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SSRN 2023年

作者： Zeng, Kai Yang, Siyu Xue, Chang Wu, Jinbo Wen, Weijia Materials Genome Institute Shanghai University China20444 China Faculty of Materials Science Shenzhen MSU-BIT University China Division of Emerging Interdisciplinary Areas Interdisciplinary Program Office The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong Department of Physics The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong

This paper describes the synthesis and characterization of a novel material with reversible thermotropic transmittance, prepared via emulsion polymerization. The material consists of 75% Oc-tadecylamine (ODA) and 1% allyl methacrylate (ALMA), which displays a discoloration phe-nomenon at 35°C with a visible light transmittance greater than 90%. The synthesized powder was characterized using differential scanning calorimetry-thermogravimetric analysis (DSC-TG) and scanning electron microscopy (SEM), which revealed good thermal processing performance, uni-form particle size, and anchoring properties. Additionally, thermochromic polyvinyl butyral (PVB) film and laminated glass were fabricated, using co-extrusion, and compared with different types of glass. The laminated glass with thermochromic PVB film showed a reduction in solar irradiance of 20-30% compared to double silver Low-E glass, demonstrating its effective shading and heat in-sulation properties. Overall, this study offers a promising approach for the development of smart materials with thermotropic transmittance for energy-efficient applications. © 2023, The Authors. All rights reserved.

关键词： Polyvinyl butyral

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Research Highlights: Shear-activated nanotherapeutics

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Nanomedicine 2012年第11期7卷 1653-1655页

作者： Sukanya Iyer Mitchel J Doktycz Graduate Program in Genome Science & Technology University of Tennessee Knoxville TN 37996 USA Biosciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge TN 37831 USA.

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Mechano-active cartilage tissue engineering: The effect of dynamic compressive stimulation

Mechano-active cartilage tissue engineering: The effect of d...

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作者： Jung, Youngmee Kim, Soo Hyun Kim, Sang-Heon Kim, Young Ha Xie, Jun Matsuda, Takehisa Min, Byoung Goo Biomaterials Research Center Korea Institute of Science and Technology P.O.Box 131 Cheongryang Seoul 130-650 Korea Republic of Interdisciplinary Program Medical and Biological Engineering Major Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of Department of Materials Science and Engineering Gwangju Institute of Science and Technology 1 Oryang Buk Gwangju 500-712 Korea Republic of Department of Orthopaedic Surgery School of Medicine Fukuoka University 8-19-1 Nanakuma Jonan Fukuoka 814-0180 Japan Genome and Biomedical Engineering Laboratory Kanazawa Institute of Technology 7-1 Ohgigaoka Nonoichi Ishikawa 921 - 8501 Japan Department of Biomedical Engineering Seoul National University 28 Yeongeon Chongro Seoul 110-790 Korea Republic of

Mechano-active scaffolds were fabricated from very elastic poly(lactide-co-carprolactone) by a gel-pressing method. The scaffolds were seeded with bone marrow stromal cells and the continuous compressive deformation was applied to cell-polymer constructs in the chondrogenic media. Then, they were implanted in nude mice subcutaneously to evaluate for the effect of dynamic compression for regeneration of cartilage. From the biochemical analyses, chondrogenic differentiation was sustained and enhanced significantly and chondral extracellular matrix was increased through mechanical stimulation. Histological analyses showed that implants stimulated mechanically formed mature and well-developed cartilaginous tissue, as evidenced by bone marrow derived chondrocytes within lacunae. Consequently, the periodic application of dynamic compression can encourage bone marrow stromal cells to differentiation to chondrogenic lineage and to maintain their phenotypes.

关键词： Cartilage

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Monitoring microbial responses to ocean deoxygenation in a model oxygen minimum zone

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Scientific Data 2017年第1期4卷 170158页

作者： Hallam, Steven J. Torres-Beltrán, Mónica Hawley, Alyse K. Department of Microbiology and Immunology University of British Columbia Vancouver V6T 1Z3 BC Canada Peter Wall Institute for Advanced Studies University of British Columbia Vancouver V6T 1Z2 BC Canada Genome Science and Technology Program University of British Columbia Vancouver V6T 1Z4 BC Canada Graduate Program in Bioinformatics University of British Columbia Vancouver V6T 1Z4 BC Canada ECOSCOPE Training Program University of British Columbia Vancouver V6T 1Z4 BC Canada

Today in Scientific Data, two compendia of geochemical and multi-omic sequence information (DNA, RNA, protein) generated over almost a decade of time series monitoring in a seasonally anoxic coastal marine setting are presented to the scientific community. These data descriptors introduce a model ecosystem for the study of microbial responses to ocean deoxygenation, a phenotype that is currently expanding due to climate change. Public access to this time series information is intended to promote scientific collaborations and the generation of new hypotheses relevant to microbial ecology, biogeochemistry and global change issues. © The Author(s) 2017.

