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Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

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The Lancet Global health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh Cogswell, Ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, Trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley Tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, Cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, Tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, Turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, Tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael Taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere Tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard T. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard Cahuana-Hurtado, Lucero Catalá-López, Ferrán Chansa, Collins Charan, Jaykaran Chattu, Vijay Kumar Chen, Simiao Chukwu, Isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El Tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95% uncertainty interval [UI] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% UI 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% UI 24·3–25·3) spent by low-income countries in 2019. That same year, $43·1 billion in development assistance was provided

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Correction: Feasibility and acceptability of implementing the Global Scales for Early Development (GSED) package for children 0-3 years across three countries

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Pilot and feasibility studies 2025年第1期11卷 34页

作者： Ambreen Nizar Merchant Raghbir Kaur Gareth McCray Vanessa Cavallera Ann Weber Melissa Gladstone Magdalena Janus Imran Nisar Patricia Kariger Sunil Sazawal Arup Dutta Salahuddin Ahmed Yunting Zhang Mariana Pacifico Mercadante Arsene Zongo Yvonne Schönbeck Tarun Dua Iris Eekhout Fahmida Tofail Maureen Black Abdullah H Baqui Dana McCoy Farzana Begum Romuald Kouadio E Anago Alexandra Brentani Fan Jiang Symone Detmar Michelle Perez Maillard Marcus Waldman Stef van Buuren Abbie Raikes Katelyn Hepworth Marta Rubio Codina Shirina Akhtar Fyezah Jehan Rasheda Khanam Hassan Naqvi Abrarul Haque Asif Junaid Mehmood Sidra Afzal Gillian Lancaster Department of Pediatrics and Child Health The Aga Khan University Karachi Pakistan. ambreen.nizar@aku.edu. Department of Mental Health and Substance Use World Health Organization Geneva Switzerland. School of Medicine Keele University Keele UK. School of Public Health University of Nevada Reno Reno NV USA. Department of Women and Children's Health Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK. Offord Centre for Child Studies Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton ON Canada. Department of Pediatrics and Child Health The Aga Khan University Karachi Pakistan. Center for Effective Global Action University of California Berkeley School of Public Health Berkeley CA USA. Center for Public Health Kinetics CPHK Global Pemba Zanzibar Tanzania. Research Projahnmo Research Foundation Dhaka Bangladesh. Child Health Advocacy Institute National Children's Medical Center Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China. Department of Pediatrics University of São Paulo Medical School São Paulo Brazil. Innovations for Poverty Action IPA Côte d'Ivoire Abidjan Côte d'Ivoire. Department of Child Health Netherlands Organization for Applied Scientific Research Leiden Netherlands. Nutrition and Clinical Services Division (NCSD) International Centre for Diarrhoeal Disease Research Bangladesh Dhaka Bangladesh. International Education RTI International Research Triangle Park NC USA. Department of Pediatrics University of Maryland School of Medicine Baltimore MD USA. International Center for Maternal and Newborn Health Department of International Health Johns Hopkins Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Education Policy and Program Evaluation Harvard Graduate School of Education Cambridge MA USA. Health Promotion University of Nebraska Medical Center College of Public

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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction (vol 53, pg 65, 2021)

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NATURE GENETICS 2021年第3期53卷 413-413页

