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Motor cortex repetitive transcranial magnetic stimulation in fibromyalgia: a multicentre randomised controlled trial

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British Journal of Anaesthesia 2025年第6期134卷 1756-1764页

作者： Silva, Valquíria A. Baptista, Abrahão F. Fonseca, Alessandra S. Carneiro, Adriana M. Brunoni, André R. Carrilho, Paulo.E.M. Lins, Catarina C. Kubota, Gabriel T. Fernandes, Ana Mércia B.L. Lapa, Jorge.D.S. dos Santos, Lucas M. Sasso, Ivo Monte-Silva, Katia Poindessous-Jazat, Frédérique Mori, Nobuhiko Miki, Kenji Baltar, Adriana Tanaka, Clarice Teixeira, Manoel J. Hosomi, Koichi Bouhassira, Didier Attal, Nadine Ciampi de Andrade, Daniel LIM 62 - Pain Center Department of Neurology São Paulo Brazil Service of Interdisciplinary Neuromodulation (SIN) Department and Institute of Psychiatry São Paulo Brazil Medical-Surgical Nursing Department University of São Paulo São Paulo Brazil Center for Mathematics Computation and Cognition Federal University of ABC São Paulo Brazil Mood Disorder Program (Pro-GRUDA) Department of Psychiatry University of São Paulo São Paulo Brazil Medicine School “Professor Orival Alves” State University of Western Paraná (UNIOESTE) Paraná Brazil Neurosurgery Unit Hospital de Cirurgia Sergipe Aracaju Brazil Department of Medicine Federal University of Sergipe Sergipe São Cristóvão Brazil LIM 54 - Physiotherapy Research Laboratory University of São Paulo São Paulo Brazil Applied Neuroscience Laboratory Universidade Federal de Pernambuco Cidade Universitária Pernambuco Brazil UVSQ-Paris-Saclay University Ambroise Paré Hospital Boulogne-Billancourt U987 France Department of Neurosurgery Osaka University Graduate School of Medicine Osaka Japan Faculty of Health Science Osaka Yukioka College of Health Science Osaka Japan Center for Pain Management Hayaishi Hospital Osaka Japan Center for Neuroplasticity and Pain (CNAP) Department of Health Science and Technology University of Aalborg Gistrup Denmark

Background: Despite affecting 2–4% of the population worldwide, fibromyalgia often remains refractory to treatment. Here we report the first international randomised double-blind, sham-controlled trial developed to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) as an add-on therapy for fibromyalgia. Methods: Women aged ≥18 yr with fibromyalgia refractory to best available treatment were enrolled in Brazil, France, and Japan, and randomised to 10 Hz motor cortex (M1) rTMS, 3000 pulses day⁻¹, or sham stimulation. This included 10 induction sessions over 2 weeks, followed by weekly maintenance (6 weeks), and fortnightly extended maintenance (8 weeks). Primary outcome was ≥50% pain reduction at week 8 compared with baseline. Secondary outcomes included pain interference, mood, global impression of change, and Fibromyalgia Impact Questionnaire (FIQ) scores at weeks 8 and 16. Results: We randomised 101 women (mean age 48 [range 25-83] yr) into active (n=52) or sham (n=49) arms. Bayesian analysis revealed a 99.4% probability of ≥50% pain reduction at week 8 in the active group vs sham (odds ratio [OR] 3.04;95% credible interval [95% CrI] 1.26–8.06), with a number needed to treat of 4.54. Frequentist analysis confirmed that relative pain reduction was higher in the active than in the sham group (40.4% vs 18.4%, P=0.028). At week 16, this probability reduced to 34.2% (OR 0.815;95% CrI 0.313–2.1), but the likelihood of FIQ score reduction was 79.1%. The intervention appeared safe. Conclusions: Add-on M1-repetitive transcranial magnetic stimulation reduced pain intensity up to 8 weeks in women with fibromyalgia. Although analgesic effects waned, functional improvements remained during extended maintenance at week 16. © 2025 The Authors

关键词： chronic pain clinical trial fibromyalgia neuromodulation transcranial magnetic stimulation

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Resistance mechanism to cisplatin in NCI-H460 non-small cell lung cancer cell line:investigating apoptosis,autophagy,and cytogenetic damage

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Cancer Drug Resistance 2018年第1期1卷 72-81页

