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IEEE/ICME International Conference on Complex Medical engineering, CME

作者： Phat. L. Tran Yee Tchao Jeong-Yeol Yoon Biomedical Engineering Graduate Interdisciplinary Program University of Arizona Tucson Tucson AZ USA Department of Veterinary Science and Microbiology University of Arizona Tucson Tucson AZ USA Department of Agricultural and Biosystems Engineering and Biomedical Engineering Graduate Interdisciplinary Program University of Arizona Tucson Tucson AZ USA

An alternative approach for fabricating a protein array at nanoscale (<100 nm) is suggested with a capability of characterization and/or localization of multiple components on a nanoarray. Basically, fluorescent micro- and nanospheres each conjugated with different proteins are size-dependently self-assembled (SDSA) onto these nanometer wells that were created on the polymethyl methacrylate (PMMA) substrate by electron beam lithography (EBL). Particles of different diameters are added serially, and electrostatically attached to the corresponding wells through electrostatic attraction between the carboxylic groups of the spheres and p-doped silicon substrate underneath the PMMA layer. Target detection utilizes fluorescence resonance energy transfer (FRET) from fluorescent beads to target (mouse immunoglobulin G = mIgG or Octamer-4 = Oct4) and its antibody bound on the beads. The 180 nm blue beads are conjugated with mIgG to capture anti-mIgG-FITC. The 50 nm green and 100 nm yellow-green beads are conjugated with anti-Oct4 to capture Oct4 peptides; where the secondary anti-Oct4 tagged with phycoerythrin via F(ab)2 fragment is then added to function as an indicator of Oct4 detection. These protein-conjugated particles are added serially from the largest to the smallest and the particles are successfully self-assembled to the respective nanometer wells to achieve size-dependent self-assembly. FRET signals are detected through fluorescence and confocal microscopes, and further confirmed by Fluorolog3 spectrofluorometer. Therefore, SDSA is a valuable approach for the fabrication of multiple components array; and FRET is a useful biorecognition technique for the detection of mIgG, Oct4 or other targets of interest.

关键词： Fluorescence Resonance Energy exchange Mice Proteins Self-assembly Immune system Electron beams Lithography Electrostatics

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Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis

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Scientific Reports 2025年第1期15卷 1-12页

作者： Wassamon Moyadee Jatuporn Rattanasrisomporn Sittiruk Roytrakul Janthima Jaresitthikunchai Narumon Phaonakrop Kiattawee Choowongkomon Sekkarin Ploypetch Natthasit Tansakul Amonpun Rattanasrisomporn Graduate Program in Animal Health and Biomedical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Department of Companion Animal Clinical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency Pathum Thani Thailand Department of Biochemistry Faculty of Science Kasetsart University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veterinary Science Mahidol University Nakhon Pathom Thailand Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Interdisciplinary of Genetic Engineering and Bioinformatics Graduate School Kasetsart University Bangkok Thailand

Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers the potential to identify novel biomarkers that could improve the diagnosis and management of FIP. This study aims to assess the serum proteome and identify proteins that differentiate healthy cats from cats diagnosed with effusive FIP using liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS). A total of 30 cats diagnosed with effusive FIP and 27 clinically normal cats were enrolled. Twenty-three proteins were significantly (p< 0.01, ≥ fivefold change in abundance) differentially expressed between cats with effusive FIP and controls. Among these, the P2X purinoceptor, DNA topoisomerase, Notch receptor 2, and cadherin-17 were identified as key proteins of interest in cats with effusive FIP. Our findings suggest that these differentially expressed proteins could serve as potential diagnostic biomarkers and therapeutic targets for FIP. However, further studies are needed to validate these findings and explore their potential applications.

