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SSRN 2019年

作者： Alonso-Serra, Juan Shi, Xueping Peaucelle, Alexis Rastas, Pasi Bourdon, Matthieu Immanen, Juha Takahashi, Junko Koivula, Hanna Eswaran, Gugan Muranen, Sampo Help, Hanna Smolander, Olli-Pekka Su, Chang Safronov, Omid Gerber, Lorenz Salojärvi, Jarkko Hagqvist, Risto Mähonen, Ari Pekka Nieminen, Kaisa Helariutta, Ykä Organismal and Evolutionary Biology Research Program Faculty of Biological and Environmental Sciences Viikki Plant Science Centre University of Helsinki Helsinki Finland Institute of Biotechnology HiLIFE University of Helsinki Helsinki Finland Key Laboratory of Horticultural Plant Biology of Ministry of Education College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan430070 China Sainsbury Laboratory University of Cambridge Cambridge United Kingdom Institut Jean-Pierre Bourgin INRA AgroParisTech CNRS Université Paris-Saclay Versailles78000 France Helsinki Finland Umeå Plant Science Center Department of Forest Genetics and Plant Physiology Swedish University of Agricultural Sciences Umeå Sweden Department of Food and Nutrition Faculty of Agriculture and Forestry University of Helsinki Finland Department of Physics Division of Materials Sciences X-ray Laboratory University of Helsinki Helsinki Finland Department of Chemistry and Biotechnology School of Science Tallinn University of Technology Tallinn Estonia Genome Institute of Singapore Singapore138672 Singapore Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological University Singapore63755 Singapore

Tree architecture has evolved to support a top-heavy above-ground biomass, but this integral feature poses a weight-induced challenge to trunk stability. Maintaining an upright stem is expected to require vertical proprioception through feedback between sensing stem weight and modulating radial growth. Despite its apparent importance, the principle by which plant stems respond to vertical loading forces remains largely unknown. Here, by manipulating the stem weight of downy birch (Betula pubescens) trees, we show that cambial development is modulated systemically along the stem. We carried out a genetic study on the underlying regulation by combining an accelerated birch flowering program with a recessive mutation at the ELIMÄKI locus (EKI), which causes a mechanically defective response to weight stimulus resulting in stem collapse after just three months. We observed delayed wood morphogenesis in eki compared with WT, along with a more mechanically elastic cambial zone and radial compression of xylem cell size, indicating that timely tissue differentiation is critical for cambial growth under mechanical stress. Furthermore, the touch-induced mechanosensory pathway was transcriptionally misregulated in eki, indicating that the ELIMÄKI locus is required to integrate the weight-growth feedback regulation. By studying this birch mutant, we were able to dissect vertical proprioception from the gravitropic response associated with reaction wood formation. Taken together, our study provides evidence for both local and systemic responses to mechanical stimuli during secondary plant development. © 2019, The Authors. All rights reserved.

关键词： Forestry

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Correction to: IonCRAM: a reference-based compression tool for ion torrent sequence files

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BMC bioinformatics 2020年第1期21卷 435页

作者： Moustafa Shokrof Mohamed Abouelhoda Faculty of Computer Science University of California at Davis Davis CA USA. King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia. mabouelhoda@***. Saudi Human Genome Program King Abdulaziz City for Science and Technology (KACST) Riyadh Saudi Arabia. mabouelhoda@***. Systems and Biomedical Engineering Department Faculty of Engineering Cairo University University Square Giza Egypt. mabouelhoda@***.

An amendment to this paper has been published and can be accessed via the original article.

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Author Correction: Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis

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Nature communications 2023年第1期14卷 6540页

作者： Hitomi Takada Yohei Sasagawa Mika Yoshimura Kaori Tanaka Yoshimi Iwayama Tetsutaro Hayashi Ayako Isomura-Matoba Itoshi Nikaido Akira Kurisaki Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. itoshi.nikaido@riken.jp. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. itoshi.nikaido@riken.jp. Master's/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan. itoshi.nikaido@riken.jp. Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. akikuri@bs.naist.jp.

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Correction to: Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival

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Journal of biomedical science 2022年第1期29卷 59页

作者： Ruei Liang Yan Chiu Lin Luan Chun Chieh Liao Li Heng Liu Fei Yun Chen Hsin Yi Chen Ruey Hwa Chen Institute of Biological Chemistry Academia Sinica Taipei 115 Taiwan. Institute of Molecular Medicine College of Medicine National Taiwan University Taipei 100 Taiwan. Genome and Systems Biology Degree Program College of Life Science National Taiwan University Taipei 106 Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Institute of Biological Chemistry Academia Sinica Taipei 115 Taiwan. rhchen@gate.sinica.edu.tw. Institute of Molecular Medicine College of Medicine National Taiwan University Taipei 100 Taiwan. rhchen@gate.sinica.edu.tw. Genome and Systems Biology Degree Program College of Life Science National Taiwan University Taipei 106 Taiwan. rhchen@gate.sinica.edu.tw.

