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Amplifying X-ray-Induced Charge Transfer Facilitates Direct Sensitization of Photosensitizers in Radiotherapy

ACS Nano 2025年第17期19卷 16775-16793页

作者： Zhang, Da Chen, Qingjing Zhang, Junrong Xing, Xiaohua Zhou, Yang Ou, Xiangyu Dai, Shuheng Chen, Qiushui Liu, Xiaolong Chen, Xiaoyuan Zeng, Yongyi The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou350025 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine Faculty of Engineering National University of Singapore Singapore119074 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore138667 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore138667 Singapore CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou350002 China Linköping University LinköpingSE-58183 Sweden MOE Key Laboratory for Analytical Science of Food Safety and Biology Fuzhou University Fuzhou350108 China Department of General Surgery Fujian Medical University Union Hospital Fuzhou350001 China Mengchao Med-X Center Fuzhou University Fuzhou350116 China Liver Disease Center The First Affiliated Hospital of Fujian Medical University Fuzhou350005 China

X-ray-induced photodynamic therapy offers substantial promise for treating deep-seated tumors, but it is still limited by highly inefficient energy transfer processes and the stringent requirements for scintillators with high luminescence quantum yield and significant singlet-triplet intersystem crossing ratios. Herein, we describe X-ray-induced electron-dynamic therapy (X-eDT), which obviates the need for intersystem crossing by exposing nonluminescent hafnium-silica nanoparticles to X-rays, to generate high-energy electrons that can sensitize lower-lying triplet states of various photosensitizers. Our approach strongly induced the production of singlet oxygen (6.18-fold) in vitro even at lower X-ray doses, and in mice it strongly inhibited the growth of xenografts derived from liver, breast, or colon cancer cell lines (CDX), and growth of patient-derived xenografts (PDX) of hepatocellular carcinoma. In these CDX preclinical systems, X-eDT was not only effective against the irradiated xenograft but also against untreated xenografts in the same animal, and these abscopal effects involved enhanced tumor infiltration by CD4+T cells, CD8+T cells, and IFN-γ-polarized M1 macrophages within the tumor microenvironment. X-eDT even stimulated the production of memory T cells that inhibited rechallenges after treatment. These findings suggest that X-eDT can be effective against primary and metastatic tumors as well as tumor recurrence, which makes it much more powerful than conventional X-PDT. © 2025 American Chemical Society.

关键词： Animal cell culture

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The Effect of Sonication Time on Physicochemical Profiles of the Nanocalsium from Snake-Head Fish Bone (Channa striata) 3

The Effect of Sonication Time on Physicochemical Profiles of...

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3rd International Symposium on Agricultural and Biosystem Engineering, ISABE 2019

作者： Tawali, A.B. Wakiah, N. Qanitah, K. Asfar, M. Sukendar, N.K. Metusalach Food Science and Technology Study Program Faculty of Agriculture Indonesia Fisheries Resources Utilization Study Program Faculty of Marine Science and Fisheries Hasanuddin University Makassar Indonesia

Snake-Head Fish bone is one of the fishery wastes that is potentially used as the raw material for calcium supplement products. In order to make the calcium products easily absorbed and utilized rapidly by human body, supplement products need to be made in nano form. The aims of this study were to determine the effect of the sonication time in the production of Snake-Head Fish bone nano calcium on the physical profile of the resulted nano calcium, and to obtain the best sonication time. The development of nanocalcium utilized sonication method with 405 Powersonic Ultrasonic Cleaner. The result showed that the best particle size distribution was found on 45 minutes sonication treatment which was 842.3 nm with the highest particle size ranging from 461,6 to 487,5 nm. The average value of the polydispersity index is 1.527. The yield of nano calcium produced from whole fish is 1.331%. The resulting nano calcium has an average white degree of 86.622% and average density of 0.73 g/ml. Some other mineral content also showed a not significant difference. © 2019 IOP Publishing Ltd. All rights reserved.

