检索结果-内蒙古大学图书馆

A Fluorescent Rosamine Compound Selectively Stains Pluripotent Stem Cells†

Angewandte Chemie 2010年第41期122卷

作者： Chang‐Nim Im Nam‐Young Kang Hyung‐Ho Ha Xuezhi Bi Jae Jung Lee Sung‐Jin Park Sang Yeon Lee Marc Vendrell Yun Kyung Kim Jun‐Seok Lee Jun Li Young‐Hoon Ahn Bo Feng Huck‐Hui Ng Seong‐Wook Yun Young‐Tae Chang Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 (Republic of Singapore) Fax: (+65) 6779‐1691 http://ytchang.science.nus.edu.sg Laboratory of Bioimaging Probe Development Singapore Bioimaging Consortium Agency for Science Technology and Research (A*STAR) 11 Biopolis Way # 02‐02 Helios Singapore 138667 (Republic of Singapore) NUS MedChem Program of Life Sciences Institute National University of Singapore Singapore 117543 (Republic of Singapore) Department of Chemistry New York University New York NY 10003 (USA) Gene Regulation Laboratory Genome Institute of Singapore Agency for Science Technology and Research (A*STAR) Singapore 138672 (Republic of Singapore) Department of Biological Sciences National University of Singapore Singapore 117543 (Republic of Singapore)

来源：评论

学校读者我要写书评

暂无评论

Finding high posterior density phylogenies by systematically extending a directed acyclic graph

arXiv

引用

arXiv 2024年

作者： Jennings-Shaffer, Chris Rich, David H. Macaulay, Matthew Karcher, Michael D. Ganapathy, Tanvi Kiami, Shosuke Kooperberg, Anna Zhang, Cheng Suchard, Marc A. Matsen, Frederick A. Public Health Sciences Division Fred Hutchinson Cancer Research Center SeattleWA United States University of Technology Sydney Australian Institute for Microbiology & Infection Sydney Australia Department of Math & Computer Science Muhlenberg College AllentownPA United States School of Mathematical Sciences Peking University Beijing China Department of Human Genetics University of California Los Angeles United States Department of Computational Medicine University of California Los Angeles United States Department of Biostatistics University of California Los Angeles United States Department of Genome Sciences University of Washington Seattle United States Howard Hughes Medical Institute Fred Hutchinson Cancer Research Center SeattleWA United States Computational Biology Program Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N. Mail stop: S2-140 SeattleWA98109-1024 United States

Bayesian phylogenetics typically estimates a posterior distribution, or aspects thereof, using Markov chain Monte Carlo methods. These methods integrate over tree space by applying local rearrangements to move a tree through its space as a random walk. Previous work explored the possibility of replacing this random walk with a systematic search, but was quickly overwhelmed by the large number of probable trees in the posterior distribution. In this paper we develop methods to sidestep this problem using a recently introduced structure called the subsplit directed acyclic graph (sDAG). This structure can represent many trees at once, and local rearrangements of trees translate to methods of enlarging the sDAG. Here we propose two methods of introducing, ranking, and selecting local rearrangements on sDAGs to produce a collection of trees with high posterior density. One of these methods successfully recovers the set of high posterior density trees across a range of data sets. However, we find that a simpler strategy of aggregating trees into an sDAG in fact is computationally faster and returns a higher fraction of probable trees. © 2024, CC BY.

关键词： Markov chains

来源：评论

学校读者我要写书评

暂无评论

Microfractures in TiO2 Enhance the Photoelectrochemical Properties of Photosystem I Bio-Sensitized Solar Cells

Microfractures in TiO2 Enhance the Photoelectrochemical Prop...

