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Calibrated Langevin-dynamics simulations of intrinsically disordered proteins

Physical Review E 2014年第4期90卷 042709-042709页

作者： W. Wendell Smith Po-Yi Ho Corey S. O'Hern Department of Physics Yale University New Haven Connecticut 06520-8120 USA Integrated Graduate Program in Physical and Engineering Biology Yale University New Haven Connecticut 06520-8114 USA Department of Mechanical Engineering and Materials Science Yale University New Haven Connecticut 06520-8286 USA Department of Applied Physics Yale University New Haven Connecticut 06520-8267 USA Program in Computational Biology and Bioinformatics Yale University New Haven Connecticut 06520 USA

We perform extensive coarse-grained (CG) Langevin dynamics simulations of intrinsically disordered proteins (IDPs), which possess fluctuating conformational statistics between that for excluded volume random walks and collapsed globules. Our CG model includes repulsive steric, attractive hydrophobic, and electrostatic interactions between residues and is calibrated to a large collection of single-molecule fluorescence resonance energy transfer data on the interresidue separations for 36 pairs of residues in five IDPs: α−, β−, and γ-synuclein, the microtubule-associated protein τ, and prothymosin α. We find that our CG model is able to recapitulate the average interresidue separations regardless of the choice of the hydrophobicity scale, which shows that our calibrated model can robustly capture the conformational dynamics of IDPs. We then employ our model to study the scaling of the radius of gyration with chemical distance in 11 known IDPs. We identify a strong correlation between the distance to the dividing line between folded proteins and IDPs in the mean charge and hydrophobicity space and the scaling exponent of the radius of gyration with chemical distance along the protein.

关键词： LANGEVIN equations SIMULATION methods & models CONFORMATIONAL analysis MICROTUBULE-associated proteins HYDROPHOBIC compounds

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Mixed effects of HDACi on host gene expression and their implications for HIV reactivation from latency

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Journal of Virus Eradication 2015年 1卷 4-4页

作者： N. Beliakova-Bethell A. Mukim S. Deshmukh C.H. White C.H. Woelk C.A. Spina Department of Medicine University of California San Diego La Jolla CA USA VA San Diego Healthcare System San Diego CA USA Graduate Program in Bioinformatics and Systems Biology University of California San Diego La Jolla CA USA Faculty of Medicine University of Southampton UK Department of Pathology University of California San Diego La Jolla CA USA

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Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8873-8879页

作者： De-Leung Gu Yen-Hsieh Chen Jou-Ho Shih Chi-Hung Lin Yuh-Shan Jou Chian-Feng Chen Institute of Biomedical Sciences Academia Sinica Institute of Microbiology and Immunology School of Life ScienceNational Yang-Ming University Bioinformatics Program Taiwan International Graduate ProgramAcademia Sinica Genome and Systems Biology Degree Program National Taiwan University VYM Genome Research Center National Yang-Ming University

High-throughput short-read sequencing of exomes and whole cancer genomes in multiple human hepatocellular carcinoma(HCC)cohorts confirmed previously identified frequently mutated somatic genes,such as TP53,CTNNB1 and AXIN1,and identified several novel genes with moderate mutation frequencies,including ARID1A,ARID2,MLL,MLL2,MLL3,MLL4,IRF2,ATM,CDKN2A,FGF19,PIK3CA,RPS6KA3,JAK1,KEAP1,NFE2L2,C16orf62,LEPR,RAC2,and *** classification of these mutated genes suggested that alterations in pathways participating in chromatin remodeling,Wnt/β-catenin signaling,JAK/STAT signaling,and oxidative stress play critical roles in HCC ***,because there are few druggable genes used in HCC therapy,the identification of new therapeutic targets through integrated genomic approaches remains an important *** a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain,copy number alteration(CNA)analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons,homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC ***,integration of CNAs with other high-throughput genomic data,such as aberrantly coding transcriptomes and non-coding gene expression in human HCC tissues and rodent HCC models,provides lines of evidence that can be used to facilitate the identification of novel HCC target genes with the potential of improving the survival of HCC patients.

