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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Qiao, Laicong Guo, Tianruo Xue, Ruier Sang, Rui Yang, Danting Deng, Fei Unsw Graduate School of Biomedical Engineering Tyree Institute of Health Engineering Sydney Australia Ningbo University School of Medicine China

ISBN: (纸本)9798350371499

Cytokines, essential regulatory proteins orchestrating various physiological processes and immune responses, play a pivotal role in assessing health status. Conventional cytokine detection methods, such as enzyme-linked immunosorbent assays, are reliable but time-consuming. Electrochemical aptamer-based sensors offer rapid response and higher selectivity, but fall short of achieving non-invasive detection. This study addresses these limitations by introducing a novel approach to improve cytokine detection performance. We employ a one-step electrodeposition method to synthesize and coat structured gold nanoparticles (Au NPs) onto a working electrode, optimizing surface morphology by manipulating applied voltage, deposition time, and reactant concentrations. The resulting nanostructured Au NPs exhibit diverse and previously unreported morphologies. Leveraging these advancements, we design a wearable device integrating the Au NPs-based sensor with structure-switch aptamers on a microfluidic chip. This wearable sensor shows a limit of detection of 0.3 pg/mL and a larger linear range of 0.3-100 pg/mL. This innovation allows for the non-invasive and continuous detection of cytokines, marking a significant step towards the development of wearable electrochemical biosensors for health *** Relevance - This research provides a novel wearable sensor for non-invasive continuous monitoring of cytokine IFN-γ from human sweat. This innovation holds immense clinical relevance, offering real-time insights into early disease responses and the onset of non-communicable health conditions. The advancement of wearable electrochemical biosensors, exhibiting enhanced performance, addresses a crucial need in clinical practice. This development offers a versatile and efficient tool for patient-friendly health monitoring, marking a significant step forward in the field. © 2024 IEEE.

关键词： Clinical research

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The Effectiveness of the Bone Suppression Algorithm and Concentration Conversion in the Detection of Lung Tumors

The Effectiveness of the Bone Suppression Algorithm and Conc...

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2023 IEEE Asia-Pacific Conference on Computer Science and Data engineering, CSDE 2023

作者： Sato, Kota Ishii, Takuro Saijo, Yoshifumi Graduate School of Biomedical Engineering Tohoku University Sendai Japan Graduate School of Biomedical Engineering Frontier Research Institute for Interdisciplinary Sciences Tohoku University Sendai Japan

ISBN: (纸本)9798350341072

Early detection of lung tumors by reading X-ray images is important for radical treatment of the disease. To decrease the risk of missed lung tumors, diagnosis support system that can provide the accurate detection of lung tumors are in high demand, and the use of artificial intelligence with deep learning is one of the promising solutions. In our research, we try to improve the accuracy of lung tumors detection by artificial intelligence using our bone suppression algorithm and the proposed concentration conversion. 604 chest X-ray images were processed using both processes and learned with a U-net deep learning model. The result showed that the combined processes successfully improved the performance of the deep learning model to identify the location of tumors (Intersection over Union) from 0.197(original images without any process) to 0.247. The combination of bone suppression and concentration conversion would be useful to improve the accuracy. © 2023 IEEE.

关键词： Image enhancement

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NIR-Responsive Methotrexate-Modified Iron Selenide Nanorods for Synergistic Magnetic Hyperthermic, Photothermal, and Chemodynamic Therapy

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ACS Applied Materials and Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien Dhawan, Udesh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to develop novel therapies to effectively treat this disease. In this study, iron selenide nanorods (FeSe2 NRs) were designed for use in magnetic hyperthermic, photothermal, and chemodynamic therapy (MHT/PTT/CDT) for breast cancer. To illustrate their efficacy, FeSe2 NRs were modified with the chemotherapeutic agent methotrexate (MTX). MTX-modified FeSe2 (FeSe2-MTX) exhibited excellent controlled drug release properties. Fe2+ released from FeSe2 NRs induced the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of CDT. Under alternating magnetic field (AMF) stimulation and 808 nm laser irradiation, FeSe2-MTX exerted potent hyperthermic and photothermal effects by suppressing tumor growth in a breast cancer nude mouse model. In addition, FeSe2 NRs can be used for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented a novel technique for the precise delivery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published by American Chemical Society