关键词： Biomarkers Cats Coronavirus Feline infectious peritonitis Proteomics Serum

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Spike train distance metric reveals plasticity in discrimination of salient calls by putative excitatory cells of the auditory cortex

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BMC Neuroscience 2012年第1期13卷 1-2页

作者： Charles L Zhao Frank Lin Robert C Liu Biomedical Engineering Graduate Program Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University Atlanta GA 30332 USA Interdisciplinary Bioengineering Graduate Program Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University Atlanta GA 30332 USA Department of Biology Emory University Atlanta GA 30322 USA

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System for unconstrained ECG measurement on a toilet seat using capacitive coupled electrodes : The efficacy and practicality

System for unconstrained ECG measurement on a toilet seat us...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Hyun Jae Baek Jung Soo Kim Ko Keun Kim Kwang Suk Park Interdisciplinary Program of Bioengineering Seoul National University Graduate School Republic of Korea Interdisciplinary Program in Medical and Biological Engineering Seoul National University Graduate School Republic of Korea Department of Biomedical Engineering Seoul National University Republic of Korea

Home healthcare is a common matter of concern to modern people. For the successful home healthcare, unconstrained bio-signal monitoring is important. Previously, unconstrained lavatory typed ECG measurement system was developed. It is enough to measure subject's ECG signal non-intrusively, but not practical because of moist environment of toilet. In this study, capacitive coupled electrode was employed for overcome above disadvantages. ECG was obtained by capacitive coupled electrode and compared with ECGs obtained from conventional Ag/AgCl electrode. Possible motion artifacts were investigated. Experimental results showed that toilet based capacitive coupled ECG signal was measured successfully.

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VR-Based Implicit Authentication Using Electromyogram and Inertial Measurement Unit 23

VR-Based Implicit Authentication Using Electromyogram and In...

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23rd International Conference on Cyberworlds, CW 2024

作者： Yu, Da-Young Lee, Hyung-Tak Kim, Youngsam Roh, Jong-Hyuk Kim, Soohyung Ku, Jeonghun Hwang, Han-Jeong Korea University Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Dept. Electronics and Information Engineering Sejong Korea Republic of Korea University Dept. Electronics and Information Engineering Sejong Korea Republic of Daejeon Korea Republic of Keimyung University College of Medicine Department of Biomedical Engineering Daegu Korea Republic of

ISBN: (纸本)9798331527174

Biometrics based on electromyogram (EMG) and inertial measurement unit (IMU) signals has received significant attention due to its resistance to forgery and tampering, as well as its relatively higher convenience and security compared to other biometric modalities. However, most EMG and IMU signal-based authentication methods require explicit authentication using unnatural gestures, which is not userfriendly. To address this, we collected EMG and IMU data during virtual reality (VR) rhythm game play, which does not require explicit gestures, and performed implicit authentication. Using a linear discriminant analysis (LDA) classifier, we achieved classification accuracies of 91.71% for human identification and 87.91% for human authentication. The result demonstrated the feasibility of a seamless and implicit authentication in VR environments. © 2024 IEEE.

关键词： Electromyography

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Quantifying the microstructure of human sclera using small angle light scattering

Quantifying the microstructure of human sclera using small a...

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10th ASME Summer Bioengineering Conference, SBC2008

作者： Eskinazi, Amanda E. Vande Geest, Jonathan P. Department of Biosystems Engineering University of Arizona Tucson AZ United States Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ United States Biomedical Engineering Graduate Interdisciplinary Program University of Arizona Tucson AZ United States BIO5 Institute University of Arizona Tucson AZ United States

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Clinical text generation through leveraging medical concept and relations

arXiv

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arXiv 2019年

作者： Lee, Wangjin Park, Hyeryun Yoon, Jooyoung Kim, Kyeongmo Choi, Jinwook Interdisciplinary Program in Bioengineering Graduate School Seoul National University Department of Biomedical Engineering College of Medicine Seoul National University

With a neural sequence generation model, this study aims to develop a method of writing the patient clinical texts given a brief medical history. As a proof-of-a-concept, we have demonstrated that it can be workable to use medical concept embedding in clinical text generation. Our model was based on the Sequence-to-Sequence architecture and trained with a large set of de-identified clinical text data. The quantitative result shows that our concept embedding method decreased the perplexity of the baseline architecture. Also, we discuss the analyzed results from a human evaluation performed by medical doctors. Copyright © 2019, The Authors. All rights reserved.