关键词： Copy number alteration High-density single nucleotide polymorphism arrays Driver genes Hepatocellular carcinoma

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Genome wide conditional mouse knockout resources

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Drug Discovery Today: Disease Models 2016年 20卷 3-12页

作者： Kaloff, C. Anastassiadis, K. Ayadi, A. Baldock, R. Beig, J. Birling, M.-C. Bradley, A. Brown, S.D.M. Bürger, A. Bushell, W. Chiani, F. Collins, F.S. Doe, B. Eppig, J.T. Finnell, R.H. Fletcher, C. Flicek, P. Fray, M. Friedel, R.H. Gambadoro, A. Gates, H. Hansen, J. Herault, Y. Hicks, G.G. Hörlein, A. Hrabé de Angelis, M. Iyer, V. de Jong, P.J. Koscielny, G. Kühn, R. Liu, P. Lloyd, K.C.K. Lopez, R.G. Marschall, S. Martínez, S. McKerlie, C. Meehan, T. von Melchner, H. Moore, M. Murray, S.A. Nagy, A. Nutter, L.M.J. Pavlovic, G. Pombero, A. Prosser, H. Ramirez-Solis, R. Ringwald, M. Rosen, B. Rosenthal, N. Rossant, J. Ruiz Noppinger, P. Ryder, E. Skarnes, W.C. Schick, J. Schnütgen, F. Schofield, P. Seisenberger, C. Selloum, M. Smedley, D. Simpson, E.M. Stewart, A.F. Teboul, L. Tocchini Valentini, G.P. Valenzuela, D. West, A.P. Wurst, W. Institute of Developmental Genetics Helmholtz Zentrum Muenchen Neuherberg D-85764 Germany Biotechnology Center (BIOTEC) of the Technische Universität Dresden Dresden 01307 Germany CELPHEDIA PHENOMIN Institut Clinique de la Souris (ICS) CNRS INSERM University of Strasbourg 1 rue Laurent Fries Illkirch-Graffenstaden F-67404 France MRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh College of Medicine and Veterinary Medicine Edinburgh EH4 2XU Scotland United Kingdom The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge CB101HH United Kingdom Mammalian Genetics Unit and Mary Lyon Centre MRC Harwell Harwell Science and Innovation Campus Oxfordshire OX110RD United Kingdom Monterotondo Mouse Clinic Italian National Research Council (CNR) Institute of Cell Biology and Neurobiology Monterotondo-Scalo Rome I-00015 Italy National Human Genome Research Institute National Institutes of Health Bethesda 20892 MD United States The Jackson Laboratory Bar Harbor 04609 ME United States Dell Pediatric Research Institute The University of Texas at Austin Austin 78712 TX United States University of Texas at Austin Austin 78712 TX United States National Institutes of Health Bethesda 20205 MD United States European Bioinformatics Institute (EBI) Hinxton Cambridge CB101ST United Kingdom Fishberg Department of Neuroscience Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York 10029 New York United States Institut de Génétique et de Biologie Moléculaire et Cellulaire Université de Strasbourg 1 rue Laurent Fries Illkirch 67404 France Centre National de la Recherche Scientifique UMR7104 Illkirch France Institut National de la Santé et de la Recherche Médicale U964 Illkirch France Université de Strasbourg 1 rue Laurent Fries Illkirch 67404 France University of Manitoba Manitoba Institute of Cell Biology Winnipeg R3EOV9 MB Canada Institute of Epidemiology II Helmh

The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (***). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research. © 2017 Elsevier Ltd

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BIVARIATE GENOME-WIDE ASSOCIATION STUDY OF ALZHEIMER DISEASE ENDOPHENOTYPES IDENTIFIES NOVEL LOCI

