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Science China Life Sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

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Wavelet approach to artifact noise removal from Capacitive coupled Electrocardiograph

Wavelet approach to artifact noise removal from Capacitive c...

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30th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS'08

作者： Seung, Min Lee Ko, Keun Kim Kwang, Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9781424418152

Capacitive coupled Electrocardiography (ECG) is introduced as non-invasive measurement technology for ubiquitous health care and appliance are spread out widely. Although it has many merits, however, capacitive coupled ECG is very weak for motion artifacts for its non-skin-contact property. There are many studies for artifact problems which treats all artifact signals below 0.8Hz. In our capacitive coupled ECG measurement system, artifacts exist not only below 0.8Hz but also over than 10Hz. Therefore, artifact noise removal algorithm using wavelet method is tested to reject artifact-wandered signal from measured signals. It is observed that using power calculation each decimation step, artifact-wandered signal is removed as low frequency artifacts as high frequency artifacts. Although some original ECG signal is removed with artifact signal, we could level the signal quality for long term measure which shows the best quality ECG signals as we can get. © 2008 IEEE.

关键词： Electrocardiography

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Artificial neural network-based estimation of the eyeball position using the magnetic contact lens sensing technique

Artificial neural network-based estimation of the eyeball po...

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2005 27th Annual International Conference of the engineering in Medicine and Biology Society, IEEE-EMBS 2005

作者： Lee, Seung Yup Kim, Keun Young Kim, Hee Chan Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)0780387406

We have created an artificial neural network based approach for measuring eye movement using a magnetic contact lens sensing technique. The sensor array is based on using four magnetoresistive sensors. A two-layer feed-forward artificial neural network was used and an artificial eyeball model was made for the test. The neural network is trained with sample data obtained from nine spots. After training, we compared the position calculated from the developed system with the real one. The result shows that there is a good linear relationship between them. This indicates the developed system is capable of recording the position of the eyeball with a high degree of accuracy. © 2005 IEEE.

关键词： Contact lenses

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Progress in BazookaSPECT

Progress in BazookaSPECT

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Penetrating Radiation Systems and Applications X

作者： Miller, Brian W. Barber, H. Bradford Furenlid, Lars R. Moore, Stephen K. Barrett, Harrison H. College of Optical Sciences United States Department of Radiology Graduate Interdisciplinary Program In Biomedical Engineering University of Arizona Tucson AZ 85721 United States

ISBN: (纸本)9780819477408

Recent progress on a high-resolution, photon-counting gamma-ray and x-ray imager called BazookaSPECT is presented. BazookaSPECT is an example of a new class of scintillation detectors based on integrating detectors such as CCD(charge-coupled device) or CMOS(complementary metal-oxide semiconductor) sensors. BazookaSPECT is unique in that it makes use of a scintillator in close proximity to a microchannel plate-based image intensifier for up-front optical amplification of scintillation light. We discuss progress made in bringing about compact BazookaSPECT modules and in real-time processing of event data using graphics processing units (GPUs). These advances are being implemented in the design of a high-resolution rodent brain imager called FastSPECT III. A key benefit of up-front optical gain is that any CCD/CMOS sensor can now be utilized for photon counting. We discuss the benefits and feasibility of using CMOS sensors as photon-counting detectors for digital radiography, with application in mammography and computed tomography (CT). We present as an appendix a formal method for comparing various photon-counting integrating detectors using objective statistical criteria. © 2009 SPIE.

关键词： Graphics processing unit

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Quantitative measurements of pressure dependent laminar cribrosa microstructure in human eyes

Quantitative measurements of pressure dependent laminar crib...

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ASME 2011 Summer Bioengineering Conference, SBC 2011

作者： Yan, Dongmei Keyes, Joseph T. Vande Geest, Jonathan P. Aerospace and Mechanical Engineering University of Arizona United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona United States Biomedical Engineering University of Arizona United States BIO5 Institute University of Arizona United States

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Activity energy expenditure assessment system based on activity classification using multi-site triaxial accelerometers

Activity energy expenditure assessment system based on activ...

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29th Annual International Conference of IEEE-EMBS, engineering in Medicine and Biology Society, EMBC'07

作者： Kim, Dongwoo Kim, Hee Chan Interdisciplinary Program Graduate School Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)1424407885

Wireless networked multisite triaxial accelerometry system was proposed to estimate activity energy expenditure during daily life. Proposed system used different estimation algorithms according to activity classification based on measured acceleration signals. The estimation results showed higher correlation (R2 = 0.98) and smaller standard errors of estimation (SEE = 0.66 kcal) than any other system in preceding reports. © 2007 IEEE.

关键词： biomedical engineering

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Computational simulation of a mems-based microactuator for tissue engineering applications

Computational simulation of a mems-based microactuator for t...

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10th ASME Summer Bioengineering Conference, SBC2008

作者： Keyes, Joseph Junkin, Michael Wong, Pak Kin Vande Geest, Jonathan P. Department of Aerospace and Mechanical Engineering United States Graduate Interdisciplinary Program in Biomedical Engineering United States BIO5 Institute for Biocollaborative Research University of Arizona Tucson AZ United States

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Alterations in finite element results given constitutive models from tubular and planar biaxial testing of the same porcine coronary arteries

Alterations in finite element results given constitutive mod...

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ASME 2012 Summer Bioengineering Conference, SBC 2012

作者： Keyes, Joseph T. Lockwood, Danielle R. Vande Geest, Jonathan P. Graduate Interdisciplinary Program in Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ 85721 United States

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BPS2025 - Spatial compartmentalization of the expression of CaM genes supports versatile Ca 2+ -CaM signaling in cardiac myocytes

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Biophysical Journal 2025年第3期124卷 109a-110a页

作者： Vladimir Bogdanov Juan Ignacio Elio Mariangelo Anastasiia Pokrass Svetlana Tikunova Galina Sakuta Andrew M. Soltisz Benjamin Hernandez Orengo Casey Beard Jenna Thuma Thomas J. Hund Rengasayee Veeraraghavan Jonathan P. Davis Sandor Gyorke Department of Physiology and Cell Biology The Ohio State University Columbus OH USA The Ohio State University Columbus OH USA Department of Biomedical Engineering The Ohio State University Columbus OH USA Interdisciplinary Biophysics Graduate Program The Ohio State University Columbus OH USA Davis Heart and Lung Research Institute The Ohio State University Columbus OH USA

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