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SSRN 2023年

作者： Abreu, Thaianaly Leite Estévez, Mario de Carvalho, Leila Moreira de Medeiros, Lorena Lucena da Silva Pereira, Valquíria Cardoso Salu, Bruno Ramos Vilela Oliva, Maria Luiza Madruga, Marta Suely Alencar Bezerra, Taliana Kênia Post-Graduate Program in Food Science and Technology Department of Food Engineering Technology Centre Federal University of Paraiba PB João Pessoa58051-900 Brazil Research Institute of Meat and Meat Products IPROCAR TECAL Research Group Universidad de Extremadura Cáceres10003 Spain Department of Biochemistry Federal University of São Paulo SP São Paulo Brazil

The large amounts of by-products generated in the coffee industry are a problem for a sustainable agro-industry. The aim of this work was to investigate the occurrence of phenolic compounds in organic coffee husks and to evaluate their potential as a source of bioactive dietary components. To achieve this objective, three extracts were prepared, namely extractable polyphenols (EP), hydrolyzable non-extractable polyphenols (HNEP) and non-extractable polyphenols (NEP). These extracts were characterized and evaluated for their bioactive properties after simulated gastrointestinal digestion. The results show that the extraction process affects the occurrence of phenols from coffee peels, especially for caffeic acid, gallic acid, and chlorogenic acid. The condensed phenols and polyphenols found in the extracts and digests not only showed antioxidant properties against ABTS, FRAP and DPPH radicals, but also had remarkable bioavailability and anticoagulant potential. These results highlight the potential health benefits of phytochemicals from coffee husks and open new perspectives for the use of such compounds in dietary supplements. © 2023, The Authors. All rights reserved.

关键词： Antioxidants

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Waterborne atenolol disrupts neurobehavioral and neurochemical responses in adult zebrafish

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Environmental science and Pollution Research 2024年第36期31卷 49200-49213页

作者： Adedara, Isaac A. Gonçalves, Falco L. Mohammed, Khadija A. Borba, João V. Canzian, Julia Resmim, Cássio M. Claro, Mariana T. Macedo, Gabriel T. Mostardeiro, Vitor B. Assmann, Charles E. Monteiro, Camila S. Emanuelli, Tatiana Schetinger, Maria R. C. Barbosa, Nilda V. Rosemberg, Denis B. Department of Food Technology and Science Center of Rural Sciences Federal University of Santa Maria Camobi RS Santa Maria97105-900 Brazil Drug Metabolism and Toxicology Research Laboratories Department of Biochemistry College of Medicine University of Ibadan Ibadan Nigeria Laboratory of Experimental Neuropsychobiology Department of Biochemistry and Molecular Biology Natural and Exact Sciences Center Federal University of Santa Maria Camobi 1000 Roraima Avenue RS Santa Maria97105-900 Brazil Graduate Program in Biological Sciences: Toxicological Biochemistry Federal University of Santa Maria Camobi 1000 Roraima Avenue RS Santa Maria97105-900 Brazil 309 Palmer Court SlidellLA70458 United States

Environmental contamination by pharmaceuticals from industrial waste and anthropogenic activities poses adverse health effects on non-target organisms. We evaluated the neurobehavioral and biochemical responses accompanying exposure to ecological relevant concentrations of atenolol (0, 0.1, 1.0, and 10 µg/L) for seven uninterrupted days in adult zebrafish (Danio rerio). Atenolol-exposed fish exhibited anxiety-like behavior, characterized by significant bottom-dwelling with marked reduction in vertical exploration. Atenolol-exposed fish exhibited marked increase in the duration and frequency of aggressive events without altering their preference for conspecifics. Biochemical data using brain samples indicated that atenolol disrupted antioxidant enzyme activities and induced oxidative stress. Exposure to atenolol markedly decreased ATP and AMP hydrolysis without affecting ADP hydrolysis and acetylcholinesterase (AChE) activity. Atenolol significantly upregulated tryptophan hydroxylase 1 (tph1) mRNA expression but downregulated brain-derived neurotrophic factor (bdnf) mRNA. Collectively, waterborne atenolol elicits aggressive and anxiety-like responses in adult zebrafish, accompanied by oxidative stress, reduced nucleotide hydrolysis, altered tph1 and bdnf mRNA expression, which may impact the survival and health of fish in aquatic environment. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Fish

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Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells

Curcumin suppresses doxorubicin-induced epithelial-mesenchym...

