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Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2024年第10期21卷 1959页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

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Author Correction: Post-treatment with PT302, a long-acting Exendin-4 sustained release formulation, reduces dopaminergic neurodegeneration in a 6-Hydroxydopamine rat model of Parkinson's disease

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Scientific reports 2018年第1期8卷 13953页

作者： Shuchun Chen Seong-Jin Yu Yazhou Li Daniela Lecca Elliot Glotfelty Hee Kyung Kim Ho-Il Choi Barry J Hoffer Nigel H Greig Dong Seok Kim Yun Wang Center for Neuropsychiatric Research National Health Research Institutes Zhunan Taiwan. Graduate Institute of Applied Science and Engineering Fu-Jen Catholic University New Taipei Taiwan. Drug Design and Development Section Translational Gerontology Branch Intramural Research Program National Institute on Aging National Institutes of Health Baltimore MD USA. Peptron Inc. Yuseong-gu Daejeon Republic of Korea. Department of Neurosurgery Case Western Reserve University School of Medicine Cleveland OH USA. Drug Design and Development Section Translational Gerontology Branch Intramural Research Program National Institute on Aging National Institutes of Health Baltimore MD USA. Greign@mail.nih.gov. Center for Neuropsychiatric Research National Health Research Institutes Zhunan Taiwan. ywang@nhri.org.tw.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Nature genetics 2019年第7期51卷 1191-1192页

作者： Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Montreal Heart Institute Université de Montréal Montreal Quebec Canada. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville TN USA. Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY USA. Department of Epidemiology University of North Carolina Chapel Hill NC USA. Human Genetics Center University of Texas School of Public Health University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston Houston TX USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genetics Harvard Medical School Boston MA USA. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA USA. Center for Applied Genomics Division of Human Genetics Children's Hospital of Philadelphia Philadelphia PA USA. Quantinuum Research LLC San Diego CA USA. Estonian Genome Center University of Tartu Tartu Estonia. Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Nashville TN USA. Institute for Translational Genomics and Population Sciences LABioMed at Harbor-UCLA Medical Center Torrance CA USA. Wellcome Trust Sanger Institute Hinxton UK. Department of Mathematical and Statistical Sciences University of Colorado Denver CO USA. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Department of Biological Sciences Faculty of Arts and Sciences Eastern Mediterranean University Famagusta Cyprus. Max Planck Institute of Immunobiology and Epigenetics Freiburg Germany. Department of Biostatistics and Center for Statistical Genetics University of M

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Author Correction: π-HuB: the proteomic navigator of the human body

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Nature 2025年第8046期637卷 E22页

作者： Fuchu He Ruedi Aebersold Mark S Baker Xiuwu Bian Xiaochen Bo Daniel W Chan Cheng Chang Luonan Chen Xiangmei Chen Yu-Ju Chen Heping Cheng Ben C Collins Fernando Corrales Jürgen Cox Weinan E Jennifer E Van Eyk Jia Fan Pouya Faridi Daniel Figeys George Fu Gao Wen Gao Zu-Hua Gao Keisuke Goda Wilson Wen Bin Goh Dongfeng Gu Changjiang Guo Tiannan Guo Yuezhong He Albert J R Heck Henning Hermjakob Tony Hunter Narayanan Gopalakrishna Iyer Ying Jiang Connie R Jimenez Lokesh Joshi Neil L Kelleher Ming Li Yang Li Qingsong Lin Cui Hua Liu Fan Liu Guang-Hui Liu Yansheng Liu Zhihua Liu Teck Yew Low Ben Lu Matthias Mann Anming Meng Robert L Moritz Edouard Nice Guang Ning Gilbert S Omenn Christopher M Overall Giuseppe Palmisano Yaojin Peng Charles Pineau Terence Chuen Wai Poon Anthony W Purcell Jie Qiao Roger R Reddel Phillip J Robinson Paola Roncada Chris Sander Jiahao Sha Erwei Song Sanjeeva Srivastava Aihua Sun Siu Kwan Sze Chao Tang Liujun Tang Ruijun Tian Juan Antonio Vizcaíno Chanjuan Wang Chen Wang Xiaowen Wang Xinxing Wang Yan Wang Tobias Weiss Mathias Wilhelm Robert Winkler Bernd Wollscheid Limsoon Wong Linhai Xie Wei Xie Tao Xu Tianhao Xu Liying Yan Jing Yang Xiao Yang John Yates Tao Yun Qiwei Zhai Bing Zhang Hui Zhang Lihua Zhang Lingqiang Zhang Pingwen Zhang Yukui Zhang Yu Zi Zheng Qing Zhong Yunping Zhu State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. hefc@***. International Academy of Phronesis Medicine (Guangdong) Guangdong China. hefc@***. Department of Biology Institute of Molecular Systems Biology ETH Zurich Zurich Switzerland. aebersold@imsb.biol.ethz.ch. Macquarie Medical School Macquarie University Sydney New South Wales Australia. Institute of Pathology and Southwest Cancer Center Southwest Hospital Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology Ministry of Education of China Chongqing China. Institute of Health Service and Transfusion Medicine Beijing China. Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore MD USA. State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai China. Department of Nephrology First Medical Center of Chinese PLA General Hospital Nephrology Institute of the Chinese People's Liberation Army State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China. Institute of Chemistry Academia Sinica Taipei China. National Biomedical Imaging Center State Key Laboratory of Membrane Biology Institute of Molecular Medicine Peking-Tsinghua Center for Life Sciences College of Future Technology Peking University Beijing China. School of Biological Sciences Queen's University of Belfast Belfast UK. Functional Proteomics Laboratory Centro Nacional de Biotecnología-CSIC Madrid Spain. Computational Systems Biochemistry Research Group Ma

