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Zwitterionic modified and freeze-thaw reinforced foldable hydrogel as intraocular lens for posterior capsule opacification prevention

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Biomaterials 2024年 309卷 122593-122593页

作者： Yang, Cheng-Jui Huang, Wei-Lun Yang, Yu Kuan, Chen-Hsiang Tseng, Ching-Li Wang, Tzu-Wei Department of Materials Science and Engineering National Tsing Hua University Hsinchu Taiwan Department of Ophthalmology National Taiwan University Hospital Hsin-Cchu Branch Hsinchu Taiwan Interdisciplinary Program of Life Science and Medicine National Tsing Hua University Hsinchu Taiwan Division of Plastic Surgery Department of Surgery National Taiwan University Hospital Taipei Taiwan Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University Taipei Taiwan

Posterior capsule opacification (PCO) is a predominant postoperative complication, often leading to visual impairment due to the aberrant proliferation and adhesion of lens epithelial cells (LECs) and protein precipitates subsequent to intraocular lens (IOL) implantation. To address this clinical issue, a foldable and antifouling sharp-edged IOL implant based on naturally-derived cellulose hydrogel is synthesized. The mechanical strength and transparency of the hydrogel is enhanced via repeated freeze-thaw (FT) cycles. The incorporated zwitterionic modifications can remarkably prevent the incidence of PCO by exhibiting proteins repulsion and cell anti-adhesion properties. The graft of dopamine onto both the haptic and the periphery of the posterior surface ensures the adhesion of the hydrogel to the posterior capsule and impedes the migration of LECs without compromising transparency. In in vivo study, the zwitterionic modified foldable hydrogel exhibits uveal and capsular biocompatibility synchronously with no signs of inflammatory response and prevent PCO formation, better than that of commercialized and PEG-modified IOL. With foldability, endurability, antifouling effect, and adhesive to posterior capsule, the reported hydrogel featuring heterogeneous surface design displays great potential to eradicate PCO and attain post-operative efficacy after cataract surgery. © 2024 Elsevier Ltd

关键词： Hydrogels

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Biomaterials: Nanowell-Trapped Charged Ligand-Bearing Nanoparticle Surfaces: A Novel Method of Enhancing Flow-Resistant Cell Adhesion (Adv. Healthcare Mater. 7/2013)

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Advanced Healthcare Materials 2013年第7期2卷

作者： Phat L. Tran Jessica R. Gamboa Katherine E. McCracken Mark R. Riley Marvin J. Slepian Jeong-Yeol Yoon Biomedical Engineering Graduate Interdisciplinary Program and Department of Biomedical Engineering The University of Arizona Tucson Arizona 85721 USA Department of Agricultural and Biosystems Engineering The University of Arizona Tucson Arizona 85721 USA Sarver Heart Center and Department of Medicine College of Medicine The University of Arizona Tucson Arizona 85721 USA

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#52. Computational modeling of signaling pathways and cell-cell interactions driving tumor-induced bone disease

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Journal of Bone Oncology 2024年 45卷 100590-100590页

作者： Vega, Alexandra Gutierrez Alshafeay, Saja Bennett, Natalie Beadle, Erik Rhoades, Julie Harris, Leonard A. Interdisciplinary Graduate Program in Cell and Molecular Biology University of Arkansas United States Vanderbilt Center for Bone Biology Vanderbilt University School of Medicine United States Department of Biomedical Engineering University of Arkansas United States

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Gene knockout inference with variational graph autoencoder learning single-cell gene regulatory networks

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Nucleic acids research 2023年第13期51卷 6578-6592页

作者： Yongjian Yang Guanxun Li Yan Zhong Qian Xu Bo-Jia Chen Yu-Te Lin Robert S Chapkin James J Cai Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA. Department of Statistics Texas A&M University College Station TX 77843 USA. Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of Statistics East China Normal University 3663 North Zhongshan Road Shanghai 200062 China. Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA. Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan. Program in Integrative & Complex Diseases Department of Nutrition Texas A&M University College Station TX 77843 USA. Interdisciplinary Program of Genetics Texas A&M University College Station TX 77843 USA.

