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Correction: An Exploration of Korean traditional parenting virtues among Korean-American parents and the impact of the Ottuki parenting program

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Asia Pacific Education Review 2025年 1-1页

作者： Cho, Younghee Lee, Rachel Yeji Jang, Sou Hyun Yu, Joon-Ho Park, Jae Hyun Kim, Sangho Kim, Eunjung Graduate School of Education Yongin University Yongin Republic of Korea Department of Biomedical Informatics Columbia University New York USA Department of Sociology Korea University Seoul Republic of Korea Department of Pediatrics University of Washington School of Medicine Seattle USA Treuman Katz Center for Pediatric Bioethics Seattle Children’s Hospital and Research Institute Seattle USA Adjunct Department of Epidemiology School of Public Health Institute for Public Health Genetics University of Washington Seattle USA Child Family and Population Health Nursing University of Washington Seattle USA Korean Community Service Center Seattle USA

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Developing a Deep Learning Model Using Transfer Learning from EfficientNet-b3 to Detect Knee Fracture on X-ray Images 23

Developing a Deep Learning Model Using Transfer Learning fro...

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7th International Conference on Medical and Health informatics, ICMHI 2023

作者： Huang, Shu-Tien Liu, Liong-Rung Tsai, Ming-Feng Huang, Ming-Yuan Chiu, Hung-Wen Department of Emergency Medicine Mackay Memorial Hospital Taipei Taiwan Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei City Taiwan Department of Medicine Mackay Medical College New Taipei City Taiwan Clinical Big Data Research Center Taipei Medical University Hospital Taipei City Taiwan

ISBN: (纸本)9798400700712

Conventional radiographs are used for fracture detection routinely in knee injury patients. Miss diagnosis is harmful to patients and stressful to physicians. Thus, a clinical decision support system utilizing a deep neural network should be helpful in preventing physicians from overlooking and also improving patient safety. This study uses a deep learning model (DLM) with transfer learning from EfficientNet-b3 to detect knee fractures on X-ray images. About 12% of the total 13,615 cases were used to test the model. The testing accuracy of the trained model was 90.56%. The area under the receiver operator characteristic curve (AUC) was 0.960. Our findings highlight that the deep learning model can detect knee fractures with remarkable performance. Further implementation into clinical use as a decision support system can be helpful to prevent misdiagnosis and subsequent patient harm. © 2023 ACM.

关键词： Decision support systems

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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses

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Cellular & Molecular Immunology 2021年第8期18卷 1956-1968页

作者： Seon-Hee Kim Rohit Singh Chungyong Han Eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim Dong Hoon Shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi Division of Tumor Immunology National Cancer CenterGoyang10408Republic of Korea Graduate School of Cancer Science and Policy National Cancer CenterGoyang10408Republic of Korea Biomedicine Production Branch Program for Immunotherapy ResearchGoyang10408Republic of Korea Eutilex Institute for Biomedical Research EutilexCo.Ltd.Seoul08594Republic of Korea Division of Convergence Technology National Cancer CenterGoyang10408Republic of Korea Division of Translational Science National Cancer CenterGoyang10408Republic of Korea Institute of Oral Biology School of DentistryGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA70112USA

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor ***,the adverse side effects associated with agonist antibodies have hindered their clinical ***,we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB *** show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1^(+)CD8^(+)T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8^(+)T cells,which was beneficial for suppressing tumor growth in the early phase of anti-4-1BB ***,repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes(TDLNs)of mice due to recruitment and accumulation of macrophages via the CD8^(+)T cell-IFN-γ*** was accompanied by excessive lymph node swelling,which impaired the sequential activation of CD8^(+)T *** data provide insights into the immune-related adverse events of long-term agonist 4-1BB antibody dosing,which should be considered during the clinical development of immunomodulating therapy.

关键词： 4-1BB Costimulation Granuloma CD8 lymphocyte Macrophage

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Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

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Genes & Diseases 2022年第4期9卷 841-844页

作者： Shang Jiunn Chuah Chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh Faculty of Dentistry National University of Singapore119085Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore117583Singapore Tissue Engineering Program Life Sciences InstituteNational University of Singapore117456Singapore Integrative Sciences and Engineering Program NUS Graduate SchoolNational University of Singapore119077Singapore

Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical *** MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.

