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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Nature communications 2023年第1期14卷 3043页

作者： Jianxin Shi Kouya Shiraishi Jiyeon Choi Keitaro Matsuo Tzu-Yu Chen Juncheng Dai Rayjean J Hung Kexin Chen Xiao-Ou Shu Young Tae Kim Maria Teresa Landi Dongxin Lin Wei Zheng Zhihua Yin Baosen Zhou Bao Song Jiucun Wang Wei Jie Seow Lei Song I-Shou Chang Wei Hu Li-Hsin Chien Qiuyin Cai Yun-Chul Hong Hee Nam Kim Yi-Long Wu Maria Pik Wong Brian Douglas Richardson Karen M Funderburk Shilan Li Tongwu Zhang Charles Breeze Zhaoming Wang Batel Blechter Bryan A Bassig Jin Hee Kim Demetrius Albanes Jason Y Y Wong Min-Ho Shin Lap Ping Chung Yang Yang She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young-Chul Kim Neil E Caporaso Jiang Chang James Chung Man Ho Michiaki Kubo Yataro Daigo Minsun Song Yukihide Momozawa Yoichiro Kamatani Masashi Kobayashi Kenichi Okubo Takayuki Honda Dean H Hosgood Hideo Kunitoh Harsh Patel Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Hidehito Horinouchi Masahiro Tsuboi Ryuji Hamamoto Koichi Goto Yuichiro Ohe Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Megumi Hara Yuichiro Nishida Kenji Takeuchi Kenji Wakai Koichi Matsuda Yoshinori Murakami Kimihiro Shimizu Hiroyuki Suzuki Motonobu Saito Yoichi Ohtaki Kazumi Tanaka Tangchun Wu Fusheng Wei Hongji Dai Mitchell J Machiela Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Gee-Chen Chang Ying-Huang Tsai Kuan-Yu Chen Ming-Shyan Huang Wu-Chou Su Yuh-Min Chen Adeline Seow Jae Yong Park Sun-Seog Kweon Kun-Chieh Chen Yu-Tang Gao Biyun Qian Chen Wu Daru Lu Jianjun Liu Ann G Schwartz Richard Houlston Margaret R Spitz Ivan P Gorlov Xifeng Wu Ping Yang Stephen Lam Adonina Tardon Chu Chen Stig E Bojesen Mattias Johansson Angela Risch Heike Bickeböller Bu-Tian Ji H-Erich Wichmann David C Christiani Gadi Rennert Susanne Arnold Paul Brennan James McKay John K Field Sanjay S Shete Loic Le Marchand Geoffrey Liu Angeline Andrew Lambertus A Kiemeney Shan Zienolddiny-Narui Kjell Grankvist Mikael Johansson Angela Cox Fiona Taylor Jian-Min Yuan Philip Lazarus Matthew B Schabath Melinda C Aldrich Hyo-Sung Jeon Shih Sheng Jiang Jae Sook Sung C Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. jianxin.shi@nih.gov. Division of Genome Biology National Cancer Research Institute Tokyo Japan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing China. Prosserman Centre for Population Health Research Lunenfeld-Tanenbaum Research Institute Sinai Health Toronto ON Canada. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Tianjin China. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Epidemiology School of Public Health China Medical University Shenyang China. Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang China. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China. S

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

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The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

NPJ Biodiversity

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NPJ Biodiversity 2024年第1期3卷 28页

