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ASME 2013 Summer Bioengineering Conference, SBC 2013

作者： Williams, Megan Barkmeier-Kraemer, Julie Utzinger, Urs Geest, Jonathan Vande Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ United States BIO5 Institute University of Arizona Tucson AZ United States Department of Biomedical Engineering University of Arizona Tucson AZ United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ United States Voice and Swallowing Center University of California-Davis Davis CA United States

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Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm

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Biomatter 2013年第3期3卷 e24648页

作者： Haskett, Darren Azhar, Mohamad Utzinger, Urs Vande Geest, Jonathan P. Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States

AAA is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was to determine any changes that occur in the biomechanical response and fiber microstructure in the ApoE(-/-) AngII mouse model of aneurysm during disease progression. Adult ApoE(-/-) AngII infused mice along with wild-type controls were taken at 14 and 28 d. Aortas were excised and tested simultaneously for biaxial mechanical response and ECM organization. Data sets were fit to a Fung-type constitutive model to give peak strains and stiffness values. Images from two photon microscopy were quantified in order to assess the preferred fiber alignment and degree of fiber orientation. Biomechanical results found significant differences that were present at 14 d had returned to normal by 28 d along with significant changes in fiber orientation and dispersion indicating remodeling occurring within the aneurysmal wall. This return of some of the normal biomechanical function, in addition the continuing changes that occur in the microstructure suggest a restorative response that occurs in the ApoE(-/-) AngII infused model after the initial aneurysm formation.

关键词： AAA aneurysm AngII ApoE mechanical microstructure mouse model two-photon

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Abstracts from the Food Allergy and Anaphylaxis Meeting 2016 Abstracts

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CLINICAL AND TRANSLATIONAL ALLERGY 2017年第SUPPL 1期7卷 10-10页

作者： [Anonymous] Department of Pediatrics Children’s Hospital Roubaix France Division of Pulmonology and Allergology Department of Pediatrics Faculty of Medicine and Children’s Hospital Lille France Allergy Vigilance Network Vandoeuvre les Nancy France Université Lille 2 CHU Lille EA 2694 - Santé Publique: épidémiologie et qualité des soins Lille France Biostatistics Unit Maison Régionale de la Recherche Clinique CHRU Lille Lille France Department of Allergology Emile Durkheim Hospital Epinal France Centre d’Epidémiologie sur les Causes Médicales de Décès INSERM CHU de Bicêtre Le Kremlin-Bicêtre France The Allergy Vigilance Network University Hospital Nancy Nancy France Pediatric Pulmonology and Allergy Department Hôpital Jeanne de Flandre CHU Lille Lille France Charité - Universitätsmedizin Berlin Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité - Universitätsmedizin Berlin Berlin Germany Institute of Social Medicine Epidemiology and Health Economics Charité Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité – Universitätsmedizin Berlin Berlin Germany Department of Dermatology and Allergy Allergie-Centrum-Charité Charité-Universiätsmedizin Berlin Berlin Germany Department of Dermatology and Allergology Comprehensive Allergy Center Charité Charité Universitätsmedizin Berlin Berlin Germany University Hospital Basel Basel Switzerland Allergy Unit Department of Dermatology University Hospital Basel Switzerland Universitätsklinikum Salzburg Salzburg Austria Department of Dermatology and Allergy Centre Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark Odense University Hospital Odense Denmark Serviço de ImunoalergologiaCentro Hospitalar de São João E.P.E. Porto Portugal GRIAC Research Institute University of Groningen University Medical Center Groningen Groningen The Netherlands Serviço de Imunoalergologia Centr

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Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

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Scientific data 2017年第1期4卷 170179页

