检索结果-内蒙古大学图书馆

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Hyoseon Jeon Sang Kyong Kim BeomSeok Jeon Kwang Suk Park Interdisciplinary Program in Medical and Biological Engineering Graduate School Seoul National University South Korea Department of Neurology Seoul National University Hospital South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea

The purpose of this paper is to assess Parkinson tremor estimating actual distance amplitude. We propose a practical, useful and simple method for evaluating Parkinson tremor with distance value. We measured resting tremor of 7 Parkinson Disease (PD) patients with triaxial accelerometer. Resting tremor of participants was diagnosed by Unified Parkinson's Disease Rating Scale (UPDRS) by neurologist. First, we segmented acceleration signal during 7 seconds from recorded data. To estimate a displacement of tremor, we performed double integration from the acceleration. Prior to double integration, moving average method was used to reduce an error of integral constant. After estimation of displacement, we calculated tremor distance during 1s from segmented signal using Euclidean distance. We evaluated the distance values compared with UPDRS. Averaged moving distance during 1 second corresponding to UPDRS 1 was 11.52mm, that of UPDRS 2 was 33.58mm and tremor distance of UPDRS 3 was 382.22 mm. Estimated moving distance during 1s was proportional to clinical rating scale — UPDRS.

关键词： Acceleration Accelerometers Educational institutions Three dimensional displays Surgery Thumb

来源：评论

学校读者我要写书评

暂无评论

High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor 16

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

引用

16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： Nanoclay

来源：评论

学校读者我要写书评

暂无评论

Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimer＇s disease diagnosis

引用

Bio-Design and Manufacturing 2018年第3期1卷 182-194页

作者： Leming Sun Zhen Fan Tao Yues Jun Yin Jianzhong FU Mingjun Zhang Department of Biomedical Engineering College ofEngineering Ohio State University Columbus OH 43210USA School of Life Sciences Northwestern PolytechnicalUniversity Xi'an 710072 Shaanxi China Department of Polymeric Materials School of MaterialScience and Engineering Tongji UniversityShanghai 201804 China Institute for Advanced Study TongjiUniversity Shanghai 200092 China School of Mechatronic Engineering and Automation Shanghai University Shanghai 200444 China The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering ZhejiangUniversity Hangzhou 310028 China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang University Hangzhou 310028 China Dorothy M. Davis Heart & Lung Research Institute The OhioState University Wexner Medical Center Columbus OH43210 USA Interdisciplinary Biophysics Graduate Program Ohio StateUniversity Columbus OH 43210 USA

This paper proposes an additive nanomanufacturing approach to fabricate a personalized lab-on-a-chip fluorescent peptide nanoparticles （f-PNPs） array for simultaneous multi-biomarker detection that can be used in Alzheimer＇s disease （AD） diagnosis. We will discuss optimization techniques for the additive nanomanufacturing process in terms of reliability, yield and manufacturing efficiency. One contribution of this paper lies in utilization of additive nanomanufacturing techniques to fabricate a patient-specific customize-designed lab-on-a-chip device for personalized AD diagnosis, which remains a major challenge for biomedical engineering. Through the integrated bio-design and bio-manufacturing process, doctor＇s check- up and computer-aided customized design are integrated into the lab-on-a-chip array for patient-specific AD diagnosis. In addition, f-PNPs with targeting moieties for personalized AD biomarkers will be self-assembled onto the customized lab-on-a- chip through the additive nanomanufacturing process, which has not been done before. Another contribution of this research is the personalized lab-on-a-chip f-PNPs array for AD diagnosis utilizing limited human blood. Blood-based AD assessment has been described as ＂the holy grail＂ of early AD detection. This research created the computer-aided design, fabrication through additive nanomanufacturing, and validation of the f-PNPs array for AD diagnosis. This is a highly interdisciplinary research contributing to nanotechnology, biomaterials, and biomedical engineering for neurodegenerative disease. The conceptual work is preliminary with intent to introduce novel techniques to the application. Large-scale manufacturing based on the proposed framework requires extensive validation and optimization.

关键词： Nanomanufacturing Lab-on-a-chip Fluorescent peptide nanoparticle Alzheimer＇s disease Diagnosis

来源：评论

学校读者我要写书评

暂无评论

Theoretical identification of thermostabilizing amino acid mutations for G-protein-coupled receptors

引用

Biophysical Reviews 2020年第2期12卷 323-332页

作者： Murata, Takeshi Yasuda, Satoshi Hayashi, Tomohiko Kinoshita, Masahiro Graduate School of Science Chiba University 1-33 Yayoi-cho Inage Chiba 263-8522 Japan Molecular Chirality Research Center Chiba University 1-33 Yayoi-cho Inage Chiba 263-8522 Japan Institute of Advanced Energy Kyoto University Uji Kyoto 611-0011 Japan Present address: Interdisciplinary Program of Biomedical Engineering Assistive Technology and Art and Sports Sciences Faculty of Engineering Niigata University 8050 Ikarashi 2-no-cho Nishi-ku Niigata 950-2181 Japan