关键词： healing clinical macrophage

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KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

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Molecular Cell 2009年第1期36卷 131-140页

作者： Lee, Dung-Fang Kuo, Hsu-Ping Liu, Mo Chou, Chao-Kai Xia, Weiya Du, Yi Shen, Jia Chen, Chun-Te Huo, Longfei Hsu, Ming-Chuan Li, Chia-Wei Ding, Qingqing Liao, Tsai-Lien Lai, Chien-Chen Lin, Ann-Chi Chang, Ya-Hui Tsai, Shih-Feng Li, Long-Yuan Hung, Mien-Chie Department of Molecular and Cellular Oncology The University of Texas M.D. Anderson Cancer Center Houston TX 77030 United States Program in Cancer Biology The University of Texas Graduate School of Biomedical Sciences at Houston Houston TX 77030 United States Division of Molecular and Genomic Medicine National Health Research Institutes Zhunan Miaoli County 350 Taiwan Graduate Institute of Chinese Medical Science China Medical University Taichung 404 Taiwan Institute of Molecular Biology National Chung Hsing University Taichung 402 Taiwan Center for Molecular Medicine Graduate Institute of Cancer Biology China Medical University and Hospital Taichung 404 Taiwan Asia University Taichung 413 Taiwan

IκB kinase β (IKKβ) is involved in tumor development and progression through activation of the nuclear factor (NF)-κB pathway. However, the molecular mechanism that regulates IKKβ degradation remains largely unknown. Here, we show that a Cullin 3 (CUL3)-based ubiquitin ligase, Kelch-like ECH-associated protein 1 (KEAP1), is responsible for IKKβ ubiquitination. Depletion of KEAP1 led to the accumulation and stabilization of IKKβ and to upregulation of NF-κB-derived tumor angiogenic factors. A systematic analysis of the CUL3, KEAP1, and RBX1 genomic loci revealed a high percentage of genome loss and missense mutations in human cancers that failed to facilitate IKKβ degradation. Our results suggest that the dysregulation of KEAP1-mediated IKKβ ubiquitination may contribute to tumorigenesis. © 2009 Elsevier Inc. All rights reserved.

关键词： PROTEINS SIGNALING

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Improved CaP Nanoparticles for Nucleic Acid and Protein Delivery to Neural Primary Cultures and Stem Cells

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ACS Nano 2024年第6期18卷 4822-4839页

作者： Chao, Yu-Wen Lee, Yen-Lurk Tseng, Ching-San Wang, Lily Ueh-Hsi Hsia, Kuo-Chiang Chen, Huatao Fustin, Jean-Michel Azeem, Sayma Chang, Tzu-Tung Chen, Chiung-Ya Kung, Fan-Che Hsueh, Yi-Ping Huang, Yi-Shuian Chao, Hsu-Wen Department of Physiology School of Medicine College of Medicine Taipei Medical University Taipei110301 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110301 Taiwan Department of Anatomy School of Medicine China Medical University Taichung40402 Taiwan Institute of Molecular Biology Academia Sinica Taipei115201 Taiwan Institute of Biomedical Sciences Academia Sinica Taipei115201 Taiwan Department of Clinical Veterinary Medicine College of Veterinary Medicine Northwest A&F University Shaanxi Yangling712100 China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture and Rural Affairs Northwest A&F University Shaanxi Yangling712100 China The University of Manchester Faculty of Biology Medicine and Health Oxford Road ManchesterM13 9PL United Kingdom Taiwan International Graduate Program in Interdisciplinary Neuroscience National Yang-Ming Chao-Tung University and Academia Sinica Taipei115201 Taiwan Institute of Molecular Medicine College of Medicine National Taiwan University Taipei10002 Taiwan Department of Biomedical Science and Environmental Biology Kaohsiung Medical University Kaohsiung80708 Taiwan

