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SSRN 2023年

作者： Banks, Emmie Gutekunst, Claire-Anne Vargish, Geoffrey A. Eaton, Anna Pelkey, Kenneth A. McBain, Chris J. Zheng, James Q. Oláh, Viktor Janos Rowan, Matthew J.M. Department of Cell Biology Emory University School of Medicine AtlantaGA30322 United States GDBBS Graduate Program Laney Graduate School Emory University United States Department of Neurosurgery Emory University School of Medicine AtlantaGA30322 United States Section on Cellular and Synaptic Physiology NICHD - Eunice Kennedy Shriver National Institute of Child Health United States Department of Biomedical Engineering Georgia Institute of Technology AtlantaGA30322 United States BethesdaMD United States Center for Neurodegenerative Disease Emory University School of Medicine United States

The mammalian brain contains the most diverse array of cell types of any organ, including dozens of neuronal subtypes with distinct anatomical and functional characteristics. The brain leverages these neuron-type-specializations to perform diverse circuit operations and thus execute different behaviors properly. Through the use of Cre lines, access to specific neuron types has steadily improved over past decades. Despite their extraordinary utility, development and cross-breeding of Cre lines is time-consuming and expensive, presenting a significant barrier to entry for many investigators. Furthermore, cell-based therapeutics developed in Cre mice are not clinically translatable. Recently, several AAV vectors utilizing neuron-type-specific regulatory transcriptional sequences (enhancer-AAVs) were developed which overcome these limitations. Using a publicly available RNAseq dataset, we evaluated the potential of several candidate enhancers for neuron-type-specific targeting in the hippocampus. Here we identified a promising enhancer-AAV for targeting dentate granule cells and validated its selectivity in wild-type adult mice. © 2023, The Authors. All rights reserved.

关键词： Neurons

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