关键词： Calcium

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Survival of potential probiotic isolated from fermented tea leaf and encapsulated in multilayer beads stored in makiang(Cleistocalyx nervosum ***)juice

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food Bioscience 2022年第6期50卷 389-395页

作者： Paramaporn Kerdsup Passarin Hattayapichat Juan L.Silva Sumate Tantratian Department of Food Technology Faculty of ScienceChulalongkorn UniversityBKK10330Thailand Program in Biotechnology Faculty of ScienceChulalongkorn UniversityBKK10330Thailand Department of Biotechnology and Agricultural Product Faculty of Agricultural Product Innovation and TechnologySrinakharinwirot UniversityNakhonnayok26120Thailand Department of Food Science Nutrition and Health PromotionMississippi State UniversityMS39762USA

Cleistocalyx nervosum *** juice or makiang juice has high content of acid and phenolic compounds which are detrimental to probiotic *** screening of potential probiotic with acid production and phenolic tolerant bacteria from fermented tea leaves revealed 5 isolates which were identified using 16s rRNA sequencing procedure and found similarity to the strain of Lactobacillus plantarum in GenBank database at 98–100%.The storage of 5 isolates and 6 probiotics in makiang juice for 24 h was indicated that *** MF105 and TISTR 2074 showed the least reduction of 30.10±1.25 and 61.41±2.37%,*** cultures were encapsulated in 2%alginate bead(Al),Al+single-layer of gelatin(ACG),and Al+double-layer of gelatin(ACGD).They were kept in makiang juice at 4℃.The physico-chemical characteristics of beads in makiang juice illustrated that the accumulation of phenolic compounds was faster than the pH decreasing and caused initial reduction of bacterial *** ACGD beads absorbed slower and accumulated less amount of phenolic compounds than *** were the most effective in cell protection,the viability of encapsulated MF105 and TISTR2074 were prolonged to more than 7 and 4 days,*** adaptation in combination with encapsulation enhanced the survival of probiotic cell in sub-lethal stress *** had shown that increasing the coating layer provided a chance to improve lethality of probiotic bacteria.

关键词： Anthocyanin Alginate gel Refrigeration temperature Adaptation

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Characterization of Modified Tapioca Starch in Atmospheric Argon Plasma under Diverse Humidity by FTIR Spectroscopy

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Chinese Physics Letters 2013年第1期30卷 215-218页

作者： P.Deeyai M.Suphantharika R.Wongsagonsup S.Dangtip Materials Science and Engineering Programme Faculty of ScienceMahidol UniversityBangkok10400Thailand Department of Biotechnology Faculty of ScienceMahidol UniversityBangkok10400Thailand Food Technology program Kanchanaburi CampusMahidol UniversityKanchanaburi71150Thailand Department of Physics Faculty of ScienceMahidol UniversityBangkok10400Thailand

Tapioca is economical crop grown in Thailand and continues to be one of the major sources of ***,tapioca starch has been widely used in industrial applications,however the native form of starch has limited the *** scientists try to modify the properties of starch for increasing the stability of the granules,pastes to low pH,heat,and shear during the food *** modify the tapioca starch by plasma treatment under an argon *** degree of modification is determined by following water content in the starch *** tablet samples of native starch are also prepared and compared with the plasma treated *** plasma treatment,the starch tablets are stored under three different relative humilities(RH)including 11%,68%,and 78%RH,*** samples are characterized using FTIR spectroscopy associated with the degree of *** results show that the water molecules are engulfed into the starch structure in two ways,a tight bond and a weak absorption of water molecules which is represented at two wave number of 1630 cm^(-1) and 3272 cm^(-1),*** degree of cross-linking can be identified from the relative intensity of these two peaks with the C–O–H peak at 993 cm^(-1).The results show that the degree of cross-linking increase in the plasma treated *** degree of cross-linking of the treated starch with high relative humidity is less than that of the treated starch with low relative humidity.