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Alzheimer's & Dementia 2014年第4期10卷 P316-P316页

作者： Jaeyoon Chung Lindsay A. Farrer Gyungah Jun Boston University Bioinformatics Graduate Program Boston Massachusetts United States Boston University School of Medicine Boston Massachusetts United States

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Development and evaluation of a hospital-wide healthcare-associated surgical site infection detection algorithm

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Journal of Microbiology, Immunology and Infection 2015年第2期48卷 S43-S43页

作者： Yi-Ju Tseng Bo-Chiang Huang Hui-Chi Lin Ming-Yuan Chen Rung-Ji Shang Wang-Huei Sheng Yee-Chun Chen Feipei Lai Shan-Chwen Chang Children's Hospital Informatics Program Boston Children's Hospital Boston MA USA Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taiwan Center for Infection Control National Taiwan University Hospital (NTUH) Taiwan Information Systems Office NTUH Taipei Taiwan Department of Internal Medicine NTUH and College of Medicine Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Taiwan Department of Computer Science and Information Engineering National Taiwan University Taiwan

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FANTOM5 CAGE profiles of human and mouse samples

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Scientific Data 2017年第1期4卷 1-10页

作者： Noguchi, Shuhei Arakawa, Takahiro Fukuda, Shiro Furuno, Masaaki Hasegawa, Akira Hori, Fumi Ishikawa-Kato, Sachi Kaida, Kaoru Kaiho, Ai Kanamori-Katayama, Mutsumi Kawashima, Tsugumi Kojima, Miki Kubosaki, Atsutaka Manabe, Ri-Ichiroh Murata, Mitsuyoshi Nagao-Sato, Sayaka Nakazato, Kenichi Ninomiya, Noriko Nishiyori-Sueki, Hiromi Noma, Shohei Saijyo, Eri Saka, Akiko Sakai, Mizuho Simon, Christophe Suzuki, Naoko Tagami, Michihira Watanabe, Shoko Yoshida, Shigehiro Arner, Peter Axton, Richard A. Babina, Magda Kenneth Baillie, J. Barnett, Timothy C. Beckhouse, Anthony G. Blumenthal, Antje Bodega, Beatrice Bonetti, Alessandro Briggs, James Brombacher, Frank Carlisle, Ailsa J. Clevers, Hans C. Davis, Carrie A. Detmar, Michael Dohi, Taeko Edge, B. Albert S. Edinger, Matthias Ehrlund, Anna Ekwall, Karl Endoh, Mitsuhiro Enomoto, Hideki Eslami, Afsaneh Fagiolini, Michela Fairbairn, Lynsey Farach-Carson, Mary C. Faulkner, Geoffrey J. Ferrai, Carmelo Fisher, Malcolm E. Forrester, Lesley M. Fujita, Rie Furusawa, Jun-Ichi Geijtenbeek, Teunis B. Gingeras, Thomas Goldowitz, Daniel Guhl, Sven Guler, Reto Gustincich, Stefano Ha, Thomas J. Hamaguchi, Masahide Hara, Mitsuko Hasegawa, Yuki Herlyn, Meenhard Heutink, Peter Hitchens, Kelly J. Hume, David A. Ikawa, Tomokatsu Ishizu, Yuri Kai, Chieko