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In Reply: Revisiting Claims of the Continued Absence of Functional Germline Stem Cells in Adult Ovaries

Stem cells (Dayton, Ohio) 2023年第2期41卷 205-206页

作者： Masahito Yoshihara Magdalena Wagner Anastasios Damdimopoulos Cheng Zhao Sophie Petropoulos Shintaro Katayama Juha Kere Fredrik Lanner Pauliina Damdimopoulou Department of Biosciences and Nutrition Karolinska Institutet Stockholm Sweden. Institute for Advanced Academic Research Chiba University Chiba Japan. Department of Artificial Intelligence Medicine Graduate School of Medicine Chiba University Chiba Japan. Division of Obstetrics and Gynecology Department of Clinical Science Intervention and Technology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden. Bioinformatics and Expression Analysis core facility Department of Biosciences and Nutrition Karolinska Institutet Stockholm Sweden. Centre de Recherche du Centre Hospitalier de l'Université de Montréal Axe Immunopathologie H2X 0A9 Montréal Canada. Département de Médecine Université de Montréal Montréal Canada. Folkhälsan Research Center Helsinki Finland. Stem Cells and Metabolism Research Program University of Helsinki Finland. Ming Wai Lau Center for Reparative Medicine Stockholm node Karolinska Institutet Stockholm Sweden.

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Cover Feature: Diversity Oriented Strategy (DOS) for the Efficient Synthesis of Benzofuro[2,3-b]pyridine Derivatives with Anticancer Activity (ChemMedChem 3/2025)

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ChemMedChem 2025年第3期20卷

作者： Reymark Ereje Jantana Yahuafai Theeranuch Jaroenchuensiri Patcharaporn Supakijjanusorn Sukanya Unson Borwornlak Toopradab Thanyada Rungrotmongkol Somsak Pianwanit Chanat Aonbangkhen Tanatorn Khotavivattana Center of Excellence in Natural Products Department of Chemistry Faculty of Science Chulalongkorn University Pathumwan Bangkok 10330 Thailand Department of Physical Sciences College of Science University of the Philippines Baguio Baguio City 2600 Philippines Clinical Research Section Division of Research and Academic Support National Cancer Institute Bangkok 10400 Thailand Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Pathumwan Bangkok 10330 Thailand Center of Excellence in Computational Chemistry Department of Chemistry Faculty of Science Chulalongkorn University Pathumwan Bangkok 10330 Thailand

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Developing zebrafish models for the study of Wnt-related central nervous system pathologies

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Neuroscience 2025年

作者： Natalia Erofeeva Murilo S. de Abreu Jiahao Cui Lee Wei Lim Longen Yang Allan V. Kalueff Institute of Translational Biomedicine St. Petersburg State University St. Petersburg Russia Institute of Experimental Medicine Almazov National Medical Research Center Ministry of Health of Russian Federation St. Petersburg Russia Graduate Program in Health Sciences Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil Department of Biosciences and Bioinformatics School of Science Xi’an Jiaotong-Liverpool University Suzhou China Suzhou Key Laboratory on Neurobiology and Cell Signaling School of Science Xi’an Jiaotong-Liverpool University Suzhou China

The wingless-related integration site (Wnt) signaling pathway plays a crucial role in the development and pathology of the central nervous system (CNS), modulating neurogenesis, synaptic plasticity and cell fate determination. Dysregulation of this pathway is strongly implicated in the pathogenesis of several CNS disorders. Recognizing the growing importance of the Wnt signaling in the brain, here we provide novel insights into experimental animal models studying this mechanism, with a particular emphasis on zebrafish ( Danio rerio ), including CNS development, and high-throughput drug screening of compounds that modulate Wnt signaling. Despite certain limitations, zebrafish provide a promising and powerful model system to increase our understanding of the role of Wnt signaling in CNS function, and to foster the development of novel therapies for brain disorders associated with this signaling pathway.