作者： Érica Ballestreri Daniel Simon Ana Paula de Souza Camila Schultz Grott Débora Dreher Nabinger Rafael Rodrigues Dihl Ivana Grivicich Laboratory of Cancer Biology Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Human Molecular Genetics Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil Laboratory of Genetic Toxicity Graduate Program in Cellular and Molecular Biology Applied to HealthLutheran University of BrazilCanoasRS 92425-900Brazil

Aim:To investigate the effects of cisplatin on the human non-small cell lung carcinoma(NCI-H460)cell line regarding cytotoxicity,genotoxicity,and expression of genes associated with apoptosis(BIRC5)and autophagy(BECN1).Methods:Cell cultures were treated with cisplatin concentrations(0.16-33.3μmol/L)for 48 *** and acute and chronic cytotoxicities were assessed using the MTT,clonogenic,and cytokinesis-block micronucleus *** expression of BIRC5 and BECN1 was evaluated by reverse transcription-polymerase chain ***:Cisplatin IC50(0.33μmol/L)increased micronucleus frequency 2.50 *** was also cytotoxic in the 0.6-33.3μmol/L range,with reduced expression of the BIRC5 gene,suggesting induction of *** reducing the expression of the BIRC5 gene,33.3μmol/L cisplatin increased the expression of the BECN1 gene,suggesting that autophagy can be related to cisplatin ***:Cisplatin inhibited NCI-H460 growth,and cisplatin IC50 induced genotoxic *** higher cisplatin concentrations are used,the expression of genes associated with apoptosis and autophagy was *** results points to a further investigation of the role of autophagy in cisplatin resistance.

关键词： BECN1 BIRC5 cisplatin cytotoxicity lung cancer

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5-Methyluridine is Ubiquitous in Pseudomonas aeruginosa tRNA and Modulates Antimicrobial Resistance and Virulence

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Journal of Molecular Biology 2025年 169020页

作者： Chittrakanwong, Jurairat Chen, Ruixi Wu, Junzhou Demott, Michael S. Sun, Jingjing Phatinuwat, Kamonwan Jaroensuk, Juthamas Atichartpongkul, Sopapan Mongkolsuk, Skorn Begley, Thomas Dedon, Peter C. Fuangthong, Mayuree Program in Applied Biological Sciences Chulabhorn Graduate Institute Bangkok Thailand Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA United States Antimicrobial Resistance Interdisciplinary Research Group Singapore-MIT Alliance for Research and Technology Singapore Singapore Center for Environmental Health Sciences Massachusetts Institute of Technology Cambridge MA United States Laboratory of Biotechnology Chulabhorn Research Institute Bangkok Thailand Center of Excellence on Environmental Health and Toxicology (EHT) Bangkok Thailand The RNA Institute and Department of Biological Sciences University at Albany Albany NY United States

Building on decades of work in characterizing the dozens of RNA modifications in the microbial epitranscriptome, recent advances in analytical technology and genetics have revealed systems-level functions for many tRNA modifications. The tRNA (uracil-5-)-methyltransferase TrmA and its product, 5-methyl uridine (m⁵U) at position 54 in the T-loop, however, has not been linked to a specific phenotype. Here, we defined the functional and biological roles of TrmA in Pseudomonas aeruginosa (PA14), a major multidrug-resistant pathogen. Surprisingly, though TrmA was found to site-specifically catalyze m⁵U54 on all PA14 tRNAs, loss of TrmA had no effect on the levels of any of 36 tRNA modifications except m⁵U and had minimal effects on multiple phenotypic parameters, including growth rate, morphology, motility, and biofilm formation. However, loss of TrmA conferred a striking polymyxin antibiotic resistance. mRNA and tRNA profiling and proteomics analyses revealed that TrmA regulates the expression of codon-biased gene families at the level of translation, including components of a type III secretion system (T3SS). Loss of TrmA upregulated T3SS, leading to increased macrophage IL-1β in bacterial challenge tests. Altogether, these results revealed novel biological functions of TrmA and its roles in modulating gene expression at multiple levels in P. aeruginosa. © 2025 Elsevier Ltd

关键词： codon usage Pseudomonas aeruginosa translation TrmA tRNA modification

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Amplification of enzymatic and microbial fuel cells using organic electrochemical transistors

