The paper is dedicated to reusing domain models from one research problem being solved in the domain community to another. The accustomed approach to research including immediate integration of existing data resources...
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The article analyzes computational architectures with data flow controlling computations. In particular, it analyzes the reasons that prevented the formation of this promising class of architectures. The paper conside...
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The principles known by FAIR abbreviation have been applied for different kinds of data management technologies to support data reuse. In particular, they are important for investigations and development in research i...
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This paper describes the final stage of the FPGA prototype development of a recurrent signal processor. During the development of this prototype, a set of tools was created, based on which design verification was carr...
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In this article, we propose an updated version of our previously developed model for predicting drug-side effect associations, applied to two case studies: long QT syndrome and asthma. The classifier accepts the name ...
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ISBN:
(数字)9798350386226
ISBN:
(纸本)9798350386233
In this article, we propose an updated version of our previously developed model for predicting drug-side effect associations, applied to two case studies: long QT syndrome and asthma. The classifier accepts the name of a specific drug side effect as input and outputs a list of drugs potentially associated with this side effect. By simulating how drug effects propagate within the interactome using the Random Walk with Restart algorithm, the classifier identifies genes potentially associated with the onset of the side effect. Based on the rationale that the more a drug perturbs these genes, the more likely it is to cause the side effect, the model identifies drugs potentially linked to the onset of the side effect. Moreover, the model enables the categorization of drugs into chemical subclasses using the ClassyFire schema, facilitating the analysis of complex side effects, such as asthma, through more specific mechanisms. The results show that the model identifies both drugs known to be associated with certain side effects, as well as drugs not officially reported by the FDA, demonstrating its generalizability and practical relevance. This method is also adaptable for analyzing other side effects.
The importance of proper data normalization for deep neural networks is well known. However, in continuous-time state-space model estimation, it has been observed that improper normalization of either the hidden state...
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The importance of proper data normalization for deep neural networks is well known. However, in continuous-time state-space model estimation, it has been observed that improper normalization of either the hidden state or hidden state derivative of the model estimate, or even of the time interval can lead to numerical and optimization challenges with deep learning based methods. This results in a reduced model quality. In this contribution, we show that these three normalization tasks are inherently coupled. Due to the existence of this coupling, we propose a solution to all three normalization challenges by introducing a normalization constant at the state derivative level. We show that the appropriate choice of the normalization constant is related to the dynamics of the to-be-identified system and we derive multiple methods of obtaining an effective normalization constant. We compare and discuss all the normalization strategies on a benchmark problem based on experimental data from a cascaded tanks system and compare our results with other methods of the identification literature.
The article presents the concept of a hybrid network topology in the enterprises with the use of a solar power plant and energy storage as well as a drive frequency converter for charging of transportation battery of ...
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The application of learning-based control methods in robotics presents significant challenges. One is that model-free reinforcement learning algorithms use observation data with low sample efficiency. To address this ...
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ISBN:
(数字)9798350377705
ISBN:
(纸本)9798350377712
The application of learning-based control methods in robotics presents significant challenges. One is that model-free reinforcement learning algorithms use observation data with low sample efficiency. To address this challenge, a prevalent approach is model-based reinforcement learning, which involves employing an environment dynamics model. We suggest approximating transition dynamics with symbolic expressions, which are generated via symbolic regression. Approximation of a mechanical system with a symbolic model has fewer parameters than approximation with neural networks, which can potentially lead to higher accuracy and quality of extrapolation. We use a symbolic dynamics model to generate trajectories in model-based policy optimization to improve the sample efficiency of the learning algorithm. We evaluate our approach across various tasks within simulated environments. Our method demonstrates superior sample efficiency in these tasks compared to model-free and model-based baseline methods.
Metaheuristic optimization algorithms present an effective method for solving several optimization problems from various types of applications and *** metaheuristics and evolutionary optimization algorithms have been ...
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Metaheuristic optimization algorithms present an effective method for solving several optimization problems from various types of applications and *** metaheuristics and evolutionary optimization algorithms have been emerged recently in the literature and gained widespread attention,such as particle swarm optimization(PSO),whale optimization algorithm(WOA),grey wolf optimization algorithm(GWO),genetic algorithm(GA),and gravitational search algorithm(GSA).According to the literature,no one metaheuristic optimization algorithm can handle all present optimization *** novel optimization methodologies are still *** Al-Biruni earth radius(BER)search optimization algorithm is proposed in this *** proposed algorithm was motivated by the behavior of swarm members in achieving their global *** search space around local solutions to be explored is determined by Al-Biruni earth radius calculation method.A comparative analysis with existing state-of-the-art optimization algorithms corroborated the findings of BER’s validation and testing against seven mathematical optimization *** results show that BER can both explore and avoid local *** has also been tested on an engineering design optimization *** results reveal that,in terms of performance and capability,BER outperforms the performance of state-of-the-art metaheuristic optimization algorithms.
The study of human engagement has significantly grown in recent years, particularly accelerated by the interaction with a growing number of smart computing machines [1, 2, 3]. Engagement estimation has significant imp...
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