引用

BioInspired Processing (BIP), IEEE International Conference on

作者： Sebastián Castro Flores Christopher Espinoza Araya Fabricio Chaverri Segura Leslie W. Pineda Barry D. Bruce Claudia C. Villarreal Escuela de Ciencia e Ingeniería de Materiales Centro de Investigación y Extensión en Ingeniería de Materiales (CIEMTEC) Instituto Tecnológico de Costa Rica Cartago Costa Rica Escuela de Ciencia e Ingeniería de Materiales Centro de Investigación y Extensión en Ingeniería de Materiales (CIEMTEC) Maestría Ingeniería en Dispositivos Médicos Instituto Tecnológico de Costa Rica Cartago Costa Rica Escuela de Química Centro de Investigación en Electroquímica y Energía Química (CELEQ) Universidad de Costa Rica San Jose Costa Ric*é Department of Biochemistry Cellular and Molecular Biology Program in Genome Science and Technology University of Tennessee Knoxville TN USA Laboratorio Nacional de Nanotecnología (LANOTEC) Centro Nacional de Alta Tecnología (CENAT) San José Costa Rica

Climate change, caused by the increasing energy demand from fossil fuels due to population growth and economic expansion, triggers the need for clean, renewable, and sustainable energy sources. The solar energy contributes to approximately 99.9% of the Earth's energy. Therefore, photovoltaic technology is considered a possible substitute for fossil fuels owing to its abundance, but the current silicon and thin film photovoltaic (PV) technologies generate greenhouse gas emissions (GHE) during manufacturing and use scarce and polluting materials. Bio-sensitized solar cells (BSSCs) offer a promising solution using simple, lower energy-demand manufacturing processes and abundant, non-toxic materials. BSSCs are derived from dye-sensitized solar cells (DSSCs) technology by replacing the synthetic dye with biological molecules, such as photosystem I (PSI), into a thin film device. We report a BSSC using PSI as a sensitizer, TiO2 as a wide-bandgap semiconductor, Co-bipyridine compound as a redox mediator in the electrolyte, and PEDOT-CNT composite as the counter electrode. This study investigates how microfractures on the TiO2 thin film induced during thermal sintering affect the photoelectrochemical performance of the BSSCs. Electrochemical characterization of the PSI-BSSCs was performed under a solar simulator using linear sweep voltammetry (LSV), open-circuit voltage decay (OCVD), chronoamperometry, and electrochemical impedance spectroscopy (EIS). SEM micrographs reveal fissures in the photoanode surface induced by the fast heating and cooling during thermal treatments. Surprisingly, the microfractures improved the performance of the solar cells and will be discussed regarding the accessibility of PSI and the mediator to penetrate the nanostructured electrode and enhance the photocurrents generated. The BSSCs improvement due to the microfractures is ascribed to the enabled diffusion of the PSI sensitizer through the nanoporous TiO2, given the significantly larger size o

关键词：

来源：评论

学校读者我要写书评

暂无评论

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution (vol 33, pg 568, 2020)