关键词： Magnetic resonance imaging

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Research on Multimodal Brain Tumor Segmentation Algorithm Based on Feature Decoupling and Information Bottleneck Theory

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Computers, Materials & Continua 2025年第2期82卷 3281-3307页

作者： Xuemei Yang Yuting Zhou Shiqi Liu Junping Yin China Academy of Engineering Physics Graduate SchoolBeijing100193China Shanghai Zhangjiang Institute of Mathematics Biomedical LaboratoryShanghai201203China Institute of Applied Physics and Computational Mathematics Tang Chuang CentreBeijing100094China

Aiming at the problems of information loss and the relationship between features and target tasks in multimodal medical image segmentation, a multimodal medical image segmentation algorithm based on feature decoupling and information bottleneck theory is proposed in this paper. Based on the reversible network, the bottom-up learning method for different modal information is constructed, which enhances the features’ expression ability and the network’s learning ability. The feature fusion module is designed to balance multi-directional information flow. To retain the information relevant to the target task to the maximum extent and suppress the information irrelevant to the target task, the feature decoupling module is designed to ensure a strong correlation between the feature and the target task. A loss function based on information bottleneck theory was intended to improve information quality and remove redundant information. Based on BraTs2021, BraTs2023-MET and ANNLIB datasets, the proposed algorithm is analyzed qualitatively and quantitatively in this paper. In the quantitative experiment, the Dice coefficient of the proposed algorithm was increased by 0.110 on average compared with other methods, and the HD95 was decreased by 28.568 on average compared with other methods. In qualitative analysis, the proposed algorithm can effectively segment the incoherent region between the lesion and the lesion boundary and achieve accurate segmentation of the lesion.

关键词： Image fusion image segmentation deep learning

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Injection-Locked Frequency Sixtuplers in 90 nm CMOS by Using the Push-Push Doubler

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IEEE Access 2023年 11卷 130048-130059页

作者： Cheng, Sheng-Jen Shen, Pi-Neng Hong, Chung-Hung Chen, Zheng-Wei Chen, Chung-Ping Jang, Sheng-Lyang Graduate Institute of Electronics Engineering National Taiwan University Taipei10617 Taiwan National Taiwan University of Science and Technology Department of Electronic Engineering Taipei106335 Taiwan China Medical University College of Biomedical Engineering Department of Biomedical Engineering Taichung404333 Taiwan National Taipei University of Technology Department of Electronic Engineering Taipei10608 Taiwan

This paper designs two single-stage LC-tank injection-locked frequency sixtuplers (ILFSs) fabricated in a 90 nm CMOS process and it describes the circuit design, operation principle, and measurement results of the ILFSs. The ILFS circuit with a differential input and single-phase output is made of a first-harmonic injection-locked oscillator (ILO), a frequency tripler, and a push-push doubler. The first ILFS uses an octagonal inductor. For a supply voltage of 0.4 V, the free-running frequency is around 41.52 GHz, DC power consumption is 9.03 mW at the incident power of 0 dBm, and the output locking range at 0 dBm input power is 10.21 %. The second ILFS uses an 8-shaped inductor for low electromagnetic (EM) noise generation. The free-running frequency is around 37.2 GHz, DC power consumption is 7.72 mW at the incident power of 0 dBm, and the output locking range at 0 dBm input power is 17.4 %. The two chips have the same area, 0.7×0.7 mm2. This paper also provides a further analysis and comparison of the RF performance of on-chip inductors designed. Simulation shows the substrate noise coupling and distance noise coupling between victim and aggressor, the 8-shaped inductor exhibits a significant reduction in coupling. By the measurement results, it is evident that the performance of the 8-shaped inductor ILFS is superior to that of the octagonal inductor ILFS. © 2023 The Authors.