作者： Conti, David V. Darst, Burcu F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R. Al Olama, Ali Amin Benlloch, Sara Dadaev, Tokhir Brook, Mark N. Sahimi, Ali Hoffmann, Thomas J. Takahashi, Atushi Matsuda, Koichi Momozawa, Yukihide Fujita, Masashi Muir, Kenneth Lophatananon, Artitaya Wan, Peggy Le Marchand, Loic Wilkens, Lynne R. Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bojesen, Stig E. Roder, Martin Andreas Iversen, Peter Batra, Jyotsna Chambers, Suzanne Moya, Leire Horvath, Lisa Clements, Judith A. Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Szulkin, Robert Eklund, Martin Nordstrom, Tobias Pashayan, Nora Dunning, Alison M. Ghoussaini, Maya Travis, Ruth C. Key, Tim J. Riboli, Elio Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Albanes, Demetrius Weinstein, Stephanie J. Mucci, Lorelei A. Giovannucci, Edward Lindstrom, Sara Kraft, Peter Hunter, David J. Penney, Kathryn L. Turman, Constance Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M., Jr. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Parent, Marie-Elise Stanford, Janet L. Ostrander, Elaine A. Geybels, Milan S. Koutros, Stella Freeman, Laura E. Beane Stampfer, Meir Wolk, Alicja Hakansson, Niclas Andriole, Gerald L. Hoover, Robert N. Machiela, Mitchell J. Sorensen, Karina Dalsgaard Borre, Michael Blot, William J. Zheng, Wei Yeboah, Edward D. Mensah, James E. Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Wu, Yudong Zhao, Shan-Chao Sun, Zan Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. West, Catharine M. L. Burnet, Neil Barnett, Gill Maier, Christiane Schnoeller, Thomas Luedeke, Manuel Kibel, Adam S. Drake, Bettina F. Cussenot, Olivier Cancel-Tassin, Gerald Center for Genetic Epidemiology Department of Preventive Medicine Keck School of Medicine University of Southern California/Norris Comprehensive Cancer Center Los Angeles CA USA The Institute of Cancer Research London UK Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland OH USA Seidman Cancer Center University Hospitals Cleveland OH USA Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge Strangeways Research Laboratory Cambridge UK Stroke Research Group Department of Clinical Neurosciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics University of California San Francisco CA USA Institute for Human Genetics University of California San Francisco CA USA Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan Department of Genomic Medicine National Cerebral and Cardiovascular Center Research Institute Suita Japan Laboratory of Clinical Genome Sequencing Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan Biobank Tokyo Japan Laboratory for Genotyping Development RIKEN Center of Integrative Medical Sciences Yokohama Japan Laboratory for Cancer Genomics RIKEN Center of Integrative Medical Sciences Yokohama Japan Division of Population Health Health Services Research and Primary Care School of Health Sciences Faculty of Biology Medicine and Health University of Manchester Manchester UK Warwick Medical School University of Warwick Coventry UK Epidemiology Program University of Hawaii Cancer Center Honolulu HI USA Behavioral and Epidemiology Research Group Research Program American Cancer Society Atlanta GA USA Institute of Biomedicine University of Turku Turku Finland Department of Medical Genetics Genomics Laboratory Division Turku University Hospital Turku Finland Department of Urolog

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,2... 详细信息

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BSBM-03 A NOVEL COMBINED IMMUNOTHERAPY TO IMPROVE THERAPEUTIC RESPONSES IN SYMPTOMATIC BRAIN METASTASIS BASED ON TARGETING A SUBPOPULATION OF IMMUNOSUPPRESSIVE ASTROCYTES

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Neuro-Oncology Advances 2023年第SUPPLEMENT_3期5卷 iii1-iii1页

作者： Neibla Priego Ana de Pablos-Aragoneses María Perea-García Laura Álvaro-Espinosa Carolina Hernández-Oliver Elena Martínez-Saez Ángel Pérez-Núñez Aurelio Hernández-Laín Rebeca Sanz-Pamplona Marc Schmitz Stephen J Crocker Diego Serrano Alfonso Calvo Asís Palazón RENACER Red Nacional de Metástasis Cerebral Manuel Valiente Brain Metastasis Group Spanish National Cancer Research Centre (CNIO) Madrid Spain Pathology Department Vall d'Hebron Hospital Barcelona Spain Spanish Biomedical Research Network Centre in Oncology (CIBERONC) Barcelona Spain Neuropathology Unit Hospital Universitario 12 de Octubre Research Institute Madrid Spain Aragon Health Research Institute (IISA) Zaragoza Spain Catalan Institute of Oncology (ICO) Oncobell Program IDIBELL and CIBERESP Barcelona Spain Institute of Immunology Faculty of Medicine Carl Gustav Carus TU Dresden Dresden Germany Department of Neuroscience University of Connecticut School of Medicine Farmington USA Center for Applied Clinical Research (CIMA)-Navarra University Pamplona Spain Center for Cooperative Research in Biosciences (CIC BioGUNE) Bilbao Spain Spanish National Cancer Research Centre (CNIO) Madrid Spain