引用

NATURE GENETICS 2020年第4期52卷 463-463页

作者： Chan-Seng-Yue, Michelle Kim, Jaeseung C. Wilson, Gavin W. Ng, Karen Figueroa, Eugenia Flores O'Kane, Grainne M. Connor, Ashton A. Denroche, Robert E. Grant, Robert C. McLeod, Jessica Wilson, Julie M. Jang, Gun Ho Zhang, Amy Liang, Sheng-Ben Borgida, Ayelet Chadwick, Dianne Kalimuthu, Sangeetha Lungu, Ilinca Bartlett, John M. S. Krzyzanowski, Paul M. Sandhu, Vandana Tiriac, Herve Froeling, Fieke E. M. Karasinska, Joanna M. Topham, James T. Renouf, Daniel J. Schaeffer, David F. Jones, Steven J. M. Marra, Marco A. Laskin, Janessa Chetty, Runjan Stein, Lincoln D. Zogopoulos, George Haibe-Kains, Benjamin Campbell, Peter J. Tuveson, David A. Knox, Jennifer J. Fischer, Sandra E. Gallinger, Steven Notta, Faiyaz Princess Margaret Cancer Centre Toronto Ontario Canada PanCuRx Translational Research Initiative Ontario Institute for Cancer Research Toronto Ontario Canada Genomics Technology Program Ontario Institute for Cancer Research Toronto Ontario Canada Wallace McCain Centre for Pancreatic Cancer Department of Medical Oncology Princess Margaret Centre University Health Network University of Toronto Toronto Ontario Canada Hepatobiliary/Pancreatic Surgical Oncology Program University Health Network Toronto Ontario Canada UHN Program in BioSpecimen Sciences University Health Network Toronto Ontario Canada Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital Toronto Ontario Canada Department of Pathology University Health Network and University of Toronto Toronto Ontario Canada Diagnostic Development Ontario Institute for Cancer Research Toronto Ontario Canada Cold Spring Harbor Laboratory Cold Spring Harbor NY USA Lustgarten Foundation Pancreatic Cancer Research Laboratory Cold Spring Harbor NY USA Department of Surgery and Cancer Imperial College London London UK Pancreas Centre BC Vancouver British Columbia Canada Department of Medical Oncology BC Cancer Vancouver British Columbia Canada Department of Pathology and Laboratory Medicine Vancouver General Hospital Vancouver British Columbia Canada Canada’s Michael Smith Genome Sciences Centre Vancouver British Columbia Canada Department of Medical Genetics University of British Columbia Vancouver British Columbia Canada Bioinformatics Ontario Institute for Cancer Research Toronto Ontario Canada Department of Molecular Genetics University of Toronto Toronto Ontario Canada Research Institute of the McGill University Health Centre Montreal Quebec Canada The Goodman Cancer Research Centre of McGill University Montreal Quebec Canada Department of Medical Biophysics University of Toronto Toronto Ontario Canada Department of Computer Science University of Toronto Toronto Ontario Canada Can

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor cellularity and extensive genomic instability. To address this, a dataset of whole genomes and transcriptomes was generated from purified epithelium of primary and metastatic tumors. Transcriptome analysis demonstrated that molecular subtypes are a product of a gene expression continuum driven by a mixture of intratumoral subpopulations, which was confirmed by single-cell analysis. Integrated whole-genome analysis uncovered that molecular subtypes are linked to specific copy number aberrations in genes such as mutant KRAS and GATA6. By mapping tumor genetic histories, tetraploidization emerged as a key mutational process behind these events. Taken together, these data support the premise that the constellation of genomic aberrations in the tumor gives rise to the molecular subtype, and that disease heterogeneity is due to ongoing genomic instability during progression.

关键词： Pancreatic cancer Transcriptomics

来源：评论

学校读者我要写书评

暂无评论

ELIMÄKI Locus Is Required for Vertical Proprioceptive Response in Birch Trees

引用

Current Biology 2020年第4期30卷 589-599.e5页

作者： Alonso-Serra, Juan Shi, Xueping Peaucelle, Alexis Rastas, Pasi Bourdon, Matthieu Immanen, Juha Takahashi, Junko Koivula, Hanna Eswaran, Gugan Muranen, Sampo Help, Hanna Smolander, Olli-Pekka Su, Chang Safronov, Omid Gerber, Lorenz Salojärvi, Jarkko Hagqvist, Risto Mähönen, Ari Pekka Helariutta, Ykä Nieminen, Kaisa Organismal and Evolutionary Biology Research Program Faculty of Biological and Environmental Sciences Viikki Plant Science Centre University of Helsinki Helsinki 00014 Finland Institute of Biotechnology HiLIFE University of Helsinki Helsinki 00014 Finland Key Laboratory of Horticultural Plant Biology of Ministry of Education College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan 430070 China Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Institut Jean-Pierre Bourgin INRA AgroParisTech CNRS Université Paris-Saclay Versailles 78000 France Production Systems Natural Resources Institute Finland (Luke) Helsinki 00790 Finland Umeå Plant Science Center Department of Forest Genetics and Plant Physiology Swedish University of Agricultural Sciences Umeå 901 83 Sweden Department of Food and Nutrition Faculty of Agriculture and Forestry University of Helsinki Helsinki 00014 Finland Department of Physics Division of Materials Sciences X-ray Laboratory University of Helsinki Helsinki 00014 Finland Department of Chemistry and Biotechnology School of Science Tallinn University of Technology Tallinn Estonia Genome Institute of Singapore Singapore 138672 Singapore Singapore Centre for Environmental Life Sciences Engineering Nanyang Technological University Singapore 63755 Singapore

