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The effect of menu labeling with calories and exercise equivalents on food selection and consumption

BMC obesity 2014年第1期1卷 21页

作者： Charles Platkin Ming-Chin Yeh Kimberly Hirsch Ellen Weiss Wiewel Chang-Yun Lin Ho-Jui Tung Victoria H Castellanos City University of New York School of Public Health Hunter College Nutrition and Food Science Program Hunter College Silberman Bldg 2180 Third Avenue New York NY 10035 USA. CUNY School of Public Health Graduate Center New York USA. Department of Applied Mathematics and Institute of Statistics National Chung Hsing University Taichung City Taiwan. Department of Healthcare Administration Asia University Taichung City Taiwan. The University of Scranton Scranton PA USA.

BACKGROUND:Better techniques are needed to help consumers make lower calorie food choices. This pilot study examined the effect of menu labeling with caloric information and exercise equivalents (EE) on food selection. Participants, 62 females, ages 18-34, recruited for this study, ordered a fast food meal with menus that contained the names of the food (Lunch 1 (L1), control meal). One week later (Lunch 2 (L2), experiment meal), participants ordered a meal from one of three menus with the same items as the previous week: no calorie information, calorie information only, or calorie information and EE. RESULTS:There were no absolute differences between groups in calories ordered from L1 to L2. However, it is noteworthy that calorie only and calorie plus exercise equivalents ordered about 16% (206 kcal) and 14% (162 kcal) fewer calories from Lunch 1 to Lunch 2, respectively; whereas, the no information group ordered only 2% (25 kcal) fewer. CONCLUSIONS:Menu labeling alone may be insufficient to reduce calories; however, further research is needed in finding the most effective ways of presenting the menu labels for general public.

关键词： Exercise equivalents Fast food Menu labeling Nutrition labeling Obesity Point-of-purchase

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Author Correction: Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson's disease

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Scientific reports 2018年第1期8卷 13953页

作者： Shuchun Chen Seong-Jin Yu Yazhou Li Daniela Lecca Elliot Glotfelty Hee Kyung Kim Ho-Il Choi Barry J Hoffer Nigel H Greig Dong Seok Kim Yun Wang Center for Neuropsychiatric Research National Health Research Institutes Zhunan Taiwan. Graduate Institute of Applied Science and Engineering Fu-Jen Catholic University New Taipei Taiwan. Drug Design and Development Section Translational Gerontology Branch Intramural Research Program National Institute on Aging National Institutes of Health Baltimore MD USA. Peptron Inc. Yuseong-gu Daejeon Republic of Korea. Department of Neurosurgery Case Western Reserve University School of Medicine Cleveland OH USA. Drug Design and Development Section Translational Gerontology Branch Intramural Research Program National Institute on Aging National Institutes of Health Baltimore MD USA. Greign@mail.nih.gov. Center for Neuropsychiatric Research National Health Research Institutes Zhunan Taiwan. ywang@nhri.org.tw.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

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Differences in body fat distribution assessed by ultrasonography in patients receiving antiretroviral drugs

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Revista da Associação Médica Brasileira (English Edition) 2012年第2期58卷 197-203页

