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Sequence-activated chemiluminescence probes:programmable illumination for high-contrast in vivo sensing and imaging

science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan Li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular EngineeringInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science&TechnologyShanghai 200237China

Sequence-activated chemiluminescence(CL)technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial *** fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest,thus enabling high-contrast signals under complex physiological *** sequential activation could be triggered by enzymes,reactive oxygen species(ROS),biothiols or changes in the *** unique sequence-activated CL probes bestow several advantages,including minimal background,deep-tissue penetration,and the ability of non-invasive or minimally invasive *** sequence-activated CL techniques represent a significant advancement in molecular imaging and *** this mini-review,we focus on the latest developments in sequential CL probes,addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

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New digital drilling process monitoring: Instrumentation, validation and calibration

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 31-54页

作者： Yanpeng Sun Zuyu Chen Fangcai Xu Yufei Zhao Ruilang Cao Dong Li State Key Laboratory of Eco-hydraulics in Northwest Arid Region Xi'an University of TechnologyXi'an710048China State Key Laboratory of Simulation and Regulation of the Water Cycle in River Basins China Institute of Water Resources and Hydropower ResearchBeijing100048China Sinohydro Foundation Engineering Co. Ltd.Tianjin301700China North China Institute of Science&Technology Langfang065201China

This study aims to enhance the digital drilling process monitoring(DPM)or monitoring while drilling(MWD)technique,which is a widely recognized method in geological exploration for evaluating rock mass ***,robust displacement and torque measurement facilities for rotary-core drilling are *** conventional cable encoder for displacement measurement is replaced with a magnetostrictive displacement sensor,which is more reliable in harsh field drilling *** enables the measurement of the bit position with an accuracy of<1 *** importantly,this new instrument is proven to be successful in improving the detection of structural discontinuities with thicknesses>1 *** addition,by measuring the electric current of the driving motor,the torque applied to the bit is conveniently and accurately *** innovations ensure high-quality data collection for DPM ***,two indices derived from DPM are proposed to quantitatively describe rock mass *** specific energy index(SEI)and specific penetration index(SPI)are based on the principles of energy conservation and Mohr-Coulomb failure criterion,*** field tests conducted in a dam grouting area confirm a linear relationship between the thrust force and penetration per rotation,and between the torque and penetration per *** correlation ratios of the related regressions are typically>*** two indices allow for the quantitative interpretation of DPM data into rock mechanics characteristics,such as uniaxial compressive strength,rock quality designation(RQD),and rock mass permeability,eliminating the need for subjective judgment normally involved in the currently used rock mass quality rating approaches.

关键词： Drilling process monitoring Specific penetration index Specific energy index Fracture identification

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AXL-Mediated Drug Resistance in ALK-Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts

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Cancer science 2025年第4期116卷 1034-1047页

作者： Utsumi, Takahiro Mizuta, Hayato Seto, Yosuke Uchibori, Ken Nishio, Makoto Okamoto, Isamu Katayama, Ryohei Division of Experimental Chemotherapy Cancer Chemotherapy Center Japanese Foundation for Cancer Research Tokyo Japan Department of Respiratory Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan Department of Applied Chemistry Faculty of Science and Technology Keio University Kanagawa Yokohama Japan Department of Thoracic Medical Oncology The Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan

Anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC) shows marked tumor shrinkage by ALK-tyrosine kinase inhibitors (TKIs). However, tumors almost inevitably relapse owing to the development of acquired resistance. Resistance mechanisms include secondary ALK mutations and the activation of bypass pathways, such as cMET, cKIT, or EGFR, though some remain unknown. In this study, we analyzed alectinib-resistant patient samples and identified a significant increase in AXL expression in the tumor, and a high level of GAS6, the ligand for AXL, in the pleural effusion. AXL-overexpressing H3122 ALK-rearranged NSCLC cells exhibited partial resistance to alectinib, which was enhanced by GAS6 supplementation but could be overcome by the ALK/AXL inhibitor gilteritinib. Moreover, GAS6-overexpressing NIH3T3 cells and AXL-expressing H3122 cells were subcutaneously injected into the left and right sides of nude mice simultaneously, followed by alectinib treatment. The supply of GAS6 from NIH3T3 may have accelerated tumor relapse under alectinib treatment. However, even without GAS6-overexpressing NIH3T3, AXL-overexpressing H3122 tumor relapsed within 1 month possibly due to increased host mouse Gas6 expression. Single-cell RNA sequencing revealed that specific cancer-associated fibroblasts (CAFs) and a subset of tumor-associated macrophages (TAMs) are the primary sources of Gas6 in the tumor microenvironment (TME). During alectinib treatment, TAMs increased their infiltration into the TME, whereas CAFs altered their expression patterns, substantially upregulating Mmp11. These findings suggest that AXL expression in resistant cancer cells, combined with increased Gas6 production in the TME, contributes to enhanced ALK-TKI resistance. © 2025 The Author(s). Cancer science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