关键词： linking humidity Starch

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Edible coating from VCO, iota-carrageenan and alginate blends for pindang fish preservation

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Green Materials 2023年第1期13卷 3-16页

作者： Iswahyuni, Hana Suyatma, Nugraha Edhi Wulandari, Nur Irianto, Hari Eko Dewi, Fera Roswita Nurhayati Sinurat, Ellya Nurbayasari, Rodiah Giyatmi Fransiska, Dina Analyst Ministry for Marine Affairs and Fisheries IPB University Bogor Indonesia Master of Food Technology Study Program Graduate School IPB University Bogor Indonesia Department of Food Science and Technology Faculty of Agricultural Engineering and Technology IPB University Bogor Indonesia Research Center for Marine and Land Bioindustry National Research and Innovation Agency of the Republic of Indonesia Lombok Indonesia Food Technology Study Program Faculty of Food Technology and Health Sahid University Jakarta Indonesia Research Center for Applied Microbiology National Research and Innovation Agency of the Republic of Indonesia Cibinong Indonesia

This study aims to develop an edible coating based on virgin coconut oil (VCO) nanoemulsion, iota-carrageenan and alginate to prolong the shelf life of pindang (mildly salted cooked) fish products. The research involved three stages: material preparation, characterization and determination of factors and responses for experimental design;parameter optimization to achieve optimal conditions;and application and analysis of pre- and post-coating characteristics of pindang fish. The parameter ranges were 0.5–1.5% for alginate concentration, 0.5–1.5% for iota-carrageenan concentration and 0.5–1.0% for VCO nanoemulsion concentration. The result of this study was an optimized food coating solution that was clear and bright white in color. Pindang fish coated with this layer showed improved quality in terms of water content (48.46%), weight loss (0.39%), pH (5.84), total volatile base (47.01%), salt content (2.9%), appearance (7), texture (7) and slime (7). At the same time, the total bacterial count remained unchanged (8 log colony-forming units (CFU)/g), the mold count remained unchanged (5 log CFU/g) and the aroma and taste received a score of 6. Thus, this study successfully produced an optimized edible coating that can enhance the quality and extend the shelf life of pindang fish, making it suitable for broader market distribution. © 2023 ICE Publishing. All rights reserved.

关键词： Fish

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Optimization of drying and extraction techniques for volatile compounds in banana pseudostem

Food Chemistry Advances

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food Chemistry Advances 2025年 7卷

作者： Pantea Salehizadeh Martin Bucknall George Srzednicki Robert Driscoll Mehdi Hajikhani Technology School of Chemical Engineering UNSW Australia Sydney NSW 2052 Australia Martin P. Bucknall is Principal Scientist Bioanalytical Mass Spectrometry Facility UNSW Australia. George Srzednicki is Principal Scientist Food Science and Technology School of Chemical Engineering UNSW Australia. Robert Driscoll is Senior Lecturer School of Chemical Engineering UNSW Australia Food Science Program University of Missouri Columbia MO 65211 USA.

This study explores the volatile organic compounds (VOCs) in the pseudostems of Musa acuminata and Musa balbisiana to assess their potential for industrial applications. Using headspace solid-phase microextraction (SPME) and gas chromatography–mass spectrometry (GC–MS), 62 VOCs were identified in Musa acuminata and 51 in Musa balbisiana, including alcohols, esters, ketones, aldehydes, and benzenes, many of which are also found in banana fruit and citrus species. The efficiency of freeze drying (FD) and heat pump drying (HPD) was compared, with FD retaining 20% more volatiles. Principal component analysis (PCA) showed distinct separations between species and drying methods, with Musa acuminata exhibiting a richer aroma profile. Key compounds such as 3-methylbenzaldehyde, menthone, and indole were prominent in both species. These findings suggest that banana pseudostems could serve as a valuable source of natural flavor compounds, offering a sustainable alternative for the food and beverage industry.

