive and it is stable in the input-to-state sense with respect to the disturbance.

关键词： Heuristic algorithms Partial differential equations Transforms Observers Nonlinear control systems Mathematical models Real-time systems Nonlinear dynamical systems Synchronous machines Robots

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Single-grain cutting based modeling of abrasive belt wear in cylindrical grinding

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Friction 2020年第1期8卷 208-220页

作者： Zhe HE Jianyong LI Yueming LIU Jiwang YAN School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Key Laboratory of Vehicle Advanced Manufacturing Measuring and Control TechnologyMinistry of EducationBeijing 100044China Department of Mechanical Engineering Faculty of Science and TechnologyKeio UniversityHiyoshi 3-14-1Kohoku-kuYokohama 223-8522Japan

A systematic wear model of the cylindrical grinding process with an alumina abrasive belt from the perspective of single grain sliding wear was established in this *** model consists of three parts:a single cutting force model derived by applying a stress integration method,a single grain wear height analysis based on the wear rate of alumina,and a grinding mileage prediction of multiple grains with Gaussian distributed protrusion *** force,single grain wear height and full‐size grinding mileage verification experiments were *** results indicated that the established model was in reasonable agreement with the experimental outcomes,which suggests that this model could be useful in the industry to predict the wear process of abrasive belts.

关键词： abrasive belt single grain cutting slide wear grinding mileage

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Local Anomalous Drug Diffusion at Healthy-Cancer Tissue Surface and Data-Driven Tumor Growth Model Prediction *

Local Anomalous Drug Diffusion at Healthy-Cancer Tissue Surf...

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American control Conference (ACC)

作者： Maria Ghita Dana Copot Charlotte Billiet Dirk Verellen Clara M. Ionescu Faculty of Engineering and Architecture Ghent University Dynamical Systems and Control Research lab Belgium EEDT - Decisions and Control Core Lab Flanders Make Consortium Belgium Faculty of Medical Science Antwerp University Antwerpen Belgium Department of Radiation Oncology Iridium Netwerk – GZA Hospital Sint Augustinus Wilrijk Belgium

This paper discusses reliable yet minimal computational models for predicting the patient’s response to anticancer multi-drug combined therapy. The distribution of the drugs into the local heterogeneity of healthy-tumor tissues can be translated into mathematical models. Ideally, these should best describe the physiological processes and physical mechanisms, together with the interactions between the contributing components of the tumor growth dynamic system. Our previously proposed pharmacokinetic-pharmacodynamic (PKPD) mathematical model is revisited for different spatiotemporal fractional drug diffusion patterns. In particular, we examine the specific diffusion-related factors that limit drug effect through the tumor’s surface. The ability of the tumor growth PKPD model to predict patient responsiveness was evaluated using prior radiation therapy data in a patient with lung cancer. This study shows that the effect of anomalous diffusion mechanisms within tumor tissue should be considered while modeling the dose-response relationship for optimal results of cancer therapies.

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Design and Regulation of Feco2s4 Nanoneedles Deposited on Carbon Felt as Binder-Free Electrodes for High-Performance Hybrid Supercapacitor

SSRN

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SSRN 2023年

作者： Li, Hongjie Liu, Hui Liu, Qifan Yang, Chao Qiu, Jianhui Zang, Limin Guangxi Key Laboratory of Optical and Electronic Materials and Devices College of Materials Science and Engineering Guilin University of Technology Guilin541004 China Guangxi Key Laboratory of Advanced Structural Materials and Carbon Neutralization Guangxi Minzu University Nanning530006 China Department of Machine Intelligence and Systems Engineering Faculty of Systems Science and Technology Akita Prefectural University Yurihonjo015-0055 Japan

Hybrid supercapacitors have drawn much attention since they possess both high energy density and power density. Carbon felt (CF) is chosen as the substrate in this work due to its 3D porous structure, good conductivity, and excellent flexibility. FeCo2S4 nanoneedles are designed and uniformly deposited on CF via hydrothermal, annealing and sulfidation processes, forming the binder-free FeCo2S4@CF electrode. The electrode with unique features is beneficial to the exposure of electroactive sites and the rapid transport of electrons/ions, showing a high specific capacitance of 847.8 mF cm−2 and outstanding rate performance. The hybrid supercapacitor assembled by FeCo2S4@CF electrode and activated carbon felt exhibits the maximum specific capacitance of 309.7 mF cm−2, energy density of 110.1 μWh cm−2 and power density of 562.4 μW cm−2. Besides, the capacitance retention of the device is 98.5% after 10000 charge-discharge cycles and 87.2% after 3000 bending cycles respectively, revealing its great cycling stability and flexibility. © 2023, The Authors. All rights reserved.

关键词： Morphology

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