Efficiently delivering exogenous materials into primary neurons and neural stem cells (NSCs) has long been a challenge in neurobiology. Existing methods have struggled with complex protocols, unreliable reproducibility, high immunogenicity, and cytotoxicity, causing a huge conundrum and hindering in-depth analyses. Here, we establish a cutting-edge method for transfecting primary neurons and NSCs, named teleofection, by a two-step process to enhance the formation of biocompatible calcium phosphate (CaP) nanoparticles. Teleofection enables both nucleic acid and protein transfection into primary neurons and NSCs, eliminating the need for specialized skills and equipment. It can easily fine-tune transfection efficiency by adjusting the incubation time and nanoparticle quantity, catering to various experimental requirements. Teleofection’s versatility allows for the delivery of different cargos into the same cell culture, whether simultaneously or sequentially. This flexibility proves invaluable for long-term studies, enabling the monitoring of neural development and synapse plasticity. Moreover, teleofection ensures the consistent and robust expression of delivered genes, facilitating molecular and biochemical investigations. Teleofection represents a significant advancement in neurobiology, which has promise to transcend the limitations of current gene delivery methods. It offers a user-friendly, cost-effective, and reproducible approach for researchers, potentially revolutionizing our understanding of brain function and development. © 2024 The Authors. Published by American Chemical Society.

关键词： Calcium phosphate

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Influenza vaccination may lead to reduction of hospitalization for heart failure in elderly patients with chronic obstructive pulmonary disease

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Journal of Experimental and Clinical medicine(Taiwan) 2013年第2期5卷 65-68页

作者： Chen, Chang-I Sung, Li-Chin Miser, James S. Fang, Yu-Ann Tsai, Ching-Quan Liu, Ju-Chi Li, Yu-Chuan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan Center of Excellence for Cancer Research Taipei Medical University Taipei Taiwan Cancer Center Taipei Medical University-Wan Fang Medical Center Taipei Taiwan Division of Cardiovascular Medicine Department of Internal Medicine Taipei Medical University-Shuang-Ho Hospital New Taipei City Taiwan College of Medical Science and Technology Taipei Medical University Taiwan Department of Internal Medicine School of Medicine Medical College Taipei Medical University Taipei City Taiwan Graduate Institute Biomedical Informatics Taipei Medical University Taipei Taiwan

Background: Vaccination against influenza may decrease the risk of an acute cardiovascular event in the elderly. The purpose of this study was to test the hypothesis that influenza vaccination could reduce hospitalizations for heart failure (HF) in patients with chronic obstructive pulmonary disease (COPD). Methods: Using Taiwan National Health Insurance Research Dataset (NHIRD) 2000 to 2007, this cohort study comprised patients with a recorded diagnosis of COPD (n = 25,609) between January 1, 2000 and December 31, 2007. Each patient was followed up until the end of 2007. Cox proportional hazard regression analysis was used to evaluate the HF-free survival rates after adjusting for known confounding factors. Results: We found that patients with COPD but no history of a cardiovascular event had a lower risk of hospitalization for HF after receiving influenza vaccination. After adjusting for potential confounders, there was a possible decrease in HF admission for the vaccinated group [hazard ratio (HR), 0.44, 95% confidence interval (CI), 0.35-0.55]. When stratified in terms of the patients' ages, the adjusted HR for hospitalization due to HF was 0.36 (95% CI, 0.28-0.46) for vaccinated patients over 64 years of age;however, the adjusted HR for HF in patients under 55 years of age who had received vaccination was not significant. Conclusion: Our data show that there was a lower rate of hospitalization from HF in patients with COPD receiving influenza vaccination, but only in patients older than 65 years. © 2013.

