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Resonant Solitary States in Complex Networks

arXiv 2024年

作者： Niehues, Jakob Yanchuk, Serhiy Berner, Rico Kurths, Jürgen Hellmann, Frank Anvari, Mehrnaz Member of the Leibniz Association P.O. Box 60 12 03 PotsdamD-14412 Germany Humboldt-Universität zu Berlin Department of Physics Newtonstraße 15 Berlin12489 Germany Technische Universität Berlin ER 3-2 Hardenbergstrasse 36a Berlin10623 Germany University College Cork School of Mathematical Sciences Western Road CorkT12 XF62 Ireland Fraunhofer Institute for Algorithms and Scientific Computing Sankt Augustin53757 Germany

Partially synchronized solitary states occur frequently when a synchronized system of networked oscillators with inertia is perturbed locally. Several asymptotic states of different frequencies can coexist at the same... 详细信息

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Evaluating digital device technology in Alzheimer’s disease via artificial intelligence

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Alzheimer's & Dementia 2021年第S6期17卷

作者： Meemansa Sood Robbert Harms Maximilian Bügler Ioannis Tarnanas Neva Coello Holger Fröhlich Bonn-Aachen International Center for IT (b-it) Bonn Germany Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Altoida Inc. Houston TX USA Altoida AG Hirschengraben Lucerne Switzerland Global Brain Health Institute Trinity College Dublin Ireland Hellenic Initiative Against Alzheimer's Disease Johns Hopkins Precision Medicine Center Baltimore MD USA Novartis Basel Switzerland

Background Digital Measures (DMs) derived from mobile devices and smartphone applications have received a strongly increasing attention during the last years, because they could allow for an accurate, quantitative mon...

Background Digital Measures (DMs) derived from mobile devices and smartphone applications have received a strongly increasing attention during the last years, because they could allow for an accurate, quantitative monitoring of disease symptoms, even outside clinics. In addition, DMs may help to diagnose Alzheimer’s Disease (AD) in a pre-symptomatic stage and thus increase the success chances of therapeutic interventions. However, before any use in clinical routine, DMs have to be evaluated carefully by assessing their relationship to established clinical scores and understanding their diagnostic benefit. In this regard the IMI project RADAR-AD ( *** ) has the ambition to evaluate a broad panel of digital technologies with respect to their potential for early disease diagnosis while focusing on functional activities of daily living. Method An example of a panel of digital technology RADAR-AD uses is a smartphone based virtual reality game resulting into an assessment of cognitive impairment. In our work we analyzed connections between digital readouts and cognitive features like MMSE (Mini Mental State Examination) via one of our recently developed Artificial Intelligence (AI) approaches called Variational Autoencoder Modular Bayesian Networks (VAMBN). Going one step further we also tested the possibility to accurately predict MMSE scores from DMs and vice versa via machine learning. Based on this finding we then simulated DMs within the ADNI cohort and re-ran VAMBN. Result Application of VAMBN on the data from virtual reality game resulted into a network comprising DMs, MMSE sub-item scores and demographic features (Figure 1). It thus allowed to disentangle and quantify the relationship between DMs and established clinical scores. The simulation of DM’s and application of VAMBN in the ADNI cohort allowed us to further predict connections of DMs with FAQ (Functional Activity Questionnaire) and even molecular mechanisms. Conclusion Our results indicate t

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Publisher Correction: ComPath: an ecosystem for exploring, analyzing, and curating mappings across pathway databases

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npj Systems Biology and Applications 2019年第1期5卷 1页

作者： Daniel Domingo-Fernández Charles Tapley Hoyt Carlos Bobis-Álvarez Josep Marín-Llaó Martin Hofmann-Apitius Department of Bioinformatics Fraunhofer Institute for Algorithms and Scientific Computing Sankt Augustin Germany Bonn-Aachen International Center for IT Rheinische Friedrich-Wilhelms-Universität Bonn Bonn Germany Faculty of Medicine and Health Sciences University of Oviedo Oviedo Spain Rovira i Virgili University Tarragona Spain