关键词： Harmonic analysis

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An Electrochemical HbA1c Immunosensor With a Simple Electrode of Gold Nanoparticle Monolayer

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IEEE Sensors Journal 2023年第15期23卷 16579-16584页

作者： Tseng, Chun-Chiang Lin, Ying-Ting Wang, Gou-Jen National Chung-Hsing University Department of Mechanical Engineering Taichung40227 Taiwan National Chung-Hsing University Program in Tissue Engineering and Regenerative Medicine Taichung40227 Taiwan National Chung-Hsing University Department of Mechanical Engineering The Graduate Institute of Biomedical Engineering Taichung40227 Taiwan

This study developed a novel electrochemical glycosylated hemoglobin (HbA1c) immunosensor. Polyethylene terephthalate (PET) was used as a substrate. After gold (Au) film sputtering on the PET surface, 1,6-hexanedithol with thiol groups on both terminals was used as an intermediary to attach a monolayer of uniformly distributed Au nanoparticles (AuNPs) to the Au thin film to form a nanostructured electrode. HbA1c antibodies were successfully immobilized on the AuNP monolayer via the self-assembled monolayer (SAM) approach. To mimic a real clinical detection environment, a calibration curve for HbA1c detection was performed in a mixture solution containing heparin sodium, red blood cell (RBC) lysis buffer, artificial human serum, and hemoglobin. The experimental results revealed that the proposed HbA1c immunosensor detected HbA1c in a linear range from 2500 to 10 000 ng/mL with a limit of detection of 2253 ng/mL. The developed HbA1c-sensing chip offers the advantages of simple operation, low cost, short detection time, and provides high feasibility for clinical application. © 2001-2012 IEEE.

关键词： Gold nanoparticles

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First-principles studies on the work function changes of ZnO(21̅1̅0) surfaces induced by NO and NO2 adsorption for gas sensors

First-principles studies on the work function changes of ZnO...

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International Symposium on Applied Science 2024, ISAS 2024

作者： Yu, Cheng-Lung Chen, Guan-Yu Ching, Congo Tak Shing Liu, Po-Liang Graduate Institute of Precision Engineering National Chung Hsing University Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taiwan Department of Applied Materials and Optoelectronic Engineering National Chi Nan University Taiwan

This study employs first-principles calculations based on density functional theory to investigate the work function changes induced by the adsorption of nitric oxide and nitrogen dioxide on clean ZnO(2 1̅1̅ 0) surfaces and Ag-decorated ZnO(2 1̅1̅ 0) surfaces. The results indicate that the maximum work function change for NO adsorption on clean ZnO(2 1̅1̅ 0) surfaces is -0.78 eV, while the maximum work function change for NO2 adsorption on Ag-decorated ZnO(21̅1̅0) surfaces is -1.74 eV. On the Ag atom initially adsorbed on the Zn site of the ZnO(21̅1̅0) surface denoted as the Ag-ZnO-Zn surface, the work function change induced by NO2 is approximately 0.89 eV more negative than that induced by NO. On the Ag atom initially adsorbed on the O site of the ZnO(21̅1̅0) surface denoted as the Ag-ZnO-O surface, the work function change induced by NO2 is approximately 0.87 eV more negative than that induced by NO. In contrast, NO adsorption on Ag-decorated ZnO(21̅1̅0) surfaces leads to notable work function changes (-0.74 eV and -0.87 eV), especially on Ag-ZnO-O surfaces, showing higher sensitivity. The largest work function changes are observed for NO2 adsorption on Ag-decorated ZnO surfaces (- 1.63 eV and - 1.74 eV), particularly on Ag-ZnO-O surfaces, indicating extremely high sensitivity. These findings suggest that Ag-decorated ZnO surfaces exhibit the highest sensitivity to NO2, especially on Ag-ZnO-O surfaces, making them the optimal choice for designing high-efficiency NO2 gas sensors. Furthermore, Ag-decorated ZnO materials also show high potential in sensing NO. These results provide important references for designing high-performance gas sensors, particularly in the context of environmental monitoring and health protection. Further research and experiments can validate these theoretical results and lead to the development of practical sensor devices. © 2025 institute of Physics Publishing. All rights reserved.