Tree architecture has evolved to support a top-heavy above-ground biomass, but this integral feature poses a weight-induced challenge to trunk stability. Maintaining an upright stem is expected to require vertical proprioception through feedback between sensing stem weight and responding with radial growth. Despite its apparent importance, the principle by which plant stems respond to vertical loading forces remains largely unknown. Here, by manipulating the stem weight of downy birch (Betula pubescens) trees, we show that cambial development is modulated systemically along the stem. We carried out a genetic study on the underlying regulation by combining an accelerated birch flowering program with a recessive mutation at the ELIMÄKI locus (EKI), which causes a mechanically defective response to weight stimulus resulting in stem collapse after just 3 months. We observed delayed wood morphogenesis in eki compared with WT, along with a more mechanically elastic cambial zone and radial compression of xylem cell size, indicating that rapid tissue differentiation is critical for cambial growth under mechanical stress. Furthermore, the touch-induced mechanosensory pathway was transcriptionally misregulated in eki, indicating that the ELIMÄKI locus is required to integrate the weight-growth feedback regulation. By studying this birch mutant, we were able to dissect vertical proprioception from the gravitropic response associated with reaction wood formation. Our study provides evidence for both local and systemic responses to mechanical stimuli during secondary plant development. Alonso-Serra et al. use birch trees to explore vertical proprioception, the growth response of stems to changes in aerial body weight. They identify a genetic locus, which is required for this developmental response, and study the consequences of cambial growth under mechanical stress. © 2019 Elsevier Ltd

关键词： Betula forward genetics mechanosensing proprioception radial growth trees wood formation

来源：评论

学校读者我要写书评

暂无评论

The Broad Institute-Six Years Later

引用

CHEMISTRY & BIOLOGY 2010年第4期17卷 311-312页

作者： McCarthy, Alice Main Text “In June 2003 the scientific and medical communities at MIT Harvard University and its affiliated hospitals and the Whitehead Institute banded together as collaborating partners to form the Eli and Edythe L. Broad Institute based in Cambridge MA. The Broad Institute established with initial funding from a $100 million philanthropic donation from the Los Angeles-based Broad family was primarily viewed as a marriage between the Whitehead Institute's Center for Genome Research (WICGR) and the Harvard Institute of Chemistry and Cell Biology (ICCB). Eli Broad founder and chairman of AIG SunAmerica Inc. explained “the purpose of the Broad Institute is to create a new type of research institute to build on the accomplishments of the human genome project and to move to clinical applications to both prevent and cure diseases.” Every Thursday morning we meet with perhaps 20 faculty members and 100 other researchers to discuss what we're all doing and should be doing next. -David Altschuler This paragraph was written five years ago when the Broad Institute was in its very earliest days as a life science research community (McCarthy 2005). Since that time “the Broad” as it's known has kept true to Eli Broad's vision having attracted a talented group of researchers faculty trainees and professional staff. This 1600 person research community known internally as “Broadies” includes faculty staff and students from throughout the MIT and Harvard biomedical research communities and beyond with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. “What is special about the Broad is that we have people from Harvard MIT and the Harvard hospitals come together and work on problems of shared interest that could not be solved in their own individuals labs” explains David Altshuler M.D. Ph.D. Deputy Director and one of the Broad's six core faculty members. “These problems require expertise beyond any one principal investigator and in