关键词： Embeddings

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Automatic control of assist flow in totally implantable left ventricular assist device using variable pump rate

Automatic control of assist flow in totally implantable left...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jonghoon Choi Jaesoon Choi Youngho Jo Wukeun Kim Byunggoo Min Interdisciplinary Program of Medical and Biological Engineering Graduate School Japan Department of Biomedical Engineering College of Medicine Seoul National University South Korea

In this study, the automatic control algorithm in implantable left ventricular assist device to regulate cardiac output to the extent of preventing atrial-collapse and the high left atrial pressure (LAP) is proposed. Intersac pressure (ISP) waveform which reflects the status of left atrial pressure is used in automatic control. By analyzing the relationship between LAP and the negative peak of ISP, the equation for making the reference of PI-controller was set. By using the reference equation the proposed automatic controller which regulates the assist flow was designed. Through mock circulatory experiments and animal experiment, the automatic control algorithm was evaluated.

关键词： Automatic control Equations Blood Algorithm design and analysis biomedical engineering Pi control engineering in medicine and biology Educational institutions Electronic mail Animals

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Effect modification by cardiovascular and metabolic disease onset on long-term PM2.5 exposure and mortality: a nationwide cohort study

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Scientific Reports 2025年第1期15卷 1-14页

作者： Hyemin Jang Jinah Park Jeongmin Moon Insung Song Ayoung Kim Cinoo Kang Jieun Oh Dohoon Kwon Ho Kim Eun Soo Lee Dongmug Kang Seoyeong Ahn Whanhee Lee Jieun Min Ejin Kim Michelle L. Bell Department of Public Health Sciences Graduate School of Public health Seoul National University Seoul South Korea Department of Occupational and Environmental Medicine Pusan National University Yangsan Hospital Yangsan South Korea Department of Preventive and Occupational & Environmental Medicine School of Medicine Pusan National University Yangsan South Korea School of Biomedical Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan South Korea Research and Management Center for Health Risk of Particulate Matter Seoul South Korea Department of Environmental Medicine College of Medicine Ewha Womans University Seoul South Korea Institute of Health and Environment Graduate School of Public Health Seoul National University Seoul South Korea School of the Environment Yale University New Haven CT USA Interdisciplinary Program in Precision Public Health Department of Public Health Sciences Graduate School of Korea University Seoul South Korea

Cardiovascular and metabolic diseases–specifically myocardial infarction, congestive heart failure, cerebrovascular disease, peripheral vascular disease, renal disease, and liver disease–are major public health concerns worldwide. However, studies examining how these diseases modify the relationship between long-term PM2.5exposure and mortality remain scarce. Using a Cox regression model with a population-representative cohort from South Korea, we estimated the modifying effects of six major cardiovascular and metabolic diseases on PM2.5-mortality association in two cohorts: (1) individuals without underlying diseases (NoUD) and (2) those with only hypertension and/or diabetes (HTN/DM). The interaction between PM2.5and each disease onset was used to estimate effect modification, with results presented as relative hazard ratios (RHRs) per 10 µg/m3increase in PM2.5. Among 183,834 subjects, non-accidental deaths occurred in 18.0% of the NoUD (N= 134,584) and 25.7% of the HTN/DM (N= 49,250). In the NoUD cohort, renal disease (RHR: 1.58; 95% CI: 1.27–1.97), myocardial infarction (1.41; 1.15–1.73), and liver disease (1.40; 1.25–1.57) significantly modified the effect of PM2.5on mortality. In the HTN/DM cohort, renal disease (1.74; 1.43–2.12), myocardial infarction (1.62; 1.29–2.05), and cerebrovascular disease (1.32; 1.17–1.51) showed higher RHRs. Our findings highlight the importance of consistent and preemptive care for renal disease and myocardial infarction and provide evidence for target-specific interventions to reduce the risk of PM2.5on mortality.

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A portable flow cytometer with simultaneous detection of impedance and fluorescence

A portable flow cytometer with simultaneous detection of imp...

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13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009

作者： Kim, Kee Hyun Joo, Segyeong Noh, Jong Min Chung, Taek Dong Kim, Hee Chan Interdisciplinary Program Graduate School Seoul National University Korea Republic of Institute of Medical and Biological Engineering Medical Research Center Seoul National University Korea Republic of Department of Chemistry Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9780979806421

A portable flow cytometer with simultaneous detection of impedance and fluorescence was constructed incorporating polyelectrolytic gel electrodes (PGE) based impedance measurement and fluorescence measurement with integrated solid-state photonic devices. Simultaneous detection of fluorescence and impedance signal was performed with fluorescent and plain beads. The fluorescence and impedance signal were in good sync with flow of beads. © 2009 CBMS.

关键词： Fluorescence

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