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作者： Chen, Wei-Chih Lai, Ying-An Lin, Ying-Chao Ma, Jui-Wen Huang, Li-Fen Yang, Ning-Sun Ho, Chi-Tang Kuo, Sheng-Chu Way, Tzong-Der Ph.D. Program for Cancer Biology and Drug Discovery College of Medicine China Medical University Taichung 40402 Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung 40402 Taiwan Division of Neurosurgery Buddhist Tzu Chi General Hospital Taichung Branch Taichung 427 Taiwan Institute of Biochemistry College of Life Science National Chung Hsing University Taichung 402 Taiwan Graduate School of Biotechnology and Bioengineering Yuan Ze University Taoyuan 320 Taiwan Agricultural Biotechnology Research Center Academia Sinica Taipei 115 Taiwan Department of Food Science Rutgers State University of New Jersey New Brunswick NJ 08901 United States Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung 40402 Taiwan Department of Health and Nutrition Biotechnology College of Health Science Asia University Taichung 413 Taiwan

Triple-negative breast cancer (TNBC) is defined by a lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (HER 2). Therefore, targeted therapy agents may not be used, and therapy is largely limited to chemotherapy. Doxorubicin treatment consequently acquires undesired malignance characteristics [i.e., epithelial-mesenchymal transition (EMT) and multi-drug resistance]. Our results illustrated that doxorubicin triggered EMT and resulted in the acquisition of a mesenchymal phenotype in TNBC cells. Moreover, we found that transforming growth factor-β (TGF-β) and PI3K/AKT signaling pathways were acquired for doxorubicin-induced EMT. Interestingly, we found that curcumin suppressed doxorubicin-induced EMT. Curcumin reversed doxorubicin-induced morphological changes, inhibited doxorubicin-induced downregulation of E-cadherin expressions, and inhibited doxorubicin-induced upregulation of vimentin expression. We also found that curcumin inhibited doxorubicin-induced EMT by inhibiting the TGF-β and PI3K/AKT signaling pathways. Moreover, curcumin enhanced the antiproliferative effects of doxorubicin in TNBC cells. In summary, our results suggest that doxorubicin in combination with curcumin may be a potential therapy for TNBC. © 2013 American Chemical Society.

关键词： Chemotherapy

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Evaluation of Oxalic Acid Extraction and Quantification Methods in the Different Purslane (Portulaca Oleracea L.) Matrices and Spinach (Spinacea Oleracea)

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SSRN 2024年

作者： de Souza, Pâmela Gomes Pallone, Juliana Azevedo Lima Orlando, Eduardo Adilson Costa-Santos, Augusto César Ayres, Ellen Mayra Menezes Rosenthal, Amauri Teodoro, Anderson Junger Laboratory of Food Analysis Graduate Program in Food Nutrition Fluminense Federal University Rua Mário Santana Braga 30 RJ Niteroi Brazil Laboratory of Food Analysis by Spectroscopy Faculty of Food Engineering State University of Campinas Rua Monteiro Lobato 80 Barão Geraldo SP Campinas Brazil Sensory and Consumer Science Laboratory Postgraduate Program in Food and Nutrition Federal University of the State of Rio de Janeiro Laboratorio Av. Pasteur -Urca 29 Rio de Janeiro Brazil Embrapa Food Technology Av. das América Guaratiba RJ Rio de Janeiro29501 Brazil

Purslane (Portulaca oleracea L.) is considered a Non-Conventional food Plant (NCFP), as it is a vegetable that is underutilized by the population. This specie, like spinach (Spinacea oleracea), has high levels of oxalic acid, an antinutrient that interferes with the bioaccessibility of minerals such as calcium and iron. The valuation of NCFP through scientific research has gained strength over the last few years and the oxalic acid content in vegetables and juices containing conventional or non-conventional vegetables, which have considerable levels of antinutrients, needs to be investigated. Therefore, evaluating and developing new alternative methods that determine the oxalic acid content with less matrix interference, such as the use of Flame Atomic Absorption Spectrometry (FAAS), can contribute to science and consumers. © 2024, The Authors. All rights reserved.

