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Microplastics in Different Fish and Shellfish Species in the Mangrove Estuary of Bangladesh and Evaluation of Human Exposure

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SSRN 2022年

作者： Sultan, Maisha Binte Rahman, Md. Mostafizur Khatun, Mst Afifa Akbor, Md. Ahedul Siddique, Md. Abu Bakar Malafaia, Guilherme Department of Environmental Science Bangladesh University of Professionals Dhaka1216 Bangladesh Laboratory of Environmental Health and Ecotoxicology Department of Environmental Sciences Jahangirnagar University Dhaka 1342 Bangladesh Food Safety and Quality Analysis Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Dhaka Savar Bangladesh Dhaka1205 Bangladesh Laboratory of Toxicology Applied to the Environment Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás GO Goiânia Brazil

The water bodies in Bangladesh thrive from plastic pollution. Estuaries are pools of environmental contaminants, and the world’s largest mangrove forest, Sundarbans’ estuary, is no exception. Thus, for the first time, we investigate MPs abundance in the muscle and gastrointestinal tract (GIT) of twenty estuarine species of fish and shellfish of the Sundarbans, as well as the human health risk. MPs abundance was evident in all the samples ranging from 5.37±1.07 to 54.30±16.53 MP items/g wet body weight (dw) in muscle samples and 7.33±1.89 to 205.61±136.88 MP items/g (dw) in GIT samples. The estimated health risk from MPs is substantial, where the average human intake will be 85,710.08 items of MPs per year per capita for the population of Bangladesh. The dominant polymer types observed using ATR-FTIR are PP and PE (17.5 %), PA (17.5 %) in the muscle tissues, and PP and PE (11.11 %), and EVA (11.11 %) in the GITs. Bottom-feeding species, such as demersal and benthic species, are more contaminated. However, the level of MPs in the species shows a negative correlation with the length and weight of the species. This study reveals that MP pollution is widespread and concerning in Bangladesh's Sundarban mangrove estuarine zone. © 2022, The Authors. All rights reserved.

关键词： Estuaries

Microcrystallized Cellulose: An Eco-Friendly Material or an Ecotoxicological Risk to Amphibians?

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SSRN 2023年

作者： de Souza, Sindoval Silva Gomes, Alex Rodrigues Guimarães, Abraão Tiago Batista de Matos, Letícia Paiva Mendonça, Juliana dos Santos da Luz, Thiarlen Marinho da Silva Matos, Stênio Gonçalves Rodrigues, Aline Sueli de Lima Senthil-Nathan, Sengottayan Rakib, Md. Refat Jahan Rocha, Thiago Lopes Towfiqul Islam, Abu Reza Md. Malafaia, Guilherme Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás GO Goiânia Brazil Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí Campus GO Urutaí Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute GO Urutaí Brazil Division of Biopesticides and Environmental Toxicology Sri Paramakalyani Centre for Excellence in Environmental Sciences Manonmaniam Sundaranar University Tirunelveli Tamil Nadu Alwarkurichi627 412 India Noakhali Science and Technology University Noakhali Bangladesh Laboratory of Environmental Biotechnology and Ecotoxicology Institute of Tropical Pathology and Public Health Federal University of Goiás Goiás Goiania Brazil Department of Disaster Management Begum Rokeya University Rangpur5400 Bangladesh

The increasing use of cellulose microparticles in the manufacture of different products implies their release in natural environments, and it is important to assess how much and how these materials can impact organisms. Thus, we aimed to evaluate the possible toxicity induced by short exposure (seven days) of Physalaemus cuvieri tadpoles to cellulose microcrystalline (CM) (at 58.29 and 100 mg/L). Although our data do not point to a neurotoxic effect of CMs (inferred by the absence of behavioral changes and changes in AChE and BChE activity), animals exposed to CMs showed differences in body condition. Furthermore, we noticed a mutagenic effect (inferred by the increase in erythrocyte nuclear abnormalities) and a genotoxic effect (assessed by the comet assay) correlated with the ingestion of CMs. We noticed that the antioxidant activity of tadpoles exposed to CMs (inferred by SOD, CAT, and DPPH radical scavenging activity) was insufficient to prevent the increase in ROS and MDA production. Furthermore, exposure to CMs induced a predominant Th2-specific immune response, marked by suppressed IFN-γ levels and increased IL -10 levels, with a consequent reduction in NO levels. Principal component analysis and IBRv-2 indicate, in general, a primarily more toxic response to animals exposed to the highest CM concentration. Therefore, our study demonstrates for the first time that CMs affect the health of P. cuvieri tadpoles and sheds light on the threat these materials pose to amphibians. © 2023, The Authors. All rights reserved.

