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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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Nature genetics 2018年第5期50卷 766-767页

作者： Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Montreal Heart Institute Université de Montréal Montreal Quebec Canada. Division of Epidemiology Department of Medicine Vanderbilt-Ingram Cancer Center Vanderbilt Epidemiology Center Vanderbilt University School of Medicine Nashville TN USA. Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Genetics of Obesity and Related Metabolic Traits Program Icahn School of Medicine at Mount Sinai New York NY USA. Department of Epidemiology University of North Carolina Chapel Hill NC USA. Human Genetics Center University of Texas School of Public Health University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences University of Texas Health Science Center at Houston Houston TX USA. Broad Institute of MIT and Harvard Cambridge MA USA. Department of Genetics Harvard Medical School Boston MA USA. Division of Endocrinology and Center for Basic and Translational Obesity Research Boston Children's Hospital Boston MA USA. Center for Applied Genomics Division of Human Genetics Children's Hospital of Philadelphia Philadelphia PA USA. Quantinuum Research LLC San Diego CA USA. Estonian Genome Center University of Tartu Tartu Estonia. Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Nashville TN USA. Institute for Translational Genomics and Population Sciences LABioMed at Harbor-UCLA Medical Center Torrance CA USA. Wellcome Trust Sanger Institute Hinxton UK. Department of Mathematical and Statistical Sciences University of Colorado Denver CO USA. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Department of Biological Sciences Faculty of Arts and Sciences Eastern Mediterranean University Famagusta Cyprus. Max Planck Institute of Immunobiology and Epigenetics Freiburg Germany. Department of Biostatistics and Center for Statistical Genetics University of M

In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article.

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Correction to:FungalTraits:a user friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2021年第2期107卷 129-132页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks LászlóIrinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew P.Nelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

Correction to:Fungal Diversity(2020)105:116 https://***/10.1007/s13225-020-00466-2 There were errors in the name of author László*** and in affiliation no.31 in the original *** original article has been cor... 详细信息

关键词： database ram friendly

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Galactic transient sources with the Cherenkov Telescope Array Observatory

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Monthly Notices of the Royal Astronomical Society 2025年第1期540卷 205–238页