关键词： Adjusted hazard ratio Cardiovascular disease Chronic obstructive pulmonary disease Cohort study Taiwan National Health Insurance Research Dataset (NHIRD)

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S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis

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Bone Research 2019年第4期7卷 424-436页

作者： Haemin Kim Bongjun Kim Sang Il Kim Hyung Joon Kim Brian YRyu Junho Chung Zang Hee Lee Hong-Hee Kim Department of Cell and Developmental Biology BK21 Program and DRISeoul National UniversitySeoulKorea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Cancer Biology Seoul National University College of MedicineSeoulKorea Department of Oral Physiology BK21 PLUS Projectand Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanKorea Interdisciplinary Program in Bioinformatics Seoul National University College of Natural SciencesSeoulKorea Department of Biomedical Sciences Seoul National University Graduate SchoolSeoulKorea

Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer *** between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and ***-derived factors play fundamental roles in this form of *** identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer *** subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor *** S100A4 stimulated osteoclastogenesis in vitro and bone loss in *** medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate ***,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown *** addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in *** together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.

关键词： S100A4 breast metastatic

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Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease

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Journal of Translational medicine 2024年第1期22卷 600页

作者： Lee, Shih-Ching Huang, Chen-Hao Oyang, Yen-Jen Huang, Hsuan-Cheng Juan, Hsueh-Fen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 10617 Taiwan Division of Rheumatology Allergy and Immunology Department of Internal Medicine Chang Gung Memorial Hospital Taoyuan 333 Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung University Taipei 11221 Taiwan Department of Life Science National Taiwan University Taipei 106 Taiwan Center for Computational and Systems Biology National Taiwan University Taipei 106 Taiwan

Background: Interstitial lung disease (ILD) is the primary cause of mortality in systemic sclerosis (SSc), an autoimmune disease characterized by tissue fibrosis. SSc-related ILD (SSc-ILD) occurs more frequently in females aged 30–55 years, whereas idiopathic pulmonary fibrosis (IPF) is more prevalent in males aged 60–75 years. SSc-ILD occurs earlier than IPF and progresses rapidly. FCN1, FABP4, and SPP1 macrophages are involved in the pathogenesis of lung fibrosis;SPP1 macrophages demonstrate upregulated expression in both SSc-ILD and IPF. To identify the differences between SSc-ILD and IPF using single-cell analysis, clarify their distinct pathogeneses, and propose directions for prevention and treatment. Methods: We performed single-cell RNA sequencing on NCBI Gene Expression Omnibus (GEO) databases GSE159354 and GSE212109, and analyzed lung tissue samples across healthy controls, IPF, and SSc-ILD. The primary measures were the filtered genes integrated with batch correction and annotated cell types for distinguishing patients with SSc-ILD from healthy controls. We proposed an SSc-ILD pathogenesis using cell–cell interaction inferences, and predicted transcription factors regulating target genes using SCENIC. Drug target prediction of the TF gene was performed using Drug Bank Online. Results: A subset of macrophages activates the MAPK signaling pathway under oxidative stress. Owing to the lack of inhibitory feedback from ANNEXIN and the autoimmune characteristics, this leads to an earlier onset of lung fibrosis compared to IPF. During initial lung injury, fibroblasts begin to activate the IL6 pathway under the influence of SPP1 alveolar macrophages, but IL6 appears unrelated to other inflammatory and immune cells. This may explain why tocilizumab (an anti-IL6-receptor antibody) only preserves lung function in patients with early SSc-ILD. Finally, we identified BCLAF1 and NFE2L2 as influencers of MAPK activation in macrophages. Metformin downregulates NFE2L2 and c

关键词： IL6 Lung fibrosis Macrophage MAPK SSc-ILD Systemic sclerosis

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Simultaneous monitoring tumor vascular and tissue oxygen tension under hyperbaric oxygen exposure

Simultaneous monitoring tumor vascular and tissue oxygen ten...

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biomedical Topical Meeting, BIO 2006

作者： Xia, Mengna Liu, Hanli Ren, Ya Mason, Ralph Levine, Benjamin Biomedical Engineering Graduate Program University of Texas at Arlington Arlington TX 76013 United States Department of Radiology UT Southwestern Medical Center at Dallas Dallas TX United States Institute of Exercise and Environmental medicine UT Southwestern Medical Center at Dallas Dallas TX United States

We demonstrate the ability to simultaneously investigate breast tumor oxygen dynamics by Steady-state diffuse reflectance spectroscopy and FOXY oxygen sensor in response to hyperbaric oxygen intervention. © 2006 ...

ISBN: (纸本)1557528071

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