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Abstracts from ISSN Brazil

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JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION 2017年第1期14卷 1-7页

作者： [Anonymous] Laboratory of Nutritional Biochemistry University of Brasilia Brasilia Brazil Applied Physiology & Nutrition Research Group University of São Paulo São Paulo Brazil São Camilo University Centre São Paulo Brazil Catholic University of Brasilia Brasilia Brazil University Center of Brasília Brasilia Brazil GEPAME – São Judas Tadeu University São Paulo Brazil Federal University of Minas Gerais Belo Horizinte Brazil Catolic University of Minas Gerais Belo Horizinte Brazil Federal University of São Paulo São Paulo Brazil Program of Post-graduation in Physical Education Catholic University of Brasilia Brasilia Brazil Graduation in Nutrition Catholic University of Brasilia Brasilia Brazil Centre of Proteomic and Biochemical Analysis Postgraduate Program in Biotechnology and Genomic Sciences Catholic University of Brasilia Brasilia Brazil S-Inova Biotech Graduate Program in Biotechnology Dom Bosco Catholic University Campo Grande Brazil Sports Nutrition Clinic Opeum Brasilia Brazil Natural Drugstore REDEPHARMA Campina Grande Brazil Laboratory of Physiology Nutrition and Health (LAFINS) Faculty of Physical Education and Dance (FEFD) Federal University of Goiás (UFG) Goiania Brazil Exercise and Immunometabolism Research Group Department of Physical Education Universidade Estadual Paulista Presidente Prudente São Paulo Brazil Clinical and Sports Nutrition Research Laboratory (Labince) Nutrition Faculty (FANUT) Federal University of Goias (UFG) Goiânia Brazil Department of Sport School of Physical Education and Sport University of São Paulo São Paulo Brazil Center and Prescription Motor Activity Laboratory Department of Physical Education Universidade Estadual Paulista Presidente Prudente São Paulo Brazil Human Movement Laboratory Universidade São Judas Tadeu São Paulo Brazil Department of Kinesiology Coastal Carolina University Conway USA Department of Physical Education of Universidade Estadual Paulista Bauru Brazil

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Author Correction: Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats

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Scientific reports 2018年第1期8卷 11944页

作者： Lizeth K Pedraza Rodrigo O Sierra Fernanda N Lotz Lucas De Oliveira Alvares Laboratório de Neurobiologia da Memória Universidade Federal do Rio Grande do Sul Porto Alegre Brazil. pedraza.lk@***. Graduate Program in Neuroscience Institute of Health Sciences 90.046-900 Universidade Federal do Rio Grande do Sul Porto Alegre Brazil. pedraza.lk@***. Laboratório de Neurobiologia da Memória Universidade Federal do Rio Grande do Sul Porto Alegre Brazil. Laboratório de Psicobiologia e Neurocomputação Biophysics Department Biosciences Institute 91.501-970 Universidade Federal do Rio Grande do Sul Porto Alegre Brazil. Laboratório de Neurobiologia da Memória Universidade Federal do Rio Grande do Sul Porto Alegre Brazil. lucas.alvares@ufrgs.br. Graduate Program in Neuroscience Institute of Health Sciences 90.046-900 Universidade Federal do Rio Grande do Sul Porto Alegre Brazil. lucas.alvares@ufrgs.br.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

