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Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

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VR-Based Implicit Authentication Using Electromyogram and Inertial Measurement Unit 23

VR-Based Implicit Authentication Using Electromyogram and In...

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23rd International Conference on Cyberworlds, CW 2024

作者： Yu, Da-Young Lee, Hyung-Tak Kim, Youngsam Roh, Jong-Hyuk Kim, Soohyung Ku, Jeonghun Hwang, Han-Jeong Korea University Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Dept. Electronics and Information Engineering Sejong Korea Republic of Korea University Dept. Electronics and Information Engineering Sejong Korea Republic of Daejeon Korea Republic of Keimyung University College of Medicine Department of Biomedical Engineering Daegu Korea Republic of

ISBN: (纸本)9798331527174

Biometrics based on electromyogram (EMG) and inertial measurement unit (IMU) signals has received significant attention due to its resistance to forgery and tampering, as well as its relatively higher convenience and security compared to other biometric modalities. However, most EMG and IMU signal-based authentication methods require explicit authentication using unnatural gestures, which is not userfriendly. To address this, we collected EMG and IMU data during virtual reality (VR) rhythm game play, which does not require explicit gestures, and performed implicit authentication. Using a linear discriminant analysis (LDA) classifier, we achieved classification accuracies of 91.71% for human identification and 87.91% for human authentication. The result demonstrated the feasibility of a seamless and implicit authentication in VR environments. © 2024 IEEE.

关键词： Electromyography

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High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor 16

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： Nanoclay

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Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application

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Journal of Pharmaceutical Analysis 2023年第7期13卷 691-693页

作者： Dan Li Zhou Fang Qiang Shi Nicholas Zhang Binsheng Gong Weida Tong Ahmet F.Coskun Joshua Xu Division of Bioinformatics and Biostatistics National Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlantaGA30332USA Machine Learning Graduate Program Georgia Institute of TechnologyAtlantaGA30332USA Division of Systems Biology National Center for Toxicological ResearchU.S.Food and Drug AdministrationJeffersonAR72079USA Interdisciplinary Bioengineering Graduate Program Georgia Institute of TechnologyAtlantaGA30332USA Parker H.Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGA30332USA

Reducing the use of animal models in drug development and safety assessment has long been supported by the *** and Drug Administration(FDA).The report by Royal Society for the Prevention of Cruelty to Animals indicates that in 2020,experiments involved the use of over 100 million animals,with the United States leading the list by utilizing 20 million *** ethical considerations associated with animal testing and the costs in terms of time and money,animal models are not always effective in predicting human reactions to drug *** animal testing has been the traditional method for assessing the safety and efficacy of drugs.

关键词： money utilizing testing

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Segmented readout for Cherenkov time-of-flight positron emission tomography detectors based on bismuth germanate

arXiv

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arXiv 2024年

作者： Yi, Minseok Lee, Daehee Gola, Alberto Merzi, Stefano Penna, Michele Lee, Jae Sung Cherry, Simon R. Kwon, Sun Il Department of Biomedical Engineering University of California Davis United States Interdisciplinary Program in Bioengineering College of Engineering Seoul National Graduate School Korea Republic of Integrated Major in Innovative Medical Science Seoul National Graduate School Korea Republic of Fondazione Bruno Kessler Italy Brightonix Imaging Inc. Korea Republic of

Positron emission tomography (PET) is the most sensitive biomedical imaging modality for noninvasively detecting and visualizing positron-emitting radiopharmaceuticals within a subject. In PET, measuring the time-of-flight (TOF) information for each pair of 511-keV annihilation photons improves effective sensitivity but requires high timing resolution. Hybrid materials that emit both scintillation and Cherenkov photons, such as bismuth germanate (BGO), recently offer the potential for more precise timing information from Cherenkov photons while maintaining adequate energy resolution from scintillation photons. However, a significant challenge in using such hybrid materials for TOF PET applications lies in the event-dependent timing spread caused by the mixed detection of Cherenkov and scintillation photons due to relatively lower production of Cherenkov photons. This study introduces an innovative approach by segmenting silicon photomultiplier (SiPM) pixels coupled to a single crystal, rather than using traditional SiPMs that are as large as or larger than the crystals they read. We demonstrated that multiple time stamps and photon counts obtained from the segmented SiPM can classify events by providing temporal photon density, effectively addressing this challenge. The approach and findings would lead to new opportunities in applications that require precise timing and photon counting, spanning the fields of medical imaging, high-energy physics, and optical physics. © 2024, CC BY.

关键词： Photons

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LoraMap: Harnessing the Power of LoRA Connections

arXiv

引用

arXiv 2024年

作者： Park, Hyeryun Kwak, Jeongwon Jang, Dongsuk Park, Sumin Choi, Jinwook Interdisciplinary Program for Bioengineering Graduate School Seoul National University Korea Republic of Integrated Major in Innovative Medical Science Graduate School Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of Medical Research Center Institute of Medical and Biological Engineering Seoul National University Korea Republic of

Fact-checking techniques can mitigate hallucinations in Large Language Models (LLMs), a prominent issue in specialized domains. As parameter-efficient techniques such as Low-Rank Adaptation (LoRA) can overcome substantial computational overhead, some studies have explored the integration of multiple LoRAs. While previous studies focus on parallel integration, this paper investigates methods to establish connections among multiple LoRAs. We create three reasoning datasets tailored to fact-checking and fine-tune individual LoRAs, allowing them to view and reason from diverse perspectives. Then, we explore strategies for allocating these reasoning LoRAs and introduce LoraMap, an approach to map connections between them. The results of the fact-checking task demonstrate that the performance of LoraMap is superior to LoraHub, an existing method for integrating LoRAs. LoraMap also outperforms with significantly fewer trainable parameters than LoraConcat, which concatenates LoRAs and further fine-tunes them. Copyright © 2024, The Authors. All rights reserved.