关键词： Cellulose

Placental metabolomics from women with gestational diabetes mellitus unveils glycolytic and one-carbon metabolism impairment

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Placenta 2024年 153卷 e19-e20页

作者： Vanessa de Araujo Goes Gabriela Dias Carolina Ferreira Deborah Bauer Layla Ranquine Carla Lai Tatiana El-Bacha Food Science post-graduation program (PPGCAL)/IQ/UFRJ Centre for Trophoblast Research/University of Cambridge Josué de Castro Nutrition Institute (INJC)/UFRJ

Impact of absence of lactose on the dynamic sensory profile of yogurt: A multiple-intake TDS approach

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LWT 2022年 162卷

作者： Souza Olegario, Lary González-Mohino, Alberto Estévez, Mario Madruga, Marta Suely Ventanas, Sonia Post-Graduate Program in Food Science and Technology Department of Food Engineering Technology Centre Federal University of Paraiba Paraíba João Pessoa58051-900 Brazil IPROCAR Research Institute TECAL Research Group Universidad de Extremadura Cáceres10003 Spain

This paper aims to evaluate the impact of lactose free yogurt version on dynamic sensory perception and consumer acceptability. A total of 46 participants evaluated classical (SNY) and lactose-free (SLF-Y) commercial version of yogurts using the multiple-intake TDS technique, providing information about the dominant sequence of six flavor and texture sensory attributes. Moreover, information regarding the overall liking of the evaluated products was obtained. During the first intake, in SLF-Y samples, sourness presented a higher dominance rate compared to SNY. A similar dominance profile was obtained during the second intake between the two yogurts. During the third intake, SNY consumption was dominated by dairy attribute whereas during SLF-Y intake, fermented and creaminess were the dominance attributes. Yogurt version and the numbers of intakes presented a significant impact on temporal perception. Moreover, similar liking scores were reported for both evaluated yogurts. The present study revealed that absence of lactose showed an impact of temporal sensory perception of yogurt and the potential modifications on sensory perception can be revealed by applying the multiple intake TDS approach. © 2022 The Authors

关键词： Sensory perception

"Microplastic Seasoning": A Study on Microplastic Contamination of Sea Salts in Bangladesh and the Risks Associated with its Consumption

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SSRN 2023年

作者： Siddique, Mohammad Abdul Momin Uddin, Azad Hossain, Md. Soliman Rahman, Shahriar Arifur Md. Rahman, M. Safiur Kibria, Golam Malafaia, Guilherme University of South Bohemia in Ceske Budejovice Faculty of Fisheries and Protection of Waters South Bohemian Research Center of Aquaculture and Biodiversity of Hydrogenases Research Institute of Fish Culture and Hydrobiology Zatisi 728/II Vodnany389 25 Czech Republic Department of Oceanography Noakhali Science and Technology University Noakhali3814 Bangladesh Department of Environmental Science and Disaster Management Noakhali Science and Technology University Noakhali3814 Bangladesh Water Quality Research Laboratory Chemistry Division Atomic Energy Center Bangladesh Atomic Energy Commission 4-Kazi Nazrul Islam Avenue Shahbag Dhaka1000 Bangladesh School of Science RMIT University Australia Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás G.O. Goiânia Brazil

This study investigated microplastics (M.P.s) in mostly used commercial sea salts from Bangladesh. The presence of M.P.s in the 18 sea salt bands was 100%, where the mean M.P.s abundance was 471.67 MPs/kg: ranging between 300 to 670 MPs/kg. The maximum number of M.P.s accounted for in the 300-1500 µm size class was significantly higher than the 1500-3000 µm and 3000-5000 µm size class. The most dominant color was black. Fibers and foams were the dominant shapes. The highest number of M.P.s was 41%, obtained from coarse salt grains. Four types of polymers were mainly identified from the analyzed samples: PP, PE, PET, and PA. The mean polymer risk index value among these sea salts was 539 to 1257. The findings of this study can be helpful for consumers, salt industries, and policymakers to be aware of or reduce M.P. contamination levels in sea salts during production and consumption. © 2023, The Authors. All rights reserved.