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PHENOTYPE/ GENOTYPE SCREENING PATTERN OF HEMOPHILIA A AND B IN SAUDI ARAB

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Hematology, Transfusion and Cell Therapy 2022年 44卷 S28-S29页

作者： Tarek Owaidah Salwa Bakr Hala AbaAlkhail Hazza Alzahrani Mahasen Saleh Abdulrahman Almusa Nouf Al-Numair Haitham Khogeer Faisal Al-Allaf Department of Pathology King Faisal Specialist hospital and Research Center Riyadh Saudi Arabia Department of Clinical Pathology/Hematology Faculty of Medicine Fayoum University Egypt Saudi Human Genome Program King Abdulaziz City for Science and Technology Riyadh Saudi Arabia Department of Medical Genetics Umm Al-Qura University Faculty of Medicine Makkah Saudi Arabia

Objective Hemophilia A and B are X-linked recessive bleeding disorder caused by variants in the factor VIII (FVIII) and factor IX (FIX) genes. There is correlation between the type of mutation and clinical severity of these patients. Establishing national screening program for haemophilia patients is highly encouraged by the World Health Organization (WHO) and World Federation of Haemophilia (WFH). Hence we aimed to establish a genotypic data base for the nature of mutations present in Saudi population. Case report This retrospective descriptive study on a cohort of 136 Saudi hemophilia A and B patients. Methodology Molecular studies were performed to identify known and novel causative variants in hemophilia A and B families and correlated with some clinical features. Results There were 129 male and 7 females with age ranged from 2 - 62 years old, 97 (71.3%) hemophilia A (HA) and 39 (28.7%) hemophilia B (HB). The clinical severity of hemophilia A ranged between mild (10, 10.3%), moderate (2, 2.1%) and severe (83, 85.6%), while for hemophilia B (mild 13 (33.3%), moderate 2 (5.1%) and severe 24 (61.5%) respectively. There were 76 (55.9%) had chronic joint disability. Factor inhibitors with different titers were detected in 24 (24.7%) of HA and only 2 (5.1%) of HB. Out of the whole cohort 136 had been tested for causative variants, 17 (12.5%) were positive for inv-22 and 4 (2.9%) for inv-1, while all negative HA were selected for analysis by next generation sequencing. We are reporting 3 cases of females with severe forms of *** are reporting different mutations that was consistent in group of tested members of same family /trip. We confirmed as previously reported high frequency of inv 22 and we found 7 novel mutation out 12 detected variants for HA and one novel mutation out of 13 detected variants for HB. Conclusion These results will enrich the spectrum of variants and enlarge the factor VIII and factor IX proteins database in the Saudi Arabian population

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Frontispiz: Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate

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Angewandte Chemie 2019年第24期131卷

作者： Beomsue Kim Masahiro Fukuda Jung‐Yeol Lee Dongdong Su Srikanta Sanu Aymeric Silvin Audrey T. T. Khoo Taejoon Kwon Xiao Liu Weijie Chi Xiaogang Liu Sejong Choi Diana S. Y. Wan Sung‐Jin Park Jin‐Soo Kim Florent Ginhoux H. Shawn Je Young‐Tae Chang Singapore Bioimaging Consortium Agency for Science Technology and Research (A*STAR) Singapore 138667 Singapore Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Singapore 169857 Singapore Department of Chemistry Pohang University of Science and Technology Pohang 37673 Korea Present address: New drug discovery center DGMIF Daegu 41061 Korea Singapore Immunology Network A*STAR Singapore 138648 Singapore Department of Biomedical Engineering Ulsan National Institute of Science and Technology Ulsan 44919 Korea Center for Self-assembly and Complexity Institute for Basic Science (IBS) Pohang 37673 Korea Singapore University of Technology and Design Singapore 487372 Singapore Department of Chemistry Seoul National University Seoul 08826 Korea Center for Genome Engineering IBS Daejeon 34047 Korea

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Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate

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Angewandte Chemie 2019年第24期131卷

Microglia, the brain‐resident macrophage, are involved in brain development and contribute to the progression of neural disorders. Despite the importance of microglia, imaging of live microglia at a cellular resolution has been limited to transgenic mice. Efforts have therefore been dedicated to developing new methods for microglia detection and imaging. Using a thorough structure–activity relationships study, we developed CDr20, a high‐performance fluorogenic chemical probe that enables the visualization of microglia both in vitro and in vivo. Using a genome‐scale CRISPR‐Cas9 knockout screen, the UDP‐glucuronosyltransferase Ugt1a7c was identified as the target of CDr20. The glucuronidation of CDr20 by Ugt1a7c in microglia produces fluorescence.