来源：评论

学校读者我要写书评

暂无评论

Correction to: Expanding the genetic heterogeneity of intellectual disability

引用

Human genetics 2018年第1期137卷 105-109页

作者： Shams Anazi Sateesh Maddirevula Vincenzo Salpietro Yasmine T Asi Saud Alsahli Amal Alhashem Hanan E Shamseldin Fatema AlZahrani Nisha Patel Niema Ibrahim Firdous M Abdulwahab Mais Hashem Nadia Alhashmi Fathiya Al Murshedi Adila Al Kindy Ahmad Alshaer Ahmed Rumayyan Saeed Al Tala Wesam Kurdi Abdulaziz Alsaman Ali Alasmari Selina Banu Tipu Sultan Mohammed M Saleh Hisham Alkuraya Mustafa A Salih Hesham Aldhalaan Tawfeg Ben-Omran Fatima Al Musafri Rehab Ali Jehan Suleiman Brahim Tabarki Ayman W El-Hattab Caleb Bupp Majid Alfadhel Nada Al Tassan Dorota Monies Stefan T Arold Mohamed Abouelhoda Tammaryn Lashley Henry Houlden Eissa Faqeih Fowzan S Alkuraya Department of Genetics King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia. Department of Molecular Neuroscience UCL Institute of Neurology London UK. Queen Square Brain Bank for Neurological Disorders Department of Molecular Neuroscience UCL Institute of Neurology University College London London UK. Department of Pediatrics Prince Sultan Military Medical City Riyadh Saudi Arabia. Department of Genetics College of Medicine Sultan Qaboos University Muscat Sultanate of Oman. Pediatric Neurology King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia. King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia. Neurology Division Department of Pediatrics King Abdulaziz Medical City Riyadh Saudi Arabia. Department of Pediatrics and Genetic Unit Armed Forces Hospital Khamis Mushayt Riyadh Saudi Arabia. Department of Obstetrics and Gynecology King Faisal Specialist Hospital Riyadh Saudi Arabia. Department of Pediatric Subspecialties Children's Hospital King Fahad Medical City Riyadh Saudi Arabia. Department of Pediatric Neurology ICH and SSF Hospital Mirpur Dhaka 1216 Bangladesh. Department of Pediatric Neurology Institute of Child Health and The Children's Hospital Lahore 381-D/2 Lahore Pakistan. Department of Ophthalmology Specialized Medical Center Hospital Riyadh Saudi Arabia. Division of Pediatric Neurology Department of Pediatrics King Khalid University Hospital and College of Medicine King Saud University Riyadh Saudi Arabia. Clinical and Metabolic Genetics Department of Pediatrics Hamad Medical Corporation Doha Qatar. Division of Neurology Department of Pediatrics Tawam Hospital Al Ain United Arab Emirates. Division of Clinical Genetics and Metabolic Disorders Department of Pediatrics Tawam Hospital Al-Ain United Arab Emirates. Spectrum Health Genetics Grand Rapids MI USA. Genetics Division Department of Pediatrics King Abdullah International Medical Research Centre King Saud bin Abdulaziz

Variant nomenclature discrepancy was identified in the article.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Publisher Correction: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

引用

Nature genetics 2023年第1期55卷 166页

作者： Huipeng Li Elise T Courtois Debarka Sengupta Yuliana Tan Kok Hao Chen Jolene Jie Lin Goh Say Li Kong Clarinda Chua Lim Kiat Hon Wah Siew Tan Mark Wong Paul Jongjoon Choi Lawrence J K Wee Axel M Hillmer Iain Beehuat Tan Paul Robson Shyam Prabhakar Computational and Systems Biology Genome Institute of Singapore Singapore Singapore. Developmental Cellomics Laboratory Genome Institute of Singapore Singapore Singapore. Department of Computer Science and Engineering and Center for Computational Biology Indraprastha Institute of Information Technology Delhi India. Synthetic Biology Genome Institute of Singapore Singapore Singapore. Cancer Therapeutics and Stratified Oncology Genome Institute of Singapore Singapore Singapore. Department of Medical Oncology National Cancer Centre Singapore Singapore Singapore. Department of Pathology Singapore General Hospital Singapore Singapore. Department of Colorectal Surgery Singapore General Hospital Singapore Singapore. Data Analytics Department Institute for Infocomm Research Singapore Singapore. Cancer Therapeutics and Stratified Oncology Genome Institute of Singapore Singapore Singapore. iain.tan.b.h@singhealth.com.sg. Department of Medical Oncology National Cancer Centre Singapore Singapore Singapore. iain.tan.b.h@singhealth.com.sg. Program in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore. iain.tan.b.h@singhealth.com.sg. Developmental Cellomics Laboratory Genome Institute of Singapore Singapore Singapore. paul.robson@***. The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA. paul.robson@***. Department of Genetics and Genome Sciences Institute for Systems Genomics University of Connecticut Farmington Connecticut USA. paul.robson@***. Department of Biological Sciences National University of Singapore Singapore Singapore. paul.robson@***. Computational and Systems Biology Genome Institute of Singapore Singapore Singapore. prabhakars@gis.a-star.edu.sg.