Device

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Device 2025年

作者： Saxena, Ravindra Zhang, Xu Cai, Rong Suggs, Olivia Bruggeman, Chase Hickey, David P. Ajo-Franklin, Caroline M. Verduzco, Rafael Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston 77005 TX United States Department of Biosciences Rice University Houston 77005 TX United States Department of Chemical Engineering and Materials Science Michigan State University East Lansing 48824 MI United States Department of Bioengineering Rice University Houston 77005 TX United States Department of Chemical and Biomolecular Engineering Rice University Houston 77005 TX United States Rice Advanced Materials Institute Rice University Houston 77005 TX United States

Organic electrochemical transistors (OECTs) are thin-film devices operated in aqueous and biological environments for sensing chemicals and biomolecules. However, most sensor configurations involve introducing the target biomolecule directly in the OECT device. This has drawbacks because it may not be possible to have an electrolyte compatible with the target biomolecule or an environment optimal for the OECT. Here, we demonstrate a general and modular approach to building electrochemical sensors by coupling OECTs electronically with either an enzymatic fuel cell (EFC) or microbial fuel cell (MFC). We demonstrate that this modular approach can amplify currents by three orders of magnitude and enhance the signal-to-noise ratio. We also show that the power generated by the fuel cell can help tune the sensor's response for different applications. This work demonstrates a simple and versatile approach for amplifying currents from MFCs and EFCs useful for the development of bioelectronic sensors. © 2025 The Authors

关键词： amplification biosensors DTI-3: Develop electro-active bacteria enzymatic fuel cells microbial fuel cells organic electrochemical transistors power

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XERICO as a target for engineering stress-resilient crops: Mechanisms, applications, and future directions

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Plant Physiology and Biochemistry 2025年 225卷 110013页

作者： Im, Jong Hee Kim, Won-Chan Han, Kyung-Hwan Ko, Jae-Heung Department of Horticulture Michigan State University East Lansing 48824 MI United States Interdisciplinary Graduate Program in Advanced Convergence Technology and Science Jeju National University Jeju 63243 South Korea DOE Great Lakes Bioenergy Research Center Michigan State University East Lansing 48824 MI United States School of Applied Biosciences Kyungpook National University Daegu 41566 South Korea Department of Forestry Michigan State University East Lansing 48824 MI United States of Green-Bio Science Kyung Hee University Yongin 17104 South Korea

XERICO's capacity to enhance ABA-driven stress responses across diverse crops, its regulatory crosstalk with other hormonal pathways, and its compatibility with advanced genetic engineering tools highlight its central role in sustainable agriculture. Leveraging XERICO in crop improvement programs aligns with the urgent need to mitigate the impacts of climate-induced stress in agriculture, offering a pathway toward resilient and high-yielding crops. By enabling crops to withstand drought and other environmental stresses, XERICO-based biotechnological approaches hold transformative potential for global food security and environmental sustainability. © 2025 Elsevier Masson SAS

关键词： ABA regulation Climate resilience Drought tolerance Environmental stress Genetic engineering Sustainable agriculture XERICO

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Overview of the Head and Neck Tumor Segmentation for Magnetic Resonance Guided Applications (HNTS-MRG) 2024 Challenge 1st

Overview of the Head and Neck Tumor Segmentation for Magneti...

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1st Challenge on Head and Neck Tumor Segmentation for MRI-Guided Applications, HNTS-MRG 2024, Held in Conjunction with 27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024

作者： Wahid, Kareem A. Dede, Cem El-Habashy, Dina M. Kamel, Serageldin Rooney, Michael K. Khamis, Yomna Abdelaal, Moamen R. A. Ahmed, Sara Corrigan, Kelsey L. Chang, Enoch Dudzinski, Stephanie O. Salzillo, Travis C. McDonald, Brigid A. Mulder, Samuel L. McCullum, Lucas Alakayleh, Qusai Sjogreen, Carlos He, Renjie Mohamed, Abdallah S. R. Lai, Stephen Y. Christodouleas, John P. Schaefer, Andrew J. Naser, Mohamed A. Fuller, Clifton D. Department of Radiation Oncology The University of Texas MD Anderson Cancer HoustonTX United States Department of Imaging Physics The University of Texas MD Anderson Cancer HoustonTX United States Transitional Year Program Corewell Health Wiliam Beaumont Royal OakMI United States Department of Radiation Oncology University of Maryland School of Medicine BaltimoreMD United States Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Alexandria University Alexandria Egypt UT MD Anderson Cancer CenterUTHealth Houston Graduate School of Biomedical Sciences Houston United States Department of Radiation Oncology Baylor College of Medicine HoustonTX United States Department of Head and Neck Surgery The University of Texas MD Anderson Cancer HoustonTX United States Elekta AtlantaGA United States Department of Computational Applied Mathematics and Operations Research Rice University HoustonTX United States

