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Multiomics analysis reveals microbial diversity and activity through spontaneous fermentation of Theobroma cacao

Heliyon 2024年第23期10卷 e40542页

作者： da Costa Fonseca, Ynara Bahule, Celina Eugenio Herrera, Hector da Silva Martins, Luiza Helena Lopes, Alessandra Santos Cassoli, Juliana Silva Trindade, Felipe Costa Chagas da Costa, Isa Rebecca Henrique de Oliveira Costa, Paulo Oliveira, Guilherme Borges da Silva Valadares, Rafael Graduate Program in Agricultural Applied Biotechnology Federal Rural University of Amazonia President Tancredo Neves Ave 2501 Belém CEP 66.077-830 Brazil Vale Institute of Technology Boaventura da Silva Street 955 Belém CEP 66050-090 Brazil Center of Studies in Science and Technology (NECET) Rovuma University Niassa Branch Lichinga Mozambique Departamento de Ciencias Forestales Facultad de Ciencias Agropecuarias y Medioambiente Universidad de La Frontera Temuco 4811230 Chile Center for Biodiversity and Ecological Sustainability (C-BEST) Facultad de Ciencias Agropecuarias y Medioambiente Universidad de La Frontera Chile Institute of Animal Health and Production Federal Rural University of Amazonia President Tancredo Neves Ave. 2501 Belém CEP 66077-830 Brazil Faculty of Food Engineering Institute of Technology Federal University of Pará Belém CEP 66075-110 Brazil Laboratory of Omics Sciences Institute of Biological Sciences Guamá Campus Federal University of Pará Belém 66075-110 Brazil

To gain insight into the active microbiota during spontaneous fermentation of Theobroma cacao L., this study assessed protein diversity during 120 h using a combined metabarconding and metaproteomics approach. During the first days of fermentation, most of the peptides were associated with T. cacao and yeast (0–72 h). Peptides associated with bacteria became more abundant after 72 h of fermentation, coinciding with a decrease in peptides associated with cocoa (96–120 h). In addition to the known microorganisms involved in fermentation, such as Saccharomyces, Lactobacillus and Acetobacter, novel genera were also metabolically active, including Microvirga, Inquilinus, Candolleomyces and Lasiodiplodia. The results showed a consistency in the main genera detected by both techniques, but the identification of unexplored genera such as Inquilinus, Microvirga, Cyphellophora and Ashbya gossypii, among others, suggests that this omics approach needs to be used together for more comprehensive results on spontaneous fermentation. In conclusion, studies combining techniques such as metabarcoding and metaproteomics should be considered in fermentation studies, as a single technique would result in omissions regarding the activity of certain microorganisms that may be important for the course of spontaneous fermentation. © 2024

关键词： Bacteria Cocoa Metabarcoding Metaproteomics

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Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways

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Chemico-Biological Interactions 2023年第1期370卷 110329页

作者： Hsu, Chia-Hung Weng, Pei-Wei Chen, Ming-Yao Yeh, Chi-Tai Setiawan, Syahru Agung Yadav, Vijesh Kumar Wu, Alexander T.H. Tzeng, David T.W. Gong, Jian-Xian Yang, Zhen Tzeng, Yew-Min Department of Emergency Medicine Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei City 11031 Taiwan Department of Emergency Medicine School of Medicine Taipei Medical University Taipei 11031 Taiwan Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Department of Orthopaedics Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Shuang Ho Hospital New Taipei City 23561 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Continuing Education Program of Food Biotechnology Applications College of Science and Engineering National Taitung University Taitung 95092 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Ph.D. Program of Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan School of Life Sciences The Chinese University of Hong Kong 999077 Hong Kong Lifebit London EC2A 2AP United Kingdom Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen 518055 China State Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education and Beijing National Laboratory for Molecular Science College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Shenzhen Bay Laboratory Shenzhen 518055 China Department of Applied Science National Taitung University Taitung

