检索结果-内蒙古大学图书馆

Correction to: Implications of sequence variation on the evolution of rRNA

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2019年第3期27卷 285页

作者： Matthew M Parks Chad M Kurylo Jake E Batchelder C Theresa Vincent Scott C Blanchard Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA. Department of Immunology Weill Cornell Medicine New York NY USA. Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA. theresa.vincent@igp.uu.se. Department of Immunology Genetics and Pathology Uppsala University Uppsala Sweden. theresa.vincent@igp.uu.se. Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA. scb2005@med.cornell.edu. Tri-Institutional PhD Program in Chemical Biology Weill Cornell Medicine New York NY USA. scb2005@med.cornell.edu.

The article Implications of sequence variation on the evolution of rRNA, written by Matthew M. Parks, Chad M. Kurylo, Jake E. Batchelder, C. Theresa Vincent and Scott C. Blanchard, was originally published electronica...

关键词：

来源：评论

学校读者我要写书评

暂无评论

Collecting and interpreting birth defects surveillance data by Hispanic ethnicity: A comparative study

引用

Teratology 1999年第1‐2期61卷

作者： Russell Kirby Ph.D., M.S., F.A.C.E. Joann Petrini Caroline Alter The Hispanic Ethnicity Birth Defects Workgroup Department of Obstetrics and Gynecology Milwaukee Clinical Campus University of Wisconsin Medical School Milwaukee Wisconsin 53201-0342 Perinatal Data Center Office of the Medical Director March of Dimes Birth Defects Foundation White Plains New York 10605 Members of the Hispanic Ethnicity Birth Defects Workgroup include: Arizona Department of Health Service Birth Defects Monitoring Program: Timothy J. Flood MD Thomas E. Hughes MA California Birth Defects Monitoring Program: Kamala Deosaransingh MPH Jackie White Wynne BA Colorado Responds to Children with Special Needs: Lisa Miller MD Heather Orton Russel Rickard MS New Jersey Birth Defects Registry and Special Needs Registry: Leslie M. Beres MS New Mexico Birth Defects Prevention and Surveillance System: Mary Olguin EdD New York State Congenital Malformations Registry: Charlotte Druschel MD MPH Jeffrey P. Hughes MPH Texas Birth Defects Monitoring Division: Mark Canfield PhD March of Dimes Birth Defects Foundation: Donald Mattison MD MPH. The assistance of Larry D. Edmonds MSPH and Paula Yoon PhD Division of Birth Defects and Pediatric Genetics National Center for Environmental Health Centers for Disease Control and Prevention is gratefully acknowledged.

来源：评论

学校读者我要写书评

暂无评论

The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases

引用

Clinical immunology (Orlando, Fla.) 2024年 260卷 109897页

作者： Hsing-Fang Lu Chen-Hsing Chou Ying-Ju Lin Shunsuke Uchiyama Chikashi Terao Yu-Wen Wang Jai-Sing Yang Ting-Yuan Liu Henry Sung-Ching Wong Sean Chun-Chang Chen Fuu-Jen Tsai Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan. PhD Program for Health Science and Industry College of Health Care China Medical University Taichung Taiwan Department of Health Services Administration China Medical University Taichung Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan. Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Clinical Research Center Shizuoka General Hospital Shizuoka Japan The Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404327 Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Chinese Medicine China Medical University Taichung Taiwan Department of Biotechnology and Bioinformatics Asia University Taichung Taiwan. Electronic address: d0704@mail.cmuh.org.tw.

Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu87 amino acid residues. The genetic correlation showed significance between IgE and allergic diseases including asthma, atopic dermatitis, and pollinosis. IgE PRS was significantly correlated with total IgE levels. Furthermore, the top decile IgE polygenic risk score (PRS) group had the highest risk of asthma for the Taiwan Biobank and Biobank Japan cohorts. IgE PRS may be used to aid in predicting the occurrence of allergic reactions before symptoms occur and biomarkers are detectable. Our study provided a more comprehensive understanding of the impact of genomic variants, including complex HLA alleles, on serum IgE levels.