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Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis

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Scientific reports 2025年第1期15卷 18899页

作者： Wassamon Moyadee Sittiruk Roytrakul Janthima Jaresitthikunchai Narumon Phaonakrop Kiattawee Choowongkomon Sekkarin Ploypetch Natthasit Tansakul Amonpun Rattanasrisomporn Jatuporn Rattanasrisomporn Graduate Program in Animal Health and Biomedical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand. Department of Companion Animal Clinical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand. National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency Pathum Thani Thailand. Department of Biochemistry Faculty of Science Kasetsart University Bangkok Thailand. Department of Clinical Sciences and Public Health Faculty of Veterinary Science Mahidol University Nakhon Pathom Thailand. Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand. Interdisciplinary of Genetic Engineering and Bioinformatics Graduate School Kasetsart University Bangkok Thailand. Graduate Program in Animal Health and Biomedical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand. fvejpn@ku.ac.th. Department of Companion Animal Clinical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand. fvejpn@ku.ac.th.

Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers the potential to identify novel biomarkers that could improve the diagnosis and management of FIP. This study aims to assess the serum proteome and identify proteins that differentiate healthy cats from cats diagnosed with effusive FIP using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). A total of 30 cats diagnosed with effusive FIP and 27 clinically normal cats were enrolled. Twenty-three proteins were significantly (p < 0.01, ≥ fivefold change in abundance) differentially expressed between cats with effusive FIP and controls. Among these, the P2X purinoceptor, DNA topoisomerase, Notch receptor 2, and cadherin-17 were identified as key proteins of interest in cats with effusive FIP. Our findings suggest that these differentially expressed proteins could serve as potential diagnostic biomarkers and therapeutic targets for FIP. However, further studies are needed to validate these findings and explore their potential applications.

关键词： Biomarkers Cats Coronavirus Feline infectious peritonitis Proteomics Serum

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An integrative and multiscale approach to study dengue virus-like particle dynamics

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Biophysical Journal 2023年第3期122卷 44a-44a页

作者： Venkata Raghuvamsi Palur Gielenny Salem Fan-Chi Chen Shang-Rung Wu Peter J. Bond Day-Yu Chao Jan K. Marzinek Bioinformatics Institute (A∗STAR) Singapore Republic of Singapore Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung City Taiwan Microbial Genomics PhD Program National Chung Hsing University and Academia Sinica Taichung City Taiwan Department of Dentistry & Institute of Oral Medicine National Cheng Kung University Tainan Taiwan Department of Biological Sciences National University of Singapore Singapore Republic of Singapore

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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress

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Nature neuroscience 2025年 2025 Jun 2页

作者： Kevin Rhine Rachel Li Hema M Kopalle Katherine Rothamel Xuezhen Ge Elle Epstein Orel Mizrahi Assael A Madrigal Hsuan-Lin Her Trent A Gomberg Anita Hermann Joshua L Schwartz Amanda J Daniels Uri Manor John Ravits Robert A J Signer Eric J Bennett Gene W Yeo Department of Cellular & Molecular Medicine University of California San Diego La Jolla CA USA. Sanford Stem Cell Institute Innovation Center and Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA. Institute for Genomic Medicine University of California San Diego La Jolla CA USA. Waitt Advanced Biophotonics Center Salk Institute for Biological Studies La Jolla CA USA. Biomedical Sciences Graduate Program University of California San Diego La Jolla CA USA. Biological Sciences Graduate Program University of California San Diego La Jolla CA USA. Center for RNA Technologies & Therapeutics University of California San Diego La Jolla CA USA. Department of Cell & Developmental Biology University of California San Diego La Jolla CA USA. Bioinformatics & Systems Biology Graduate Program University of California San Diego La Jolla CA USA. Department of Neurosciences School of Medicine University of California San Diego La Jolla CA USA. Division of Regenerative Medicine Department of Medicine Sanford Stem Cell Institute Moores Cancer Center University of California San Diego La Jolla CA USA. Department of Cellular & Molecular Medicine University of California San Diego La Jolla CA USA. geneyeo@ucsd.edu. Sanford Stem Cell Institute Innovation Center and Sanford Consortium for Regenerative Medicine University of California San Diego La Jolla CA USA. geneyeo@ucsd.edu. Institute for Genomic Medicine University of California San Diego La Jolla CA USA. geneyeo@ucsd.edu. Biomedical Sciences Graduate Program University of California San Diego La Jolla CA USA. geneyeo@ucsd.edu. Biological Sciences Graduate Program University of California San Diego La Jolla CA USA. geneyeo@ucsd.edu. Center for RNA Technologies & Therapeutics University of California San Diego La Jolla CA USA. geneyeo@ucsd.edu. Bioinformatics & Systems Biology Graduate Program University of California San Diego La Jolla CA USA. geneyeo@ucsd.edu.

Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged healthy donors directly into neurons, which retained their aging hallmarks, and we verified key findings in aged human and mouse brain tissue. Here we show that aged neurons are broadly depleted of RNA-binding proteins, especially spliceosome components. Intriguingly, splicing proteins-like the dementia- and ALS-associated protein TDP-43-mislocalize to the cytoplasm in aged neurons, which leads to widespread alternative splicing. Cytoplasmic spliceosome components are typically recruited to stress granules, but aged neurons suffer from chronic cellular stress that prevents this sequestration. We link chronic stress to the malfunctioning ubiquitylation machinery, poor HSP90α chaperone activity and the failure to respond to new stress events. Together, our data demonstrate that aging-linked deterioration of RNA biology is a key driver of poor resiliency in aged neurons.

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PP 4.15 – 00181 Distinctive cytoskeletal properties are implicated in the resistance of a fraction of productively HIV-infected CD4+ T-cells to killing by cytotoxic T lymphocytes (CTL)

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Journal of Virus Eradication 2022年 8卷

作者： L. Leyre A. Herrera P. Zumbo J. Weiler Y. Zhang E. McNeil N. Linden D. Betel S.R. Manalis R.B. Jones D.C. Copertino S. Terry Infectious Disease Division Weill Cornell Medicine New York USA Immunology and Microbial Pathogenesis Program Weill Cornell Graduate School of Medical Sciences New York NY USA Applied Bioinformatics Core Weill Cornell Medicine New York USA Koch Institute For Integrative Cancer Research Massachusetts Institute of Technology Cambridge USA

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Retraction Note: A new EEG software that supports emotion recognition by using an autonomous approach

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Neural Computing and Applications 2024年第28期36卷 17759-17759页

作者： Munoz, Roberto Olivares, Rodrigo Taramasco, Carla Villarroel, Rodolfo Soto, Ricardo Alonso-Sánchez, María Francisca Merino, Erick de Albuquerque, Victor Hugo C. Escuela de Ingeniería Civil Informática Universidad de Valparaíso Valparaíso Chile Centro de Investigación y Desarrollo en Ingeniería en Salud Universidad de Valparaíso Valparaíso Chile Pontificia Universidad Católica de Valparaíso Valparaíso Chile Escuela de Fonoaudiología Facultad de Salud Universidad Santo Tomás Viña del Mar Chile Graduate Program in Applied Informatics Laboratory of Bioinformatics University of Fortaleza Fortaleza Brazil

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Author Correction: Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis

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Nature communications 2023年第1期14卷 6540页

作者： Hitomi Takada Yohei Sasagawa Mika Yoshimura Kaori Tanaka Yoshimi Iwayama Tetsutaro Hayashi Ayako Isomura-Matoba Itoshi Nikaido Akira Kurisaki Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan. itoshi.nikaido@riken.jp. Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan. itoshi.nikaido@riken.jp. Master's/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan. itoshi.nikaido@riken.jp. Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan. akikuri@bs.naist.jp.

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Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants (vol 11, 955, 2020)

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NATURE COMMUNICATIONS 2020年第1期11卷 955页

作者： Donovan, Margaret K. R. D'Antonio-Chronowska, Agnieszka D'Antonio, Matteo Frazer, Kelly A. University of California San Diego Bioinformatics and Systems Biology Graduate Program La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Department of Biomedical Informatics La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Department of Pediatrics and Rady Children’s Hospital La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Department of Pediatrics and Rady Children’s Hospital La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Institute for Genomic Medicine La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词： Gene expression Genetic association study RNA sequencing

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