In this paper, we introduce Gene Knockout Inference (GenKI), a virtual knockout (KO) tool for gene function prediction using single-cell RNA sequencing (scRNA-seq) data in the absence of KO samples when only wild-type (WT) samples are available. Without using any information from real KO samples, GenKI is designed to capture shifting patterns in gene regulation caused by the KO perturbation in an unsupervised manner and provide a robust and scalable framework for gene function studies. To achieve this goal, GenKI adapts a variational graph autoencoder (VGAE) model to learn latent representations of genes and interactions between genes from the input WT scRNA-seq data and a derived single-cell gene regulatory network (scGRN). The virtual KO data is then generated by computationally removing all edges of the KO gene-the gene to be knocked out for functional study-from the scGRN. The differences between WT and virtual KO data are discerned by using their corresponding latent parameters derived from the trained VGAE model. Our simulations show that GenKI accurately approximates the perturbation profiles upon gene KO and outperforms the state-of-the-art under a series of evaluation conditions. Using publicly available scRNA-seq data sets, we demonstrate that GenKI recapitulates discoveries of real-animal KO experiments and accurately predicts cell type-specific functions of KO genes. Thus, GenKI provides an in-silico alternative to KO experiments that may partially replace the need for genetically modified animals or other genetically perturbed systems.

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Plasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics

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Advanced Healthcare Materials 2023年第28期12卷 e2301504页

作者： Liu, Chia-Hung Liu, Ming-Che Jheng, Pei-Ru Yu, Jiashing Fan, Yu-Jui Liang, Jia-Wei Hsiao, Yu-Cheng Chiang, Chih-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Mansel, Bradley W Chen, Yan-Ting Nguyen, Hieu Trung Chuang, Er-Yuan Department of Urology School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center of Urology and Kidney Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Urology Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road Zhonghe District New Taipei City23561 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei11031 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering Graduate Institute of Biomedical Optomechatronics School of Biomedical Engineering Research Center of Biomedical Device Innovation Entrepreneurship Education Center College of Interdisciplinary Studies Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering College of Engineering National Taiwan University Taipei106 Taiwan Department of Orthopedics Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Department of Physical Electronics Faculty of Science Masaryk University Brno60177 Czech Republic Department of Materials Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City24301 Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Cell Physiology and Molecular Image Research Center Taipei Medical University Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) phototherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by ≈80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment. © 2023 Wiley-VCH GmbH.

关键词： Diseases

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Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis

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IBRO Reports 2019年 6卷 S342-S343页

作者： Hyowon Hong Kwangsic Joo Sang Min Park Jimyung Seo Min Hwan Kim Eunbie Shin Hae Il Cheong Jeong Ho Lee Joon Kim Biomedical Science and Engineering Interdisciplinary Program KAIST Daejeon Republic of Korea Department of Opthalmology Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon Republic of Korea Research Coordination Center for Rare Disease Seoul National University Hospital Seoul Republic of Korea

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Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs

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EXPERIMENTAL AND MOLECULAR MEDICINE 2023年第12期55卷 2609-2609页

作者： Kim, Junsoo Youn, Daehwa Choi, Seunghoon Lee, Youn Woo Sumberzul, Dulguun Yoon, Jeongeun Lee, Hanju Bae, Jong Woo Noh, Hyuna On, Dain Hong, Seung-Min An, Se-Hee Jang, Hui Jeong Kim, Seo Yeon Kim, Young Been Hwang, Ji-Yeon Lee, Hyo-Jung Kim, Hong Bin Park, Jun Won Yun, Jun-Won Shin, Jeon-Soo Seo, Jun-Young Nam, Ki Taek Choi, Kang-Seuk Lee, Ho-Young Chang, Hyeshik Seong, Je Kyung Cho, Jun Center for RNA Research Institute for Basic Science (IBS) Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Korea Mouse Phenotyping Center (KMPC) Seoul National University Seoul Republic of Korea Laboratory of Developmental Biology and Genomics Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Department of Nuclear Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea School of Biological Sciences Seoul National University Seoul Republic of Korea Laboratory of Avian Diseases Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Preclinical Research Center Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Periodontology Section of Dentistry Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea Division of Biomedical Convergence College of Biomedical Science Kangwon National University ChunCheon Republic of Korea Laboratory of Veterinary Toxicology College of Veterinary Medicine Seoul National University Seoul Republic of Korea Severance Biomedical Science Institute Graduate School of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul Republic of Korea Department of Nuclear Medicine Seoul National University College of Medicine Seoul Republic of Korea Interdisciplinary Program and BIO MAX Institute Seoul National University