关键词： Allergy genome-wide association study human leukocyte antigen immunoglobulin E

来源：评论

学校读者我要写书评

暂无评论

P–074 Chromatin Maturity Index (CMI) in unfixed and live spermatozoa and Aniline Blue (AB) stained as an additional evaluation parameter in idiopathic male infertility

引用

Human Reproduction 2021年第SUPPLEMENT_1期36卷

作者： Notari, T Piscopo, M Bosco, L Pecoraro, S Serra, N Ricciardi, D Capra, G Montano, L Check Up - Day Surgery Polydiagnostic Centre Salerno- Italy. Check Up Research Unit Salerno Italy University of Naples “Federico II” Department of Biology Napoli Italy University of Palermo Department of Biomedicine- Neuroscience and Advanced Diagnostics Bi.N.D- Section of Biology and Genetics- Palermo- Italy IRCCS Neuromed “Malzoni Clinic” Department of Uro-Andrology- Avellino Italy University of Naples “Federico II” Department of Public Health Napoli Italy “Ricciardi” Diagnostic Centre Seminology Lab Pollena Trocchia- Napoli Italy University of Palermo Department of Sciences for Health Promotion and Mother-Child Care ‘G. D’Alessandro’ PROSAMI- Palermo Italy Local Health Authority ASL-Salerno.. Andrology Unit and Service of Lifestyle Medicine in UroAndrology- Coordination Unit of the network for Environmental and Reproductive Health EcoFoodFertility project- “Oliveto Citra Hospital”- Salerno. PhD Program

来源：评论

学校读者我要写书评

暂无评论

Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

引用

NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

来源：评论

学校读者我要写书评

暂无评论

Association between Nuclear SET Domain (NSD) Protein Lysine Methyltransferases (KMT) Expression and Poor Prognosis in Acute Promyelocytic Leukemia (APL) Patients Treated with ATRA and Anthracycline Protocol

引用

BLOOD 2017年 130卷 2702-2702页

作者： Wagatsuma, Virginia Mara De Deus Pereira-Martins, Diego A. Mendoza, Silvia Elena Sanchez Koury, Luisa C. A. Nascimento, Mariane Cristina Melo, Raul Antonio Morais Bittencourt, Rosane Pagnano, Katia B. Pasquini, Ricardo Chiattone, Carlos Fagundes, Evandro Maranhao Chauffaille, Maria de Lourdes Lucena-Araujo, Antonio R. Tallman, Martin S. Schrier, Stanley L. Ribeiro, Raul C. Ganser, Arnold Lowenberg, Bob Lo Coco, Francesco Sanz, Miguel A. Berliner, Nancy Rego, Eduardo Magalhaes Ribeirão Preto Medical School University of São Paulo Ribeirão Preto Medical School Ribeirao Preto Brazil Internal medicine University of São Paulo Ribeirão Preto Brazil Center for Cell Based Therapy Ribeirão Preto Medical School São Paulo University ribeirao preto Brazil 3PhD Fellow from the Students Agreement Postgraduate ProgramPECPG Ribeirão Preto Brazil Medical School of Ribeirao Preto Ribeirão Preto BRA UNIVERSIDADE DE PERNAMBUCO / HEMOPE RECIFE BRA Hematology Division University Hospital of the Federal University of Rio Grande do Sul Porto Alegre Brazil Centro de Hematologia e Hemoterapia Hematology and Hemotherapy Center Campinas Brazil Hematology Division Federal University of Paraná Curitiba Brazil Hematology Division Santa Casa Medical School São Paulo Brazil Hematology Division Federal University of Minas Gerais Belo Horizonte Brazil Hematology and Hemotherapy Universidade Federal de São Paulo Sao Paulo Brazil Department of Genetics Federal University of Pernambuco Recife Brazil Division of Hematologic Oncology Leukemia Service Memorial Sloan-Kettering Cancer Center New York NY Stanford University Stanford Department of Oncology and Global Medicine International Outreach Program St. Jude Children's Research Hospital Memphis TN Department of Hematology Hemostasis Oncology and Stem Cell Transplantation Hannover Medical School Hannover Germany Department of Hematology Erasmus University Medical Center Rotterdam Netherlands Department of Biomedicine and Prevention University Tor Vergata Rome Italy Department of Medicine Hospital Universitari i Politecnic La Fe and Centro de Investigación Biomédica en Red de Cáncer University of Valencia and Instituto Carlos III Madrid Madrid Spain Division of Hematology Department of Internal Medicine University of São Paulo Ribeirão Preto Brazil Center for Cell-Based Therapy Medical School of Ribeirão Preto University of São Paulo Ribeirão Preto São Paulo Brazil

