Penile cancer, although rare, has an increasing mortality rate in Brazil, highlighting the need for effective diagnostic methods. Artificial Intelligence (AI) in histopathological analysis can speed up and objectify d...
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This study aimed to analyze the factors associated with catheter-related bloodstream infection (CRBSI) in newborns undergoing infusion therapy using a peripherally inserted central catheter (PICC). A prospective cohor...
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Although the toxicity of selenium (Se) and carbamazepine (CBZ) has already been demonstrated, the possible effects of freshwater fish co-exposure to these pollutants have not been explored. Thus, we aimed to evaluate ...
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This study aims to develop an edible coating based on virgin coconut oil (VCO) nanoemulsion, iota-carrageenan and alginate to prolong the shelf life of pindang (mildly salted cooked) fish products. The research involv...
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Leishmaniases are a group of tropical and neglected diseases caused by the protozoa of the genus Leishmania which are transmitted by insect sandflies. Despite of the major efforts undertaken at global level for the co...
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Poly(polyol sebacate) (PPS) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Po...
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Poly(polyol sebacate) (PPS) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-PEG) has been developed to fabricate PPS-based hydrogels;however, current PXS-co-PEG hydrogels presented limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. Here, we fabricate a new type of PXS-co-PEG hydrogels through the use of multifunctional crosslinkers as well as dynamic bonds. In our design, polyethyleneimine-polydopamine (PEI-PDA) macromers are utilized to crosslink aldehyde-functionalized PXS-co-PEG (APP) through imine bonds and hydrogen bonds. PEI-PDA/APP hydrogels present multiple functional properties (e.g., fluorescent, elastomeric, biodegradable, self-healing, bioadhesive, antioxidant, and antibacterial behaviors). These properties of PEI-PDA/APP hydrogels can be fine-tuned by changing the PDA grafting degrees in the PEI-PDA crosslinkers. Most importantly, PEI-PDA/APP hydrogels are considered promising wound dressings to promote tissue remodeling and prevent bacterial infection in vivo. Taken together, PEI-PDA/APP hydrogels have been demonstrated as versatile biomaterials to provide multiple tailorable properties and desirable functions to expand the utility of PPS-based hydrogels for advanced biomedical applications. Statement of significance: Various strategies have been developed to fabricate poly(polyol sebacate) (PPS)-based hydrogels. However, current PPS-based hydrogels present limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. This work describes that co-engineering crosslinkers and interfacial crosslinking is a promising approach to synthesizing a new type of poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-
Penile cancer, although rare, has an increasing mortality rate in Brazil, highlighting the need for effective diagnostic methods. Artificial Intelligence (AI) in histopathological analysis can speed up and objectify d...
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Penile cancer, although rare, has an increasing mortality rate in Brazil, highlighting the need for effective diagnostic methods. Artificial Intelligence (AI) in histopathological analysis can speed up and objectify diagnosis, but designing an ideal architecture is challenging. In this study, we propose a neural architecture search (NAS) methodology for detecting penile cancer in digital histopathology images. We explored different configurations of stem blocks and the inclusion of attention mechanisms, highlighting specific preferences depending on the magnification of the images. The results showed that the NAS methodology enabled the discovery of more accurate and optimized architectures for this task, surpassing conventional models. The proposed models achieve 89.5% and 88.5% F1-Score for 40X and 100X magnification, respectively.
Injuries to the nervous system present formidable challenges to scientists, clinicians, and patients. While regeneration within the central nervous system is minimal, peripheral nerves can regenerate, albeit with limi...
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Introduction: The intensive care of neonates is associated with the entry of a large volume of data in their medical records. The treatment of this data can be done through Machine Learning: a tool capable of assistin...
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Introduction: Aging is the biggest cancer risk, and immune checkpoint (IC) inhibition (ICI) is a revolutionary cancer immunotherapy approach. Nonetheless, there are limited preclinical/clinical data regarding aging ef...
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