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Corrigendum to "Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol" [Mol. Cell. Endocrinol. 157 (2016) 679-691]

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Molecular and cellular endocrinology 2016年 428卷 171-173页

作者： Ali Yasrebi Anna Hsieh Kyle J Mamounis Elizabeth A Krumm Jennifer A Yang Jason Magby Pu Hu Troy A Roepke Department of Animal Sciences School of Environmental and Biological Sciences Rutgers The State University of New Jersey New Brunswick NJ USA. Department of Animal Sciences School of Environmental and Biological Sciences Rutgers The State University of New Jersey New Brunswick NJ USA Nutritional Sciences Graduate Program Rutgers The State University of New Jersey New Brunswick NJ USA. Graduate Program in Endocrinology and Animal Biosciences Rutgers The State University of New Jersey New Brunswick NJ USA. Nutritional Sciences Graduate Program Rutgers The State University of New Jersey New Brunswick NJ USA Graduate Program in Endocrinology and Animal Biosciences Rutgers The State University of New Jersey New Brunswick NJ USA New Jersey Institute for Food Nutrition and Health Rutgers The State University of New Jersey New Brunswick NJ USA. Electronic address: ta.roepke@rutgers.edu.

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Supporting US public health experts (vol 38, pg 1381, 2020)

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NATURE BIOTECHNOLOGY 2021年第1期39卷 115-115页

作者： Cohen, Ron Francois, Cedric Crowley, John Hastings, Paul King, Rachel Love, Ted W. Maraganore, John McMurry-Heath, Michelle Levin, Jeremy President and CEO Acorda Therapeutics Ardsley NY USA President and CEO Apellis Pharmaceuticals Waltham MA USA Chairman and CEO Amicus Therapeutics Cranbury NJ USA President and CEO Nkarta Therapeutics South San Francisco CA USA CEO GlycoMimetics Rockville MD USA President and CEO Global Blood Therapeutics South San Francisco CA USA CEO Alnylam Pharmaceuticals Cambridge MA USA President and CEO Biotechnology Innovation Organization Washington DC USA Chairman and CEO Ovid Therapeutics New York NY USA Chairman Biotechnology Innovation Organization Washington DC USA Founder and CEO Cydan II Inc. Cambridge MA USA President and CEO Beacon Discovery San Diego CA USA Chairman and CEO Veracyte Inc. South San Francisco CA USA President and CEO Arrowhead Pharmaceuticals Pasadena CA USA Managing Director Health Catalysts Group Tucson AZ USA Entrepreneur in Residence Third Rock Ventures Boston MA USA President and CEO Principia Biopharma Inc. South San Francisco CA USA CEO Edison Oncology Holding Corp. Menlo Park CA USA President and CEO AVEO Oncology Cambridge MA USA Partner MPM Impact Fund Boston MA USA CEO Lasson Therapeutics San Diego CA USA Partner Atlas Venture Cambridge MA USA Cofounder and CEO Strand Therapeutics Cambridge MA USA Founder Bluebird Ventures Palo Alto CA USA President and CEO Cytokinetics Inc. South San Francisco CA USA President and CEO Wave Life Sciences Cambridge MA USA Chairman of the Board Alnylam Pharmaceuticals Boston MA USA Chairman of the Board Kaleido Biosciences Boston MA USA Chairman of the Board Magenta Boston MA USA Chairman of the Board Arrakis Therapeutics Cambridge MA USA CEO Avidity Biosciences La Jolla CA USA Head of Biotechnology and Pharma William Blair and Company Boston MA USA CEO Locanabio San Diego CA USA Partner Kleiner Perkins Caulfield Byers Menlo Park CA USA President Human BioMolecular Research Institute San Diego CA USA Cofounder and

A Correction to this paper has been published: https://***/10.1038/s41587-020-00792-5.