作者： Mc Cartney, Ann M. Formenti, Giulio Mouton, Alice De Panis, Diego Marins, Luísa S. Leitão, Henrique G. Diedericks, Genevieve Kirangwa, Joseph Morselli, Marco Salces-Ortiz, Judit Escudero, Nuria Iannucci, Alessio Natali, Chiara Svardal, Hannes Fernández, Rosa De Pooter, Tim Joris, Geert Strazisar, Mojca Wood, Jonathan M. D. Herron, Katie E. Seehausen, Ole Watts, Phillip C. Shaw, Felix Davey, Robert P. Minotto, Alice Fernández, José M. Böhne, Astrid Alegria, Carla Alioto, Tyler Alves, Paulo C. Amorim, Isabel R. Aury, Jean-Marc Backstrom, Niclas Baldrian, Petr Baltrunaite, Laima Barta, Endre Bedhom, Bertrand Belser, Caroline Bergsten, Johannes Bertrand, Laurie Bilandija, Helena Binzer-Panchal, Mahesh Bista, Iliana Blaxter, Mark Borges, Paulo A. V. Dias, Guilherme Borges Bosse, Mirte Brown, Tom Bruggmann, Rémy Buena-Atienza, Elena Burgin, Josephine Buzan, Elena Cariani, Alessia Casadei, Nicolas Chiara, Matteo Chozas, Sergio Jr, Fedor Čiampor Crottini, Angelica Cruaud, Corinne Cruz, Fernando Dalen, Love Biase, Alessiode Delcampo, Javier Delic, Teo Dennis, Aliceb. Derks, Martijn F. L. Diroma, Maria Angela Djan, Mihajla Duprat, Simone Eleftheriadi, Klara Feulner, Philine G. D. Flot, Jean-François Forni, Giobbe Fosso, Bruno Fournier, Pascal Fournier-Chambrillon, Christine Gabaldon, Toni Garg, Shilpa Gissi, Carmela Giupponi, Luca Gomez-Garrido, Jessica González, Josefa Grilo, Miguel L. Grüning, Björn Guerin, Thomas Guiglielmoni, Nadege Gut, Marta Haesler, Marcel P. Hahn, Christoph Halpern, Balint Harrison, Peter W. Heintz, Julia Hindrikson, Maris Höglund, Jacob Howe, Kerstin Hughes, Graham M. Istace, Benjamin Cock, Mark J. Janžekovič, Franc Jonsson, Zophonias O. Joye-Dind, Sagane Koskimäki, Janne J. Krystufek, Boris Kubacka, Justyna Kuhl, Heiner Kusza, Szilvia Labadie, Karine Lähteenaro, Meri Lantz, Henrik Lavrinienko, Anton Leclère, Lucas Lopes, Ricardo Jorge Madsen, Ole Magdelenat, Ghislaine Magoga, Giulia Manousaki, Tereza Mappes, Tapio Marques, Joao Pedro Redondo, Gemma I. Martinez Maumus, Florian McCarthy, Shane A. M Genomics Institute University of California SantaCruz CA United States TheVertebrate Genome Laboratory The Rockefeller University NewYork NY United States Department of Biology University of Florence Sesto Fiorentino Italy InBios-Conservation Genetics Laboratory University of Liege Liege Belgium Leibniz Institut für Zoo und Wildtierforschung Berlin Germany Berlin Center for Genomics in Biodiversity Research Berlin Germany Department of Biology University of Antwerp Antwerp Belgium Institute of Zoology University of Cologne Cologne Germany Department of Chemistry Life Sciences and Environmental Sustainability University of Parma Parma Italy Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra Barcelona Spain Naturalis Biodiversity Center Leiden Netherlands Neuromics Support Facility VIB Center for Molecular Neurology VIB Antwerp Belgium Neuromics Support Facility Department of Biomedical SciencesUniversity ofAntwerp Antwerp Belgium Tree of Life WellcomeSanger Institute Cambridge Hinxton United Kingdom School of Biology and Environmental Science University College Dublin Belfield Ireland Aquatic Ecology & Evolution Institute of Ecology & Evolution University of Bern Bern Switzerland Department of Fish Ecology & Evolution Eawag Kastanienbaum Switzerland Department of Biological and Environmental Science University of Jyvaskyla Jyvaskyla Finland The EarlhamInstitute NorwichResearchPark Norwich United Kingdom Digital Science London United Kingdom Barcelona Supercomputing Center Spanish National Bioinformatics Institute ELIXIR Spain Getafe Spain Leibniz Institute for the Analysis of Biodiversity Change Museum Koenig Bonn Bonn Germany CE3C—Centre for Ecology Evolution and Environmental Changes & CHANGE—Global Change and Sustainability Institute Faculdade de Ciências Universidade de Lisboa Campo Grande Lisboa Portugal Centro Nacional de Análisis Genómico (CNAG) Barcelona Spain Universitat de Barcelona (UB) Barcelona Spain CIBIO Cen