关键词： Sustainable chemistry

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Different Particle Sizes of Momordica Charantia Leaf Powder Modify the Rheological and Textural Properties of Corn Starch-Based 3d food Printing Ink

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SSRN 2023年

作者： Fan, Meiqi Choi, Young-Jin Wedamulla, Nishala Erandi Oh, Mirae Bae, Sung Mun Yang, Daeun Kang, Hyo Tang, Yujiao Moon, Sang-Ho Kim, Eun-Kyung Division of Food Bioscience College of Biomedical and Health Sciences Konkuk University Chungju27478 Korea Republic of Department of Food Science and Nutrition College of Health Science Dong-A University Busan49315 Korea Republic of Department of Health Sciences The Graduate School of Dong-A University Busan49315 Korea Republic of Department of Food Science and Technology Faculty of Animal Science and Export Agriculture Uva Wellassa University Badulla90000 Sri Lanka Grassland and Forages Division National Institute of Animal Science Rural Development Administration Cheonan31000 Korea Republic of Gyeongnam Agricultural Research and Extension Services Jinju52733 Korea Republic of BK-21 Four Graduate Program Department of Chemical Engineering Dong-A University Busan49315 Korea Republic of School of Bio-Science and Food Engineering Changchun University of Science and Technology Changchun130600 China Center for Food and Bio Innovation Dong-A University Busan49315 Korea Republic of Nutritional Education Major Graduate School of Education Dong-A University Busan49315 Korea Republic of Nutrinomics Lab. Co. Ltd. Busan49315 Korea Republic of

The study determined the effect of incorporating Momordica charantia leaf powder (MCLP) into corn-starch 3D food-printing ink as a functional ingredient. The effects of the particle size (75, 131, and 200 μm) and quantity of MCLP on 3D printing performance, structural, textural, and rheological properties of corn starch gel were evaluated with different concentrations (5, 10, and 15% (w/w)) of corn starch. The viscoelastic properties of food inks were determined considering their behavior during extrusion and self-recovery after printing. Scanning electron microscope was used to characterize the microstructure. Based on the results, a high starch content (15%) with 5% MCLP was more favorable for 3D food printing. In addition, 3D printing performance, textural and rheological properties of formulated ink was mainly governed by the particle size of MCLP. The food ink with a 5% mass fraction of 200 μm MCLP had the highest printing precision and the best masticatory properties. © 2023, The Authors. All rights reserved.

关键词： Particle size

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Revisiting some overlooked registered Thai traditional medicine preparations: an alert to a regulatory affair

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Bulletin of the National Research Centre 2022年第1期46卷 1-9页

作者： Vimolmangkang, Sornkanok Rani, Dolly Prestwong, Naruemon Sutcharitchan, Chayanis Pakdeesattayapong, Duangkamol Department of Pharmacognosy and Pharmaceutical Botany Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand Center of Excellence in Plant Produced Pharmaceuticals Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand Graduate Program in Pharmaceutical Science and Technology Faculty of Pharmaceutical Sciences Chulalongkorn University Bangkok Thailand Herbal Products Division Food and Drug Administration Thailand Ministry of Public Health Nonthaburi Thailand

This study evaluated the heavy metal identity and content of registered Thai Traditional medicine (TTM) preparations in Thailand to ensure consumer safety. Both qualitative and quantitative information about the elemental composition of the heavy metal content in each TTM crude drug and the heavy metal content in some registered TTM preparations in Thailand was performed. Seven kinds of mineral-based TTM crude drugs, namely realgar, orpiment, Chinese powder, Sen, vermilion, natural vermilion, and cinnabar, were analyzed with X-ray diffraction and scanning electron microscopy and energy-dispersive spectroscopy techniques to determine the type of metal and elemental composition to confirm their chemical formulas. Furthermore, the number of heavy metals, such as arsenic (As), lead (Pb), and mercury (Hg), was in three samples of realgar-containing preparations; one sample of Sen-containing preparation, and eight samples of cinnabar-containing preparations. Heavy metals were determined with inductively coupled plasma-optical emission spectrometry. It was observed that realgar and orpiment consisted of arsenic sulfide (AsS) and arsenic trisulfide (As2S3), respectively. Both crude drugs contained approximately 50% of As. Vermilion, natural vermilion, and cinnabar consisted of mercuric sulfide (HgS), with Hg accounting for approximately 66%. Sen consisted of Pb (II, IV) oxide (Pb3O4) with an approximate Pb percentage of 80%. However, Pb was absent in Chinese powder and consisted mainly of calcium carbonate (CaCO3). A traditional detoxification procedure can reduce the amount of As and Hg in processed crude drugs by at least 20%. Pb was higher in some TTM preparations, and no CaCO3 was detected in Chinese powder. Our results raise concerns on both safety and efficacy to consumers and alert public health policymakers that they should implement regulations so that the quality (authenticity) and quantity of elemental medicine used in traditional medicine are correctly labeled a