Until recently, sorafenib has been the only treatment approved by the U.S. food and Drug Administration for patients with advanced hepatocellular carcinoma (HCC). Some patients, however, exhibit resistance to this treatment and subsequently experience cancer progression, recurrence, or death. Therefore, identifying a new alternative treatment for patients with little or no response to sorafenib treatment is vital. In this study, we explored the therapeutic potential and underlying molecular mechanism of antrocinol ((3aS,4R,6aS,10aR)-4-(hydroxymethyl)-7,7-dimethyldecahydro-1H-naphtho[1,8a-c]furan-1-one) in patients with HCC. The results indicated that antrocinol was more therapeutically effective than antrocin, Stivarga, and sorafenib against HCC cell lines. Antrocinol also substantially suppressed the expression of KRAS-GTP, p-MEK1/2, p-ERK1/2, and p-AKT in the Huh7 cell line. Additionally, antrocinol-induced apoptosis in the Huh7 cell line, inhibited the formation of tumorspheres, and suppressed the expression of cancer stem cell markers CD133, KLF4, CD44, OCT4, SOX2, and c-Myc. Animal studies revealed that antrocinol alone considerably suppressed tumor growth in nonobese diabetic/severe combined immunodeficient mice inoculated with Huh7 tumorspheres. It also synergistically enhanced the anticancer effect of sorafenib, resulting in enhanced suppression of tumor growth (p < 0.001) and tumorsphere formation (p < 0.001). In tumor samples resected from mice treated with antrocinol alone or in combination with sorafenib, immunohistochemical analysis revealed an increase in BAX expression and a decrease in ERK and AKT protein expression. To the best of our knowledge, this is the first report of the anti-HCC activity of antrocinol. With its higher therapeutic efficacy than that of sorafenib, antrocinol is a candidate drug for patients with HCC who demonstrate little or no response to sorafenib treatment. © 2022 Elsevier B.V.

关键词： Antrocinol Cancer stemness Hepatocellular carcinoma KRAS/AKT/ERK axis Sorafenib

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The effect of soaking time on mucilage removal from the coffee bean using pectinase enzyme

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IOP Conference Series: Earth and Environmental science 2021年第2期807卷

作者： Fitri A B Tawali A Laga Agricultural Science Study Program Graduate School Hasanuddin University Jl. Perintis Kemerdekaan Km 10 Tamalanrea Makassar 90245 Food Science and Technology Study Program Department of Agricultural Technology Faculty of Agriculture Hasanuddin University Jl. Perintis Kemerdekaan Km.10 Tamalanrea Makassar 90245

The perfect coffee fermentation process is characterized by the release of mucilage that covers the coffee beans. The mucilage that doesn't come off entirely from the coffee beans can affect the taste of the coffee. The mucilage, which is composed of pectin, can be removed using the pectinase enzyme. This study aims to determine the optimal soaking time required to remove the mucilage from the coffee beans. Coffee beans are soaked in a liquid containing the pectinase enzyme for 1, 2, 3, and 4 hours. The results showed that soaking coffee beans for 4 hours in the pectinase enzyme was the best contact time in releasing the coffee bean mucilage. Soaking coffee beans for 4 hours in the pectinase enzyme produced a pectin yield of 0.25%, total dissolved solids 1.05°Brix, pH 6.55, and total sugar 15.67%.

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Natural sweetener glycyrrhizin protects against precocious puberty by modulating the gut microbiome

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Life sciences 2024年 350卷 122789页

作者： Nguyen, Nam Nhat Lin, Chia-Yuan Tsai, Wan-Ling Huang, Hui-Yu Chen, Chung-Ming Tung, Yu-Tang Chen, Yang-Ching International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan Department of Food Science National Taiwan Ocean University Keelung 202 Taiwan Department of Family Medicine School of Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan Department of Health Promotion and Gerontological Care College of LOHAS Taipei University of Marine Technology New Taipei City 251 Taiwan Graduate Institute of Metabolism and Obesity Sciences Taipei Medical University Taipei 110 Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan Department of Pediatrics Taipei Medical University Hospital Taipei 110 Taiwan Graduate Institute of Biotechnology National Chung Hsing University Taichung 402 Taiwan Department of Family Medicine Wan Fang Hospital Taipei Medical University Taipei 116 Taiwan School of Nutrition and Health Sciences College of Nutrition Taipei Medical University Taipei 110 Taiwan Nutrition Research Center Taipei Medical University Hospital Taipei 110 Taiwan