Kawamoto, Hiroshi Kawamura, Yuki I. Kempfle, Judith S. Kenna, Tony J. Kere, Juha Khachigian, Levon M. Kitamura, Toshio Klein, Sarah Peter Klinken, S. Knox, Alan J. Kojima, Soichi Koseki, Haruhiko Koyasu, Shigeo Lee, Weonju Lennartsson, Andreas MacKay-Sim, Alan Mejhert, Niklas Mizuno, Yosuke Morikawa, Hiromasa Morimoto, Mitsuru Moro, Kazuyo Morris, Kelly J. Motohashi, Hozumi Mummery, Christine L. Nakachi, Yutaka Nakahara, Fumio Nakamura, Toshiyuki Nakamura, Yukio Nozaki, Tadasuke Ogishima, Soichi Ohkura, Naganari Ohno, Hiroshi Ohshima, Mitsuhiro Okada-Hatakeyama, Mariko Okazaki, Yasushi Orlando, Valerio Ovchinnikov, Dmitry A. Passier, Robert Patrikakis, Margaret Pombo, Ana Pradhan-Bhatt, Swati Qin, Xian-Yang Rehli, Michael Rizzu, Patrizia Roy, S Division of Genomic Technologies RIKEN Center for Life Science Technologies Yokohama Kanagawa 230-0045 Japan RIKEN Omics Science Center Yokohama Kanagawa 230-0045 Japan Department of Medicine Karolinska Institutet Stockholm 14186 Sweden Karolinska University Hospital Center for Metabolism and Endocrinology Stockholm 14186 Sweden Scottish Centre for Regenerative Medicine University of Edinburgh 5 Little France Drive Edinburgh EH164UU United Kingdom Department of Dermatology and Allergy Charite University Medicine Berlin Charitéplatz 1 Berlin 10117 Germany Roslin Institute and Royal School of Veterinary Studies University of Edinburgh Edinburgh EH259RG United Kingdom Australian Infectious Diseases Research Centre University of Queensland St Lucia 4072 QLD Australia School of Chemistry and Molecular Biosciences University of Queensland St Lucia 4072 QLD Australia Bio-Rad Laboratories Pty Ltd Hercules 94547 CA United States University of Queensland Diamantina Institute University of Queensland Woolloongabba 4102 QLD Australia IRCCS Fondazione Santa Lucia Via del Fosso di Fiorano 64 Rome 00143 Italy Australian Institute for Bioengineering and Nanotechnology University of Queensland Brisbane St Lucia 4072 QLD Australia Division of Immunology Institute of Infectious Diseases and Molecular Medicine University of Cape Town Anzio Road Observatory 7925 South Africa Immunology of Infectious Diseases Faculty of Health Sciences South African Medical Research Council University of Cape Town Anzio Road 7925 South Africa International Centre for Genetic Engineering and Biotechnology Cape Town Component Anzio Road 7925 South Africa Hubrecht Institute Royal Netherlands Academy of Arts and Sciences Uppsalalaan 8 3584 Netherlands University Medical Centre Utrecht Postbus 85500 Utrecht 3508 Netherlands Genomics Cold Spring Harbor Laboratory Cold Spring Harbor New York 11797 NY United States Institute of Pharmaceutical Sciences ETH Zurich Vladi