A genomic database of all Earth’s eukaryotic species could contribute to many scientific discoveries;however, only a tiny fraction of species have genomic information available. In 2018, scientists across the world united under the Earth BioGenome Project (EBP), aiming to produce a database of highquality reference genomes containing all ~1.5 million recognized eukaryotic species. As the European node of the EBP, the European Reference Genome Atlas (ERGA) sought to implement a new decentralised, equitable and inclusive model for producing reference genomes. For this, ERGA launched a Pilot Project establishing the first distributed reference genome production infrastructure and testing it on 98 eukaryotic species from 33 European countries. Here we outline the infrastructure and explore its effectiveness for scaling high-quality reference genome production, whilst considering equity and inclusion. The outcomes and lessons learned provide a solid foundation for ERGA while offering key learnings to other transnational, national genomic resource projects and the EBP. © The Author(s) 2024, corrected publication 2024.

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The Expectations and Challenges of Wildlife Disease Research in the Era of Genomics: Forecasting with a Horizon Scan-like Exercise (vol 110, pg 261, 2019)

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JOURNAL OF HEREDITY 2019年第5期110卷 639-639页

作者： Fitak, R. R. Department of Biology Duke University Durham NC USA Address correspondence to R. R. Fitak at the address above or e-mail: rfitak9@***. Department of Forestry & Natural Resources Purdue University West Lafayette IN The Zoo New England Division of Animal Health and Conservation Boston MA The Instituto BIOSFERA and Colegio de Ciencias Biológicas y Ambientales Universidad San Francisco de Quito vía Interoceánica y Diego de Robles Quito Ecuador The Institute for Conservation Research San Diego Zoo Global Escondido CA The Institute for Conservation Research San Diego Zoo Global Escondido CA Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO The U. S. Geological Survey National Wildlife Health Center Madison WI The Interdisciplinary Graduate Program of Genetics Texas A&M University College Station TX The Department of Veterinary Population Medicine University of Minnesota St. Paul MN The Department of Veterinary Population Medicine University of Minnesota St. Paul MN The Department of Veterinary Population Medicine University of Minnesota St. Paul MN The Department of Biology Colorado State University Fort Collins CO The Department of Biology Colorado State University Fort Collins CO The University of Tennessee Knoxville TN The Encinitas CA The Odum School of Ecology University of Georgia Athens GA The Department of Pathobiology Canadian Wildlife Health Cooperative University of Guelph Guelph Ontario Canada The School of Food and Agriculture

The outbreak and transmission of disease-causing pathogens are contributing to the unprecedented rate of biodiversity decline. Recent advances in genomics have coalesced into powerful tools to monitor, detect, and reconstruct the role of pathogens impacting wildlife populations. Wildlife researchers are thus uniquely positioned to merge ecological and evolutionary studies with genomic technologies to exploit unprecedented “Big Data” tools in disease research; however, many researchers lack the training and expertise required to use these computationally intensive methodologies. To address this disparity, the inaugural “Genomics of Disease in Wildlife” workshop assembled early to mid-career professionals with expertise across scientific disciplines (e.g., genomics, wildlife biology, veterinary sciences, and conservation management) for training in the application of genomic tools to wildlife disease research. A horizon scanning-like exercise, an activity to identify forthcoming trends and challenges, performed by the workshop participants identified and discussed 5 themes considered to be the most pressing to the application of genomics in wildlife disease research: 1) “Improving communication,” 2) “Methodological and analytical advancements,” 3) “Translation into practice,” 4) “Integrating landscape ecology and genomics,” and 5) “Emerging new questions.” Wide-ranging solutions from the horizon scan were international in scope, itemized both deficiencies and strengths in wildlife genomic initiatives, promoted the use of genomic technologies to unite wildlife and human disease research, and advocated best practices for optimal use of genomic tools in wildlife disease projects. The results offer a glimpse of the potential revolution in human and wildlife disease research possible through multi-disciplinary collaborations at local, regional, and global scales.