关键词： Health risks

Characterization of Microplastic Pollution in the Pasur River of the Sundarbans Ecosystem (Bangladesh) with Emphasis on Water, Sediments, and Fish

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SSRN 2022年

作者： Nawar, Nowshin Rahman, Md. Mostafizur Marzia, Shumayta Ali, Mir Mohammad Akbor, Md. Ahedul Siddique, Md. Abu Bakar Khatun, Mst Afifa Shahjalal, Md. Huque, Roksana Malafaia, Guilherme Department of Environmental Science Bangladesh University of Professionals Dhaka1216 Bangladesh Laboratory of Environmental Health and Ecotoxicology Department of Environmental Sciences Jahangirnagar University Dhaka1342 Bangladesh Department of Aquaculture Sher-e-Bangla Agricultural University Dhaka1207 Bangladesh Dhanmondi Dhaka1205 Bangladesh Food Safety and Quality analysis Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Dhaka Savar Bangladesh Laboratory of Toxicology Applied to the Environment Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás GO Goiânia Brazil

An emerging concern of today’s world, due to their universal dispersion worldwide, is the environment's microplastic pollution. The Sundarbans, the world’s largest mangrove, have unique and dynamic environmental settings with numerous pollution risk exposures, including microplastics (MPs). Thus, the present study has focused on the MP pollution in water, sediment, and fish samples of the Sundarbans of Bangladesh for the first time. Water and sediment samples were collected (n=30/each) from sampling locations along the Pasur river (Bangladesh). Furthermore, nine species of fish samples were collected from a local fish market situated at the Mongla port. Results show that 100% of the analyzed samples have evidence of MPs. On average, 2.66 x 103 plastic particles/L and 1.57 x 105 particles/kg were found in water and sediment samples, respectively. Furthermore, results show a higher number of MPs in the animals' gastrointestinal tract (GIT) (10.41 particles/g), concerning the average concentration recorded in the muscles (4.68 particles/g). O. pama and H. nehereus were the species that showed the highest MPs accumulation in the GIT. In the muscles, the highest MP levels were observed in T. ilisha and L. calcarifer. Most of the particles were smaller than 1 mm;black-colored particles dominated the pool. FT-IR analysis revealed the presence of seven polymer types where polyamide was abundant in water and sediment samples. SEM analysis showed morphological structures and adsorbed particles on the surface of plastic samples, and the spatial distribution of MPs indicates that the location with high human intervention has elevated levels of MPs. Therefore, our study demonstrates that Sundarbans mangrove forests are highly contaminated with MPs and that its fisheries can be a potential source of human exposure to these pollutants. © 2022, The Authors. All rights reserved.

关键词： Sediments

Eco-Friendly Bioremediation of Pollutants from Contaminated Sewage Wastewater Using Special Reference Bacterial Strain of Bacillus Cereus Sdn1 and Their Genotoxicological Assessment in Allium Cepa

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SSRN 2022年

作者： Anusha, Ponniah Ragavendran, Chinnasamy Kamaraj, Chinnaperumal Natarajan, Devarajan Thesai, Annadurai Sakthi Malafaia, Guilherme Sangeetha, K. Department of Science and Humanities Kongunadu College of Engineering and Technology Tholurpatti Tamil Nadu Trichy621 215 India Kattankulathur Tamil Nadu Chennai603 203 India Natural Drug Research Laboratory Department of Biotechnology School of Biosciences Periyar University Tamil Nadu Salem India Department of Microbiology Sona College of Technology Sona College of Arts and Science Salem636 005 India Laboratory of Toxicology Applied to the Environment Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás GO Goiânia Brazil

The present study aimed to assess the Bacillus cereus SDN1 native bacterium's ability to clean up contaminated, polluted water. This bacterium was identified by its morphological and biochemical characteristics, which were then confirmed at the genus level. Furthermore, the isolated B. cereus (NCBI accession No: MW828583) was identified genomically by PCR amplifying 16s rDNA using a universal primer. The phylogenetic analysis of the rDNA sequence was conducted to determine the taxonomic and evolutionary profile of the isolate of the previously identified Bacillus sp. Besides, B. cereus and the bacterial consortium were treated using sewage wastewater. After 15 days of treatment, the following pollutants were reduced: total hardness particles removal varied from 63.33% to 67.55%, calcium removal varied from 90% to 93.33%, and total nitrate decreased range from 37.77% to 22.22%, respectively. Electrical conductivity ranged from 1809 mS/cm to 2500 mS/cm, and pH values ranged from 6.5 to 8.95. The outcome of in-situ remediation results suggests that B. cereus has a noticeable remediation efficiency to the suspended particles. A root tip test was also utilized to investigate the genotoxicity of treated and untreated sewage-contaminated waters on onion (Allium cepa) root cells. The highest chromosomal aberrations and mitotic inhibition were found in roots exposed to contaminated water. The study can thus be applied as a biomarker to identify the genotoxic impacts of sewage water pollution on biota. It may be concluded that employing bacterial consortia for domestic wastewater treatment could be a suitable strategy for chemical contaminants removal. Additionally, based on an identified bacterial consortium, this work offers a low-cost and eco-favorable method for treating household effluent. © 2022, The Authors. All rights reserved.