2702

关键词：

来源：评论

学校读者我要写书评

暂无评论

106 Outcomes Following Hematopoietic Cell Transplant for CD3δ Severe Combined Immune Deficiency: a PIDTC Natural History Study

引用

Clinical Immunology 2024年 262卷 110048-110048页

作者： Kalashnikova, Tatiana Cuvelier, Geoff Logan, Brent Grunebaum, Eyal Guilcher, Gregory Lewis, Victor McAuley, Grace Marwaha, Ashish Murguia-Favela, Luis Prince, Bradley Romero, Zulema Rubin, Tamar Suresh, Sneha Buckley, Rebecca Dvorak, Christopher Satter, Lisa Aquino, Victor Bunin, Nancy Joshi, Avni Prokop, Susan Heimall, Jennifer Haddad, Elie Leiding, Jennifer Puck, Jennifer Burroughs, Lauri Griffith, Linda Notarangelo, Luigi Pulsipher, Michael Cowan, Morton Marsh, Rebecca Pai, Sung-Yun Torgerson, Troy Kohn, Donald B. Wright, Nicola Clinical Research Fellow in Clinical Immunology/University of Calgary Section Head Pediatric Hematology-Oncology-BMT/CancerCare Manitoba Professor and Director Division of Biostatistics/Medical College of Wisconsin Clinical Immunology/Hospital for Sick Children Associate Professor of Oncology and Pediatrics/University of Calgary/Alberta Children’s Hospital Associate Professor/Alberta Children’s Hospital MD-PhD Student/UC San Diego School of Medicine Clinical Assistant Professor/University of Calgary Clinical Associate Professor Pediatric Immunology/Alberta Children’s Hospital University of Calgary Resident Physician Medical Genetics/University of Calgary Assistant Adjunct Professor/UCLA Assistant Professor/University of Manitoba Assistant Professor/University of Alberta James Buren Sidberry Professor Emeritus of Pediatrics and Professor Emeritus of Immunology/Duke University Professor/UCSF Assistant Professor/Pediatrics-Allergy and Immunology Baylor College of Medicine Professor of Pediatric/UT Southwestern Medical Center Dallas Director BMT Program/Children’s Hospital of Philadelphia Chair Division of Pediatric Allergy and Immunology/Mayo Clinic Associate Professor of Pediatrics/Harvard Medical School Clinical Associate Professor/University of Calgary

来源：评论

学校读者我要写书评

暂无评论

The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

引用

NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

引用

NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

来源：评论

学校读者我要写书评

暂无评论

Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)