作者： Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmu Department of Molecular Biology Massachusetts General Hospital Boston Massachusetts USA. Program in Medical and Population Genetics Broad Institute Cambridge Massachusetts USA. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor Michigan USA. Wellcome Trust Centre for Human Genetics Nuffield Department of Medicine University of Oxford Oxford UK. Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts USA. Department of Statistics University of Oxford Oxford UK. Genetics of Complex Traits University of Exeter Medical School University of Exeter Exeter UK. MRC Epidemiology Unit Institute of Metabolic Science University of Cambridge Cambridge UK. Department of Twin Research and Genetic Epidemiology King's College London London UK. Oxford Centre for Diabetes Endocrinology and Metabolism Radcliffe Department of Medicine University of Oxford Oxford UK. Department of Human Genetics Wellcome Trust Sanger Institute Hinxton Cambridgeshire UK. School of Computer Science McGill University Montreal Quebec Canada. McGill University and Génome Québec Innovation Centre Montreal Quebec Canada. Human Genetics Center The University of Texas Graduate School of Biomedical Sciences at Houston The University of Texas Health Science Center at Houston Houston Texas USA. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA. National Heart Lung and Blood Institute's Framingham Heart Study Framingham Massachusetts USA. Medical Genomics and Metabolic Genetics Branch National Human Genome Research Institute National Institutes of Health Bethesda Maryland USA. Department of Biostatistics Harvard School of Public Health Boston Massachusetts USA. Chronic Disease Epidemiology Swiss Tropical and Public Health Institute University of Basel Basel Switzerland. Institute of Genetic Epidemiology Helmholtz Zentrum München German R

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

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Alterations in finite element results given constitutive models from tubular and planar biaxial testing of the same porcine coronary arteries

Alterations in finite element results given constitutive mod...

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ASME 2012 Summer Bioengineering Conference, SBC 2012

作者： Keyes, Joseph T. Lockwood, Danielle R. Vande Geest, Jonathan P. Graduate Interdisciplinary Program in Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ 85721 United States

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Estimation of sleep onset latency based on the correlation between blood pressure and heart beat interval

Estimation of sleep onset latency based on the correlation b...

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IEEE-EMBS International Conference on biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on biomedical and Health engineering

作者： Jung, Da Woon Chung, Gih Sung Hwang, Su Hwan Park, Kwang Suk Interdisciplinary Program of Bioengineering Seoul National University Graduate School Seoul 100 799 Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul 100 799 Korea Republic of

ISBN: (纸本)9781457721779

Sleep onset latency (SOL) provides an objective assessment of sleepiness and it also clinically useful as a sleep deprivation diagnostic tool. In this study, we suggest a new approach to estimate SOL based on the correlation between blood pressure (BP) and heart beat interval (HBI). This approach facilitates less intrusive finding of SOL as compared with currently using polysomnographic method. We hypothesized that the arterial baroreflex, one kind of reflex mechanism to regulate BP, takes a role of maintaining sleep's toning-down effect on BP. At the time of transition from full wakefulness to sleep, the toning-down effect starts to drop the BP and the arterial baroreflex is activated to maintain lowered BP by leading to increase in HBI for the elevated BP. Consequently, there is a great contribution of arterial baroreflex to HBI control. With a quantitative evaluation of the contribution, we tried to estimate SOL. For six healthy subjects (27.5 ± 3.15 years), the mean absolute error (MAE) was 0.3 ± 0.42 minutes. We expect our method can be applicable to non-intrusive and automatic SOL estimation system by not using electroencephalogram (EEG) sensors. © 2012 IEEE.

关键词： Blood pressure

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Biomaterials: Nanowell-Trapped Charged Ligand-Bearing Nanoparticle Surfaces: A Novel Method of Enhancing Flow-Resistant Cell Adhesion (Adv. Healthcare Mater. 7/2013)

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Advanced Healthcare Materials 2013年第7期2卷

作者： Phat L. Tran Jessica R. Gamboa Katherine E. McCracken Mark R. Riley Marvin J. Slepian Jeong-Yeol Yoon Biomedical Engineering Graduate Interdisciplinary Program and Department of Biomedical Engineering The University of Arizona Tucson Arizona 85721 USA Department of Agricultural and Biosystems Engineering The University of Arizona Tucson Arizona 85721 USA Sarver Heart Center and Department of Medicine College of Medicine The University of Arizona Tucson Arizona 85721 USA

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Spike train distance metric reveals plasticity in discrimination of salient calls by putative excitatory cells of the auditory cortex

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BMC Neuroscience 2012年第1期13卷 1-2页

作者： Charles L Zhao Frank Lin Robert C Liu Biomedical Engineering Graduate Program Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University Atlanta GA 30332 USA Interdisciplinary Bioengineering Graduate Program Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University Atlanta GA 30332 USA Department of Biology Emory University Atlanta GA 30322 USA

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Progressive alterations in biomechanical response of a mouse model of aneurysm

Progressive alterations in biomechanical response of a mouse...