关键词： biodiversity bioinformatics comparative genomics host next generation DNA sequencing pathogen

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Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

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Nature Communications 2023年第1期14卷 1页

作者： Josepmaria Argemi Joel P. Gue Meritxell Ventura-Cots Ramon Bataller Maria U. Latasa Carmen Berasain Matias A. Avila Stephen R. Atkinson Mark R. Thursz Ilya O. Blokhin Claes Wahlestedt Veronica Massey Joaquin Cabezas Gemma Odena Juan J. Lozano Juan Caballeria Pau Sancho-Bru Derek Van Booven Aaron Bell Juan L. Gomez Satdarshan P. Monga Sheng Cao Juan P. Arab Vijay H. Shah Lawrence A. Vernetti D. Lansing Taylor Lia R. Edmunds Michael J. Jurczak Constantino Fondevila Peter Stärkel Laurent Dubuquoy Alexandre Louvet Philippe Mathurin Tomas Aragon Jose Altamirano Marsha Y. Morgan Shinji Furuya Ivan Rusyn Carolin Lackner Jelena Mann Division of Gastroenterology Hepatology and Nutrition Pittsburgh Liver Research Center University of Pittsburgh Medical Center (UPMC) Pittsburgh PA 15261 USA Liver Unit Clínica Universidad de Navarra University of Navarra Pamplona 31008 Spain Division of Gastroenterology and Hepatology Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies University of North Carolina at Chapel Hill Chapel Hill NC 27516 USA Hepatology Program Center for Applied Medical Research (CIMA) University of Navarra Pamplona 31008 Spain Centro de Investigacion Biomedica en Red Enfermedades Hepáticas y Digestivas (CIBERehd) Madrid 28029 Spain Division of Digestive Diseases Department of Surgery and Cancer Imperial College London London SW7 2AZ UK Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami FL 33136 USA Departament of Hepatology Marqués de Valdecilla University Hospital Santander 39008 Spain Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona 08036 Spain John P. Hussman Institute of Human Genomics. Miller School of Medicine University of Miami Miami FL 33136 USA Departments of Pathology and Medicine Pittsburgh Liver Research Center University of Pittsburgh School of Medicine Pittsburgh PA 15261 USA Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN 55905 USA Departamento de Gastroenterologia Escuela de Medicina Pontificia Universidad Catolica de Chile Santiago Chile University of Pittsburgh Drug Discovery Institute Department of Computational & Systems Biology University of Pittsburgh Pittsburgh PA 15261 USA Department of Medicine Division of Endocrinology and Metabolism Center for Metabolic and Mitochondrial Medicine University of Pittsburgh Pittsburgh PA 15261 USA Liver Transplant Unit Department of Surgery Hospital Clinic University of Barcelona Barcelona 08036 Spain Service d’Hépato-gastroentérologie

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Technical recommendations for analyzing oxylipins by liquid chromatography-mass spectrometry

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Science signaling 2025年第887期18卷 eadw1245页