作者： Abe, K Abe, S Abhir, J Abhishek, A Acero, F Acharyya, A Adam, R Aguasca-Cabot, A Agudo, I Aguirre-Santaella, A Alfaro, J Alfaro, R Alvarez-Crespo, N Alves Batista, R Amans, J-P Amato, E Ambrosi, G Ambrosino, F Angüner, E O Antonelli, L A Aramo, C Arcaro, C Arnesen, T T H Asano, K Ascasibar, Y Aschersleben, J Ashkar, H Augusto Stuani, L Baack, D Backes, M Balazs, C Balbo, M Baquero Larriva, A Barbosa Martins, V Barres de Almeida, U Barrio, J A Barrios-Jiménez, L Batković, I Batzofin, R Baxter, J Becerra González, J Becker Tjus, J Belmont, R Benbow, W Bernete, J Bernlöhr, K Berti, A Bertucci, B Beshley, V Bhattacharjee, P Bhattacharyya, S Bigongiari, C Bissaldi, E Blanch, O Blazek, J Bocchino, F Boisson, C Bolmont, J Bonnoli, G Bonollo, A Bordas, P Bosnjak, Z Bottacini, E Böttcher, M Bradascio, F Bronzini, E Brown, A M Brunelli, G Bulgarelli, A Burelli, I Burger-Scheidlin, C Burmistrov, L Burton, M Buscemi, M Cailleux, J Campoy-Ordaz, A Cantlay, B K Capasso, G Caproni, A Capuzzo-Dolcetta, R Caraveo, P Caroff, S Carosi, A Carosi, R Carquin, E Carrasco, M-S Cascone, E Cassol, F Castaldini, L Castrejon, N Castro-Tirado, A J Cerasole, D Ceribella, G Cerruti, M Chadwick, P M Chaty, S Chen, A W Chernyakova, M Chiavassa, A Chudoba, J Chytka, L Cicciari, G M Cifuentes, A Coimbra Araujo, C H Colapietro, M Conforti, V Contreras, J L Cortina, J Costa, A Costantini, H Cotter, G Cristofari, P Cuevas, O Curtis-Ginsberg, Z D’Aì, A D’Amico, G D’Ammando, F Dai, S Dazzi, F de Bony de Lavergne, M De Caprio, V De Cesare, G De Frondat Laadim, F de Gouveia Dal Pino, E M De Lotto, B De Lucia, M de Martino, D de Menezes, R de Naurois, M de Ona Wilhelmi, E de Souza, V del Peral, L del Valle, M V Delgado, C Dell’aiera, M Della Valle, M della Volpe, D Depaoli, D Devin, J Di Girolamo, T Di Piano, A Di Pierro, F Di Tria, R Di Venere, L Diebold, S Dignam, C Dima, R Dinesh, A Djuvsland, J Dominik, R M Dominis Prester, D Donini, A Dorner, D Dörner, J Doro, M Dubos, C Ducci, L Dwarkadas, V V Ebr, J Eckner, C Egberts, K Einecke, S Elsässer, D Emery Department of Physics Tokai University 4-1-1 Kita-Kaname Hiratsuka Kanagawa 259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Kashiwa Chiba 277-8582 Japan ETH Zürich Institute for Particle Physics and Astrophysics Otto-Stern-Weg 5 CH-8093 Zürich Switzerland INFN and Università degli Studi di Siena Dipartimento di Scienze Fisiche della Terra e dell’Ambiente (DSFTA) Sezione di Fisica Via Roma 56 I-53100 Siena Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM F-91191 Gif-sur-Yvette Cedex France FSLAC IRL 2009 CNRS/IAC E-38205 La Laguna Tenerife Spain University of Alabama Tuscaloosa Department of Physics and Astronomy Gallalee Hall Box 870324 Tuscaloosa AL 35487-0324 USA Université Côte d’Azur Observatoire de la Côte d’Azur CNRS Laboratoire Lagrange UF 06304 Nice France Laboratoire Leprince-Ringuet CNRS/IN2P3 École Polytechnique Institut Polytechnique de Paris F-91120 Palaiseau France Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 E-08028 Barcelona Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n E-18008 Granada Spain Institute for Computational Cosmology and Department of Physics Durham University South Road Durham DH1 3LE UK Pontificia Universidad Católica de Chile Av. Libertador Bernardo O’Higgins 340 8331150 Santiago Chile Universidad Nacional Autónoma de México Delegación Coyoacán 04510 Ciudad de México Mexico IPARCOS-UCM Instituto de Física de Partículas y del Cosmos and EMFTEL Department Universidad Complutense de Madrid E-28040 Madrid Spain Instituto de Física Teórica UAM/CSIC and Departamento de Física Teórica Universidad Autónoma de Madrid c/ Nicolás Cabrera 13-15 Campus de Cantoblanco UAM E-28049 Madrid Spain LUTH GEPI and LERMA Observatoire de Paris Université PSL Université Paris Cité CNRS 5 place Jules Janssen F-92190 Meudon France INAF – Osservatorio

A wide variety of Galactic sources show transient emission at soft and hard X-ray energies: low- and high-mass X-ray binaries containing compact objects, isolated neutron stars exhibiting extreme variability as magnetars as well as pulsar-wind nebulae. Although most of them can show emission up to MeV and/or GeV energies, many have not yet been detected in the TeV domain by Imaging Atmospheric Cherenkov Telescopes. In this paper, we explore the feasibility of detecting new Galactic transients with the Cherenkov Telescope Array Observatory (CTAO) and the prospects for studying them with Target of Opportunity observations. We show that CTAO will likely detect new sources in the TeV regime, such as the massive microquasars in the Cygnus region, low-mass X-ray binaries with low-viewing angle, flaring emission from the Crab pulsar-wind nebula or other novae explosions, among others. Since some of these sources could also exhibit emission at larger time-scales, we additionally test their detectability at longer exposures. We finally discuss the multiwavelength synergies with other instruments and large astronomical facilities.

关键词： binaries: general stars: magnetars novae cataclysmic variables pulsars: general gamma-rays: general

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Proceedings from the 9th annual conference on the science of dissemination and implementation: Washington, DC, USA. 14-15 December 2016

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Implement Sci 2017年第SUPPL 1期12卷 48-48页