Aims: Precocious puberty (PP) may lead to many adverse outcomes. Recent evidence suggests that PP is a gut–brain disease. On the other hand, the use of glycyrrhizin, a natural sweetener, has become popular in the past decade. Glycyrrhizin possesses various health benefits, but its impact on PP has yet to be investigated. We aimed to explore the protective effects of glycyrrhizin against PP in both humans (observational) and animals (interventional). Materials and methods: In the human cohort, we investigated the association between glycyrrhizin consumption and risk of PP. In the animal experiment, we observed puberty onset after feeding danazol-induced PP rats with glycyrrizin. Blood, fecal, and hypothalamic samples were harvested to evaluate potential mechanistic pathways. We also performed a fecal microbiota transplantation to confirm to causal relationship between glycyrrhizin and PP risk. Key findings: Glycyrrhizin exhibited a protective effect against PP in children (OR 0.60, 95%CI: 0.39–0.89, p = 0.013), primarily driven by its significance in girls, while no significant effect was observed in boys. This effect was consistent with findings in rodents. These benefits were achieved through the modulation of the gut microbiome, which functionally suppressed the hypothalamic–pituitary–gonadal axis and prevented PP progression. A fecal microbiota transplantation indicated that the causal correlation between glycyrrhizin intake and PP is mediated by the gut microbiome alterations. Significance: Our findings suggest that glycyrrhizin can protect against PP by altering the gut microbiome. Long term use of glycyrrhizin is safe and tolerable. Therefore, glycyrrhizin can serve as a safe and affordable complementary therapy for PP. © 2024 Elsevier Inc.

关键词： Fecal microbiota transplantation Glycyrrhizin Gut microbiome Gut-brain disease Hypothalamic-pituitary-gonadal axis Natural sweetener Precocious puberty

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Polyelectrolyte nanoparticles derived from durian seed gum modified with chitosan for selective targeting in cancer cells

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International Journal of Biological Macromolecules 2025年 315卷 144625页

作者： Putro, Jindrayani Nyoo Bintang Ilhami, Fasih Cheng, Chih-Chia Imanuela, Keziah Janice Mangindaan, Dave Irawaty, Wenny Rahmawati, Astrid Shimomura, Osamu Ismadji, Suryadi Chemical Engineering Master Program Faculty of Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Collaborative Research Center for Sustainable and Zero Waste Industries Jl. Kalijudan 37 East Java Surabaya60114 Indonesia Department of Natural Science Faculty of Mathematics and Natural Science Universitas Negeri Surabaya Surabaya60231 Indonesia Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Professional Engineer Program Department Faculty of Engineering Bina Nusantara University K.H. Syahdan No. 9 Jakarta11480 Indonesia Waste-Food-Environmental Nexus Research Interest Group Bina Nusantara University K.H. Syahdan No. 9 Jakarta11480 Indonesia Department of Applied Chemistry Osaka Institute of Technology 5-16-1 Omiya Ashahi-ku Osaka535-8585 Japan

The synthesis of natural polysaccharides from durian seed gum-modified chitosan as complex nanoparticles was successfully developed. The complex formation of nanoparticles was confirmed by 1H NMR, indicating the interpenetrating polymer network between the durian seed gum and chitosan. The material's physical properties were analyzed using ZETA potential, SEM, FTIR, swelling assay, and spectrofluorometer. The material showed a pH-responsive behavior as evidenced by the swelling assay, in which the complex nanoparticle has a smaller swelling index in pH 5.5 and 7.4 than pH 2.1. The stability of the material was tested by checking the hydrodynamic diameter, which resulted in the modification of chitosan having higher kinetic stability than the durian seed gum under a diameter smaller than 1 μm. The chitosan-modified durian seed gum's hemolytic activity indicates blood compatibility with 4 % hemolytic activity under high nanoparticle concentration (400 μg/mL). More importantly, the cytotoxicity test of complex nanoparticles showed biocompatibility with NIH/3 T3 cells, whereas complex nanoparticles exhibited high toxicity towards HeLa cells. Moreover, complex nanoparticles showed strong intracellular blue fluorescence with selective activity towards cancer cells. Hence, this newly developed green synthesis of polyelectrolyte nanoparticles derived from durian seed gum modified with chitosan improved selectivity and intracellular fluorescence in tracking cancer cells. © 2025 Elsevier B.V.