关键词： Zinc oxide

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Feasibility Study of Finger Interface for Miniature Surgical Instruments 1

Feasibility Study of Finger Interface for Miniature Surgical...

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1st IEEE Conference on Telepresence, Telepresence 2024

作者： Cha, Serin Kim, Sebin Ryu, Seok Chang Ewha Womans University Graduate Program in Smart Factory BioRobotics Laboratory Department of Mechanical and Biomedical Engineering Seoul03760 Korea Republic of Ewha Womans University BioRobotics Laboratory Department of Mechanical and Biomedical Engineering Korea Republic of

ISBN: (纸本)9798331528249

This paper presents a study on the design of a finger interface to improve the teleoperation of a miniaturized surgical instrument with a bendable distal section. A unique design principle employing the kinematic similarity between the human motion and the follower robot has been proposed for such instruments, which may result in embodied teleoperation, enhancing the overall telepresence experience. According to the principle, a design for an index finger interface was proposed, consisting of a sub-unit measuring finger motion and a handle. When the interface is connected to a robotic platform, it can control the entire tool motion in two separate ways: distal bending by the sub-unit and overall tool motion by the handle. A human subject test was conducted for trajectory-following tasks in a virtual environment, and their performance score was quantified for analysis of the learning curve. Based on the satisfactory learning rate of 75.78% for all nine subjects, the proposed finger interface could be a promising interface for a miniature surgical instrument with a long bendable section at the distal end. © 2024 IEEE.

关键词： Machine design

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BLOCKCHAIN TECHNOLOGY IMPLEMENTATION FOR HEALTHCARE PRIVACY DATA SYSTEMS IN THE UAE 50

BLOCKCHAIN TECHNOLOGY IMPLEMENTATION FOR HEALTHCARE PRIVACY ...

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50th International Conference on Computers and Industrial engineering: Sustainable Digital Transformation, CIE 2023

作者： Alshamsi, Hessa Marei, Fatemaal Marwan, Tasnim Shamayleh, Abdulrahim Department of Industrial Engineering American University of Sharjah Sharjah United Arab Emirates Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates Department of Industrial Engineering Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781713886952

Blockchain technology is being recognized as a significant solution to technical issues across various industries, including healthcare. In the healthcare sector, Blockchain has the potential to revolutionize processes such as transferring patient medical records, managing the medicine supply chain, and aiding healthcare researchers in unlocking genetic code. The United Arab Emirates (UAE) has emerged as a developed country actively exploring blockchain technology to enhance its healthcare sector. Despite efforts to improve healthcare in the UAE, integrating new technologies has been limited. The focus has primarily been on improving equipment and procedures rather than adopting innovative solutions. The growing population and increasing emphasis on medical tourism have also amplified the demand for advanced healthcare services. Therefore, immediate action is required to initiate significant developments in the healthcare sector. This research aims to highlight the importance and role of blockchain technology, specifically in the UAE healthcare sector. It seeks to improve the competence and privacy of healthcare data systems while addressing concerns related to centralization. The study presents recent findings concerning the initiatives and vision of the UAE government to establish a globally outstanding healthcare sector. It defines blockchain technology and emphasizes its positive impact on enhancing healthcare data systems. Furthermore, the research showcases various applications of blockchain technology that can be implemented in the healthcare sector. By demonstrating blockchain technology's benefits and potential applications, this research endeavors to encourage the strategic adoption of blockchain solutions in the healthcare sector. Such initiatives can pave the way for advancements in patient data systems and privacy. © 2023 Computers and Industrial engineering. All rights reserved.

关键词： Blockchain

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