作者： Dario Jose Hart Pontes Signorini Ana Maria Schmidt de Oliveira Netto Michelle Carreira Miranda Monteiro Dario Hart Signorini Cláudia Torres Codeço Francisco I. Bastos Sergio Gabbay Marion de Fátima Castro de Andrade PhD in Public Health (Epidemiology) Escola de Saúde Pública Sérgio Arouca (ENSP) Fundação Oswaldo Cruz (Fiocruz) Adjunct Professor Universidade Federal do Estado do Rio de Janeiro (UNIRIO) Rio de Janeiro RJ Brazil Postgraduate in Endocrinology Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio) Ultrasonographist Instituto Brasileiro de Ultrassonografia Rio de Janeiro RJ Brazil Postgraduate in Endocrinology UNIRIO Assistant Physician Hospital Universitário Gaffrée e Guinle (HUGG) Rio de Janeiro RJ Brazil Medical Student Medical School Universidade Estácio de Sá Graduate Student HUGG Rio de Janeiro RJ Brazil PhD in Quantitative Biology Researcher Scientific Computing Program Fiocruz Rio de Janeiro RJ Brazil PhD in Public Health at ENSP-Fiocruz Researcher Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (ICICT) Fiocruz Rio de Janeiro RJ Brazil MSc in Nuclear Biosciences Universidade Estadual do Rio de Janeiro (UERJ) Head of the Nuclear Medicine Service Hospital Federal dos Servidores do Estado (HFSE) Rio de Janeiro RJ Brazil Postgraduate in Immunology and Pediatrics Universidade Federal do Rio de Janeiro (UFRJ) Assistant Physician of HUGG Rio de Janeiro RJ Brazil

Objective This study aimed to evaluate the body fat content of HIV patients according to the duration of antiretroviral therapy use (DURARV), < 1 year and ≥ 1 year. Methods Multiple linear regression was used to investigate the association between ultrasonographic variables of body fat compartments (BFCs) of the face, arm, subcutaneous and visceral abdomen, and the following explanatory variables: gender, age, BMI, and DURARV. Results Of all patients (187), 102 of them with DURARV ≥ 1 year were suffering from HIV-related lipodystrophy (HIV-LD), diagnosed through clinical questionnaires. Those with DURARV < 1 year (n = 85, ≈ 46%) did not have HIV-LD. Regarding the visceral compartment, the difference between those with DURARV ≥ 1 year and < 1 year was 11 mm of additional fat content in those with DURARV ≥ 1 year. Women had more fat than men in all peripheral BFCs, while men had 7.2 mm more visceral fat than women, on average. Conclusion Ultrasonography is a method capable of measuring the thickness of BFCs and is applicable to clinical practice to diagnose HIV-LD.

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50

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Cytokine 2013年第3期63卷 255-255页

作者： Sandra T. Clarke Martin Kalmokoff Stephen P.J. Brooks Premysl Bercik Dan Ramdath Julia M. Green-Johnson Applied Bioscience Graduate Program & Faculty of Science University of Ontario Institute of Technology Oshawa Ont. Canada Atlantic Food and Horticulture Research Center Agriculture and Agri-Food Canada Kentville NS Canada Bureau of Nutritional Sciences Health Canada Ottawa Ont. Canada Department of Medicine McMaster University Medical Center Hamilton Ont. Canada Guelph Food Research Centre Agriculture and Agri-Food Canada Guelph Ont. Canada

A double-blind, placebo-controlled, randomized crossover clinical trial involving 30 healthy adults was conducted to examine the impact of fructans on both the gut microbiota and immune system. Along with their regular diet, trial participants consumed either an oligofructose-enriched inulin supplement as the test diet or food grade maltodextrin as the control diet for a 28 day period, with a minimum 2 week washout period before cross-over. The trial supplements were coded as “A” or “B”, and will remain coded until the completion of all analyses. Serum immunoglobulin concentrations were quantified by Luminex multiplexing technology. IgM was significantly higher after 28 days of supplement A consumption (821.3 ng/mL ± 138.3) than after supplement B consumption (485.8 ng/mL ± 66.5) ( P = 0.0118). IgA was also significantly higher ( P = 0.0092) after supplement A consumption (1967.3 ng/mL ± 374.4) than after supplement B consumption (911.7 ng/mL ± 138.2). Active transforming growth factor-beta (TGF- β ) concentration was measured in plasma and serum cytokine concentrations were quantified by Enzyme-linked immunosorbent assay (ELISA). Levels of active TGF- β were 5.4 pg/mL ± 2.1 after consumption of supplement B, in comparison to 3.4 pg/mL ± 1.5 after supplement A consumption, although this difference was not statistically significant. IL-10 concentrations were significantly lower ( P = 0.0172) after supplement B consumption (41.2 pg/mL ± 29.0) than after supplement A consumption (79.8 pg/mL ± 42.1). Granulocyte colony-stimulating factor (G-CSF) levels were also significantly lower ( P = 0.0265) after supplement B consumption (5.4 pg/mL ± 2.5) than levels after supplement A consumption (14.4 pg/mL ± 3.6). No differences were observed between subjects consuming supplement A and B in Interleukin-8 (IL-8) and IL-1Ra concentrations. Analysis of cytokine profiles will provide insight into the e