作者： David Chambers Lisa Simpson Gila Neta Ulrica von Thiele Schwarz Antoinette Percy-Laurry Gregory A. Aarons Ross Brownson Amanda Vogel Shannon Wiltsey Stirman Kenneth Sherr Rachel Sturke Wynne E. Norton Allyson Varley Cynthia Vinson Lisa Klesges Suzanne Heurtin-Roberts M. Rashad Massoud Leighann Kimble Arne Beck Claire Neely Jennifer Boggs Carmel Nichols Wen Wan Erin Staab Neda Laiteerapong Nathalie Moise Ravi Shah Susan Essock Margaret Handley Amy Jones Jay Carruthers Karina Davidson Lauren Peccoralo Lloyd Sederer Todd Molfenter Ashley Scudder Sarah Taber-Thomas Kristen Schaffner Amy Herschell Eva Woodward Jeffery Pitcock Mona Ritchie JoAnn Kirchner Julia E. Moore Sobia Khan Shusmita Rashid Jamie Park Melissa Courvoisier Sharon Straus Daniel Blonigen Allison Rodriguez Luisa Manfredi Andrea Nevedal Joel Rosenthal David Smelson Christine Timko Nicole Stadnick Jennifer Regan Miya Barnett Anna Lau Lauren Brookman-Frazee Erick Guerrero Karissa Fenwick Yinfei Kong Gregory Aarons Rebecca Lengnick-Hall Benjamin Henwood Nina Sayer Craig Rosen Robert Orazem Brandy Smith Lindsey Zimmerman David Lounsbury Rachel Kimerling Jodie A. Trafton Steven Lindley Rahul Bhargava Hal Roberts Laura Gibson Gabriel J. Escobar Vincent Liu Benjamin Turk Arona Ragins Patricia Kipnis Ashley Ketterer Gruszkowski Michael W. Kennedy Emily Rentschler Drobek Lior Turgeman Aleksandra Sasha Milicevic Terrence L. Hubert Larissa Myaskovsky Youxu C. Tjader Robert J. Monte Kathryn G. Sapnas Edmond Ramly Diane R Lauver Christie M Bartels Shereef Elnahal Andrea Ippolito Hillary Peabody Carolyn Clancy Randall Cebul Thomas Love Douglas Einstadter Shari Bolen Brook Watts Vera Yakovchenko Angela Park William Lukesh Donald R. Miller David Thornton Mari-Lynn Drainoni Allen L. Gifford Shawna Smith Julia Kyle Mark S Bauer Daniel Eisenberg Celeste Liebrecht Michelle Barbaresso Amy Kilbourne Elyse Park Giselle Perez Jamie Ostroff Sarah Greene Michael Parchman Brian Austin Eric Larson Stefanie Ferreri Chris Shea Megan Smith Kea Turner Jennifer Bacci Kyle Bigham Geoffr Division of Cancer Control and Population Sciences National Cancer Institute Rockville MD 20850 USA AcademyHealth Washington DC 20009 USA Department of Learning Informatics Management and Ethics Karolinska Institutet Stockholm 17177 Sweden Department of Psychiatry University of California San Diego San Diego CA 92093 USA George Warren Brown School of Social Work Washington University in St. Louis St. Louis MO 63130 USA Center for Global Health National Cancer Institute Rockville MD 20850 USA Dissemination and Training Division VA National Center for PTSD Palo Alto CA 94305 USA Department of Global Health University of Washington Seattle WA 98105 USA Center for Global Health Studies Fogarty International Center National Institutes of Health Bethesda MD 20912 USA School of Public Health University of Alabama at Birmingham Birmingham AL 35243 USA School of Public Health University of Memphis Memphis TN 38152 USA USAID Applying Science to Strengthen and Improve Systems (ASSIST) Project Bethesda Maryland 20814 USA Institute for Health Research Kaiser Permanente Denver CO 80231 USA ICSI Institute for Clinical Systems Improvement Bloomington MN 55425 USA Medicine University of Chicago Chicago IL 60637 USA Medicine Columbia University Medical Center New York NY 10032 USA Psychiatry Columbia University New York NY 10032 USA General Internal Medicine Epidemiology and Biostatistics University of California San Francisco San Francisco CA 94110 USA New York State Office of Mental Health New York NY 10001 USA Medicine Icahn School of Medicine at Mount Sinai New York NY 10029 USA Center for Health Enhancement System Studies University of Wisconsin Madison WI 53706 USA Department of Psychiatry University of Pittsburgh Pittsburgh PA 15213 USA Psychology University at Buffalo Buffalo NY 14260 USA Department of Psychology West Virginia University Morgantown WV 26506 USA MIRECC VA North Little Rock AR 72114 USA QUERI for Team-Based Behavioral Health Centr

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Combining Time-Lapse Imaging and Next Generation RNA-Sequencing to assess Equine Embryo Developmental Potential

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Journal of Equine Veterinary Science 2016年 41卷 80-81页