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ASME 2012 Summer Bioengineering Conference, SBC 2012

作者： Haskett, Darren Utzinger, Urs Azhar, Mohamad Geest, Jonathan Vande Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ 85721 United States Department of Biomedical Engineering University of Arizona Tucson AZ 85721 United States BIO5 Institute University of Arizona Tucson AZ 85721 United States Department of Cell Biology and Anatomy University of Arizona Tucson AZ 85721 United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ 85721 United States

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Proceedings of the 3rd IPLeiria's International Health Congress Abstracts

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BMC HEALTH SERVICES RESEARCH 2016年第3期16卷 111-242页

作者： [Anonymous] Health Sciences Research Unit: Nursing Collegue of College of Health Technology of Coimbra Coimbra Portugal Sisters Hospitallers of the Sacred Heart of Jesus Casa de Saúde Rainha Santa Isabel Coimbra Portugal Research Unit for Sport and Physical Activity Faculty of Sport Sciences and Physical Education University of Coimbra Coimbra Portugal Complementary Sciences- INESCC Coimbra Portugal CUF Hospitals Lisbon Portugal Breast Unit Champalimaud Clinical Center Lisbon Portugal Swiss Centre for Medical Simulation & Swiss Association of Simulation in Healthcare Basel Switzerland Basel University Hospital Basel Switzerland HELPO Association Cascais Portugal Centro de Linguística Universidade de Lisboa Lisboa Portugal Centro Superior de Estudios Universitarios La Salle Madrid Spain Universidade da Madeira Funchal Portugal Serviço de Saúde da Região Autónoma da Madeira E.P.E. Funchal Portugal Escola Superior de Enfermagem de Lisboa Lisboa Portugal Instituto Superior Miguel Torga Coimbra Portugal Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo Comportamental Universidade de Coimbra Coimbra Portugal Escola Superior de Saúde de Leiria & Unidade de Investigação em Saúde Instituto Politécnico de Leiria Leiria Portugal National School of Public Health & Centro de Investigação em Saúde Pública Universidade Nova de Lisboa Lisboa Portugal Agrarian Superior School Polytechnic Institute of Viseu Viseu Portugal Laboratory of Microbiology Department of Biological Sciences Faculty of Pharmacy University of Porto Porto Portugal Unit for Multidisciplinary Biomedical Research Institute of Biomedical Sciences Abel Salazar University of Porto Porto Portugal Agrupamento de Centros de Saúde (ACES) Baixo Mondego Figueira da Foz Portugal Universidade de Trás-os-Montes e Alto Douro Vila Real Portugal Centro de Salud La Paz Badajoz España Centro de Salud San Fernando Badajoz España Complejo Hospitalario Universitario de Badajoz Badajoz España Hospital Don Beni

S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion of a home fortification programme with micronutrient powders (MNP) in the Autonomous Region of Príncipe, São Tomé and Príncipe Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Bonfim, Carina Silva S6 Safety culture of the patient: a reflexion about the therapeutic approach on the patient with vocal pathology Débora Franco S7 About wine, fortune cookies and patient experience Jesús Alcoba González O1 The psychological impact on the emergency crews after the disaster event on February 20, 2010 Helena G. Jardim, Rita Silva O2 Musculoskeletal disorders in midwives Cristina L. Baixinho, Mª Helena Presado, Mª Fátima Marques, Mário E. Cardoso O3 Negative childhood experiences and fears of compassion: Implications for psychological difficulties in adolescence Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto O4 Optimal age to give the first dose of measles vaccine in Portugal João G. Frade, Carla Nunes, João R. Mesquita, Maria S. Nascimento, Guilherme Gonçalves O5 Functional assessment of elderly in primary care Conceição Castro, Alice Mártires, Mª João Monteiro, Conceição Rainho O6 Smoking and coronary events in a population of Spanish health-care centre: An observational study Francisco P. Caballero, Fatima M. Monago, Jose T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco B. Ramirez O7 Prevalence of musculoskeletal injuries in Por

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