ISBN: (纸本)9783031832734

Magnetic resonance (MR)-guided radiation therapy (RT) is enhanc- ing head and neck cancer (HNC) treatment through superior soft tissue con- trast and longitudinal imaging capabilities. However, manual tumor segmentation remains a significant challenge, spurring interest in artificial intelligence (AI)- driven automation. To accelerate innovation in this field, we present the Head and Neck Tumor Segmentation for MR-Guided Applications (HNTS-MRG) 2024 Challenge, a satellite event of the 27th International Conference on Medical Image Computing and Computer Assisted Intervention. This challenge addresses the scarcity of large, publicly available AI-ready adaptive RT datasets in HNC and explores the potential of incorporating multi-timepoint data to enhance RT auto- segmentation performance. Participants tackled two HNC segmentation tasks: automatic delineation of primary gross tumor volume (GTVp) and gross metastatic regional lymph nodes (GTVn) on pre-RT (Task 1) and mid-RT (Task 2) T2- weighted scans. The challenge provided 150 HNC cases for training and 50 for final testing hosted on *** using a Docker submission framework. In total, 19 independent teams from across the world qualified by submitting both their algorithms and corresponding papers, resulting in 18 submissions for Task 1 and 15 submissions for Task 2. Evaluation using the mean aggregated Dice Simi- larity Coefficient showed top-performing AI methods achieved scores of 0.825 in Task 1 and 0.733 in Task 2. These results surpassed clinician interobserver vari- ability benchmarks, marking significant strides in automated tumor segmentation for MR-guided RT applications in HNC. © The Author(s) 2025.

关键词： Deep learning

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Budgeting and controllable cost variances - The case of multiple diagnoses, multiple services, and multiple resources

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Journal of Medical Systems 1982年第6期6卷 599-611页

作者： Broyles, Robert W. Lay, Colin M. From the Center of Management and Applied Economics Health and Medical Services Administration Widener University Chester Pennsylvania United States From the Graduate Program in Health Administration University of Ottawa Ottawa Ontario Canada

This paper examines an unfavorable cost variance in an institution which employs multiple resources to provide stay specific and ancillary services to patients presenting multiple diagnoses. It partitions the difference between actual and expected costs into components that are the responsibility of an identifiable individual or group of individuals. The analysis demonstrates that the components comprising an unfavorable cost variance are attributable to factor prices, the use of real resources, the mix of patients, and the composition of care provided by the institution. In addition, the interactive effects of these factors are also identified. © 1982 Plenum Publishing Corporation.

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Plastic dispersion in Northeast Brazil beaches and plastic contaminant detection in Brazilian coast fishing nets

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Marine Pollution Bulletin 2025年 218卷

作者： Greici Gubert Bruna de Ramos Ronei Cardoso de Oliveira Karolliny Barbosa de Araújo Arthur Martins Gabriel Kátia Alves Ribeiro Emilly de Souza Cordeiro Daniele dos Santos Aragão José Domingos dos Santos Silva Monica Ferreira da Costa Emerson Rodrigues de Camargo Wallace Duarte Fragoso Sherlan Guimarães Lemos Ernesto Chaves Pereira de Souza Priscila Gubert Chemistry Department Federal University of São Carlos São Carlos Brazil Oceanography Department Federal University of Pernambuco Recife Brazil Coastal Sea Geography Group Leibniz-Institute for Baltic Sea Research Seestrasse 15 18119 Rostock-Warnemünde Germany Postdoctoral Program in Physics Federal University of São Carlos São Carlos Brazil Keizo Asami Institute iLIKA Federal University of Pernambuco Recife Brazil Graduate Program in Pure and Applied Chemistry POSQUIPA Federal University of Western of Bahia Bahia Brazil Department of Chemistry Federal University of Paraíba João Pessoa Brazil Graduate Program in Biology Applied to Health PPGBAS Federal University of Pernambuco Recife Brazil