作者： B.L. Daughtry K.R. Masterson E.S. Metcalf D. Battaglia S.S. Fei L. Carbone R. Beck N. Cook S.L. Chavez Department of Cell Developmental & Cancer Biology Graduate Program in Molecular & Cellular Biosciences Oregon Health & Science University (OHSU) School of Medicine Portland Oregon 97239 Division of Reproductive & Developmental Sciences Oregon National Primate Research Center (ONPRC) Beaverton Oregon 97006 Division of Reproductive Endocrinology and Infertility Department of Obstetrics & Gynecology OHSU School of Medicine Portland Oregon 97239 Division of Neuroscience Primate Genetics Section ONPRC Beaverton Oregon 97006 Department of Behavioral Neuroscience OHSU School of Medicine Portland Oregon 97239 Foal Inc. Hemet CA 92545 Advanced Equine Reproduction Solvang CA 93463 Departments of Obstetrics & Gynecology and Physiology & Pharmacology OHSU School of Medicine Portland Oregon 97239

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Glyphosate-Residues in Roundup-Ready Soybean Impair Daphnia magna Life-Cycle

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Journal of Agricultural Chemistry and Environment 2015年第1期4卷 24-36页

作者： Marek Cuhra Terje Traavik Mickael Dando Raul Primicerio Daniel Ferreira Holderbaum Thomas Bohn Faculty of Health Sciences The Arctic University of NorwayTromsoNorway GenOk—Centre for Biosafety The Science ParkTromsoNorway Faculty of Biosciences Fisheries and EconomicsThe Arctic University of NorwayTromsoNorway Graduate Program in Plant Genetic Resources Federal University of Santa Catarina(UFSC)FlorianópolisBrazil

Herbicide tolerant plants such as Roundup-Ready soybean contain residues of glyphosate herbicide. These residues are considered safe and previous animal-feeding-studies have failed to find negative effects related to such chemical residues. The present study tests 8 experimental soy- meal diets as feed in groups (each containing 20 individuals) of test-animals (D. magna). The diets have different levels of glyphosate residues and we show that animal growth, reproductive maturity and number of offspring are correlated with these chemicals. The tested soybeans are from ordinary agriculture in Iowa USA and the residues are below the regulatory limits. Despite this, clear negative effects are seen in life-long feeding. The work enhances the need for including analysis of herbicide residues in future assessment of GMO.

关键词： Transgenic GTS 40-3-2 Roundup-Ready Soybean Glyphosate Residues Life-Long Animal Feeding Study GMO Risk-Assessment Herbicide-Tolerant Cultivar Quality Aquatic Invertebrate Ecotoxicology

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Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption

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Nature Genetics 2025年 1-15页

作者： Nava, Caroline Cogne, Benjamin Santini, Amandine Leitão, Elsa Lecoquierre, François Chen, Yuyang Stenton, Sarah L. Besnard, Thomas Heide, Solveig Baer, Sarah Jakhar, Abhilasha Neuser, Sonja Keren, Boris Faudet, Anne Forlani, Sylvie Faoucher, Marie Uguen, Kevin Platzer, Konrad Afenjar, Alexandra Alessandri, Jean-Luc Andres, Stephanie Angelini, Chloé Aral, Bernard Arveiler, Benoit Attie-Bitach, Tania Aubert Mucca, Marion Banneau, Guillaume Barakat, Tahsin Stefan Barcia, Giulia Baulac, Stéphanie Beneteau, Claire Benkerdou, Fouzia Bernard, Virginie Bézieau, Stéphane Bonneau, Dominique Bonnet-Dupeyron, Marie-Noelle Boussion, Simon Boute, Odile Brischoux-Boucher, Elise Bryen, Samantha J. Buratti, Julien Busa, Tiffany Caliebe, Almuth Capri, Yline Cassinari, Kévin Caumes, Roseline Cenni, Camille Chambon, Pascal Charles, Perrine Christodoulou, John Colson, Cindy Conrad, Solène Cospain, Auriane Coursimault, Juliette Courtin, Thomas Couse, Madeline Coutton, Charles Creveaux, Isabelle D’Gama, Alissa M. Dauriat, Benjamin de Sainte Agathe, Jean-Madeleine Del Gobbo, Giulia Delahaye-Duriez, Andrée Delanne, Julian Denommé-Pichon, Anne-Sophie Dieux-Coeslier, Anne Do Souto Ferreira, Laura Doco-Fenzy, Martine Drukewitz, Stephan Duboc, Véronique Dubourg, Christèle Duffourd, Yannis Dyment, David El Chehadeh, Salima Elmaleh, Monique Faivre, Laurence Fennelly, Samuel Fischer, Hanna Fradin, Mélanie Galludec Vaillant, Camille Ganne, Benjamin Ghoumid, Jamal Goel, Himanshu Gokce-Samar, Zeynep Goldenberg, Alice Gonfreville Robert, Romain Gorokhova, Svetlana Goujon, Louise Granier, Victoria Gras, Mathilde Greally, John M. Greiten, Bianca Gueguen, Paul Guerrot, Anne-Marie Guha, Saurav Guimier, Anne Haack, Tobias B. Hadj Abdallah, Hamza Halleb, Yosra Harbuz, Radu Harris, Madeleine Hentschel, Julia Héron, Bénédicte Hitz, Marc-Phillip Innes, A. Micheil Jadas, Vincent Januel, Louis Jean-Marçais, Nolwenn Jobanputra, Vaidehi Jobic, Florence Jornea, Ludmila Jost, Céline Julia, Sophie Kaiser, Frank J. Kaschta, Daniel Kaya, Sabine Ketteler, Petra Khadi Sorbonne Université Institut du Cerveau—Paris Brain Institute—ICM Inserm CNRS APHP Hôpital Pitié-Salpêtrière Paris France Assistance Publique-Hôpitaux de Paris (APHP) Sorbonne Université Département de Génétique Médicale Hôpital Pitié-Salpêtrière Paris France Laboratoire SeqOIA Paris France Nantes Université CHU de Nantes Service de Génétique Médicale Nantes France Nantes Université CHU de Nantes CNRS INSERM l’institut du thorax Nantes France Univ. Rouen Normandie Normandie Univ. Inserm U1245 Rouen France Institute of Human Genetics University Hospital Essen University Duisburg–Essen Essen Germany Univ. Rouen Normandie Normandie Univ. Inserm U1245 and CHU Rouen Department of Genetics and Reference Center for Developmental Abnormalities Rouen France Big Data Institute University of Oxford Oxford United Kingdom Centre for Human Genetics University of Oxford Oxford United Kingdom Broad Center for Mendelian Genomics Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA United States Division of Genetics and Genomics Boston Children’s Hospital Harvard Medical School Boston MA United States Service de Neuropédiatrie Hôpitaux Universitaires de Strasbourg Strasbourg France Institute of Genetics and Cellular and Molecular Biology (IGBMC) INSERM-U964 CNRS-UMR7104 University of Strasbourg Illkirch France CNRS Inserm Université de Strasbourg IGBMC UMR 7104-UMR-S 1258 Illkirch France Department of Integrated Structural Biology IGBMC Illkirch France Institute of Human Genetics University of Leipzig Medical Center Leipzig Germany Laboratoire de Génétique Moléculaire et Génomique FHU GenOMedS CHU Rennes Rennes France University of Rennes CNRS INSERM IGDR (Institut de Génétique et Développement de Rennes)-UMR 6290 ERL U1305 Rennes France GCS AURAGEN Lyon France Univ. Brest Inserm EFS UMR 1078 GGB Brest France Service de Génétique Médicale et Biologie de la Reproduction CHRU de Brest Brest France Assistan

The major spliceosome contains five small nuclear RNAs (snRNAs;U1, U2, U4, U5 and U6) essential for splicing. Variants in RNU4-2, encoding U4, cause a neurodevelopmental disorder called ReNU syndrome. We investigated de novo variants in 50 snRNA-encoding genes in a French cohort of 23,649 individuals with rare disorders and gathered additional cases through international collaborations. Altogether, we identified 145 previously unreported probands with (likely) pathogenic variants in RNU4-2 and 21 individuals with de novo and/or recurrent variants in RNU5B-1 and RNU5A-1, encoding U5. Pathogenic variants typically arose de novo on the maternal allele and cluster in regions critical for splicing. RNU4-2 variants mainly localize to two structures, the stem III and T-loop/quasi-pseudoknot, which position the U6 ACAGAGA box for 5′ splice site recognition and associate with different phenotypic severity. RNU4-2 variants result in specific defects in alternative 5′ splice site usage and methylation patterns (episignatures) that correlate with variant location and clinical severity. This study establishes RNU5B-1 as a neurodevelopmental disorder gene, suggests RNU5A-1 as a strong candidate and highlights the role of de novo variants in snRNAs. © The Author(s) 2025.