来源：评论

学校读者我要写书评

暂无评论

Small-molecule dissolution of stress granules by redox modulation benefits ALS models

引用

Nature Chemical Biology 2025年 1-12页

作者： Uechi, Hiroyuki Sridharan, Sindhuja Nijssen, Jik Bilstein, Jessica Iglesias-Artola, Juan M. Kishigami, Satoshi Casablancas-Antras, Virginia Poser, Ina Martinez, Eduardo J. Boczek, Edgar Wagner, Michael Tomschke, Nadine de Jesus Domingues, António M. Pal, Arun Doeleman, Thom Kour, Sukhleen Anderson, Eric Nathaniel Stein, Frank Lee, Hyun O. Zhang, Xiaojie Fritsch, Anatol W. Jahnel, Marcus Fürsch, Julius Murthy, Anastasia C. Alberti, Simon Bickle, Marc Fawzi, Nicolas L. Nadler, André David, Della C. Pandey, Udai B. Hermann, Andreas Stengel, Florian Davis, Benjamin G. Baldwin, Andrew J. Savitski, Mikhail M. Hyman, Anthony A. Wheeler, Richard J. Max Planck Institute of Molecular Cell Biology and Genetics Dresden Germany Genome Biology Unit European Molecular Biology Laboratory Heidelberg Germany Department of Chemistry University of Oxford Oxford United Kingdom Kavli Institute for Nanoscience Discovery University of Oxford Oxford United Kingdom Dewpoint Therapeutics Boston MA United States Department of Neurology Technische Universität Dresden Dresden Germany Division of Child Neurology Department of Pediatrics Children’s Hospital of Pittsburgh University of Pittsburgh Medical Center Pittsburgh PA United States Department of Human Genetics University of Pittsburgh Graduate School of Public Health Pittsburgh PA United States Department of Neurology University of Pittsburgh School of Medicine Pittsburgh PA United States Proteomics Core Facility European Molecular Biology Laboratory (EMBL) Heidelberg Germany Cluster of Excellence Physics of Life TU Dresden Dresden Germany Biotechnology Center (BIOTEC) CMCB TU Dresden Dresden Germany University of Konstanz Department of Biology Konstanz Germany Konstanz Research School Chemical Biology University of Konstanz Konstanz Germany Graduate Program in Molecular Biology Cell Biology and Biochemistry Brown University Providence RI United States Department of Molecular Biology Cell Biology and Biochemistry Brown University Providence RI United States German Centre for Neurodegenerative Diseases Tübingen Germany Center for Regenerative Therapies TU Dresden (CRTD) Technische Universität Dresden Dresden Germany Center for Transdisciplinary Neurosciences Rostock (CTNR) University Medical Center Rostock University of Rostock Rostock Germany Translational Neurodegeneration Section ‘Albrecht Kossel’ Department of Neurology University Medical Center Rostock Rostock Germany Deutsches Zentrum für Neurodegenerative (DZNE) Rostock/Greifswald Rostock Germany Department of Pharmacology University of Oxford Oxford United Kingdom The Rosalind Franklin Instit