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Cytokine 2013年第3期63卷 298-298页

作者： Padmaja Shastri Justin McCarville Stephen P.J. Brooks Martin Kalmokoff Julia M. Green-Johnson Applied Bioscience Graduate Program and Faculty of Science University of Ontario Institute of Technology Oshawa Ontario L1H 7K4 Canada Bureau of Nutritional Sciences Health Canada Ottawa Ontario K1A 0K9 Canada Atlantic Food and Horticulture Research Center Agriculture and Agri-Food Canada Kentville Nova Scotia B4N 1J5 Canada

Gut microbiota-mediated effects on the immune system can influence cytokine production in gut-associated lymphoid tissues (GALT). The extent to which gender-associated differences in gut microbiota composition influence mucosal cytokine patterns is as yet undetermined, as is the impact such differences may have on the ability of fermentable material to modulate immune activity through effects on the gut microbiota. To explore these questions, we analyzed the effects of a fructo-oligosaccharide (FOS)-supplemented Purina chow diet on mucosal cytokine profiles, focusing on IL-6 (pro-inflammatory), IL-4 (TH 2 ) and IL-10 (regulatory T reg ). To compare gender-associated effects of FOS at the gut microbial and intestinal epithelial level, we measured fecal short chain fatty acid profiles (by gas chromatography) and mucin gene MUC2 expression (determined by quantitative real-time PCR). No major FOS-induced changes in cytokine profiles (vs. control) were observed in the ileum of male or female rats, although gender-specific differences in cytokine levels were observed. Cecal IL-6 (7732.49 ± 863 pg/g) was higher in FOS-fed male rats compared to FOS-fed female rats (5057.9 ± 536.5 pg/g). Cecal IL-10 was significantly lower in male rats fed the control diet (5301.2 ± 241.6 pg/g) relative to female rats fed the same diet (8164 ± 843.6 pg/g). However, cecal IL-10 was elevated in FOS-fed male rats (6484.3 ± 1269.7 pg/g) to levels similar to those of FOS-fed female rats (6662.4 ± 335.6 pg/g), indicating a potential differential effect of dietary FOS on this regulatory cytokine in males and females. Fecal butyric acid concentrations in FOS-fed male rats (35.1 ± 7.1 mmol/g) were significantly higher than those in FOS-fed female rats (13.6 ± 2.6 mmol/g), suggesting a gender-associated difference in the effects of FOS at the gut microbial level. Preliminary results indicate higher cecal MUC2 expression in male rats relative to female ra

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Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3

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Biomedicine and Pharmacotherapy 2024年 180卷 117533-117533页

作者： Asensio, Maitane Briz, Oscar Herraez, Elisa Perez-Silva, Laura Espinosa-Escudero, Ricardo Bueno-Sacristan, Diego Peleteiro-Vigil, Ana Hammer, Helen Pötz, Oliver Kadioglu, Onat Banales, Jesus M. Martinez-Chantar, Maria L. Avila, Matias A. Macias, Rocio I.R. Efferth, Thomas Marin, Jose J.G. Lozano, Elisa Experimental Hepatology and Drug Targeting (HEVEPHARM) University of Salamanca Salamanca Spain Institute for Biomedical Research of Salamanca (IBSAL) Salamanca Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) Carlos III National Institute of Health Madrid Spain Service of Pathology University Hospital of Salamanca Salamanca Spain Signatope GmbH Reutlingen Germany Natural and Medical Sciences Institute at the University of Tubingen (NMI) Reutlingen Germany Department of Pharmaceutical Biology Institute of Pharmaceutical and Biomedical Sciences Johannes Gutenberg University Mainz Germany Department of Liver and Gastrointestinal Diseases Biogipuzkoa Health Research Institute Donostia University Hospital University of the Basque Country (UPV/EHU) San Sebastian Ikerbasque Spain Department of Biochemistry and Genetics School of Sciences University of Navarra Pamplona Spain Liver Disease Laboratory Center for Cooperative Research in Biosciences (CICbioGUNE) Basque Research and Technology Alliance (BRTA) Derio Spain Hepatology Laboratory Solid Tumors Program Center for Applied Medical Research (CIMA) University of Navarra Pamplona Spain