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Effect of climate on traits of dominant and rare tree species in the world's forests

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Nature communications 2025年第1期16卷 4773页

作者： Iris Hordijk Lourens Poorter Jingjing Liang Peter B Reich Sergio de-Miguel Gert-Jan Nabuurs Javier G P Gamarra Han Y H Chen Mo Zhou Susan K Wiser Hans Pretzsch Alain Paquette Nicolas Picard Bruno Hérault Jean-Francois Bastin Giorgio Alberti Meinrad Abegg Yves C Adou Yao Angelica M Almeyda Zambrano Braulio V Alvarado Esteban Alvarez-Davila Patricia Alvarez-Loayza Luciana F Alves Iêda Amaral Christian Ammer Clara Antón-Fernández Alejandro Araujo-Murakami Luzmila Arroyo Valerio Avitabile Gerardo A Aymard C Timothy Baker Olaf Banki Jorcely Barroso Meredith L Bastian Luca Birigazzi Philippe Birnbaum Robert Bitariho Pascal Boeckx Frans Bongers Olivier Bouriaud Pedro H S Brancalion Susanne Brandl Francis Q Brearley Roel Brienen Eben N Broadbent Helge Bruelheide Roberto Cazzolla Gatti Ricardo G Cesar Goran Cesljar Robin L Chazdon Chelsea Chisholm Emil Cienciala Connie J Clark David B Clark Gabriel Colletta David Coomes Fernando Cornejo Valverde Jose J Corral-Rivas Philip Crim Jonathan Cumming Selvadurai Dayanandan André L de Gasper Mathieu Decuyper Géraldine Derroire Ben DeVries Ilija Djordjevic Aurélie Dourdain Jiri Dolezal Nestor Laurier Engone Obiang Brian Enquist Teresa Eyre Adandé Belarmain Fandohan Tom M Fayle Leandro V Ferreira Ted R Feldpausch Leena Finér Markus Fischer Christine Fletcher Lorenzo Frizzera Damiano Gianelle Henry B Glick David Harris Andrew Hector Andreas Hemp John Herbohn Annika Hillers Eurídice N Honorio Coronado Cang Hui Hyunkook Cho Thomas Ibanez Ilbin Jung Nobuo Imai Andrzej M Jagodzinski Bogdan Jaroszewicz Vivian Johannsen Carlos A Joly Tommaso Jucker Viktor Karminov Kuswata Kartawinata Elizabeth Kearsley David Kenfack Deborah Kennard Sebastian Kepfer-Rojas Gunnar Keppel Mohammed Latif Khan Timothy Killeen Hyun Seok Kim Kanehiro Kitayama Michael Köhl Henn Korjus Florian Kraxner Diana Laarmann Mait Lang Simon Lewis Huicui Lu Natalia Lukina Brian Maitner Yadvinder Malhi Eric Marcon Beatriz Schwantes Marimon Ben Hur Marimon-Junior Andrew Robert Marshall Emanuel Martin Olga Martynenko Jorge A Mea Institute of Integrative Biology ETH Zurich (Swiss Federal Institute of Technology) Zurich Switzerland. irishordijk@***. Wageningen University and Research Wageningen The Netherlands. irishordijk@***. Wageningen University and Research Wageningen The Netherlands. Department of Forestry and Natural Resources Purdue University West Lafayette IN USA. Department of Forest Resources University of Minnesota St Paul MN USA. Hawkesbury Institute for the Environment Western Sydney University Penrith NSW Australia. Department of Agricultural and Forest Sciences and Engineering University of Lleida Lleida Spain. Forest Science and Technology Centre of Catalonia (CTFC) Solsona Spain. Forestry Division Food and Agriculture Organization of the United Nations Rome Italy. Faculty of Natural Resources Management Lakehead University Thunder Bay ON Canada. Manaaki Whenua-Landcare Research Lincoln New Zealand. Chair for Forest Growth and Yield Science TUM School for Life Sciences Technical University of Munich Munich Germany. Centre for Forest Research Université du Québec à Montréal Montréal QC Canada. GIP ECOFOR Paris France. CIRAD Forêts et Sociétés Montpellier France. Forêts et Sociétés Univ Montpellier CIRAD Montpellier France. Gembloux Agro Bio-Tech University of Liege Liege Belgium. Faculty of Science and Technology Free University of Bolzano Bolzano Italy. Department of Agricultural Food Environmental and Animal Sciences University of Udine Udine Italy. Swiss Federal Institute for Forest Snow and Landscape Research WSL Birmensdorf Switzerland. UFR Biosciences University Félix Houphouët-Boigny Abidjan Côte d'Ivoire. Spatial Ecology and Conservation Laboratory Center for Latin American Studies University of Florida Gainesville FL USA. Forestry School Tecnológico de Costa Rica TEC Cartago Costa Rica. Fundacion ConVida Universidad Nacional Abierta y a Distancia UNAD Medellin Colombia. Field Museum of Natural History Chicago IL USA. Center for Trop