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Publisher Correction: Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

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Nature neuroscience 2020年第9期23卷 1176页

作者： Elaine T Lim Mohammed Uddin Silvia De Rubeis Yingleong Chan Anne S Kamumbu Xiaochang Zhang Alissa M D'Gama Sonia N Kim Robert Sean Hill Arthur P Goldberg Christopher Poultney Nancy J Minshew Itaru Kushima Branko Aleksic Norio Ozaki Mara Parellada Celso Arango Maria J Penzol Angel Carracedo Alexander Kolevzon Christina M Hultman Lauren A Weiss Menachem Fromer Andreas G Chiocchetti Christine M Freitag George M Church Stephen W Scherer Joseph D Buxbaum Christopher A Walsh Division of Genetics and Genomics Manton Center for Orphan Disease Research and Howard Hughes Medical Institute Boston Children's Hospital Boston Massachusetts USA. elimtt@***. Departments of Pediatrics and Neurology Harvard Medical School Boston Massachusetts USA. elimtt@***. Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge Massachusetts USA. elimtt@***. Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts USA. elimtt@***. Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine Dubai United Arab Emirates. Seaver Autism Center for Research and Treatment Icahn School of Medicine at Mount Sinai New York New York USA. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA. Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge Massachusetts USA. Wyss Institute for Biologically Inspired Engineering Harvard University Boston Massachusetts USA. Division of Genetics and Genomics Manton Center for Orphan Disease Research and Howard Hughes Medical Institute Boston Children's Hospital Boston Massachusetts USA. Departments of Pediatrics and Neurology Harvard Medical School Boston Massachusetts USA. Department of Psychiatry Center For Excellence in Autism Research University of Pittsburgh Pittsburgh Pennsylvania USA. Department of Psychiatry Nagoya University Graduate School of Medicine Nagoya Japan. Child and Adolescent Psychiatry Department Hospital General Universitario Gregorio Marañón School of Medicine Universidad Complutense IiSGM CIBERSAM Madrid Spain. Child and Adolescent Psychiatry Department Hospital General Universitario Gregorio Marañón IiSGM CIBERSAM Madrid Spain. Grupo de Medicina Xenomica Universidade de Santiago de Compostela Centro Nacional de Genotipado-Plataforma de Recursos Biomoleculares y Bioinformaticos-Instituto de Salud Carlos III (CeGen-PRB2-ISCIII) Santiago de Co

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities

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Biochemistry and Biophysics Reports 2016年 6卷 135-141页

作者： Cherdtrakulkiat, Rungrot Boonpangrak, Somchai Sinthupoom, Nujarin Prachayasittikul, Supaluk Ruchirawat, Somsak Prachayasittikul, Virapong Department of Clinical Microbiology and Applied Technology Faculty of Medical Technology Mahidol University Bangkok 10700 Thailand Center for Innovation Development and Technology Transfer Faculty of Medical Technology Mahidol University Bangkok 10700 Thailand Center of Data Mining and Biomedical Informatics Faculty of Medical Technology Mahidol University Bangkok 10700 Thailand Laboratory of Medicinal Chemistry Chulabhorn Research Institute and Program in Chemical Biology Chulabhorn Graduate Institute Bangkok 10210 Thailand Center of Excellence on Environmental Health and Toxicology Commission on Higher Education (CHE) Ministry of Education Thailand

8-Hydroxyquinoline (8HQ) compounds have been reported to possess diverse bioactivities. In recent years, drug repositioning has gained considerable attention in drug discovery and development. Herein, 8HQ (1) and its derivatives (2-9) bearing various substituents (amino, nitro, cyano and halogen) were investigated for their antimicrobial against 27 microorganisms (agar dilution method) and antioxidant (DPPH method) activities. The parent 8HQ (1) exerted a highly potent antimicrobial activity against Gram-positive bacteria including diploid fungi and yeast with MIC values in the range of 3.44-13.78 μM. Moreover, the halogenated 8HQ, especially 7-bromo-8HQ (4) and clioquinol (6), displayed a high antigrowth activity against Gram-negative bacteria compared with the parent compound (1). Apparently, the derivatives with a relatively high safely index, e.g., nitroxoline (2), exhibited strong antibacterial activity against Aeromonas hydrophila (MIC=5.26 μM) and selectively inhibited the growth of P. aeruginosa with the MIC value of 84.14 μM;cloxyquin (3) showed a strong activity against L. monocytogenes and P. shigelloides with MIC values of 5.57 and 11.14 μM, respectively. Most compounds displayed an antioxidant activity. Specifically, 5-amino-8HQ (8) was shown to be the most potent antioxidant (IC₅₀=8.70 μM) compared with the positive control (α-tocopherol) with IC₅₀ of 13.47 μM. The findings reveal that 8HQ derivatives are potential candidates to be further developed as antimicrobial and antioxidant agents. © 2016 The Authors.

关键词： 8-Hydroxyquinoline Antimicrobial Antioxidant Clioquinol Cloxyquin Nitroxoline

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