This study investigates the dispersion of floating plastic from Recife-PE harbor using a particle tracking model and examines contaminants in fishing nets collected from Brazilian beaches. Simulations were conducted for both dry and rainy seasons. Fishing nets were collected from eight beaches for analysis. The plastic movement simulation showed particles dispersed 0.41 km southward during the dry season and 177.50 km northward during the rainy season. Most particles (90 %) beached within the first week, indicating localized litter distribution. The study identified 14 pesticide residues in the collected nets, along with heavy metals such as arsenic, cadmium, chromium, copper, nickel, zinc, and iron, detected via Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). The pesticide and metal data were used to calculate the toxicological priority index (ToxPi), showing the sample from Joaquina-SC had the highest toxicity, while the sample from Sancho-PE had the lowest. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) revealed pollution patterns, with potential associations between pesticides and metals. These findings raise concerns about the contaminants' impact on marine organisms and human health, highlighting the importance of understanding plastic pollution dynamics and associated risks. Also, the outcomes emphasize the need to reevaluate environmental regulations to better protect ecosystems and species from harmful pollutants, including plastics.

关键词： Fishing nets Contaminant Plastic Dispersion Pesticide Heavy metals

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Relationship between prospective memory and vigilance: Evidence from ERP

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Chinese Science Bulletin 2012年第31期57卷 4057-4063页

作者： WANG Ya LI XueBing HUANG Jia CAO XiaoYan CUI JiFang ZHAO Qing WANG YuNa SHUM David H K CHAN Raymond C K Neuropsychology and Applied Cognitive Neuroscience Laboratory Key Laboratory of Mental HealthInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100049China Nattonal Instttute of Educatton Sczences Beijing 100088China Behavioural Basis of Health Program Griffith Health Institute and School of Applied PsychologyGriffith UniversityBrisbane 4122Australia

Event-related potentials (ERPs) were used in this study to investigate the neural correlates of prospective memory (PM) and vigilance. Twenty college or graduate students participated in this study. They were administered a PM and a vigilance task and physiological data were collected at the same time. Behavioral results showed that the RT associated with PM cues was longer than those associated with vigilance targets. ERP results showed that PM cues and vigilance targets did not show significant difference in the N2 but PM cues evoked greater N300 than vigilance targets, and vigilance targets evoked greater parietal positivity/P3 than PM cues, suggesting vigilance and PM have similar but also distinctive neural basis.

关键词： ERP 记忆证据事件相关电位生理数据 PM 研究生神经

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Cross-Cultural Comparison of Adaptive Behaviour Between British and Brazilian Clinical Samples With Neurodevelopmental Disorders

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Child: Care, health and Development 2025年第3期51卷 e70098页

作者： Tally Lichtensztejn Tafla Kate Anne Woodcock Tatiana Pontrelli Mecca Maria Cristina Triguero Veloz Teixeira Center for Research on Childhood and Adolescence Human Developmental Sciences Graduate Program Mackenzie Presbyterian University São Paulo São Paulo Brazil Centre for Applied Psychology School of Psychology and Institute for Mental Health University of Birmingham Birmingham UK Department of Mental Health Santa Casa de São Paulo School of Medical Sciences São Paulo São Paulo Brazil

Adaptive behaviour deficits are limitations in executing daily activities and difficulties in responding to environmental changes, which impact social participation and independence across contexts. Adaptive behaviour measures can be used to guide interventions for individuals with neurodevelopmental disorders. Cross-cultural studies can contribute to the understanding of adaptive functioning of neurodivergence across countries. Purpose The purpose of this study is to evaluate and compare the adaptive behaviour profiles of children and adolescents with neurodevelopmental condition from different countries. Methods Forty-eight children with an autism spectrum diagnosis were equally separated into country groups (Brazil and the United Kingdom) and ages (5–10 and 11–17 years old) and were evaluated with the Adaptive Behavior Assessment System, 3rd Edition (ABAS-3), the Parent Form (Ages 5–21), using the raw scores of the questionnaire. Results The only scale in which a difference between nationality groups was identified was the self-direction scale, which evaluates skills needed for independence, responsibility and self-control, with older Brazilians scoring higher than their British peers in the same age group. Conclusion Similar profiles of adaptive functioning in individuals with ASD were found across cultures, with a singular difference in the self-direction scale. The study's findings shed light on the need for interventions to increase adaptive functioning skills acquisition, regardless of the culture or country in which the individual is.

关键词： ABAS-3 adaptive functioning autism cross-cultural comparison

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