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The Transcription Factor IRF8 is a Key Transcription Factor for Basophil Development

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BLOOD 2013年第21期122卷 1197-1197页

作者： Kurotaki, Daisuke Sasaki, Haruka Osato, Naoki Sasaki, Izumi Kaneda, Chika Sato, Hideaki Nishiyama, Akira Kaisho, Tsuneyasu Aburatani, Hiroyuki Morse, Herbert C., III Ozato, Keiko Tamura, Tomohiko Department of Immunology Yokohama City University Graduate School of Medicine Yokohama Japan Division of Genome Science Research Center for Advanced Science and Technology The University of Tokyo Tokyo Japan Laboratory for Immune Regulation Immunology Frontier Research Center Osaka University Osaka Japan Genome Science Division Research Center for Advanced Science and Technology The University of Tokyo Tokyo Japan Laboratory of Immunogenetics National Institute of Allergy and Infectious Disease NIH Rockville MD USA Program in Genomics of Differentiation National Institute of Child Health and Human Development NIH Bethesda MD USA

1197

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Correction: Spatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer

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Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2025年 2025 May 16页

作者： Ryan Yong Kiat Tay Manavi Sachdeva Haoran Ma Young-Woo Kim Myeong-Cherl Kook Hyunki Kim Jae-Ho Cheong Lindsay C Hewitt Katharina Nekolla Günter Schmidt Takaki Yoshikawa Takashi Oshima Tomio Arai Supriya Srivastava Ming Teh Xuewen Ong Su Ting Tay Taotao Sheng Joseph J Zhao Patrick Tan Heike I Grabsch Raghav Sundar Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Singapore 119228 Singapore. Department of Haematology-Oncology National University Cancer Institute National University Hospital Singapore Singapore. Cancer and Stem Cell Biology Program Duke-NUS Medical School Singapore Singapore. Department of Cancer Policy and Population Health National Cancer Center Graduate School of Cancer Science and Policy and Center for Gastric Cancer and Department of Surgery National Cancer Center Goyang Republic of Korea. Center for Gastric Cancer Department of Pathology National Cancer Center Goyang Republic of Korea. Department of Pathology Yonsei University College of Medicine Seoul Republic of Korea. Department of Surgery Yonsei University College of Medicine Seoul Republic of Korea. Department of Pathology GROW Research Institute for Oncology and Reproduction Maastricht University Medical Center+ Maastricht The Netherlands. Department of Precision Medicine GROW School for Oncology and Reproduction Maastricht University Center+ Maastricht The Netherlands. Computational Pathology Oncology R&D AstraZeneca Munich Germany. Department of Surgery Kanagawa Cancer Center Yokohama Japan. Department of Surgery Yokohama City University Yokohama Japan. Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan. Department of Pathology Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan. Department of Medicine National University of Singapore Singapore Singapore. Department of Pathology National University Hospital Singapore Singapore. Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore. Cancer Science Institute of Singapore National University of Singapore Singapore Singapore. Cellular and Molecular Research National Cancer Centre Singapore Singapore. Singhealth/Duke-NUS Institute of Precision Medicine National Heart Centre Singapore

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Rice transformation treatments leave specific epigenome changes beyond tissue culture

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Plant physiology 2023年第2期193卷 1297-1312页

作者： Jo-Wei Allison Hsieh Pearl Chang Lin-Yun Kuang Yue-Ie C Hsing Pao-Yang Chen Institute of Plant and Microbial Biology Academia Sinica Taipei 115201 Taiwan. Genome and Systems Biology Degree Program Academia Sinica and National Taiwan University Taipei 10617 Taiwan. Department of Tropical Agriculture and International Cooperation/Department of Biological Science and Technology National Pingtung University of Science and Technology Pingtung 91201 Taiwan. The Transgenic Plant Core Facility Agricultural Biotechnology Research Center Academia Sinica Taipei 115201 Taiwan.