关键词： Heat pump drying Freeze-drying SPME Vacuum distillation Voc analysisOC analysis

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Antifungal ellagitannin isolated from Euphorbia antisyphilitica Zucc

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Asian Pacific Journal of Tropical Biomedicine 2013年第1期3卷 41-46页

作者： Juan Ascacio-Valdés Edgardo Burboa Antonio F Aguilera-Carbo Mario Aparicio Ramón Pérez-Schmidt Raúl Rodríguez Cristóbal N Aguilar Department of Food Science and Technology Universidad Autónoma de Coahuila Department of Forest Engineering Universidad Autonoma Indigena de Mexico Department of Food Science and Technology Universidad Autonoma Agraria "Antonio Narro" Agilent Technologies Inc.Varian's EduCare Training Program Instrumentation Analitica SA de CV Department of Food Science and Technology Universidad Autonoma de Coahuila Department of Food Science and Technology Universidad Autonóma de Coahuila

Objective:To study antifungal activity of a new ellagitannin isolated from the plant residues of Euphorbia antisyphilitica(***)Zucc in the wax extraction ***:An extract was prepared from dehydrated and pulverized residues and fractionated by liquid chromatography on Amberilte XAD-16,until obtained an ellagitannin-rich ethanolic fraction which was treated by rotaevaporation to recover the ellagitannin as fine *** aqueous solution was prepared and treated through ionic exchange liquid chromatography(Q XL)and gel permeation chromatography(G 25).The ellagitannin-rich fraction was thermogravimetrically evaluated(TGA and DTA)to test the thermo-stability of ellagic acid(monomeric unit).Then ellagitannin powder was analyzed by infrared spectrospcopy to determinate the functional groups *** mass spectroscopy was used to determine the molecular ***:The principal functional groups of ellagitannin were determined,the molecular weight was 860.7 g/mol;and an effective antifungal activity against phytopathogenic fungi was ***:It can be concluded that the new ellagitannin(860.7 g/mol)isolated from *** Zucc is an effective antifungal agent against Alternaria alternata,Fusarium oxyzporum,Colletotrichum gloeosporoides and Rhizoctnia solani.

关键词： Isolated Ellagitannin Euphorbia antisyphilitica Zucc Antifungal activity

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Effects of slurry concentration and rotational speeds of drum drier to the characteristics of pregelatinized breadfruit (Artocarpus altilis) flours 1

Effects of slurry concentration and rotational speeds of dru...

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1st International Conference on Mechanical Electronic and Biosystem Engineering, MEBSE 2018

作者： Sunarti, T.C. Sinaga, W.S.L. Pandji, C. Department of Agroindustrial Technology Faculty of Agricultural Engineering and Technology Bogor Agricultural University Indonesia Program Study of Food Science Faculty of Science and Technology University of Pelita Harapan Tangerang Indonesia

Breadfruit is one alternative carbohydrate source in Indonesia. However, breadfruit is seasonal and climacteric crops;it should be processed immediately to produce flour. Native breadfruit flour has many limitations since it is difficult to be solubilized and swollen in cold water. The flour is modified physically by pregelatinization to improve its properties. Pragelatinized breadfruit flour can be used as instant food, porridge, and baby food. This research is aimed to investigate the effect of slurry concentration (20 and 30%) of native breadfruit flour and rotational speeds (4, 6 and 8 rpm) of double drum drier to the chemical composition and physico-chemical properties of the pregelatinized flours. The results showed that pregelatinization did not influence to the chemical composition. Pregelatinization of the flour improved the water solubility and swelling power on room (30°C) and hot (70°C) solutions, reduced the freeze-thaw stability, caused partial gelatinization which is monitored by losing the birefringence of starch granule, and darkened the flour. The pregelatinization also reduced the gelatinization temperature and had low final viscosity. Low concentration of slurry and low rotation speed of drum increased the gelatinized part of the flour, which is influenced to the cold and hot water solubility. © Published under licence by IOP Publishing Ltd.

关键词： Solubility

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New insights into chemical compositions and health benefits of white tea and development of new products derived from white tea

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food science and Human Wellness 2024年

作者： Tharuka Wijesekara Yongxiang Liu Baojun Xu Food Science and Technology Program， Department of Life Sciences， BNU-HKBU United International College Department of Food Science and Agricultural Chemistry， Faculty of Agricultural and Environmental Sciences， McGill University