关键词： Problem oriented languages

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Thermodynamics of the Solid-Liquid Phase Equilibrium of a Binary System: Effect of a Chemical Reaction in the Liquid and Epitaxial Strain in the Solid

SSRN

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SSRN 2023年

作者： Deymier, Alix C. Deymier, Pierre Alix Muralidharan, Krishna Latypov, Marat I. Department of Biomedical Engineering UConn Health FarmingtonCT06030 United States Department of Materials Science and Engineering University of Arizona TucsonAZ85721 United States Graduate Interdisciplinary Program in Applied Mathematics University of Arizona TucsonAZ85721 United States

We introduce two thermodynamics models of solid-liquid phase equilibrium of a binary system in the presence of (a) a chemical reaction in the liquid involving only one of the binary components and, (b) strain-inducing epitaxial conditions on the solid in addition to the chemical reaction in the liquid. These models show the existence of the counter intuitive behavior that epitaxy may promote recrystallization of the solid in spite of the reaction driving dissolution. The conditions for this recrystallization behavior are determined by the value of the epitaxial lattice matching composition, the temperature and the overall composition of the binary solid-liquid system. © 2023, The Authors. All rights reserved.

关键词： Chemical reactions

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VR-Based Implicit Authentication Using Electromyogram and Inertial Measurement Unit

VR-Based Implicit Authentication Using Electromyogram and In...

引用

International Conference on Cyberworlds

作者： Da-Young Yu Hyung-Tak Lee Youngsam Kim Jong-Hyuk Roh Soohyung Kim Jeonghun Ku Han-Jeong Hwang Dept. Electronics and Information Engineering Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong Republic of Korea Dept. Electronics and Information Engineering Korea University Sejong Republic of Korea Electronics and Telecommunications Research Institute (ETRI) Daejeon Republic of Korea Department of Biomedical Engineering College of Medicine Keimyung University Daegu Republic of Korea

ISBN: (数字)9798331527174

ISBN: (纸本)9798331527181

关键词： Biometrics Solid modeling Measurement units Accuracy Authentication Inertial navigation Games Virtual reality Rhythm Electromyography

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Water Activated Catechol Adhesive Allows Dip Coated Antimicrobial Coatings

SSRN

引用

SSRN 2023年

作者： Ghosh, Animesh Singh, Juhi Lim, Sierin Steele, Terry W.J. 639798 Singapore NTU Institute for Health Technologies Interdisciplinary Graduate Program Nanyang Technological University 61 Nanyang Drive 637335 Singapore School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive Block N1.3 637457 Singapore

Bioadhesives comprising of catechol crosslinkers have displayed broad utility against both soft and hard substrates. However, catechol’s two-part adhesion chemistry requires oxidative chemicals that are detrimental to organic substrates. Herein, a water-activated adhesive with inherent antibacterial properties is prepared by grafting catechol groups onto branched polyethylenimine (PEI-DBA20). The resultant PEI-DBA20 is stable in organic solvents but undergoes curing in the presence of water. The in-built oxidation method relies on the close proximity of catechol/Schiff-base functional groups that form tautomers in the presence of aqueous solvents. The curing mechanism is demonstrated by dip coating hydrated substrates, where the grafted dendrimers subsequently crosslink and form thin films. Coated PET films and polyester textiles exhibit an antimicrobial surface with 4-6 log reduction against model Gram-negative bacteria. © 2023, The Authors. All rights reserved.

关键词： Adhesion

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Spatial Distribution of Reduced Density of Hard Spheres Near a Hard-Sphere Dimer: Results from Three-Dimensional Ornstein–Zernike Equations Coupled with Several Different Closures and from Grand Canonical Monte Carlo Simulation

SSRN

引用

SSRN 2023年

作者： Matsuo, Mika Nakamura, Yuka Kinoshita, Masahiro Akiyama, Ryo Department of Chemistry Kyushu University Fukuoka819-0395 Japan Interdisciplinary Program of Biomedical Engineering Assistive Technology and Art and Sports Sciences Faculty of Engineering Niigata University Niigata950-2181 Japan Department of Chemistry Graduate School of Science Chiba University Chiba263-8522 Japan Center for the Promotion of Interdisciplinary Education and Research Kyoto University Kyoto606-8501 Japan

We calculated the spatial distribution of the reduced density and pair distribution function (PDF) of solvent hard spheres near a solute using three-dimensional Ornstein–Zernike (OZ) equations coupled with closures in which Percus–Yevick (PY) and hypernetted–chain (HNC) approximations were used or in which the bridge functions (BFs)proposed by Verlet, Duh and Henderson, and Kinoshita were incorporated. The solute was formed by two solvent hard spheres in contact with each other, with the result that the system was not radial-symmetric, necessitating the extension of the Verlet, Duh–Henderson, and Kinoshita BFs to three-variable functions considered in the Cartesian coordinate system. The results were compared with those from grand canonical Monte Carlo (MC) simulations. In terms of the PDF, HNC was superior to PY in the sense that the results from the former are closer to those from MC. Incorporation of the three BFs made the results even closer to those from MC. The three BFs shared almost the sameperformance for a solute immersed in a one-component solvent at the infinite-dilution limit. Analyses on the triplet distribution function (TDF) were also performed. It was found that in terms of the TDF, the incorporation of the BFs does not necessarily lead to improvement. © 2023, The Authors. All rights reserved.

关键词： Distribution functions

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