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The Standardized Wood Extract of Albizia myriophylla: Its Potential as an Active Ingredient in an Anti-inflammatory Herbal Gel Formulation

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Planta Medica 2021年第12期88卷 964-974页

作者： Nazneen Bakasatae Warissara Sangkaew Nongluk Kunworarath Julalak Chorachoo Ontong Sathianpong Phoopha Chutha Takahashi Yupanqui Supayang Piyawan Voravuthikunchai Nantiya Joycharat Traditional Thai Medical Research and Innovation Center Faculty of Traditional Thai Medicine Prince of Songkla University Songkhla Thailand Cosmetic Technology and Dietary Supplement Products Program Faculty of Agro and Bio Industry Thaksin University Phatthalung Thailand Interdisciplinary Graduate School of Nutraceutical and Functional Food Prince of Songkla University Songkhla Thailand Excellent Research Laboratory on Natural Products Faculty of Science and Natural Product Research Center of Excellence Prince of Songkla University Songkhla Thailand Division of Biological Science Faculty of Science Prince of Songkla University Songkhla Thailand

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Coffee Authentication Via Targeted Metabolomics and Machine Learning: Unveiling Origins and Their Discriminating Biochemicals

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SSRN 2023年

作者： Aurum, Fawzan Sigma Zaman, Muhammad Zukhrufuz Purwanto, Edi Praseptiangga, Danar Nakano, Kohei Doctoral Program of Agricultural Science Faculty of Agriculture Universitas Sebelas Maret Jl. Ir. Sutami 36 A Kentingan Central Java Surakarta57126 Indonesia The United Graduate School of Agricultural Science Gifu University 1-1 Yanagido Gifu501-1193 Japan Research Center for Food Technology and Processing National Research and Innovation Agency Jl. Jogja – Wonosari Km 31.5 Yogyakarta55861 Indonesia Department of Food Science and Technology Faculty of Agriculture Universitas Sebelas Maret Jl. Ir. Sutami 36 A Kentingan Central Java Surakarta57126 Indonesia

Coffee is an export commodity that is prone to fraudulent practices. Therefore, this study presents a novel approach to authenticate coffee origins using targeted metabolomics with gas chromatography-mass spectrometry (GC-MS) and machine learning models. A total of 200 coffee samples from different harvest years and areas from Indonesia were extracted using the derivatisation method and then analysed for their metabolite profiles. Several supervised machine-learning models were tested to classify coffee origins and discover their potential markers. The study found various metabolite features spanning diverse chemical classes, encompassing sugar alcohols, carbohydrates, amino acids, organic acids, fatty acids, and phenols. Random forest (RF) and partial least squares discriminant analysis (PLS-DA) were among the most accurate models in predicting the origin of coffee from several classes in the validation dataset. The accuracy of both models is in the range of 91% to 100%. Furthermore, this study proposes a new strategy for determining "intersection features" as the set of features that are important and common to both RF and PLS-DA models, thereby providing a robust selection of coffee origin markers. Overall, the approach and findings of this study have far-reaching implications for coffee authentication. © 2023, The Authors. All rights reserved.