During transgenic plant production, tissue culture often carries epigenetic, and genetic changes that underlie somaclonal variations, leading to unpredictable phenotypes. Additionally, specific treatments for rice (Oryza sativa) transformation processes may individually or jointly contribute to somaclonal variations, but their specific impacts on rice epigenomes toward transcriptional variations remain unknown. Here, the impact of individual transformation treatments on genome-wide DNA methylation and the transcriptome were examined. In addition to activating stress-responsive genes, individual transformation components targeted different gene expression modules that were enriched in specific functional categories. The transformation treatments strongly impacted DNA methylation and expression; 75% were independent of tissue culture. Furthermore, our genome-wide analysis showed that the transformation treatments consistently resulted in global hypo-CHH methylation enriched at promoters highly associated with downregulation, particularly when the promoters were colocalized with miniature inverted-repeat transposable elements. Our results clearly highlight the specificity of impacts triggered by individual transformation treatments during rice transformation with the potential association between DNA methylation and gene expression. These changes in gene expression and DNA methylation resulting from rice transformation treatments explain a significant portion of somaclonal variations, that is, way beyond the tissue culture effect.

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Micropatterning of functional lipid bilayer assays for quantitative bioanalysis

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Biomicrofluidics 2023年第3期17卷 031302页

作者： Montalbo, Reynaldo Carlos K. Tu, Hsiung-Lin Institute of Chemistry Academia Sinica Taipei11529 Taiwan Nanoscience and Technology Taiwan International Graduate Program Academia Sinica Taipei11529 Taiwan Department of Engineering and System Science National Tsing-Hua University Hsinchu300044 Taiwan Genome and Systems Biology Degree Program Academia Sinica National Taiwan University Taipei10617 Taiwan

Interactions of the cell with its environment are mediated by the cell membrane and membrane-localized molecules. Supported lipid bilayers have enabled the recapitulation of the basic properties of cell membranes and have been broadly used to further our understanding of cellular behavior. Coupled with micropatterning techniques, lipid bilayer platforms have allowed for high throughput assays capable of performing quantitative analysis at a high spatiotemporal resolution. Here, an overview of the current methods of the lipid membrane patterning is presented. The fabrication and pattern characteristics are briefly described to present an idea of the quality and notable features of the methods, their utilizations for quantitative bioanalysis, as well as to highlight possible directions for the advanced micropatterning lipid membrane assays. © 2023 Author(s).

关键词： Lipid bilayers

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Building better interdisciplinary scientists: creating graduate level courses to address the communication gap in interdisciplinary research

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BMC Bioinformatics 2012年第12期13卷 1-2页

作者： Denise R Koessler Elizabeth G Johnson Jordan M Utley Harry A Richards Cynthia B Peterson Department of Electrical Engineering and Computer Science The University of Tennessee Knoxville TN 37996 USA Department of Microbiology The University of Tennessee Knoxville TN 37996 USA UT/ORNL Graduate School of Genome Science and Technology The University of Tennessee Knoxville TN 37996 USA SCALE-IT Program Administrator The University of Tennessee Knoxville TN 37996 USA Department of Biochemistry and Molecular Biology The University of Tennessee Knoxville TN 37996 USA

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Incorporating animal forensics in routine meat inspection in the Philippines

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Forensic science International: Animals and Environments 2021年 1卷

作者： Fortajada, Enrykie B. Fontanilla, Ian Kendrich C. De Ungria, Maria Corazon A. Biodiversity Ethnicity and Forensics Program Philippine Genome Center University of the Philippines Philippines Science Education Institute Department of Science and Technology Taguig City Philippines DNA Barcoding Laboratory Institute of Biology University of the Philippines Diliman Philippines DNA Analysis Laboratory Natural Sciences Research Institute University of the Philippines Diliman Philippines

Robust species identification of unprocessed and processed meat is essential to ensure the safety and quality of food products. Meat adulteration results from the wrong identification of animal sources, contamination of different meats during processing, or intentional meat substitution using those from other species and non-meat products of lower economic value. This review discusses the potential applications of DNA barcoding in routine meat inspections in the Philippines. Developing mini-barcode primer sets to enhance the utility of conventional techniques is critical in adopting DNA barcoding technology as a robust tool for routine inspections of meat sold commercially, including those intended for the halal meat industry. Increasing the ability of the Philippine National Meat Inspection Service to document the number, types, and scope of meat fraud is a step forward in finally using animal forensic science as a valuable component of its regulatory functions for the protection of the meat-consuming public. © 2021 The Author(s)

关键词： Animal forensics DNA barcoding DNA mini-barcoding Meat adulteration Meat inspection Meat species identification

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