关键词： Chitosan

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Android-Based oil palm farmer’s income analysis to support precision agriculture

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AIP Conference Proceedings 2023年第1期2594卷

作者： M. P. Bimantio A. Ferhat L. Isnaini D. P. Putra T. Suparyanto B. Pardamean Department of Food and Agricultural Technology Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Department of Agricultural Socio-Economics Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Department of Agricultural Socio-Economics Gadjah Mada University Yogyakarta Indonesia 55281 Department of Agrotechnology Institute of Agriculture STIPER Yogyakarta Indonesia 55281 Computer Science Department BINUS Graduate Program – Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480 Bioinformatics & Data Science Research Center Bina Nusantara University Jakarta Indonesia 11480

The purpose of this research is to create a simulator application in calculating farmer's income from the sale of fresh fruit bunches. Farmers can easily find out the outcomes based on how many kilograms of crops are sold through this application. This research was conducted in Mesuji Regency, Lampung Province, using primary data and descriptive analysis. The sampling technique utilized a proportional random sampling method and consisted of 88 oil palm farmers. The results indicated that the application made it simpler for farmers to find out their income. Farmers only needed to input the land area, the harvest number obtained on the harvest day that had been carried out, and the price of fresh fruit bunches so that they would know the estimated monthly and annual income calculations. These calculations can be used by farmers as a predicting and planning tool to avoid losses.

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Application of Emerging Innovations in Microbiome science to Space Development and Settlement Systems 73

Application of Emerging Innovations in Microbiome Science to...

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73rd International Astronautical Congress, IAC 2022

作者： Nastasi, Nicholas Anderson, Matthew Z. Balasubrahmaniam, Neeraja Bope, Ashleigh Britt, Rodney D. Cochran, Samuel J. Gill, Samuel J. Hegarty, Bridget Lee, Jiyoung Stamps, Blake W. Stickney, Amanda Taylor, Christopher G. Tram, Nguyen K. Van Dusen, John Varaljay, Vanessa A. Weir, Mark H. Horack, John M. Oglesbee, Michael Sullivan, Matthew B. Dannemiller, Karen C. Department of Civil Environmental & Geodetic Engineering Ohio State University ColumbusOH United States Division of Environmental Health Sciences College of Public Health Ohio State University ColumbusOH United States Environmental Sciences Graduate Program Ohio State University ColumbusOH United States Department of Microbiology College of Arts and Sciences Ohio State University ColumbusOH United States Department of Microbial Infection and Immunity Ohio State University ColumbusOH United States Center for Perinatal Research The Abigail Wexner Research Institute Nationwide Children's Hospital Department of Pediatrics Ohio State University ColumbusOH United States Department of Civil and Environmental Engineering Case School of Engineering Case Western Reserve University ClevelandOH United States Department of Food Science and Technology Ohio State University ColumbusOH United States Infectious Diseases Institute Ohio State University ColumbusOH United States Soft Matter Materials Branch Materials and Manufacturing Directorate Air Force Research Laboratory Wright - Patterson AFBOH United States Department of Plant Pathology College of Food Agriculture and Environmental Science Ohio State University ColumbusOH United States Department of Anesthesiology & Pain Medicine Nationwide Children's Hospital ColumbusOH United States Airman Systems Directorate 711th Human Performance Wing Air Force Research Laboratory WPAFBOH United States Sustainability Institute Ohio State University ColumbusOH United States Department of Mechanical and Aerospace Engineering College of Engineering John Glenn College of Public Affairs Ohio State University ColumbusOH United States Department of Veterinary Biosciences College of Veterinary Medicine Ohio State University ColumbusOH United States Center of Microbiome Science Ohio State University ColumbusOH United States