作者： Nils Helge Schebb Nadja Kampschulte Gerhard Hagn Kathrin Plitzko Sven W Meckelmann Soumita Ghosh Robin Joshi Julia Kuligowski Dajana Vuckovic Marina T Botana Ángel Sánchez-Illana Fereshteh Zandkarimi Aditi Das Jun Yang Louis Schmidt Antonio Checa Helen M Roche Aaron M Armando Matthew L Edin Fred B Lih Juan J Aristizabal-Henao Sayuri Miyamoto Francesca Giuffrida Arieh Moussaieff Rosário Domingues Michael Rothe Christine Hinz Ujjalkumar Subhash Das Katharina M Rund Ameer Y Taha Robert K Hofstetter Markus Werner Oliver Werz Astrid S Kahnt Justine Bertrand-Michel Pauline Le Faouder Robert Gurke Dominique Thomas Federico Torta Ivana Milic Irundika H K Dias Corinne M Spickett Denise Biagini Tommaso Lomonaco Helena Idborg Jun-Yan Liu Maria Fedorova David A Ford Anne Barden Trevor A Mori Paul D Kennedy Kirk Maxey Julijana Ivanisevic Hector Gallart-Ayala Cécile Gladine Markus Wenk Jean-Marie Galano Thierry Durand Ken D Stark Coral Barbas Ulrike Garscha Stacy L Gelhaus Uta Ceglarek Nicolas Flamand Julian L Griffin Robert Ahrends Makoto Arita Darryl C Zeldin Francisco J Schopfer Oswald Quehenberger Randall Julian Anna Nicolaou Ian A Blair Michael P Murphy Bruce D Hammock Bruce Freeman Gerhard Liebisch Charles N Serhan Harald C Köfeler Per-Johan Jakobsson Dieter Steinhilber Michael H Gelb Michal Holčapek Ruth Andrew Martin Giera Garret A FitzGerald Robert C Murphy John W Newman Edward A Dennis Kim Ekroos Ginger L Milne Miguel A Gijón Hubert W Vesper Craig E Wheelock Valerie B O'Donnell School of Mathematics and Natural Sciences University of Wuppertal Wuppertal Germany. Unit of Integrative Metabolomics Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden. Applied Analytical Chemistry University of Duisburg-Essen Essen Germany. Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Neonatal Research Group Health Research Institute La Fe (IIS La Fe) Valencia Spain. Department of Chemistry and Biochemistry Concordia University Montreal Canada. School of Biological Sciences Victoria University of Wellington Wellington New Zealand. Department of Analytical Chemistry University of Valencia Burjassot Spain. Mass Spectrometry Core Facility Department of Chemistry Columbia University New York NY USA. School of Chemistry and Biochemistry Georgia Institute of Technology Atlanta GA USA. Department of Entomology University of California Davis CA USA. Department of Pharmaceutical and Medicinal Chemistry Institute of Pharmacy University of Greifswald Greifswald Germany. Nutrigenomics Research Group UCD Conway Institute School of Public Health Physiotherapy and Sports Science University College Dublin Ireland. Institute for Global Food Security Queen's University Belfast Belfast Northern Ireland. Department of Pharmacology and Department of Chemistry and Biochemistry University of California at San Diego La Jolla CA USA. Division of Intramural Research National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park Durham NC USA. BPG Bio Framingham MA USA. Department of Biochemistry Institute of Chemistry University of São Paulo São Paulo Brazil. Nestlé Institute of Food Safety and Analytical Sciences Société des Produits Nestlé Lausanne Switzerland. Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel. Department of Chemistry University of Aveiro Aveiro Portugal. Lipidomix GmbH Ber

Several oxylipins are potent lipid mediators that regulate diverse aspects of health and disease and whose quantitative analysis by liquid chromatography-mass spectrometry (LC-MS) presents substantial technical challenges. As members of the lipidomics community, we developed technical recommendations to ensure best practices when quantifying oxylipins by LC-MS.

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Addressing climate change with behavioral science: A global intervention tournament in 63 countries

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Science Advances 2024年第6期10卷 eadj5778页