Neurodegenerative diseases, such as amyotrophic lateral sclerosis, are often associated with mutations in stress granule proteins. Aberrant stress granule condensate formation is associated with disease, making it a potential target for pharmacological intervention. Here, we identified lipoamide, a small molecule that specifically prevents cytoplasmic condensation of stress granule proteins. Thermal proteome profiling showed that lipoamide stabilizes intrinsically disordered domain-containing proteins, including SRSF1 and SFPQ, which are stress granule proteins necessary for lipoamide activity. SFPQ has redox-state-specific condensate dissolving behavior, which is modulated by the redox-active lipoamide dithiolane ring. In animals, lipoamide ameliorates aging-associated aggregation of a stress granule reporter protein, improves neuronal morphology and recovers motor defects caused by amyotrophic lateral sclerosis-associated FUS and TDP-43 mutants. Thus, lipoamide is a well-tolerated small-molecule modulator of stress granule condensation, and dissection of its molecular mechanism identified a cellular pathway for redox regulation of stress granule formation. (Figure presented.) © The Author(s) 2025.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Democratising Knowledge Representation with BioCypher

arXiv

引用

arXiv 2022年

作者： Lobentanzer, Sebastian Aloy, Patrick Baumbach, Jan Bohar, Balazs Charoentong, Pornpimol Danhauser, Katharina Doğan, Tunca Dreo, Johann Dunham, Ian Fernandez-Torras, Adrià Gyori, Benjamin M. Hartung, Michael Hoyt, Charles Tapley Klein, Christoph Korcsmaros, Tamas Maier, Andreas Mann, Matthias Ochoa, David Pareja-Lorente, Elena Popp, Ferdinand Preusse, Martin Probul, Niklas Schwikowski, Benno Sen, Bünyamin Strauss, Maximilian T. Turei, Denes Ulusoy, Erva Heidrun Wodke, Judith Andrea Saez-Rodriguez, Julio Heidelberg University Faculty of Medicine Heidelberg University Hospital Institute for Computational Biomedicine Bioquant Heidelberg Germany The Barcelona Institute of Science and Technology Catalonia Barcelona Spain Catalonia Barcelona Spain Institute for Computational Systems Biology University of Hamburg Germany Earlham Institute Norwich United Kingdom Biological Research Centre Szeged Hungary Heidelberg University Im Neuenheimer Feld 267 Heidelberg69120 Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Department of Pediatrics Dr. von Hauner Children’s Hospital University Hospital LMU Munich Germany Biological Data Science Lab Department of Computer Engineering Hacettepe University Ankara Turkey Department of Bioinformatics Graduate School of Health Sciences Hacettepe University Ankara Turkey Computational Systems Biomedicine Lab Department of Computational Biology Institut Pasteur Université Paris Cité Paris France Bioinformatics and Biostatistics Hub Institut Pasteur Université Paris Cité Paris France Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Open Targets Wellcome Genome Campus Cambridgeshire HinxtonCB10 1SD United Kingdom Laboratory of Systems Pharmacology Harvard Medical School Boston United States Imperial College London London United Kingdom Quadram Institute Bioscience Norwich United Kingdom Proteomics Program Novo Nordisk Foundation Centre for Protein Research University of Copenhagen Copenhagen Denmark Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry Martinsried Germany Im Neuenheimer Feld 460 Heidelberg69120 Germany Neuherberg Germany Medical Informatics Laboratory University Medicine Greifswald Germany

Standardising the representation of biomedical knowledge among all researchers is an insurmountable task, hindering the effectiveness of many computational methods. To facilitate harmonisation and interoperability despite this fundamental challenge, we propose to standardise the framework of knowledge graph creation instead. We implement this standardisation in BioCypher, a FAIR (findable, accessible, interoperable, reusable) framework to transparently build biomedical knowledge graphs while preserving provenances of the source data. Mapping the knowledge onto biomedical ontologies helps to balance the needs for harmonisation, human and machine readability, and ease of use and accessibility to nonspecialist researchers. We demonstrate the usefulness of this framework on a variety of use cases, from maintenance of task-specific knowledge stores, to interoperability between biomedical domains, to on-demand building of task-specific knowledge graphs for federated learning. BioCypher (https://***) frees up valuable developer time;we encourage further development and usage by the community. © 2022, CC BY-NC-ND.

关键词： Ontology

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：