Aims: Drug export through ABC proteins hinders cancer response to chemotherapy. Here, we have evaluated the relevance of MRP3 (ABCC3) in cholangiocarcinoma (CCA) as a potential target to overcome drug resistance. Methods: Gene expression was analyzed in silico using the TCGA-CHOL database and experimentally (mRNA and protein) in resected CCA tumors. The effect of manipulating MRP3 function/expression was evaluated in vitro and in vivo. Results: High MRP3 expression at the plasma membrane of human CCA cells was found. MRP3 overexpression in HEK293T cells selectively impaired the cytotoxic effect of etoposide, cisplatin, SN-38, and mitoxantrone. Reduced MRP3 activity with shRNAs or pan-MRP blockers enhanced the sensitivity to these drugs. MRP3 interaction with natural and semisynthetic compounds (≈40,000) was evaluated by virtual drug screening and molecular docking. Two identified potential MRP3 inhibitors (EM-114, EM-188), and sorafenib impaired MRP3 transport activity and enhanced sensitivity of CCA cells to etoposide and cisplatin. The antitumor effect of cisplatin in the mouse xenograft model was enhanced by co-treatment with sorafenib, which was accompanied by a higher intratumor accumulation of cisplatin. Conclusions: Genetic and pharmacological MRP3 inhibition enhances the anti-CCA effect of several drugs, which constitutes a promising strategy to improve the response to chemotherapy in CCA patients. © 2024 The Authors

关键词： ABC transporters Biliary tract cancer Chemosensitization Natural products Tyrosine kinase inhibitors

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Commentaries on Viewpoint: Physiology and fast marathons

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Journal of applied physiology (Bethesda, Md. : 1985) 2020年第4期128卷 1069-1085页