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Correction: Analysis of Photoplethysmography-Based Surgical Pain Severity Assessment Markers

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Journal of Electrical engineering & Technology 2024年第8期19卷 5439-5439页

作者： Ryu, Gayeon Choi, Jae Moon Lee, Jaehyung Seok, Hyeon Seok Shin, Hangsik Choi, Byung-Moon Department of Digital Medicine Brain Korea 21 Project Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea Department of Anesthesiology and Pain Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea Interdisciplinary Program of Biomedical Engineering Graduate School Chonnam National University Yeosu Republic of Korea

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Electron Tomography Finds Three-Dimensional Chromatin Packing Domain Structure in Single Cell Different from Topological Associated Domains

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Microscopy and Microanalysis 2024年第SUPPLEMENT_1期30卷

作者： Li, Wing Shun Carter, Lucas Almassalha, Luay Pujadas, Emily Carignano, Marcelo Bleher, Reiner dos Reis, Roberto Backman, Vadim Dravid, Vinayak Applied Physics Program Northwestern University Evanston IL USA Department of Biomedical Engineering Northwestern University Evanston IL USA IBIS Interdisciplinary Biological Sciences Graduate Program Northwestern University Evanston IL USA Department of Materials Sciences and Engineering Northwestern University Evanston IL USA Northwestern University Atomic and Nanoscale Characterization Experimental (NUANCE) Center Northwestern University Evanston IL USA International Institute of Nanotechnology Northwestern University Evanston IL USA

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Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification

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Nature Communications 2024年第1期15卷 2187页

作者： Turner, Mackenzie E. Blum, Kevin M. Watanabe, Tatsuya Schwarz, Erica L. Nabavinia, Mahboubeh Leland, Joseph T. Villarreal, Delaney J. Schwartzman, William E. Chou, Ting-Heng Baker, Peter B. Matsumura, Goki Krishnamurthy, Rajesh Yates, Andrew R. Hor, Kan N. Humphrey, Jay D. Marsden, Alison L. Stacy, Mitchel R. Shinoka, Toshiharu Breuer, Christopher K. Center for Regenerative Medicine Research Institute at Nationwide Children’s Hospital Columbus OH United States Molecular Cellular and Developmental Biology Graduate Program The Ohio State University Columbus OH United States The Ohio State University College of Medicine Columbus OH United States Department of Biomedical Engineering Yale University New Haven CT United States Biomedical Sciences Graduate Program The Ohio State University College of Medicine Columbus OH United States Department of Exercise and Health Science National Taipei University of Nursing and Health Sciences Taipei City Taiwan Pathology Department at Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Medical Safety Management Tokyo Women’s Medical University Tokyo Japan Department of Radiology Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Pediatrics The Ohio State University College of Medicine Columbus OH United States The Heart Center Nationwide Children’s Hospital Columbus OH United States Departments of Pediatrics and Bioengineering Stanford University Stanford CA United States Department of Surgery The Ohio State University College of Medicine Columbus OH United States Interdisciplinary Biophysics Graduate Program The Ohio State University Columbus OH United States Department of Cardiothoracic Surgery Nationwide Children’s Hospital Columbus OH United States Department of Surgery Nationwide Children’s Hospital Columbus OH United States

Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p < 0.001) and animal models (p < 0.0001). Further assessments of graft compliance reveal that tissue-engineered vascular grafts maintain greater compliance (p < 0.0001) and distensibility (p < 0.001) than polytetrafluoroethylene grafts. These properties improve graft hemodynamic performance, as validated through computational fluid dynamics simulations. We demonstrate the promise of tissue engineered vascular grafts, remaining compliant and distensible while resisting long-term calcification, to enhance the long-term success of congenital heart surgeries. © The Author(s) 2024.

关键词： Translational research Cardiac device therapy Cardiovascular models

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