作者： Vlasceanu, Madalina Doell, Kimberly C. Bak-Coleman, Joseph B. Todorova, Boryana Berkebile-Weinberg, Michael M. Grayson, Samantha J. Patel, Yash Goldwert, Danielle Pei, Yifei Chakroff, Alek Pronizius, Ekaterina van den Broek, Karlijn L. Vlasceanu, Denisa Constantino, Sara Morais, Michael J. Schumann, Philipp Rathje, Steve Fang, Ke Aglioti, Salvatore Maria Alfano, Mark Alvarado-Yepez, Andy J. Andersen, Angélica Anseel, Frederik Apps, Matthew A.J. Asadli, Chillar Awuor, Fonda Jane Azevedo, Flavio Basaglia, Piero Bélanger, Jocelyn J. Berger, Sebastian Bertin, Paul Bialek, Michal Bialobrzeska, Olga Blaya-Burgo, Michelle Bleize, Daniëlle N.M. Bø, Simen Boecker, Lea Boggio, Paulo S. Borau, Sylvie Bos, Björn Bouguettaya, Ayoub Brauer, Markus Brick, Cameron Brik, Tymofii Briker, Roman Brosch, Tobias Buchel, Ondrej Buonauro, Daniel Butalia, Radhika Carvacho, Héctor Chamberlain, Sarah A.E. Chan, Hang-Yee Chow, Dawn Chung, Dongil Cian, Luca Cohen-Eick, Noa Contreras-Huerta, Luis Sebastian Contu, Davide Cristea, Vladimir Cutler, Jo D'Ottone, Silvana De Keersmaecker, Jonas Delcourt, Sarah Delouvée, Sylvain Diel, Kathi Douglas, Benjamin D. Drupp, Moritz A. Dubey, Shreya Ekmanis, Jānis Elbaek, Christian T. Elsherif, Mahmoud Engelhard, Iris M. Escher, Yannik A. Etienne, Tom W. Farage, Laura Farias, Ana Rita Feuerriegel, Stefan Findor, Andrej Freira, Lucia Friese, Malte Gains, Neil Philip Gallyamova, Albina Geiger, Sandra J. Genschow, Oliver Gjoneska, Biljana Gkinopoulos, Theofilos Goldberg, Beth Goldenberg, Amit Gradidge, Sarah Grassini, Simone Gray, Kurt Grelle, Sonja Griffin, Siobhán M. Grigoryan, Lusine Grigoryan, Ani Grigoryev, Dmitry Gruber, June Guilaran, Johnrev Hadar, Britt Hahnel, Ulf J.J. Halperin, Eran Harvey, Annelie J. Haugestad, Christian A.P. Herman, Aleksandra M. Hershfield, Hal E. Himichi, Toshiyuki Hine, Donald W. Hofmann, Wilhelm Howe, Lauren Huaman-Chulluncuy, Enma T. Huang, Guanxiong Ishii, Tatsunori Ito, Ayahito Jia, Fanli Jost, John T. Jovanović, Veljko Jurgiel, Dominika Kácha, Ondřej Kankaanpää, Reeta Kant Department of Psychology New York University New YorkNY10003 United States Department of cognition emotion and Methods in Psychology Faculty of Psychology University of Vienna Vienna1010 Austria Craig newmark center for Journalism ethics and Security Columbia University New YorkNY10018 United States Institute for Rebooting Social Media Harvard University CambridgeMA02138 United States Department of Psychology Stanford University StanfordcA94305 United States San luis Obispo cA93405 United States Copernicus institute of Sustainable development Utrecht University Utrecht3584 cB Netherlands Department of Psychology University of Pittsburgh PittsburghPA15260 United States School of Public Policy and Urban Affairs Northeastern University BostonMA02115 United States Department of Psychology Northeastern University BostonMA02115 United States Amazon SeattleWA98109 United States Department of Psychology Carl von Ossietzky University of Oldenburg Oldenburg26129 Germany Santa lucia Foundation IRccS Rome179 Italy Department of Psychology Sapienza University of Rome Rome185 Italy Department of Philosophy Macquarie University SydneynSW2000 Australia Universidad Peruana cayetano heredia San Martín de Porres15102 Peru Post-Graduation Program in linguistics Federal University of Paraná Curitiba80060150 Brazil UnSW Business School University of new South Wales SydneynSW2052 Australia Centre for human Brain health School of Psychology University of Birmingham BirminghamB15 2tt United Kingdom Psychology Scientific Research institute Baku Azerbaijan Kenya Marine and Fisheries Research institute Kisumu1881-40100 Kenya Department of Psychology University of Groningen Groningen9712tS Netherlands Department of economics University of hamburg Hamburg20146 Germany De-partment of Psychology New York University Abu dhabi Abu dhabi129188 United Arab Emirates Department of Sociology University of Bern Bern3012 Switzerland LAPcOS Univers

Effectively reducing climate change requires marked, global behavior change. However, it is unclear which strategies are most likely to motivate people to change their climate beliefs and behaviors. Here, we tested 11 expert-crowdsourced interventions on four climate mitigation outcomes: beliefs, policy support, information sharing intention, and an effortful tree-planting behavioral task. Across 59,440 participants from 63 countries, the interventions’ effectiveness was small, largely limited to nonclimate skeptics, and differed across outcomes: Beliefs were strengthened mostly by decreasing psychological distance (by 2.3%), policy support by writing a letter to a future-generation member (2.6%), information sharing by negative emotion induction (12.1%), and no intervention increased the more effortful behavior—several interventions even reduced tree planting. Last, the effects of each intervention differed depending on people’s initial climate beliefs. These findings suggest that the impact of behavioral climate interventions varies across audiences and target behaviors. © 2024 American Association for the Advancement of Science. All rights reserved.