关键词： ALK AXL drug resistance GAS6 sc-RNA-seq

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QUALITY-OF-LIFE-ADJUSTED SURVIVAL FOR COMPARING CANCER TREATMENTS - A COMMENTARY ON TWIST AND Q-TWIST

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CANCER 1991年第3期67卷 851-854页

作者： FELDSTEIN, ML Frontier Science and Technology Research Foundation Brookline Massachusetts

In chronic disease situations where treatment comparisons favor no particular therapy, or where definitive outcome requires a considerable follow-up period, it is useful to have additional and perhaps intermediate endpoints of relevant clinical significance to compare treatments. One such endpoint is Time Without Symptoms and Toxicity (TWiST) which, together with Q-TWiST, attempts to address the quality of life of patients receiving the competing regimens. This paper provides a commentary on these techniques with an emphasis on the problems inherent in implementing Q-TWiST, a measure that attempts to incorporate patient value preferences into TWiST. It is argued that while Q-TWiST is intuitively appealing in the clinical setting, there are formidable design and psychometric hurdles that must be overcome to fully operationalize the concept.

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Exploring the effective parameters on the photocatalytic activity of TiO₂ nanoparticles

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South African Journal of Chemical Engineering 2025年 53卷 127-141页

作者： Halim, Norhana Abdul Tajuddin, Hairul Anuar Norrrahim, Mohd Nor Faiz Demon, Siti Zulaikha Ngah Ros, Fadhlina Che Aziz, Shujahadeen Hamsan, Muhammad Hafiz Azmi, Ahmad Farid Mohd Abidin, Nadiah Husseini Zainol Faculty for Defence Science and Technology National Defence University of Malaysia Sungai Besi Camp57000 Sungai Besi Kuala Lumpur Malaysia Centre for Defence Foundation Studies National Defence University of Malaysia Sungai Besi Camp 57000 Sungai Besi Kuala Lumpur Malaysia Centre for Fundamental and Frontier Sciences in Nanostructure Self-Assembly Department of Chemistry Faculty of Science Univerisiti Malaya Kuala Lumpur 50603 Malaysia Research Centre for Chemical Defence National Defence University of Malaysia Sungai Besi Camp 57000 Sungai Besi Kuala Lumpur Malaysia Research and Development Center University of Sulaimani Qlyasan Street Kurdistan Regional Government Sulaymaniyah 46001 Iraq Pusat Pengajian Citra Universiti Jalan Temuan Universiti Kebangsaan Malaysia Selangor Bangi 43600 Malaysia Wireless and Photonic Networks Research Centre Faculty of Engineering Universiti Putra Malaysia Serdang 43400 Malaysia

The growing challenge of environmental pollution has driven intense research into advanced materials for pollutant degradation. Among them, titanium dioxide (TiO2) nanoparticles stand out for their efficiency in the p... 详细信息

The growing challenge of environmental pollution has driven intense research into advanced materials for pollutant degradation. Among them, titanium dioxide (TiO₂) nanoparticles stand out for their efficiency in the photocatalytic degradation of organic pollutants, offering a promising solution for environmental remediation. In this study, TiO₂ nanoparticles were synthesized and characterized to measure their structural, morphological, and optical properties, which directly influence their photocatalytic degradation of methylene blue (MB), a model organic dye. TiO₂ nanoparticles were synthesized via the sol-gel method, enabling fine-tuned control over their crystallization and purity, and subsequently characterized using UV–Vis spectroscopy, field emission scanning electron microscopy (FESEM), Raman spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and a particle size analyzer. The photocatalytic activity was evaluated by measuring the degradation rate of MB under UV light irradiation. One hour of sonication was employed after the optimization study to enhance the dispersion of the nanoparticles, resulting in a more uniform size and shape for further characterization. Raman spectroscopy confirmed the presence of both anatase and rutile phases, with peaks at 386 cm⁻¹ and 516 cm⁻¹ indicating anatase, while the rutile phase was identified by peaks at 451 cm⁻¹ and 615 cm⁻¹. Fourier Transform Infrared (FTIR) spectroscopy confirmed characteristic bond formations at 1643 cm⁻¹ (Ti-OH) and 3338 cm⁻¹(O–H). The degradation analysis was performed via UV–Vis spectrophotometer, which demonstrated a decrease in absorbance at λ_max of 662 nm within 240 min. Additionally, UV–Vis spectroscopy was employed to determine the band gap energy of TiO₂, calculated to be approximately 3.19 eV. Morphological analysis using FESEM revealed f

关键词： Methylene blue (MB) Photocatalytic degradation Sol-gel method TiO2 UV–Vis spectroscopy

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Welfare technology Developers' Views Concerning Responsible Innovation and Implementation of Care Robots in Ireland and Japan 6

Welfare Technology Developers' Views Concerning Responsible ...