Species' traits and environmental conditions determine the abundance of tree species across the globe. The extent to which traits of dominant and rare tree species differ remains untested across a broad environmental range, limiting our understanding of how species traits and the environment shape forest functional composition. We use a global dataset of tree composition of >22,000 forest plots and 11 traits of 1663 tree species to ask how locally dominant and rare species differ in their trait values, and how these differences are driven by climatic gradients in temperature and water availability in forest biomes across the globe. We find three consistent trait differences between locally dominant and rare species across all biomes; dominant species are taller, have softer wood and higher loading on the multivariate stem strategy axis (related to narrow tracheids and thick bark). The difference between traits of dominant and rare species is more strongly driven by temperature compared to water availability, as temperature might affect a larger number of traits. Therefore, climate change driven global temperature rise may have a strong effect on trait differences between dominant and rare tree species and may lead to changes in species abundances and therefore strong community reassembly.

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World Congress Integrative Medicine & health 2017: Part one: Berlin, Germany. 3-5 May 2017

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BMC Complement Altern Med 2017年第SUPPL 1期17卷 322-322页

作者： Benno Brinkhaus Torkel Falkenberg Aviad Haramati Stefan N. Willich Josephine P. Briggs Merlin Willcox Klaus Linde Töres Theorell Lisa M. Wong Jeffrey Dusek Darong Wu David Eisenberg Bettina Berger Kathi Kemper Beate Stock-Schröer Hedda Sützl-Klein Rosaria Ferreri Gary Kaplan Harald Matthes Gabriele Rotter Elad Schiff Zahi Arnon Eckhard Hahn Christina M. Luberto David Martin Silke Schwarz Diethard Tauschel Andrew Flower Harsha Gramminger Hedwig H. Gupta S. N. Gupta Annette Kerckhoff Christian S. Kessler Andreas Michalsen Eun S. Kim Eun H. Jang Rana Kim Sae B. Jan Martin Mittwede Wiebke Mohme Eran Ben-Arye Massimo Bonucci Bashar Saad Thomas Breitkreuz Elio Rossi Rejin Kebudi Michel Daher Samaher Razaq Nahla Gafer Omar Nimri Mohamed Hablas Gunver Sophia Kienle Noah Samuels Michael Silbermann Lena Bandelin Anna-Lena Lang Eva Wartner Christoph Holtermann Maxwell Binstock Robert Riebau Edin Mujkanovic Holger Cramer Romy Lauche Andres Michalsen Lesley Ward Dominik Irnich Wolfram Stör Geoffrey Burnstock Hans-Georg Schaible Thomas Ots Jost Langhorst Tobias Sundberg Catherina Amarell Melanie Anheyer Marion Eckert Mercedes Ogal Annette Schönauer Birgit Reisenberger Bernhard Brand Dennis Anheyer Gustav Dobos Matthias Kroez Aldo Ammendola Jun J. Mao Claudia Witt Yufei Yang Miriam Oritz Markus Horneber Petra Voiß Alexandra von Rosenstiel Catharina Amarell Friedemann Schad Marc Schläppi Matthias Kröz Arndt Büssing Gil Bar-Sela David Avshalomov Samuel Attias Sian Cotton Miek Jong Mats Jong Christian Scheffer Friedrich Edelhäuser Abdullah AlBedah Myeong Soo Lee Mohamed Khalil Keiko Ogawa Yoshiharu Motoo Junsuke Arimitsu Masao Ogawa Genki Shimizu Rainer Stange Karin Kraft Kenny Kuchta Kenji Watanabe D Bonin Harald Gruber Sabine Koch Urs Pohlmann Christine Caldwell Barbara Krantz Ria Kortum Lily Martin Lisa S. Wieland Ben Kligler Susan Gould-Fogerite Yuqing Zhang John J. Riva Michael Lumpkin Emily Ratner Liu Ping Pei Jian Gesa-Meyer Hamme Xiaosong Mao Han Chouping Sven Schröder Josef Hummelsberger Michael Wullinger Marc Brodzky Chr Institute for Social Medicine Epidemiology and Health Economics Charité – Universitätsmedizin Berlin Berlin Germany Department of Neurobiology Care Sciences and Society Division of Nursing Research Group Integrative Care Karolinska Institutet Stockholm Sweden I C – The Integrative Care Science Center Järna Sweden Department of Biochemistry Molecular and Cellular Biology Georgetown University Medical Center Washington DC USA Department of Medicine Georgetown University Medical Center Washington DC USA NCCIH NIH Bethesda MD USA Department of Primary Care and Population Sciences University of Southampton Aldermoor Health Centre Coxford Rd Southampton 2016 5ST UK Institute of General Practice Technical University Munich Munich Germany Department of Neuroscience Karolinska Institute Stockholm Sweden Stress Research Institute Stockholm University Stockholm Sweden Arts and Humanities Initiative Harvard Medical School Boston MA 02115 USA Psychosomatic medicine Neuropsychology Allina Health Minneapolis MN USA nd Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China Department of Nutrition Harvard University T H Chan School of Public Health Boston MA 02115 USA Department of Health University of Witten/Herdecke Witten/Herdecke Germany OSU Blacklick OH USA Carstens-Foundation and FORUM D-45276 Essen Germany ESIHR (European Society for Integrative Health Care) A-1070 Vienna Austria Hospital Centre of Integrated Medicine Hospital of Pitiglian o ASL SudEst Toscana Grosseto Italy The Kaplan Center for Integrative Medicine Georgetown University McLean VA USA Hospital Havelhöhe Berlin Germany Institute for Social Medicine Epidemiology and Health Economics Charité University Hospital Berlin Germany Internal medicine and Complementary medicine service Bnai Zion Medical Center Haifa Israel Complementary-Integrative Surgery Service Bnai Zion Medical Center Haifa Israel The Emek Yezreel Academic College Yezreel Valley Israel Medicine