The diagnosis of brain metastasis involves high morbidity and mortality. Recently, immune checkpoint blockade antibodies (ICB) have shown clinical benefits mainly when applied to asymptomatic brain metastasis patients. However, variability is broad and responses to this therapy drop considerably when treating clinically relevant disease. Although potentially involved in the lack of response to immunotherapy, corticoids do not seem to fully explain this situation. Thus, it is currently unknown how to effectively target symptomatic brain metastases with immunotherapy. We previously reported a clinically relevant protumoral program driven by STAT3 activation in a subpopulation of reactive astrocytes during advanced stages of the disease. By further exploiting astrocyte heterogeneity, we have found a potential strategy to improve the number of responders to immunotherapy in symptomatic brain metastasis. Specifically, we have developed a comprehensive strategy including genetic and pharmacologic approaches to define a novel immunosuppressive axis involving astrocyte-secreted TIMP1 signaling on CD63+ CD8+ T cells. Based on these findings, we developed a combined immunotherapy to boost the systemic activation of T cells with ICB while blocking local TIMP1-dependent immunosuppression in various preclinical models. Furthermore, the detection of TIMP1 in the CSF provides a biomarker to select patients who would benefit the most from the combined immunotherapy. Even more, our data using Patient Derived Organotypic Cultures from fresh brain metastasis neurosurgeries confirmed that our therapeutic strategy is valid for symptomatic brain metastases from any primary source. In conclusion, our study has identified a novel combined immunotherapy that could be especially relevant for symptomatic brain metastases. Our findings have emerged from a strong scientific rationale whereby a specific subpopulation of astrocytes is shown to activate the local immunosuppressive environment for

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Cellulose microcrystalline: A promising ecofriendly approach to control Culex quinquefasciatus larvae

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The Science of the total environment 2023年 901卷 165952页

作者： Sindoval Silva de Souza Alex Rodrigues Gomes Abraão Tiago Batista Guimarães Aline Sueli de Lima Rodrigues Letícia Paiva de Matos Juliana Dos Santos Mendonça Thiarlen Marinho da Luz Stênio Gonçalves da Silva Matos M Safiur Rahman Chinnasamy Ragavendran Sengottayan Senthil-Nathan Ajay Guru Md Refat Jahan Rakib Nabisab Mujawar Mubarak Md Mostafizur Rahman Thiago Lopes Rocha Abu Reza Md Towfiqul Islam Guilherme Malafaia Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil Laboratory of Toxicology Applied to the Environment Goiano Federal Institute - Urutaí Campus. Rodovia Geraldo Silva Nascimento 25 km Zona Rural Urutaí GO Brazil. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute - Urutaí Campus. Rodovia Geraldo Silva Nascimento 25 km Zona Rural Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Department of Environmental Science and Disaster Management Noakhali Science and Technology University Noakhali 3814 Bangladesh. Saveetha Dental College and Hospitals (SIMATS) Saveetha University Chennai Tamil Nadu India. Division of Biopesticides and Environmental Toxicology Sri Paramakalyani Centre for Excellence in Environmental Sciences Manonmaniam Sundaranar University Alwarkurichi Tirunelveli Tamil Nadu 627 412 India. Department of Cariology Saveetha Dental College and Hospitals SIMATS Chennai 600 077 Tamil Nadu India. Noakhali Science and Technology University Noakhali Bangladesh. Petroleum and Chemical Engineering Faculty of Engineering Universiti Teknologi Brunei Bandar Seri Begawan BE1410 Brunei Darussalam Department of Biosciences Saveetha School of Engineering Saveetha institute of Medical and Technical Sciences Chennai India. Jahangirnagar University Dhaka-1342 Bangladesh. Laboratory of Environmental Biotechnology and Ecotoxicology Institute of Tropical Pathology and Public Health Federal University of Goiás Goiânia Goiás Brazil. Department of Disaster Management Begum Rokeya University Rangpur 5400 Bangladesh. Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Conservation of Cerrado Natural

The growing use of synthetic chemical compounds/substances in vector control of mosquitoes, associated with their adverse effects on the environment and non-target organisms, has demanded the development of eco-friend... 详细信息

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