Thermostabilization of a membrane proteins, especially G-protein-coupled receptors (GPCRs), is often necessary for biochemical applications and pharmaceutical studies involving structure-based drug design. Here we review our theoretical, physics-based method for identifying thermostabilizing amino acid mutations. Its novel aspects are the following: The entropic effect originating from the translational displacement of hydrocarbon groups within the lipid bilayer is treated as a pivotal factor;a reliable measure of thermostability is introduced and a mutation which enlarges the measure to a significant extent is chosen;and all the possible mutations can be examined with moderate computational effort. It was shown that mutating the residue at a position of N_BW = 3.39 (N_BW is the Ballesteros-Weinstein number) to Arg or Lys leads to the stabilization of significantly many different GPCRs of class A in the inactive state. Up to now, we have been successful in stabilizing several GPCRs and newly solving three-dimensional structures for the muscarinic acetylcholine receptor 2 (M2R), prostaglandin E receptor 4 (EP4), and serotonin 2A receptor (5-HT_2AR) using X-ray crystallography. The subjects to be pursued in future studies are also discussed. © 2020, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： G-protein-coupled receptor Integral equation theory Lipid bilayer Membrane protein Morphometric approach Protein folding Solvation thermodynamics Thermostabilizing mutation

来源：评论

学校读者我要写书评

暂无评论

A Mechanized Pediatric Elbow Joint Powered by a De-Based Artificial Skeletal Muscle*

A Mechanized Pediatric Elbow Joint Powered by a De-Based Art...

引用

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： A. Behboodi C. DeSantis J. Lubsen S.C.K. Lee Venture Development Center University of Delaware Newark DE USA Mechanical Engineering Department University of Delaware Newark DE USA Departments of Physical Therapy Biomedical Engineering and Interdisciplinary Graduate Program in Biomechanics and Movement Science University of Delaware Newark DE USA

ISBN: (数字)9781728119908

ISBN: (纸本)9781728119915

To increase the acceptability of exoskeletons, there is growing attention toward finding an alternative soft actuator that can safely perform at close vicinity of the human body. In this study, we investigated the capability of the dielectric elastomer actuators (DEAs), for muscle-like actuation of rehabilitation robots. First, an artificial skeletal muscle was configured using commercially available stacked DEAs arranged in a 3×4 array of three parallel fibers consisting of four DEAs connected in series. The shortening and force generation capabilities of this artificial muscle were then measured. An alternate 3×5 version of this muscle was mounted on the forearm of an upper extremity phantom model to actuate its elbow joint. The actuation capability of this muscle was then tested under various tensile loads, 1 N to 4 N, placed at the center of mass of the forearm+hand of the phantom model. The active range of motion and angular velocity of the phantom model's tip of the hand were measured using a motion capture system. The 3×4 artificial muscle produced 30.47 N of force and 5.3 mm of maximum shortening. The 3×5 artificial muscle was capable of actuating the elbow flexion 19.5 o with 16.2 o /s angular velocity in the sagittal plane, under a 1 N tensile load. The active range of motion was substantially reduced as the tensile loads increased, which limits the capability of these muscles in the current upper extremity exoskeleton design.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm

引用

Biomatter 2013年第3期3卷 e24648页

作者： Haskett, Darren Azhar, Mohamad Utzinger, Urs Vande Geest, Jonathan P. Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States Graduate Interdisciplinary Program of Biomedical Engineering University of Arizona Tucson AZ USA BIO5 Institute University of Arizona Tucson AZ USA Department of Biomedical Engineering University of Arizona Tucson AZ USA Department of Aerospace and Mechanical Engineering University of Arizona Tucson AZ USA United States

AAA is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was to determine any changes that occur in the biomechanical response and fiber microstructure in the ApoE(-/-) AngII mouse model of aneurysm during disease progression. Adult ApoE(-/-) AngII infused mice along with wild-type controls were taken at 14 and 28 d. Aortas were excised and tested simultaneously for biaxial mechanical response and ECM organization. Data sets were fit to a Fung-type constitutive model to give peak strains and stiffness values. Images from two photon microscopy were quantified in order to assess the preferred fiber alignment and degree of fiber orientation. Biomechanical results found significant differences that were present at 14 d had returned to normal by 28 d along with significant changes in fiber orientation and dispersion indicating remodeling occurring within the aneurysmal wall. This return of some of the normal biomechanical function, in addition the continuing changes that occur in the microstructure suggest a restorative response that occurs in the ApoE(-/-) AngII infused model after the initial aneurysm formation.

关键词： AAA aneurysm AngII ApoE mechanical microstructure mouse model two-photon

来源：评论

学校读者我要写书评

暂无评论

Effect of sensor configurations on indirect-contact photoplethysmogram measurement system

Effect of sensor configurations on indirect-contact photople...