关键词： Biologische Aktivität Fluoreszsonden Kontrastmittel Mikroglia Struktur-Aktivitäts-Bezieung

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Frontispiece: Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate

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Angewandte Chemie International Edition 2019年第24期58卷

作者： Dr. Beomsue Kim Dr. Masahiro Fukuda Dr. Jung-Yeol Lee Dr. Dongdong Su Dr. Srikanta Sanu Dr. Aymeric Silvin Audrey T. T. Khoo Prof. Taejoon Kwon Xiao Liu Dr. Weijie Chi Prof. Xiaogang Liu Sejong Choi Diana S. Y. Wan Dr. Sung-Jin Park Prof. Jin-Soo Kim Prof. Florent Ginhoux Prof. H. Shawn Je Prof. Young-Tae Chang Singapore Bioimaging Consortium Agency for Science Technology and Research (A*STAR) Singapore 138667 Singapore Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Singapore 169857 Singapore Department of Chemistry Pohang University of Science and Technology Pohang 37673 Korea Present address: New drug discovery center DGMIF Daegu 41061 Korea Singapore Immunology Network A*STAR Singapore 138648 Singapore Department of Biomedical Engineering Ulsan National Institute of Science and Technology Ulsan 44919 Korea Center for Self-assembly and Complexity Institute for Basic Science (IBS) Pohang 37673 Korea Singapore University of Technology and Design Singapore 487372 Singapore Department of Chemistry Seoul National University Seoul 08826 Korea Center for Genome Engineering IBS Daejeon 34047 Korea

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Magnetically Tuned Continuous Transition from Weak to Strong Coupling in Terahertz Magnon Polaritons

arXiv

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arXiv 2022年

作者： Baydin, Andrey Hayashida, Kenji Makihara, Takuma Tay, Fuyang Ma, Xiaoxuan Ren, Wei Ma, Guohong Noe, G. Timothy Katayama, Ikufumi Takeda, Jun Nojiri, Hiroyuki Cao, Shixun Bamba, Motoaki Kono, Junichiro Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States The Smalley-Curl Institute Rice University HoustonTX77005 United States Division of Applied Physics Graduate School of Engineering Hokkaido University Hokkaido Sapporo060-8628 Japan Department of Physics and Astronomy Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Physics International Center of Quantum and Molecular Structures Materials Genome Institute Shanghai University Shanghai200444 China Department of Physics Graduate School of Engineering Science Yokohama National University Yokohama240-8501 Japan Institute for Materials Research Tohoku University Sendai980-8577 Japan The Hakubi Center for Advanced Research Kyoto University Kyoto606-8502 Japan Department of Physics I Kyoto University Kyoto606-8502 Japan PRESTO Japan Science and Technology Agency Kawaguchi332-0012 Japan Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States

Depending on the relative rates of coupling and dissipation, a light-matter coupled system is either in the weak- or strong-coupling regime. Here, we present a unique system where the coupling rate continuously increases with an externally applied magnetic field while the dissipation rate remains constant, allowing us to monitor a weak-to-strong coupling transition as a function of magnetic field. We observed a Rabi splitting of a terahertz magnon mode in yttrium orthoferrite above a threshold magnetic field of ∼14 T. Based on a microscopic theoretical model, we show that with increasing magnetic field the magnons transition into magnon polaritons through an exceptional point, which will open up new opportunities for in situ control of non-Hermitian systems. Copyright © 2022, The Authors. All rights reserved.

关键词： Polariton

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programmable Chromism and Photoluminescence of Spiropyran-Based Liquid Crystalline Polymer with Tunable Glass Transition Temperature

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Angewandte Chemie 2021年第35期133卷

作者： Wei Hu Chang Sun Yunxiao Ren Shengyu Qin Yu Shao Lanying Zhang Yu Wu Qian Wang Huai Yang Dengke Yang Beijing Advanced Innovation Center for Materials Genome Engineering & Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 P. R. China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 P. R. China Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 P. R. China Chemical Physics Interdisciplinary Program in Liquid Crystal Institute Kent State University Kent OH 44242 USA

Spiropyran-based materials (SPBMs) can give responses to the stimulations induced by the light, heat, force, or pH, which have been used as triggers for many smart materials. Here, a cross-linkable SPBM containing mesogenic-units is synthesized, which is pale-colored, non-photoluminescent and non-mesogenic at a spiro form, but dark-colored, photoluminescent, and mesogenic at a merocyanine form. Moreover, the dynamic interconversion behavior of the form in the different chemical environments are distinct. Liquid crystalline polymers (LCPs) containing the SPBMs cross-linked via visible light, own a photoswitchable glass transition temperature ( T g ) and retain the switchable property; however, the SPBMs cross-linked via UV light will be locked at the MC state, because the molecular movement was frozen at the room temperature lower than the given T g of the LCP. Thus, programmable chromism and photoluminescence based on the tunable T g can be endowed to the functional materials prepared from the SPBMs.

关键词： chromism liquid crystalline polymer photoluminescence spiropyran-based tunable Tg

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