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A multimodal digital biomarker of functional deficits in early-stage Alzheimer’s disease: results of the RADAR-AD study

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Alzheimer's & Dementia 2023年第S15期19卷

作者： Srinivasan Vairavan Manuel Lentzen Marijn Muurling Casper de Boer Alankar Atreya Jelena Curcic Chris Hinds Pauline Conde Margarita Grammatikopoulou Gaetano Scebba Ioulietta Lazarou Spiros Nikolopoulos Anna-Katharine Brem Neva Coello Pieter Jelle Visser Holger Fröhlich Vaibhav A Narayan Gayle Wittenberg Dag Aarsland Janssen Research and Development Titusville NJ USA Correspondece Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany VU University Medical Center Amsterdam Netherlands University of Oxford Oxford United Kingdom Novartis Institutes for BioMedical Research Basel Switzerland King’s College London London United Kingdom Centre for Research & Technology Hellas Thessaloniki Greece Davos Alzheimers Collaborative Wayne PA USA Janssen Research and Development LLC Titusville NJ USA

Background Remote monitoring technologies (RMTs), such as smartphone apps, smartwatches, and in-home sensors, are rapidly changing the way functional and cognitive performance is measured in Alzheimer’s disease (AD) ...

Background Remote monitoring technologies (RMTs), such as smartphone apps, smartwatches, and in-home sensors, are rapidly changing the way functional and cognitive performance is measured in Alzheimer’s disease (AD) patients. Here, we present results from the European RADAR-AD study on the use of multimodal data streams for the identification of functional deficits across all syndromic stages of AD. Method Four study groups (Healthy controls (HC), preclinical AD (pre. AD), prodromal AD (pro. AD), and mild AD) were included in this cross-sectional study. The RMT features (gait measures from Timed up and Go (TUG), Dual Task Effect (DTE) using physilog, acoustic features from Speech task in Mezurio, neurocognitive function using Altoida, managing finances with Banking app) with in-clinic neuropsychological (NP) tests, activities of daily living with Amsterdam IADL and demographics (age, gender, education years) were analyzed for different combinations of the multimodal digital biomarker of disease stage in AD across different pairwise comparisons. The analysis includes data from 175 participants (HC = 67, *** = 26, *** = 50, Mild AD = 32) collected for 8 weeks. An extreme gradient boosting (XGBoost) machine learning model was trained to obtain a multimodal biomarker of AD disease stage with repeated cross-validation (5-fold with 4 repeats) (Figure 1). This investigation is part of the ongoing RADAR-AD study. Result The multimodal combination of RMTs achieved a mean AUC of > 0.60 in all pairwise comparisons with a mean AUC > 0.65 for HC vs (***, *** and Mild) (Figures 2 and 3). The addition of NP tests increases the performance considerably across all pairwise comparisons except HC vs ***. Conclusion Our results highlight the advantage of combining RMTs to identify functional deficits in the early stage of AD. In particular, in prodromal and mild AD patients, a combined signal shows much more strength compared to individual tests. This work has received s

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Progression subtypes in Parkinson's disease: Results of an AI-based multi-cohort analysis

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Clinical Neurophysiology 2024年 159卷 e39-e39页

作者： Hähnel, T. Raschka, T. Sapienza, S. Klucken, J. Glaab, E. Corvol, J. Falkenburger, B. Fröhlich, H. Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus TUD Dresden University of Technology Dresden Germany Department of Bioinformatics Fraunhofer Institute for Algorithms and Scientific Computing (SCAI) Sankt Augustin Germany Bonn-Aachen International Center for IT University of Bonn Bonn Germany Biomedical Data Science Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg Esch-sur-Alzette Luxembourg Luxembourg Institute of Health (LIH) Strassen Luxembourg Centre Hospitalier de Luxembourg (CHL) Luxembourg Sorbonne Université Paris Brain Institute – ICM Inserm CNRS Assistance Publique Hôpitaux de Paris Pitié-Salpêtrière Hospital Department of Neurology Paris France German Center for Neurodegenerative Diseases (DZNE) Tatzberg 41 01307 Dresden Germany

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Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