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Operative Technique for Correction of Gigantomastia,Using the Superior Pedicle,with Special Care for the Nipple-Papillary Grafts:A 13-Year Retrospective Study

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Modern Plastic Surgery 2015年第3期5卷 34-46页

作者： Jose Humberto Cardoso Resende Lucilia Feliciano Marques di Carlantonio Luiz Celio Martins Freitas Teresa Tonini Nebia Maria Almeida de Figueiredo Luiz Carlos Santiago Nursing and Biosciences Federal University of Rio de Janeiro State(UNIRIO)Rio de JaneiroBrazil Member of the Brazilian Society of Plastic Surgery(SBCP) Rio de JaneiroBrazil Brazilian College of Surgeons(CBC) Rio de JaneiroBrazil President of the Catheters committee of the National Cancer Institute(INCa) Rio de JaneiroBrazil Public Health from State of Rio de Janeiro University(UERJ) Rio de JaneiroBrazil Coordinator of the Post-graduate Program in Nursing and Bioscience of UNIRIO Rio de JaneiroBrazil Nursing Federal University of Rio de Janeiro State(UNIRIO)Rio de JaneiroBrazil

This is a retrospective study on gigantomastia correction in obesity facing the technique of nipple-areolar grafts and its complexity. The main question is the technical-surgical care during its execution aiming to achieve reparative results that can return to these women the desire to live with better quality of life and health. Method: We performed a retrospective study of all obese patients with severe gigantomastia who underwent reduction mammaplasty with an operative technique using the superior pedicle, with special care for the nipple-papillary grafts. The study was carried out at a single institution between 2001 and 2013, in a total of 30 cases. This operative technique was presented at first time in 1980, with no changes up to now. We emphasized the perfect decortication of the areola and nipples until they were translucent after the maneuvers of Schwartzman and subsequent grafts operated in both breasts. Results: Results were considered satisfactory, from the reparative and aesthetic point of view, emphasizing the degree of improvement observed in women undergoing technique. Discussion: We can say that during all this time of aesthetic and therapeutic-restorative surgery, due to its realization in a single surgical time, there was big impact on the aesthetics of patients and on their families, even taking into account possible complications in the post-operative. Conclusion: The superior pedicle technique, performed as described here, is a safe and reliable procedure in patients with severe gigantomastia.

关键词： Mammoplasty Gigantomastia Resende’s Technique Surgical Flaps Bariatric Surgery Obesity

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