Future human spaceflight beyond low-Earth orbit will bring substantial changes and new requirements to the development of fully sustainable, healthy indoor human environments across a range of gravitational, radiative, and thermal conditions. One key aspect is understanding (and potentially leveraging) microorganisms that must coexist with humans, plants, and animals in enclosed habitats (their microbiota or microbiomes). Modern, genome-resolved microbiome science provides an opportunity to better understand how we can utilize microbes to optimize space missions and protect human health and well-being long-term. Microorganisms will be critical to mission success due to their direct or indirect interactions with 1) humans, 2) other living systems (e.g., plant and animal life as a food source and for experimentation), and 3) the built environment. For example, the human gut microbiome is a complex community that has important implications for human health and performance that include mental health, nutrition intake, and immune system function. The health of plant microbiomes is also critical for sustainable, dependable, and nutritious food production. Humans, plants, and other living systems (e.g., animals used in experimentation) will also shed microbes into the built environment, which may impact human exposure, plant health, system integrity, and planetary protection from microbial contamination in both forward and reverse directions. Microbes from all three systems will interact, resulting in potentially important 'non-linear' system implications that must be understood for the overall long-term sustainability of hardware, crew, and other living systems. This paper discusses recent advances in technology that expand measurement capabilities to ultra-low-biomass samples and now allow for better understanding of microbial taxa, community structure and drivers, and functional capacity, which together will empower microbiome-optimized deep-space human exploration miss

关键词： Bacteria

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Author Correction: Genetic analysis of seed traits in Sorghum bicolor that affect the human gut microbiome

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Nature communications 2022年第1期13卷 6743页

作者： Qinnan Yang Mallory Van Haute Nate Korth Scott E Sattler John Toy Devin J Rose James C Schnable Andrew K Benson Department of Food Science and Technology University of Nebraska Lincoln NE USA. Nebraska Food for Health Center University of Nebraska Lincoln NE USA. Complex Biosystems Graduate Program University of Nebraska Lincoln NE USA. Wheat Sorghum and Forage Research Unit USDA-ARS Lincoln NE USA. Department of Agronomy and Horticulture University of Nebraska Lincoln NE USA. Center for Plant Science Innovation University of Nebraska Lincoln NE USA. Department of Food Science and Technology University of Nebraska Lincoln NE USA. abenson1@unl.edu. Nebraska Food for Health Center University of Nebraska Lincoln NE USA. abenson1@unl.edu.

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Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice

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Nutrition & diabetes 2024年第1期14卷 65页

作者： Suraphan Panyod Wei-Kai Wu Ya-Chi Hsieh Yea-Jing Tseng Sin-Yi Peng Rou-An Chen Huai-Syuan Huang Yi-Hsun Chen Ting-Chin David Shen Chi-Tang Ho Chun-Jen Liu Hsiao-Li Chuang Chi-Chang Huang Ming-Shiang Wu Lee-Yan Sheen Institute of Food Science and Technology National Taiwan University Taipei Taiwan ROC. Center for Food and Biomolecules National Taiwan University Taipei Taiwan ROC. Department of Internal Medicine College of Medicine National Taiwan University Taipei Taiwan ROC. Department of Medical Research National Taiwan University Hospital Taipei Taiwan ROC. Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan ROC. Bachelor Program of Biotechnology and Food Nutrition National Taiwan University Taipei Taiwan ROC. Division of Gastroenterology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Food Science Rutgers University New Brunswick NJ USA. National Laboratory Animal Center National Applied Research Laboratories Taipei Taiwan ROC. Graduate Institute of Sports Science National Taiwan Sport University Taoyuan City Taiwan ROC. Department of Internal Medicine College of Medicine National Taiwan University Taipei Taiwan ROC. mingshiang@ntu.edu.tw. Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan ROC. mingshiang@ntu.edu.tw. Institute of Food Science and Technology National Taiwan University Taipei Taiwan ROC. lysheen@ntu.edu.tw. Center for Food and Biomolecules National Taiwan University Taipei Taiwan ROC. lysheen@ntu.edu.tw. National Center for Food Safety Education and Research National Taiwan University Taipei Taiwan ROC. lysheen@ntu.edu.tw.

BACKGROUND:Diet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH. METHODS:We investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model. RESULTS:GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance. CONCLUSION:This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.

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