引用

Cairo International biomedical engineering Conference, CIBEC

作者： Hyun Jae Baek Soo Young Sim Jung Soo Kim Kwang Suk Park Graduate Program in Bioengineering and Advanced Biometric Research Center Seoul National University South Korea Samsung Group Interdisciplinary Program in Medical and Biological Engineering Seoul National University South Korea Department of Biomedical Engineering College of Medicine and Advanced Biometric Research Center Seoul National University South Korea

Indirect-contact photoplethysmography is a new approach to measure photoplethysmogrm over clothing for unconstrained and unconscious monitoring purpose. In this paper, the effect of sensor configurations on indirect-contact photoplehysmography was investigated. Sensor configuration was classified into two groups. One was multiple light sources with centered photo-detector configuration and the other was multiple photo-detectors with centered light source configuration. Total 8 kinds of sensors were tested. Experimental results showed that although both sensor groups have possibility to photoplethysmogram measurement over clothing, sensors with multiple light sources showed better performance when thick clothes were considered. Sensor configuration should be selected with regard to its application considerations such as power consumption or target subjects.

关键词： Light sources Light emitting diodes Photonics biomedical measurements Cotton Clothing Thickness measurement

来源：评论

学校读者我要写书评

暂无评论

Thermodynamics of the Solid-Liquid Phase Equilibrium of a Binary System: Effect of a Chemical Reaction in the Liquid and Epitaxial Strain in the Solid

SSRN

引用

SSRN 2023年

作者： Deymier, Alix C. Deymier, Pierre Alix Muralidharan, Krishna Latypov, Marat I. Department of Biomedical Engineering UConn Health FarmingtonCT06030 United States Department of Materials Science and Engineering University of Arizona TucsonAZ85721 United States Graduate Interdisciplinary Program in Applied Mathematics University of Arizona TucsonAZ85721 United States

We introduce two thermodynamics models of solid-liquid phase equilibrium of a binary system in the presence of (a) a chemical reaction in the liquid involving only one of the binary components and, (b) strain-inducing epitaxial conditions on the solid in addition to the chemical reaction in the liquid. These models show the existence of the counter intuitive behavior that epitaxy may promote recrystallization of the solid in spite of the reaction driving dissolution. The conditions for this recrystallization behavior are determined by the value of the epitaxial lattice matching composition, the temperature and the overall composition of the binary solid-liquid system. © 2023, The Authors. All rights reserved.

关键词： Chemical reactions

来源：评论

学校读者我要写书评

暂无评论

Development and in vivo application of the nerve stimulator and EMG analysis system for selective posterior rhizotomy

Development and in vivo application of the nerve stimulator ...

引用

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： S.H. Kwon H.C. Kim C.W. Oh Interdisciplinary Program of Medical and Biological Engineering Graduate School College of Medicine Seoul National University South Korea Department of Biomedical Engineering College of Medicine Seoul National University South Korea Department of Neurosurgery College of Medicine Seoul National University South Korea

A computerized system composed of neurostimulator and EMG signal acquisition and real-time analysis system has been developed to be used for selective posterior rhizotomy. As a preliminary study for the clinical application of the developed system, we performed a series of animal experiments using cats. From the results of in vivo application, we verified the basic system performance and found that latency, amplitude variance and waveform variance are useful parameters to differentiate sensory nerve from motor nerve. The underlying mechanisms of these phenomena were also provided. These findings were utilized in establishing the objective criterion in nerve selection for selective posterior rhizotomy.

关键词： In vivo Electromyography Pulse amplifiers Signal analysis Space vector pulse width modulation Neurosurgery Animals Extremities Voltage biomedical engineering

来源：评论

学校读者我要写书评

暂无评论

Segmented readout for Cherenkov time-of-flight positron emission tomography detectors based on bismuth germanate

arXiv

引用

arXiv 2024年

作者： Yi, Minseok Lee, Daehee Gola, Alberto Merzi, Stefano Penna, Michele Lee, Jae Sung Cherry, Simon R. Kwon, Sun Il Department of Biomedical Engineering University of California Davis United States Interdisciplinary Program in Bioengineering College of Engineering Seoul National Graduate School Korea Republic of Integrated Major in Innovative Medical Science Seoul National Graduate School Korea Republic of Fondazione Bruno Kessler Italy Brightonix Imaging Inc. Korea Republic of

Positron emission tomography (PET) is the most sensitive biomedical imaging modality for noninvasively detecting and visualizing positron-emitting radiopharmaceuticals within a subject. In PET, measuring the time-of-flight (TOF) information for each pair of 511-keV annihilation photons improves effective sensitivity but requires high timing resolution. Hybrid materials that emit both scintillation and Cherenkov photons, such as bismuth germanate (BGO), recently offer the potential for more precise timing information from Cherenkov photons while maintaining adequate energy resolution from scintillation photons. However, a significant challenge in using such hybrid materials for TOF PET applications lies in the event-dependent timing spread caused by the mixed detection of Cherenkov and scintillation photons due to relatively lower production of Cherenkov photons. This study introduces an innovative approach by segmenting silicon photomultiplier (SiPM) pixels coupled to a single crystal, rather than using traditional SiPMs that are as large as or larger than the crystals they read. We demonstrated that multiple time stamps and photon counts obtained from the segmented SiPM can classify events by providing temporal photon density, effectively addressing this challenge. The approach and findings would lead to new opportunities in applications that require precise timing and photon counting, spanning the fields of medical imaging, high-energy physics, and optical physics. © 2024, CC BY.

关键词： Photons

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：