引用

European journal of epidemiology 2025年 2025 May 12页

作者： Álvaro Hernáez Anna Camps-Vilaró Sara Polo-Alonso Isaac Subirana Rafel Ramos Rafael de Cid Fernando Rodríguez-Artalejo Roberto Elosua M Dolores Chirlaque Pilar Amiano Marcelino Bermúdez-López Marcela Guevara Sergio Cinza-Sanjurjo María-José Sánchez Antonio Cabrera de León Martín Laclaustra Gemma Rojo-Martínez María J Guembe-Suescun Beatriz Pérez-Gómez Tomás Vega-Alonso Pere Torán-Monserrat David Lora-Pablos José María Huerta José M Valdivielso Irene R Dégano Francisco J Félix-Redondo Ana María Gandarillas Sergio Valdés Xavier Mundet-Tuduri Pedro L Sánchez Vicente Martín-Sánchez Fernando Rigo Manuela Alonso-Sampedro Conchi Moreno-Iribas Juan Carlos Martín-Escudero Elías Delgado Maria Grau Inés Urrutia Diana Ovejero Inés Quintela Ruth Martí-Lluch Natalia Blay José R Banegas Helena Tizón-Marcos Jesús Humberto Gómez Amaia Aizpurua Eva Castro-Boqué Josu Delfrade Miguel Ángel Prieto-Díaz Miguel Rodríguez-Barranco Delia Almeida-González Belén Moreno-Franco Wasima Oualla-Bachiri Carmen Sayón-Orea Elena Plans-Beriso José Eugenio Lozano Víctor M López-Lifante Pilar Cancelas-Navia Natalia Cabrera-Castro Serafí Cambray Lluís Zacarías-Pons Daniel Fernández-Bergés Encarnación Donoso-Navarro Cristina Maldonado-Araque Josep Franch-Nadal Pedro Ignacio Dorado-Díaz Alejandro Villarín-Castro Guillem Frontera-Juan Francisco Gude Naroa Andueza María Téllez-Plaza Jessica Ares-Blanco Raquel Cruz Marc Ribas-Aulinas Jordi Barretina Pilar Guallar-Castillón Miguel Caínzos-Achirica Sandra Milena Colorado-Yohar Adrián Llorente Juan Miguel Diaz-Tocados Eva Ardanaz Rafael Manuel Micó-Pérez Nicolás Francisco Fernandez-Martinez María Del Cristo Rodríguez-Pérez Ana Cenarro Alfonso L Calle-Pascual Jaume Marrugat REGICOR Study Group Hospital del Mar Research Institute (IMIM) Carrer Doctor Aiguader 88 08003 Barcelona Spain. ahernaez@***. CIBER de Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III Madrid Spain. ahernaez@***. Blanquerna School of Health Sciences University Ramon Llull Barcelona Spain. ahernaez@***. REGICOR Study Group Hospital del Mar Research Institute (IMIM) Carrer Doctor Aiguader 88 08003 Barcelona Spain. CIBER de Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III Madrid Spain. School of Medicine University of Vic-Central University of Catalonia (UVic-UCC) Vic Spain. PhD Program Barcelona Spain. Cardiovascular Epidemiology and Genetics Research Group Hospital del Mar Research Institute (IMIM) Barcelona Spain. Department of Medical Science Faculty of Medicine University of Girona (UdG) Girona Spain. Vascular Health Research Group Institut Universitari Per a La Recerca en Atenció Primària de Salut Jordi Gol I Gurina (IDIAPJGol) Girona Spain. Girona Biomedical Research Institute (IDIBGI) Doctor Trueta University Hospital Girona Spain. Network for Research On Chronicity Primary Care and Health Promotion (RICAPPS) Instituto de Salud Carlos III Madrid Spain. Genomes For Life-GCAT Lab CORE Program Germans Trias I Pujol Research Institute (IGTP) Badalona Spain. Grup de Recerca en Impacte de les Malalties Cròniques I les Seves Trajectòries (GRIMTRA) Germans Trias I Pujol Research Institute (IGTP) Badalona Spain. Department of Preventive Medicine and Public Health School of Medicine Universidad Autónoma de Madrid Madrid Spain. IMDEA/Food Institute. CEI UAM+CSIC Madrid Spain. CIBER de Epidemiología y Salud Pública (CIBERESP) Instituto de Salud Carlos III Madrid Spain. Department of Epidemiology Regional Health Council IMIB-Arrixaca Murcia Spain. Department of Health and Social Sciences University of Murcia Murcia Spain. Sub Directorate for Public Health and Addictions of Gipuzkoa Ministry of Health of the Basque G

The CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population, improve predictions of cardiovascular incidence using genomic and clinical data, and identify subgroups that would benefit most from targeted pharmacological and lifestyle interventions. CORDELIA includes 196,632 individuals (ages 18-84, 54% female, 96% born in Spain, 20% with higher education, recruited from 1989 to 2020, with follow-up periods ranging from 5 to 30 years), with DNA samples available for 117,342 participants (60%). Of the participants, 24% were current smokers, 43% hypertensive, 11% diabetic, 15% medicated with lipid-lowering drugs, 44% overweight, and 27% obese. If not already available, genotyping is being performed using the Axiom™ Spain Biobank array (~ 750,000 variants, including 115,000 specific and 50,000 rare functional variants from the Spanish population). The cohort also includes incident events (coronary heart disease, stroke, heart failure, peripheral artery disease, hypertension, diabetes); date and cause of death; and harmonized data on risk factors (body mass index, waist circumference, lipid profile, blood pressure, glucose, creatinine), lifestyle (smoking, physical activity, diet, alcohol), and socioeconomic status. 99,019 participants (50%) also provide plasma samples. CORDELIA will significantly contribute to understanding the complex interplay of risk factors contributing to cardiovascular disease and advance the fields of precision medicine and public health in Southern European individuals.

关键词： Cardiovascular disease Cohort Genome-wide association study Mortality Southern Europe

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：