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Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier-Chebbah Carsten Claussen Christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas Lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski Francesco Parino Gery Pruvost Andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal Crépey Laurent Coudeville Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada Department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland Department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA Departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des Deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance Decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occ... 详细信息

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Assessment of RMTs for Discriminating Stages of Alzheimer’s Disease

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Alzheimer's & Dementia 2023年第S22期19卷

作者： Manuel Lentzen Srinivasan Vairavan Jelena Curcic Alankar Atreya Chris Hinds Marijn Muurling Pauline Conde Margarita Grammatikopoulou Ioulietta Lazarou Spiros Nikolopoulos Neva Coello Casper de Boer Dag Aarsland Anna-Katharine Brem Holger Fröhlich RADAR-AD Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Bonn-Aachen International Center for IT (b-it) Bonn Germany Janssen Research and Development LLC Titusville NJ USA Novartis Institutes for BioMedical Research Basel Switzerland University of Oxford Oxford United Kingdom VU University Medical Center Amsterdam Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Netherlands Amsterdam Neuroscience Neurodegeneration Amsterdam Netherlands King’s College London London United Kingdom Centre for Research & Technology Hellas Thessaloniki Greece Amsterdam Neuroscience Neurodegeneration Amsterdam Noord-Holland Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Noord-Holland Netherlands

Background RADAR-AD is a European project in the context of the Innovative Medicine Initiative (IMI) focusing on the earlier identification of patients at risk for developing Alzheimer’s Disease (AD) via a panel of r...

Background RADAR-AD is a European project in the context of the Innovative Medicine Initiative (IMI) focusing on the earlier identification of patients at risk for developing Alzheimer’s Disease (AD) via a panel of remote monitoring technologies (RMTs), including smartphone apps and wearable devices. Method We examined the ability of 6 RMTs (Altoida, Axivity, Banking app, Fitbit, Physilog, and Mezurio) to distinguish between healthy controls (HC) and disease stages of preclinical (PreAD), prodromal (ProAD), and mild to moderate Alzheimer’s disease (MildAD) based on 175 patients (interim analysis). We trained three machine learning classifiers (Logistic Regression, Random Forest, and XGBoost) in a pairwise setting (HC vs. PreAD, HC vs. ProAD, HC vs. MildAD, PreAD vs. ProAD, and ProAD vs. MildAD). Since the interim dataset is still limited, we performed repeated, stratified nested cross-validation to get a robust performance estimate. Each classifier was trained with the features of the different devices and a set of baseline variables. The latter include a patient’s gender, age, years of education, and body mass index (BMI) when physical conditions might play a role (Axivitiy, Fitbit, Physilog). In addition, we checked whether specific patterns of the study groups allowed discrimination of the different study groups based on the baseline variables alone. Therefore, we trained one Logistic Regression model with these variables and compared the performance of the other three models with this baseline. The models trained with the baseline and questionnaire-based data served as the reference value in our benchmark that represents how well the discrimination of the different groups works with clinical tests. Result Our preliminary data show that RMTs can identify patients already in a prodromal disease stage (AUC ∼69%, Figure 1). Furthermore, the pairwise combination of data from a banking app and an app monitoring functional cognitive abilities via an augmented reality g

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Motor-cognitive dual tasking in the clinical setting: a sensitive measure of functional impairment in early Alzheimer’s disease

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Alzheimer's & Dementia 2023年第S14期19卷

作者： Anna-Katharine Brem Gaetano Scebba Jelena Curcic Marijn Muurling Casper de Boer Neva Coello Alankar Atreya Pauline Conde Holger Fröhlich Margarita Grammatikopoulou Chris Hinds Ioulietta Lazarou Manuel Lentzen Vaibhav A Narayan Rouba Kozak Spiros Nikolopoulos Srinivasan Vairavan Pieter Jelle Visser Gayle Wittenberg Dag Aarsland RADAR-AD Consortium University Hospital of Old Age Psychiatry University of Bern Bern Switzerland King’s College London London United Kingdom Correspondece Novartis Institutes for BioMedical Research Basel Switzerland Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Noord-Holland Netherlands University of Oxford Oxford United Kingdom Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Centre for Research & Technology Hellas Thessaloniki Greece Davos Alzheimers Collaborative Wayne PA USA Novartis Cambridge MA USA Janssen Research and Development LLC Titusville NJ USA Alzheimer Center Amsterdam Department of Neurology Amsterdam University Medical Center Amsterdam Netherlands Maastricht University Maastricht Netherlands Stavanger University Hospital Stavanger Norway

Background Gait is a complex everyday activity that depends upon supraspinal activity and a host of cognitive functions such as attention and executive functions. As cognition declines in neurodegenerative diseases, t...