关键词： Bacillus cereus

Synthesize Palladium Nanoparticles from the Macroalgae Sargassum Fusiforme: An Eco-Friendly Tool in the Fight Against Plasmodium Falciparum?

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SSRN 2022年

作者： Kamaraj, Chinnaperumal Ragavendran, Chinnasamy Kumar, R.C. Satish Sabarathinam, Sarvesh Vetrivel, Cittrarasu Vaithiyalingam, Mariyappan Malafaia, Guilherme Drug Testing Laboratory Directorate of Research SRM Institute Science and Technology Tamil Nadu Kattankulathur603 203 India Department of Cariology Saveetha Dental College and Hospitals Tamil Nadu Chennai India Carbon Capture Lab Department of Chemical Engineering SSN College of Engineering Kalavakkam Tamil Nadu Chennai603110 India Department of Chemistry SRM Institute of Science and Technology Kattankulathur Tamilnadu Chengalpattu603203 India Laboratory of Toxicology Applied to the Environment Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute GO Urutaí Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás GO Goiânia Brazil

Although numerous drugs are practiced to control malaria and its vectors, more recently, eco-friendly control tools have been proposed to battle its etiologic agents. Thus, using green bionanotechnology approaches, we aimed to synthesize palladium nanoparticles (Pd NPs) from the macroalgae Sargassum fusiforme (Sf), its potential antiparasitic activity against P. falciparum, as well as its possible cytotoxicity, in HeLa cells. After the biosynthesis of the PdSf NPs, their characterization was carried out by UV–Vis, FESEM, and EDX analyses, and their hydrodynamic size, zeta potential, and surface area were determined. Furthermore, the functional groups of the PdSf NPs were analyzed by FT-IR and GC–MS. While PdSf NPs had an IC50 of 7.68 µg/mL (Chloroquine (C)-s) and 16.42 µg/mL, S. fusiforme extract had an IC50 of 14.38 µg/mL (CQ-s) and 35.27 µg/mL (CQ- r). With an IC50 value of 94.49 µg/mL, PdSf NPs exhibited the least toxic effect on the HeLa cells. The Lipinski rule of five and ADMET prediction were used to assess the in-silico models of caffeine acid hexoside and quercetin 7-O-hexoside for the presence of drug-like properties. Pathogenic proteins, primarily responsible for motility, binding, and disease-causing, were the target of the structurally based docking studies between plant-derived compounds and pathogenic proteins. Thus, our study pioneered promising results that support the potential antiplasmodial activity of eco-friendly synthesized PdSf NPs using S. fusiforme extract against P. falciparum, opening perspectives for further exploration into the use of these NPs in malaria therapy. © 2022, The Authors. All rights reserved.

关键词： Nanoparticles

Improving iPSC Differentiation Using a Nanodot Platform

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ACS Applied Materials and Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

Differentiation of induced pluripotent stem cells (iPSCs) is an extremely complex process that has proven difficult to study. In this research, we utilized nanotopography to elucidate details regarding iPSC differentiation by developing a nanodot platform consisting of nanodot arrays of increasing diameter. Subjecting iPSCs cultured on the nanodot platform to a cardiomyocyte (CM) differentiation protocol revealed several significant gene expression profiles that were associated with poor differentiation. The observed expression trends were used to select existing small-molecule drugs capable of modulating differentiation efficiency. BRD K98 was repurposed to inhibit CM differentiation, while iPSCs treated with NSC-663284, carmofur, and KPT-330 all exhibited significant increases in not only CM marker expression but also spontaneous beating, suggesting improved CM differentiation. In addition, quantitative polymerase chain reaction was performed to determine the gene regulation responsible for modulating differentiation efficiency. Multiple genes involved in extracellular matrix remodeling were correlated with a CM differentiation efficiency, while genes involved in the cell cycle exhibited contrasting expression trends that warrant further studies. The results suggest that expression profiles determined via short time-series expression miner analysis of nanodot-cultured iPSC differentiation can not only reveal drugs capable of enhancing differentiation efficiency but also highlight crucial sets of genes related to processes such as extracellular matrix remodeling and the cell cycle that can be targeted for further investigation. Our findings confirm that the nanodot platform can be used to reveal complex mechanisms behind iPSC differentiation and could be an indispensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published by American Chemical Society.

关键词： Efficiency