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6th Social Robots with AI: Prospects, Risks, and Responsible Methods Robophilosophy, RP 2024

作者： Kodate, Naonori Maeda, Yurie Yumoto, Akiyo Donnelly, Sarah Tsujimura, Mayuko Mannan, Hasheem Suwa, Sayuri Yu, Wenwei Kohli, Pranav Obayashi, Kazuko Masuyama, Shigeru O'Shea, Diarmuid School of Social Policy Social Work and Social Justice University College Dublin Ireland School of Business Technology Retail and Supply Technological University Dublin Ireland Graduate School of Nursing Chiba University Japan Graduate School of Nursing Shiga University of Medical Science Japan School of Nursing Midwifery and Health Systems University College Dublin Ireland Center for Frontier Medical Engineering Chiba University Japan Ottawa Community Housing Foundation Canada Universal Accessibility & Ageing Research Centre Japan Tokyo Medical University Tokyo Japan Royal College of Physicians of Ireland Dublin Ireland

ISBN: (纸本)9781643685670

Care robots are now seen as part of the solution to global aging. This article asks: how has responsible robotics been perceived? What are the missing elements that would enable responsible robotics (in research, development, and wider use) in different jurisdictions? In order to answer these questions, the article explores the views of welfare technology (WT) developers concerning the current state of robotics development and use in care settings in Ireland and Japan. Semi-structured in-depth interviews were conducted with 14 technology developers in total. The findings indicate that technology developers strongly believe that the use of care robots and WTs would strengthen the long-term care systems in both countries, if ethical and other aspects are taken into consideration. The uniform long-term care system can facilitate the top-down introduction of care robots, but a mismatch can be widened between users' needs and the solutions that WTs can provide. The inclusion of WTs in professional curricula and training programs and changing the often-skewed media representation of AI and robotics were presented as a possible way forward. © 2025 IOS Press. All rights reserved.

关键词： ethics Responsible robotics social policy sustainable development goals welfare technology

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Polymerizable AEE-active Dye with Optical Activity for Fluorescent Nanoparticles Based on Phenothiazine:Synthesis,Self-assembly and Biological Imaging

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Chinese Journal of Polymer science 2021年第11期39卷 1431-1440页

作者： Zeng-Fang Huang Ya-Li Chen Chao-Yue Zhou Yan-Hong Li Mei Li Xiao-Bo Liu Liu-Cheng Mao Jin-Ying Yuan Lei Tao Yen Wei School of Materials&Food Engineering Zhongshan InstituteUniversity of Electronic Science&Technology of ChinaZhongshan 528402China School of Materials and Energy University of Electronic Science&Technology of ChinaChengdu 610054China Department of Chemistry the Tsinghua Center for Frontier Polymer ResearchTsinghua UniversityBeijing 100084China

In consideration of various advantages such as less harm,higher sensitivity,and deeper imaging depth,etc.,AIE materials with longwave emission are attracting extensive attention in the fields of vascular visualization,organelle imaging,cells tracker,forensic detection,bioprobe and chemosensor,*** this work,a novel fluorescent(R)-PVHMA monomer with chirality and aggregation-induced emission enhancement(AEE)characteristics was acquired through enzymatic transesterification reaction basing on phenothiazine,and its[α]D25℃value was about-6.39°with a 3.08 eV bandgap calculated by the quantum ***,a series of PEG-PVH1 and PEG-PVH2 copolymers with chirality feature were achieved through RAFT polymerization of the obtained(R)-PVHMA and PEGMA with various feed *** the feed molar ratio of(R)-PVHMA increased from 21.5%to 29.6%,its actual molar fractions in the PEG-PVH1 and PEG-PVH2 copolymers accordingly increased from 18.1%to 25.7%.The molecular weight of PEG-PVH1 was about 2.2×10^(4) with a narrow PDI,and their kinetics estimation showed a first-order quasilinear *** aqueous solution,the amphiphilic copolymers PEG-PVH could self-assemble into about 100 nm *** a 90%water solution of H_(2)O and THF mixture,the fluorescence intensity had the maximum value,and the emission wavelength presented at 580 and 630 *** investigation of cytotoxicity and cells uptake showed that PEG-PVH FONs performed outstanding biocompatibility and excellent cells absorption effects,which have great potential in bioimaging application.