In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.

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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Nature genetics 2018年第5期50卷 766-767页

作者： Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Montreal Heart Institute Université de Montréal Montreal Quebec Canada. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville TN USA. Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY USA. Department of Epidemiology University of North Carolina Chapel Hill NC USA. Human Genetics Center University of Texas School of Public Health University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston Houston TX USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genetics Harvard Medical School Boston MA USA. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA USA. Center for Applied Genomics Division of Human Genetics Children's Hospital of Philadelphia Philadelphia PA USA. Quantinuum Research LLC San Diego CA USA. Estonian Genome Center University of Tartu Tartu Estonia. Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Nashville TN USA. Institute for Translational Genomics and Population Sciences LABioMed at Harbor-UCLA Medical Center Torrance CA USA. Wellcome Trust Sanger Institute Hinxton UK. Department of Mathematical and Statistical Sciences University of Colorado Denver CO USA. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Department of Biological Sciences Faculty of Arts and Sciences Eastern Mediterranean University Famagusta Cyprus. Max Planck Institute of Immunobiology and Epigenetics Freiburg Germany. Department of Biostatistics and Center for Statistical Genetics University of M

In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

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Erratum to: The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species

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Genome biology 2017年第1期18卷 11页

作者： Alexie Papanicolaou Marc F Schetelig Peter Arensburger Peter W Atkinson Joshua B Benoit Kostas Bourtzis Pedro Castañera John P Cavanaugh Hsu Chao Christopher Childers Ingrid Curril Huyen Dinh HarshaVardhan Doddapaneni Amanda Dolan Shannon Dugan Markus Friedrich Giuliano Gasperi Scott Geib Georgios Georgakilas Richard A Gibbs Sarah D Giers Ludvik M Gomulski Miguel González-Guzmán Ana Guillem-Amat Yi Han Artemis G Hatzigeorgiou Pedro Hernández-Crespo Daniel S T Hughes Jeffery W Jones Dimitra Karagkouni Panagiota Koskinioti Sandra L Lee Anna R Malacrida Mosè Manni Kostas Mathiopoulos Angela Meccariello Monica Munoz-Torres Shwetha C Murali Terence D Murphy Donna M Muzny Georg Oberhofer Félix Ortego Maria D Paraskevopoulou Monica Poelchau Jiaxin Qu Martin Reczko Hugh M Robertson Andrew J Rosendale Andrew E Rosselot Giuseppe Saccone Marco Salvemini Grazia Savini Patrick Schreiner Francesca Scolari Paolo Siciliano Sheina B Sim George Tsiamis Enric Ureña Ioannis S Vlachos John H Werren Ernst A Wimmer Kim C Worley Antigone Zacharopoulou Stephen Richards Alfred M Handler Hawkesbury Institute for the Environment Western Sydney University Sydney Australia. Justus-Liebig-University Giessen Institute for Insect Biotechnology 35394 Giessen Germany. Department of Biological Sciences Cal Poly Pomona Pomona CA 91768 USA. Department of Entomology and Center for Disease Vector Research University of California Riverside Riverside CA 92521 USA. Interdepartmental Graduate Program in Genetics Genomics & Bioinformatics University of California Riverside Riverside CA 92521 USA. Department of Biological Sciences University of Cincinnati Cincinnati OH 45221 USA. Insect Pest Control Laboratory Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture Seibersdorf Vienna Austria. Department of Environmental and Natural Resources Management University of Patras Agrinio Greece. Department of Environmental Biology Centro de Investigaciones Biológicas CSIC 28040 Madrid Spain. Human Genome Sequencing Center Department of Human and Molecular Genetics Baylor College of Medicine 77030 Houston TX USA. National Agricultural Library USDA 20705 Beltsville MD USA. Georg-August-Universität Göttingen Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie 37077 Göttingen Germany. Department of Biology University of Rochester 14627 Rochester NY USA. Department of Biological Sciences Wayne State University 48202 Detroit MI USA. Department of Biology and Biotechnology University of Pavia 27100 Pavia Italy. USDA-ARS Pacific Basin Agricultural Research Center 96720 Hilo HI USA. DIANA-Lab Department of Electrical & Computer Engineering University of Thessaly 382 21 Volos Greece and Hellenic Pasteur Institute 11521 Athens Greece. Department of Entomology University of Illinois at Urbana-Champaign 61801 Urbana IL USA. Department of Biological Sciences Oakland University 48309 Rochester MI USA. Department of Biochemistry and Biotechnology University of Thessaly Larissa Greece. Department of Biology Univer

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A VARIANT IN STK24 ACHIEVES GENOME-WIDE SIGNIFICANCE IN AFRICAN AMERICANS USING A LIABILITY MODEL

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Alzheimer's & Dementia 2014年第4期10卷 P481-P481页

作者： Jesse Mez Jaeyoon Chung Matthew Schu Logue Mark Gyungah Jun Kathryn Lunetta Lindsay A. Farrer Boston University School of Medicine Boston Massachusetts United States Boston University Bioinformatics Graduate Program Boston Massachusetts United States Boston University School of Public Health Boston Massachusetts United States

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