关键词： Climate change

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Erratum to: Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy

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Journal of gastroenterology 2018年第1期53卷 161-162页

作者： Kazuhiko Masuda Atsushi Ono Hiroshi Aikata Tomokazu Kawaoka C Nelson Hayes Yuji Teraoka Kana Daijo Yuki Nakamura-Inagaki Kei Morio Hatsue Fujino Hiromi Kan Takuro Uchida Keiichi Masaki Tomoki Kobayashi Takashi Nakahara Grace Naswa Makokha Yizhou Zhang Yuko Nagaoki Daiki Miki Masataka Tsuge Akira Hiramatsu Michio Imamura Hiromi Abe-Chayama Yoshiiku Kawakami Hidenori Ochi Kazuaki Chayama Department of Gastroenterology and Metabolism Applied Life Science Institute of Biomedical and Health Science Hiroshima University 1-2-3 Kasumi Minami-ku Hiroshima 734-8551 Japan. masu6743@hiroshima-u.ac.jp. Department of Gastroenterology and Metabolism Applied Life Science Institute of Biomedical and Health Science Hiroshima University 1-2-3 Kasumi Minami-ku Hiroshima 734-8551 Japan. atsushi-o@hiroshima-u.ac.jp. Liver Research Project Center Hiroshima University Hiroshima Japan. atsushi-o@hiroshima-u.ac.jp. Laboratory for Digestive Diseases Center for Genomic Medicine The Institute of Physical and Chemical Research (RIKEN) Hiroshima Japan. atsushi-o@hiroshima-u.ac.jp. Division of Liver Diseases Department of Medicine Liver Cancer Program Tisch Cancer Institute Graduate School of Biomedical Sciences Icahn School of Medicine at Mount Sinai 1470 Madison Ave Box 1123 New York NY 10029 USA. atsushi-o@hiroshima-u.ac.jp. Department of Gastroenterology and Metabolism Applied Life Science Institute of Biomedical and Health Science Hiroshima University 1-2-3 Kasumi Minami-ku Hiroshima 734-8551 Japan. Liver Research Project Center Hiroshima University Hiroshima Japan. Laboratory for Digestive Diseases Center for Genomic Medicine The Institute of Physical and Chemical Research (RIKEN) Hiroshima Japan.

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Linguistic and content validity of the patient-generated subjective global assessment translated and culturally adapted to the Brazilian setting: A multicenter study

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Clinical Nutrition 2018年 37卷 S230-S230页

作者： M.C. Gonzalez S.P. Orlandi F.D. Ottery H. Jager-Wittenaar Post-graduate Program in Health and Behavior Catholic Univeristy of Pelotas Brazil Nutrition College Federal University of Pelotas Pelotas Brazil Research Group Healthy Ageing Hanze University of Applied Sciences Groningen Netherlands Ottery & Associates Vernon Hills United States Department of Maxillofacial Surgery University Medical Center Groningen Groningen Netherlands

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Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (MAP-CARE): A protocol for a randomized clinical trial

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Acta anaesthesiologica Scandinavica 2025年第6期69卷 e70040页