关键词： AEE dye Optical activity RAFT polymerization Long-wave emission Biological imaging

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A comparative study on demineralization of coals by acid-washing and solvent-extraction methods for low temperature catalytic coal gasification application

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Carbon Resources Conversion 2019年第3期2卷 175-181页

作者： Atul Sharma Akimitsu Matsumura Research Institute of Energy Frontier Non-conventional Carbon Resources GroupNational Institute of Advanced Industrial Science&Technology16-1OnogawaTsukubaJapan

Catalytic coal gasification is an efficient way to achieve high conversion rates at low *** loss due to the reaction between the inherent mineral matter in the coal and the catalyst is a major hurdle for its practical *** problem may be overcome by removing the mineral matter from the coal before *** demineralizing approaches,acid-washing and solvent-extraction methods are investigated for demineralizing the *** analysis,XRD analysis,NMR analysis,and N_(2)adsorption analysis were made to compare the demineralization efficiency,crystallographic carbon microstructure,chemical structure,and micro-porosity,***-extraction method was found be more efficient for *** was observed in the chemical structure and micro-porosity while crystallographic carbon-microstructure was found to be ***-catalytic and catalytic gasification reactivity of the chars obtained by the two methods was *** composition and gas evolution profiles were also obtained and found to be influenced by the degree of demineralization.

关键词： Coal Demineralization Acid washing Solvent extraction Catalytic gasification

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Two-dimensional talc as a natural hyperbolic material

arXiv

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arXiv 2025年

作者： Feres, Flávio H. Maia, Francisco C.B. Chen, Shu Mayer, Rafael A. Obst, Maximillian Hatem, Osama Wehmeier, Lukas Nörenberg, Tobias Queiroz, Matheus S. Mazzotti, Victor Klopf, J. Michael Kehr, Susanne C. Eng, Lukas M. Cadore, Alisson R. Hillenbrand, Rainer Freitas, Raul O. Barcelos, Ingrid D. SP Campinas Brazil Terahertz Technology Innovation Research Institute National Basic Science Center—Terahertz Science and Technology Frontier Shanghai Key Lab of Modern Optical System University of Shanghai for Science and Technology Terahertz Precision Biomedical Discipline 111 Project Shanghai China SP Campinas Brazil Institute of Applied Physics Technische Universität Dresden Dresden01062 Germany National Synchrotron Light Source II Brookhaven National Laboratory UptonNY11973 United States State University of Santa Cruz Iheus BA Brazil SP Campinas Brazil Institute of Radiation Physics Helmholtz-Zentrum Dresden-Rossendorf Dresden01328 Germany SP Campinas Brazil Donostia-San Sebastian20018 Spain IKERBASQUE Basque Foundation for Science Bilbao48013 Spain

This study demonstrates that two-dimensional ‘talc’, a naturally abundant mineral, supports hyperbolic phonon-polaritons (HPhPs) at mid-infrared wavelengths, thus offering a low-cost alternative to synthetic polaritonic materials. Using scattering scanning near-field optical microscopy (s-SNOM) and synchrotron infrared nano spectroscopy (SINS), we reveal tunable HPhP modes in talc flakes of a long lifetime. These results highlight the potential of natural 2D talc crystals to constituting an effective platform for establishing scalable optoelectronic and photonic devices. © 2025, CC BY-NC-ND.

关键词： Near field scanning optical microscopy

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Inhibition of the toxic byproduct during photocatalytic NO oxidation via La doping in ZnO

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Chinese Chemical Letters 2020年第3期31卷 751-754页

作者： Chaowei Yuan Wen Cui Yanjuan Sun Jiadong Wang Ruimin Chen Jin Zhang Yuxin Zhang Fan Dong Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China Research Center for Environmental Science&Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China The Center of New Energy Materials and Technology School of Materials Science and EngineeringSouthwest Petroleum UniversityChengdu 610500China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

It is of a great challenge to develop semiconductor photocatalysts with potential possibilities to simultaneously enhance photocatalytic efficiency and inhibit generation of toxic *** this study,we developed a facile method to induce the La doping and cationic vacancie(V(Zn))on ZnO for the highly efficient complete NO *** photocatalytic NO removal efficiency increases from 36.2%to 53,6%.Most importantly,a significant suppressed NO2 production also has been *** to the DFT calculations,ESR spectra and in situ FTIR spectra,the introduction of La^3+induce the redistribution of charge carriers in La-ZnO,which promote the production of·O2^- and lead to the formation of V(Zn)for the formation of·OH,contributing to the complete oxidation of NO to ***,the conversion pathway of photocatalytic NO oxidation has been elaborated,This work paves a new way to simultaneously realize the photocatalytic pollutants removal and the inhibition of toxic intermediates generation for efficient and safe air purification.

关键词： Photocatalytic NO oxidation Toxic byproduct Reactive oxygen species ZnO Cationic vacancie

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