Background Gait is a complex everyday activity that depends upon supraspinal activity and a host of cognitive functions such as attention and executive functions. As cognition declines in neurodegenerative diseases, the interaction and competition for neuronal resources during motor-cognitive dual-tasking (e.g., walking while talking) might be a sensitive measure of subtle functional impairments in early Alzheimer’s disease (AD). Here, we aim to identify gait deficits due to neuronal competition across the AD spectrum. Method This investigation is part of the ongoing Remote Assessment of Disease and Relapse – Alzheimer’s Disease (RADAR-AD) study. We attached three inertial measurement units (accelerometer and gyroscope) to both feet and one hip to assess dual task effects (DTE) assessing gait performance with/without concurrent serial subtraction-by-1 task in four groups: 1) amyloid negative healthy controls (HC, N = 59); and 2) amyloid positive preclinical AD (PreAD, N = 30); 3) prodromal AD (ProAD, N = 51); and 4) mild-to-moderate AD dementia (MildAD, N = 44) (Table 1). We furthermore investigated associations of DTE with observer-reported cognition. Result Group comparisons showed that dual-tasking induced lower cadence and increased stance, which were significantly different between HC and ProAD. Several DTE measures of variability differed significantly between PreAD and MildAD, with variability in the path length separating best between PreAD and ProAD (Table 2, Figure 1). DTE measures were associated with observer-rated divided attention only in the MildAD group. Conclusion Neuronal competition as assessed with motor-cognitive dual-tasking, specifically the DTE variability, might reflect functional deficits already in early AD, and could be a valuable additional measure to detect early impairments not captured by cognitive or motor tests alone. Future studies should implement an adaptive cognitive load to improve sensitivity/specificity in early AD stages and

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App-based augmented reality to assess cognitive impairment in early Alzheimer’s disease

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Alzheimer's & Dementia 2023年第S14期19卷

作者： Anna-Katharine Brem Marijn Muurling Casper de Boer Jelena Curcic Alankar Atreya Neva Coello Pauline Conde Holger Fröhlich Margarita Grammatikopoulou Chris Hinds Ioulietta Lazarou Manuel Lentzen Robbert Harms Maximilian Bügler Vaibhav A Narayan Rouba Kozak Spiros Nikolopoulos Srinivasan Vairavan Pieter Jelle Visser Gayle Wittenberg Dag Aarsland RADAR-AD Consortium King’s College London London United Kingdom University Hospital of Old Age Psychiatry University of Bern Bern Switzerland Correspondece Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Noord-Holland Netherlands Novartis Institutes for BioMedical Research Basel Switzerland University of Oxford Oxford United Kingdom Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Centre for Research & Technology Hellas Thessaloniki Greece Altoida Inc. Washington DC USA Davos Alzheimers Collaborative Wayne PA USA Novartis Cambridge MA USA Janssen Research and Development LLC Titusville NJ USA Alzheimer Center Amsterdam Department of Neurology Amsterdam University Medical Center Amsterdam Netherlands Maastricht University Maastricht Netherlands Stavanger University Hospital Stavanger Norway

Background Augmented reality apps merge real world with virtual experiences and can be used to remotely assess complex instrumental activities of daily living (iADL) that are affected early in Alzheimer’s disease (AD...