作者： V H Niemelä M Reinikainen N Nielsen F Bass P Young G Lilja J Dankiewicz N Hammond J Hästbacka H Levin M Moseby-Knappe M Saxena M Tiainen A Ceric J Holgersson C B Kamp J Tirkkonen T Oksanen T Kaakinen S Bendel J Düring A Lybeck J Johnsson J Unden A Lundin J Kåhlin J Grip E Lotman L Romundstad P Seidel P Stammet T Graf A Mengel C Leithner J Nee P Druwé K Ameloot M P Wise P J McGuigan J White M Govier M Maccaroni M Ostermann P Hopkins A Proudfoot R Handslip D Pogson P Jackson A Nichol M Haenggi M P Hilty M Iten C Schrag M Nafi M Joannidis C Robba T Pellis J Belohlavek D Rob Y Arabi S Buabbas C Yew Woon A Aneman A Stewart C Arnott M Ramanan R Panwar A Delaney M Reade B Venkatesh L Navarra B Crichton D Knight A Williams H Friberg T Cronberg J C Jakobsen M B Skrifvars Department of Anaesthesia and Intensive Care Helsinki University Hospital and University of Helsinki Helsinki Finland. Institute of Clinical Medicine University of Eastern Finland Kuopio Finland. Department of Anaesthesiology and Intensive Care Kuopio University Hospital Kuopio Finland. Department of Clinical Sciences Lund Anesthesia and Intensive Care Lund University Lund Sweden. Department of Anesthesia and Intensive Care Helsingborg Hospital Helsingborg Sweden. The George Institute for Global Health Sydney Australia. Royal North Shore Hospital Sydney Australia. Intensive Care Unit Wellington Hospital Wellington New Zealand. Medical Research Institute of New Zealand Wellington New Zealand. Australian and New Zealand Intensive Care Research Centre Monash University Melbourne Victoria Australia. Department of Critical Care University of Melbourne Melbourne Victoria Australia. Neurology Department of Clinical Sciences Lund Lund University Lund Sweden. Department of Neurology Skåne University Hospital Lund Sweden. Department of Clinical Sciences Lund Section of Cardiology Skåne University Hospital Lund Sweden. Critical Care Program The George Institute for Global Health UNSW Sydney Australia. Malcolm Fisher Department of Intensive Care Royal North Shore Hospital Sydney New South Wales Australia. Wellbeing Services County of Pirkanmaa and Tampere University Faculty of Medicine and Health Technology Tampere University Hospital Tampere Finland. Department of Clinical Sciences Lund Lund University Lund Sweden. Department of Research Development Education and Innovation Skåne University Hospital Lund Sweden. Department of Neurology and Rehabilitation Skåne University Hospital Lund Sweden. Critical Care Division Department of Intensive Care Medicine The George Institute for Global Health Sydney Australia. St George Hospital Clinical School University of New South Wales Sydney New South Wales Australia. Department of Neurology Helsinki University

BACKGROUND:In patients resuscitated after cardiac arrest, a higher mean arterial pressure (MAP) may increase cerebral perfusion and attenuate hypoxic brain injury. Here we present the protocol of the mean arterial pressure after cardiac arrest and resuscitation (MAP-CARE) trial aiming to investigate the influence of MAP targets on patient outcomes. METHODS:MAP-CARE is one component of the Sedation, Temperature and Pressure after Cardiac Arrest and Resuscitation (STEPCARE) 2 x 2 x 2 factorial randomized trial. The MAP-CARE trial is an international, multicenter, parallel-group, investigator-initiated, superiority trial designed to test the hypothesis that targeting a higher (>85 mmHg) (intervention) versus a lower (>65 mmHg) (comparator) MAP after resuscitation from cardiac arrest reduces 6-month mortality (primary outcome). Trial participants are adults with sustained return of spontaneous circulation who are comatose following resuscitation from out-of-hospital cardiac arrest. The two other components of the STEPCARE trial evaluate sedation and temperature control strategies. Apart from the STEPCARE trial interventions, all other aspects of general intensive care will be according to the local practices of the participating site. Neurological prognostication will be performed according to European Resuscitation Council and European Society of Intensive Care Medicine guidelines by a physician blinded to allocation group. The sample size of 3500 participants provides 90% power with an alpha of 0.05 to detect a 5.6 absolute risk reduction in 6-month mortality, assuming a mortality of 60% in the control group. Secondary outcomes will be poor functional outcome 6 months after randomization, patient-reported overall health 6 months after randomization, and the proportion of participants with predefined severe adverse events. CONCLUSION:The MAP-CARE trial will investigate if targeting a higher MAP compared to a lower MAP during intensive care of adults who are comatose fo

关键词： blood pressure cardiac arrest randomized clinical trial target

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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