作者： Jordan Santos-Concejero Fernando González-Mohíno José María González-Ravé Stephane Perrey Arthur H. Dewolf Brandon A. Yates Anton Ušaj Tadej Debevec José Manuel González-Rayas Ana Lilia Rayas-Gómez José Manuel González-Yáñez Romuald Lepers Paul Stapley Julien Louis Felix Proessl P T Nikolaidis B Knechtle D Muniz-Pumares B Hunter L Bottoms Bastien Bontemps Pedro L. Valenzuela Daniel Boullosa Juan Del Coso Richard C. Blagrove Philip R. Hayes Gregoire P. Millet Davide Malatesta Yuri de Almeida Costa Campos Miller Pereira Guimarães Jeferson Macedo Vianna Sandro Fernandes da Silva Paulo Henrique Silva Marques de Azevedo Hunter L. Paris Margaret A. Leist Mast T. Lige William Malysa Alicia S. Oumsang Erin C. Sinai Rasmus K. Hansen Niels H. Secher Stefanos Volianitis Laura Hottenrott Kuno Hottenrott Thomas Gronwald Jonathon W. Senefeld Ricardo J. Fernandes João Paulo Vilas-Boas Alain Riveros-Rivera Dieter Böning Daniel H. Craighead Shalaya Kipp Rodger Kram Christoph Zinner Billy Sperlich Hans-Christer Holmberg Borja Muniz-Pardos Shaun Sutehall Konstantinos Angeloudis Fergus M. Guppy Andrew Bosch Yannis Pitsiladis David C. Andrade Rodrigo Del Rio Rodrigo Ramirez-Campillo Thiago Ribeiro Lopes Bruno Moreira Silva Stephen J. Ives Peter G. Weyand Cayque Brietzke Paulo Estevão Franco-Alvarenga Tony Meireles dos Santos Flávio Oliveira Pires Gwenael Layec Wouter Hoogkamer Christopher S. Balestrini Curtis S. Goss Mikaela C. Gabler Albaro Escalera Shane A. Bielko Robert F. Chapman Department of Physical Education and Sport University of the Basque Country UPV/EHU Vitoria-Gasteiz Spain University of Castilla-La Mancha Sport Training Lab Toledo Spain Facultad de Lenguas y Educación Universidad Nebrija Madrid Spain EuroMov Digital Health in Motion University of Montpellier IMT Mines Ales Montpellier France Department of Systems Medicine and Center of Space Biomedicine University of Rome Tor Vergata Rome Italy Department of Kinesiology Indiana University-Purdue University of Indianapolis Indianapolis Indiana Indiana Center for Musculoskeletal Health Indiana University School of Medicine Indianapolis Indiana Faculty of Sport University of Ljubljana Ljubljana Slovenia Department of Automation Biocybernetics and Robotics Jozef Stefan Institute Ljubljana Slovenia School of Medicine and Health Sciences Monterrey Institute of Technology and Higher Education Monterrey México Hospital San José de Querétaro Querétaro México INSERM UMR1093-CAPS UFR des Sciences du Sport Université Bourgogne Franche-Comté Dijon France Neural Control of Movement Laboratory School of Medicine Faculty of Science Medicine and Health Illawarra Health and Medical Research Institute University of Wollongong New South Wales Australia Research Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United Kingdom Neuromuscular Research Laboratory University of Pittsburgh Pittsburgh Pennsylvania School of Health and Caring Sciences University of West Attica Athens Greece Institute of Primary Care University of Zurich Zurich Switzerland Department of Psychology and Sport Sciences School of Life and Medical Sciences University of Hertfordshire Hatfield United Kingdom Unité de recherche Impact de l’Activité Physique sur la Santé (UR IAPS Number 201723207F) University of Toulon Toulon France Department of Systems Biology University of Alcalá Madrid Spain Department of Sport and Health Spanish Agency for Health Protection in Sport (AEPSAD)

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Establishing a community for planetary health in the Philippines

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The Lancet. Planetary health 2021年第7期5卷 e396-e397页

作者： Renzo R Guinto Marilen Parungao-Balolong Ronilo Jose D Flores Marianne K Bongcac Planetary and Global Health Program St Luke's Medical Center College of Medicine-William H Quasha Memorial Quezon City 1112 Philippines PH Lab Manila Philippines. Electronic address: guinto.rl.f@slmc-cm.edu.ph. Applied Microbiology for Health and Environment Research Group College of Arts and Sciences University of the Philippines Manila Manila Philippines. Environmental Biology Division Institute of Biological Sciences and Graduate School University of the Philippines Los Baños Laguna Philippines. PH Lab Manila Philippines.

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Correction to: Views, knowledge, and practices of hospital pharmacists about using clinical pharmacokinetics to optimize pharmaceutical care services: a cross-sectional study

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BMC health services research 2022年第1期22卷 525页

作者： Ramzi Shawahna Naser Shraim Rafeef Aqel Department of Physiology Pharmacology and Toxicology Faculty of Medicine and Health Sciences An-Najah National University P.O. Box 7 New Campus Building: 19 Ofce: 1340 Nablus Palestine. ramzi_shawahna@***. An-Najah BioSciences Unit Centre for Poisons Control Chemical and Biological Analyses An-Najah National University Nablus Palestine. ramzi_shawahna@***. Department of Pharmacy Faculty of Medicine and Health Sciences An-Najah National University Nablus Palestine. N_shraim@najah.edu. Master of Clinical Pharmacy Program Faculty of Graduate Studies An-Najah National University Nablus Palestine.