关键词： Mass spectrometry

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Amazonian fruits: A systematic review of the literature and critical analysis of its trends

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food Bioscience 2024年 62卷

作者： Cruz, Josias Martins dos Anjos Corrêa, Renilto Frota Sanches, Edgar Aparecido Campelo, Pedro Henrique Bezerra, Jaqueline de Araújo Center for Studies in Science and Technology in the Amazon (NECTAM) Amazonas Manaus Brazil Graduate Program in Chemistry Federal University of Amazonas (UFAM) Amazonas Manaus Brazil Laboratory of Nanostructured Polymers Federal University of Amazonas (UFAM) Amazonas Manaus Brazil Department of Food Technology Federal University of Viçosa (UFV) Minas Gerais Viçosa Brazil

The Amazon is rich in fruits that are primarily used by the local population for food purposes. In addition to their nutritional benefits, they are also important for the economic development of the region. In recent years, these fruits have attracted considerable attention from researchers due to their chemical composition, properties, and potential applications. The aim of this study was to analyze the research trends surrounding Amazonian fruits. The documents used in this review include 75 research articles (identified through the Ordinatio index) retrieved from Scopus, and 21 patents retrieved from Google Patents and Espacenet, focusing on the use of Amazonian fruits in food technology. Amazonian fruits have been explored for their content of phenolic compounds (especially anthocyanins), carotenoids, vitamins (mainly ascorbic acid), oils, and fibers, all of which are associated with various bioactivities. In addition to the pulp, the waste generated from these fruits also contains chemical constituents with high potential, although they are usually discarded. Therefore, there is a need for discussion among different industrial and governmental sectors to implement production chains, generate income, and provide appropriate disposal for the by-products generated during the processing of Amazonian fruits, thus contributing to sustainable economic development in the Amazon. However, in general, it is observed that although many interesting results have been published, much of the academic knowledge produced has yet to be converted into income generation, mainly through the patenting of products and processes. This may be linked to a lack of investment and/or interest/awareness from the researchers themselves. © 2024

关键词： Amazon Bioactive compounds Native fruits Sustainability

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[email protected] nanocomposite modified electrode for sensitive and simultaneous detection of Cd (II) and Pb (II)

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Synthetic Metals 2018年 245卷 251-259页

作者： Jutiporn Yukird Pongsakorn Kongsittikul Jiaqian Qin Orawon Chailapakul Nadnudda Rodthongkum Nanoscience and Technology Interdisciplinary Program Graduate School Chulalongkorn University Phayathai Road Patumwan Bangkok 10330 Thailand Petrochemical and Polymer Science Faculty of Science Chulalongkorn UniversityPhayathai Road Pathumwan Bangkok 10330 Thailand Metallurgy and Materials Science Research Institute Chulalongkorn University Soi Chula 12 Phayathai Road Pathumwan Bangkok 10330 Thailand Electrochemistry and Optical Spectroscopy Research Unit Department of Chemistry Faculty of Science Chulalongkorn University Phayathai Road Pathumwan Bangkok 10330 Thailand Nanotec-CU Center of Excellent on Food and Agriculture Chulalongkorn University Phayathai Road Patumwan Bangkok 10330 Thailand

Zinc Oxide (ZnO) nanorods were synthesized by using zinc acetate as a precursor via thermal decomposition method and then used to prepare [email protected] nanocomposite by facile room-temperature approach using a colloidal coagulation effect. The as prepared [email protected] nanocomposite was applied to modify the working electrode surface in an electrochemical sensor of Cd 2+ and Pb 2+ for the first time. The morphologies of ZnO and [email protected] nanocomposite were characterized by transmission electron microscopy, that exhibits the nanorod shape with an average diameter of 89 ± 18 nm, uniformly dispersed and intercalated between each G layer. Furthermore, the important factors affecting on the sensor sensitivity, including [email protected] ratio, [email protected] concentration, Bi 3+ concentration and electrochemical parameters were systematically investigated using square-wave anodic stripping voltammetry. Under the optimal conditions, a linear range was found to be 10–200 μg L −1 and the detection limits were 0.6 and 0.8 μg L -1 for Cd 2+ and Pb 2+ , respectively. Eventually, it was successfully used for the simultaneous detection of Cd 2+ and Pb 2+ in real wastewater samples and the results corresponded well with a standard inductively coupled plasma-optical emission spectroscopy.

关键词： Zinc oxide nanorod Graphene Nanocomposite Electrochemical sensor Cadmium Lead

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