This study reviews the health benefits of white tea and the development of new products derived from white tea. The core processing procedures such as withering and drying play a pivotal role in shaping the unique characteristics of white tea. In the withering phase， water gradually diminishes， and endogenous polyphenol oxidase induces a slight oxidation of polyphenols which leads to a delicate fermentation process. This not only helps preserve the integrity of most components but also imparts an exclusive flavor and taste to white tea. Additionally， white tea stands out as a rich source of polyphenols， polysaccharides， and saponins. These bioactive components which can be extractable during brewing are conferring a myriad of health benefits. These benefits include antioxidant， anti-inflammatory， anti-aging， anti-radiation， anti-hyperglycemia， anti-hyperlipidemia， neuroprotection， and cardiovascular-protection properties. Innovative applications range from ready-to-drink infusions to skincare products. The review proposes white tea as a raw material for supplements， meal replacements， and confectionery. Various studies suggest its potential in enhancing gut health， supporting endurance， and contributing to photoprotection in skincare. The article concludes by highlighting white tea's adaptability， its role as a bridge between tradition and modernity， and its potential to shape the future of functional foods and beverages. Overall， white tea emerges as a versatile resource with applications extending beyond traditional consumption， offering a holistic approach to health and wellness.

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Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition

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Biomedicine & Pharmacotherapy 2025年 188卷 118169-118169页

作者： Kim, Minji Lim, Dong Wook Kim, Min-Sun Nam, Heejin Shin, Sooim Lee, Changho Um, Min Young Food Functionality Research Division Korea Food Research Institute Wanju 55365 Republic of Korea Department of Food Biotechnology University of Science & Technology Daejeon 34113 Republic of Korea Interdisciplinary Program of Bioenergy and Biomaterials Graduate School College of Engineering Chonnam National University Gwangju 61186 Republic of Korea Department of Biotechnology & Bioengineering College of Engineering Chonnam National University Gwangju 61186 Republic of Korea

AbstractDepression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties; however, its role in reducing stress hormone-induced depression remains unclear. This study examined the antidepressant effects of Rosa multiflora fructus extract (RMFE) on corticosterone (CORT)-induced depressive-like behaviors in mice and explored the underlying molecular mechanisms. ICR mice were administered CORT (40 mg/kg/day, i.p.) for 8 weeks to induce depressive-like behaviors. They were then treated with RMFE (100 or 300 mg/kg/day, p.o.) or selegiline (10 mg/kg/day, p.o.) as a positive control. RMFE treatment significantly alleviated depressive-like behaviors, as evaluated by the tail suspension and forced swimming tests. Furthermore, RMFE reduced hippocampal astrocyte hypertrophy and lowered the protein and mRNA expression of monoamine oxidase A and B (MAOA and MAOB). Phytochemical analysis using UPLC-MS/MS identified five flavonoids in RMFE, including ellagic acid (EA), hyperoside, isoquercetin, quercetin, and quercetin-3-glucuronide. In silico molecular docking revealed that these phenolic compounds interact with MAOA and MAOB, with EA exhibiting the strongest binding affinity. Consistently, EA administration effectively alleviated depressive-like behaviors and increased monoamine neurotransmitter levels in CORT-treated mice. These results suggest that RMFE exerts antidepressant effects by inhibiting MAO, restoring monoamine levels, and modulating hippocampal astrocytic hypertrophy, with EA identified as the primary bioactive compound driving its efficacy.

关键词： BBB blood-brain barrier BDNF brain-derived neurotrophic factor CORT corticosterone DAPI fluoroshield™ with 4,6-diamidino-2-phenylindole DMSO dimethyl sulfoxide EA ellagic acid FST forced swim test GFAP glial fibrillary acidic protein HPA axis hypothalamic-pituitary-adrenal axis HYP hyperoside IL-6 interleukin 6 ISOQ isoquercetin MAO monoamine oxidase OFT open field test PBS phosphate-buffered saline QUE quercetin QUE-3-G quercetin-3-glucuronide RMFE Rosa multiflora fructus extract SEL selegiline SEM standard error of the mean TBS tris-buffered saline TST tail suspension test UPLC-MS ultra-performance liquid chromatography-mass spectrometry Corticosterone Depression Ellagic acid Monoamine oxidase Rosa multiflora fructus

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