Background Augmented reality apps merge real world with virtual experiences and can be used to remotely assess complex instrumental activities of daily living (iADL) that are affected early in Alzheimer’s disease (AD). Our aim was to compare standard clinical measures with an augmented reality app to assess iADL that are related to memory and spatial navigation in early AD and its feasibility in the home-setting. Method We administered an augmented reality app (Altoida Inc., Washington DC, USA) in an on-going cross-sectional study (RADAR-AD: Remote Assessment of Disease and Relapse – Alzheimer’s Disease) in three groups: 1) amyloid negative healthy controls (HC, N = 49); and amyloid positive 2) preclinical AD (PreAD, N = 17); and 3) prodromal AD (ProAD, N = 29) (Table 1). Altoida’s research algorithm DNS-MCI (Digital Neuro Signature) produces the outcome of a machine learning model trained to identify cognitively normal individuals from those with cognitive impairment). DNS-MCI reflects performance in app-based tasks assessing memory and visuo-spatial function (placing and finding virtual objects, fire drill simulation) further including attention and motor performance (reaction time, finger tapping, navigational trajectory). At baseline, app-based tasks were performed in the clinic together with a standard neuropsychological assessment and iADL questionnaires (Figure 1). Participants were furthermore given the option of using Altoida in the home environment. Result The DNS-MCI score could significantly distinguish HC and PreAD participants from the ProAD group and was correlated with all neuropsychological tests and iADL questionnaires (Figures 1 and 2). Participants used the app on average 3-4 times at home (Table 1). Baseline in-clinic assessments were strongly correlated with at-home assessments (r = 0.53, p <.001). Conclusion App-based augmented reality tasks are applicable in the home setting and successful in capturing cognitive impairment in early AD. Future

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Brain based BMIgap as a new tool to correlate obesity and neural alterations – a multicohort study

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Neuroscience Applied 2022年 1卷

作者： A. Khuntia R. Paul O.A. Andreassen F. Degenhard R. Eils J. Erdmann C. Herrmann M. Hofmann-Apitius T. Kaufmann A.T. Kodamullil S. Mucha M.M. Nöthen M.L. Pedersen A. Quintero H. Schunkert A. Sharma H. Tost L.T. Westlye Y. Zhang J. Kambeitz N. Koutsouleris 1Department of Psychiatry and Psychotherapy- Ludwig-Maximilian-University Psychiatry Munich Germany 2Max Plank Institute of Psychiatry Psychiatry Munich Germany 3Department of Psychiatry and Psychotherapy- Ludwig-Maximilian-University- Munich- Germany Department of Psychiatry and Psychotherapy München Germany 4Norwegian Centre for Mental Disorders Research NORMENT Division of Mental Health and Addiction Oslo Norway 5Institute of Human Genetics- University of Bonn School of Medicine Bonn Germany 6Health Data Science Unit Heidelberg University Hospital- and BioQuant Heidelberg Germany 7Institute for Cardiogenetics University of Lübeck Lübeck Germany 8Heidelberg University Hospital- and BioQuant Health Data Science Unit Heidelberg Germany 9Fraunhofer Institute for Algorithms and Scientific Computing SCAI Bioinformatics Sankt Augustin Germany 10Fraunhofer Institute for Algorithms and Scientific Computing SCAI- Bioinformatics Sankt Augustin Germany 11Institute for Cardiogenetics- University of Lübeck- DZHK Cardiogenetics Lübeck Germany 12Institute of Human Genetics- University of Bonn Human Genetics Bonn Germany 13University of Oslo Department of Psychology Oslo Norway 14Deutsches Herzzentrum München- Technische Universität München Department of Cardiology Munich Germany 15Heidelberg University Hospital- and BioQuant Health Data Science Unit- Heidelberg Germany 16Central Institute of Mental Health Department of Psychiatry and Psychotherapy- Mannheim Germany 17University of Cologne Department of Psychiatry and Psychotherapy- Cologne Germany 18University of Turku Department of Psychiatry- Turku Finland 19Neuroscience and Sense Organs- University of Bari Aldo Moro Department of Basic Medical Science Bari Italy 20Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico Department of Neurosciences and Mental Health Milano Italy 21Institute of Mental Health- University of Birmingham Psychiatry Birmingham United Kingdom 22University of Birmingham School of Psyc

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