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Digital health literacy and well-being among university students: Mediating roles of fear of COVID-19, information satisfaction, and internet information search

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Digital health 2023年 9卷

作者： Sheng-Chih Chen Nhi Thi Hong Nguyen Cheng-Yu Lin Le Duc Huy Chih-Feng Lai Loan T Dang Nguyen L T Truong Nhi Y Hoang Thao T P Nguyen Tan N Phaṇ Kevin Dadaczynski Orkan Okan Tuyen Van Duong Graduate Program in Digital Content and Technologies College of Communication National Chengchi University Taipei Taiwan. School of Health Care Administration College of Management Taipei Medical University Taipei Taiwan. Health Personnel Training Institute University of Medicine and Pharmacy Hue University Hue Vietnam. Department of Radio Television & Film Shih Hsin University Taipei Taiwan. Department of Education National Taichung University of Education Taichung Taiwan. Faculty of Nursing and Midwifery Hanoi Medical University Hanoi Vietnam. School of Nursing National Taipei University of Nursing and Health Sciences Taipei Taiwan. Pharmacy Department School of Medicine Vietnam National University Ho Chi Minh City Binh Duong Vietnam. Pharmacy Department Thong Nhat Hospital Ho Chi Minh City Vietnam. School of Nutrition and Health Sciences Taipei Medical University Taipei Taiwan. Institute for Community Health Research University of Medicine and Pharmacy Hue University Hue Vietnam. Department of Tropical Diseases Cho Ray Hospital Ho Chi Minh City Vietnam. International Health Program College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan. Public Health Centre Fulda Fulda University of Applied Sciences Fulda Germany. Center for Applied Health Science Leuphana University of Lueneburg Lueneburg Germany. Department of Sport and Health Sciences Technical University of Munich Munich Germany.

Background:Digital health literacy (DHL) enables healthy decisions, improves protective behaviors and adherence to COVID-19 measures, especially during the era of the "infodemic", and enhances psychological well-being. Objective:We aimed to explore the mediating roles of fear of COVID-19, information satisfaction, and the importance of online information searching on the association between DHL and well-being. Methods:A cross-sectional web-based survey was conducted among 1631 Taiwanese university students, aged 18 years and above, from June 2021 to March 2022. The collected data include sociodemographic characteristics (sex, age, social status, and financial satisfaction), the importance of online information searching, information satisfaction, fear of COVID-19, DHL, and well-being. A linear regression model was utilized to investigate factors associated with well-being, followed by a pathway analysis to assess the direct and indirect relationship between DHL and well-being. Results:The scores of DHL and overall well-being were 3.1 ±0.4 and 74.4 ± 19.7, respectively. Social status (B = 2.40, 95% confidence interval (CI) 1.73-3.07, < 0.001), DHL (B 0.29, 95% CI 0.10-0.49, < 0.001), importance of online information searching (B = 0.78, 95% CI 0.38-1.17, < 0.001), and information satisfaction (B = 3.59, 95% CI 2.22-4.94, < 0.001) were positively associated with well-being, whereas higher fear of COVID-19 scores (B = -0.38, 95% CI -0.55-(-0.21), < 0.001) and female (B = -2.99, 95% CI -5.02-0.6, = 0.004) were associated with lower well-being, when compared with lower fear scores and male, respectively. Fear of COVID-19 (B = 0.03, 95% CI 0.016-0.04, < 0.001), importance of online information searching (B = 0.03, 95% CI 0.01-0.05, = 0.005), and information satisfaction (B = 0.05, 95% CI 0.023-0.067, < 0.001) were significantly mediated the relationship between DHL and well-being. Conclusion:Higher DHL scores show direct and indirect associations with higher well

关键词： COVID-19 Taiwanese students digital health literacy mediator pathway analysis well-being

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