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Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study

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Psychiatry Research 2024年 342卷 115972-115972页

作者： Solmi, Marco Thompson, Trevor Estradé, Andrés Agorastos, Agorastos Radua, Joaquim Cortese, Samuele Dragioti, Elena Vancampfort, Davy Thygesen, Lau Caspar Aschauer, Harald Schlögelhofer, Monika Aschauer, Elena Schneeberger, Andres Huber, Christian G. Hasler, Gregor Conus, Philippe Cuénod, Kim Q. Do von Känel, Roland Arrondo, Gonzalo Fusar-Poli, Paolo Gorwood, Philip Llorca, Pierre-Michel Krebs, Marie-Odile Scanferla, Elisabetta Kishimoto, Taishiro Rabbani, Golam Skonieczna-Żydecka, Karolina Brambilla, Paolo Favaro, Angela Takamiya, Akihiro Zoccante, Leonardo Colizzi, Marco Bourgin, Julie Kamiński, Karol Moghadasin, Maryam Seedat, Soraya Matthews, Evan Wells, John Vassilopoulou, Emilia Gadelha, Ary Su, Kuan-Pin Kwon, Jun Soo Kim, Minah Lee, Tae Young Papsuev, Oleg Manková, Denisa Boscutti, Andrea Gerunda, Cristiano Saccon, Diego Righi, Elena Monaco, Francesco Croatto, Giovanni Cereda, Guido Demurtas, Jacopo Brondino, Natascia Veronese, Nicola Enrico, Paolo Politi, Pierluigi Ciappolino, Valentina Pfennig, Andrea Bechdolf, Andreas Meyer-Lindenberg, Andreas Kahl, Kai G. Domschke, Katharina Bauer, Michael Koutsouleris, Nikolaos Winter, Sibylle Borgwardt, Stefan Bitter, Istvan Balazs, Judit Czobor, Pál Unoka, Zsolt Mavridis, Dimitris Tsamakis, Konstantinos Bozikas, Vasilios P. Tunvirachaisakul, Chavit Maes, Michael Rungnirundorn, Teerayuth Supasitthumrong, Thitiporn Haque, Ariful Brunoni, Andre R. Costardi, Carlos Gustavo Schuch, Felipe Barreto Polanczyk, Guilherme Luiz, Jhoanne Merlyn Fonseca, Lais Aparicio, Luana V. Valvassori, Samira S. Nordentoft, Merete Vendsborg, Per Hoffmann, Sofie Have Sehli, Jihed Sartorius, Norman Heuss, Sabina Guinart, Daniel Hamilton, Jane Kane, John Rubio, Jose Sand, Michael Koyanagi, Ai Solanes, Aleix Andreu-Bernabeu, Alvaro Cáceres, Antonia San José Arango, Celso Díaz-Caneja, Covadonga M. Hidalgo-Mazzei, Diego Vieta, Eduard Gonzalez-Peñas, Javier Fortea, Lydia Parellada, Mara Fullana, Miquel A. Verdolini, Norma Andrlíková, Eva Janků, Karolina Millan, Mark J. Honciuc, Mihaela Moniuszko-Mal University of Ottawa Department of Psychiatry ON Canada The Ottawa Hospital Department of Mental Health ON Canada Ottawa Hospital Research Institute (OHRI) Neurosciences Program Ottawa Ontario Canada Early Psychosis: Interventions and Clinical-detection (EPIC) Lab Department of Psychosis Studies Institute of Psychiatry Psychology & Neuroscience King's College London London United Kingdom Centre for Innovation in Mental Health-Developmental Lab School of Psychology University of Southampton and NHS Trust Southampton United Kingdom Charité Universitätsmedizin Berlin Department of Child and Adolescent Psychiatry Berlin Germany Centre for Chronic Illness and Ageing University of Greenwich London United Kingdom University of Southampton Centre for Innovation in Mental Health Southampton United Kingdom Universidad Católica Department of Psychology Montevideo Uruguay Aristotle University of Thessaloniki II. Dept. of Psychiatry Division of Neurosciences Medical School Faculty of Health Sciences Greece Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Imaging of Mood- and Anxiety-Related Disorders (IMARD) University of Barcelona CIBERSAM Instituto de Salud Carlos III Barcelona Spain Karolinska Institutet Centre for Psychiatric Research and Education Department of Clinical Neuroscience Stockholm Sweden Linköping University Pain and Rehabilitation Centre and Department of Health Medicine and Caring Sciences Linköping Sweden University of Ioannina Research Laboratory Psychology of Patients Families & Health Professionals Department of Nursing School of Health Sciences Ioannina Greece Katholieke Universiteit Leuven (KU Leuven) Department of Rehabilitation Sciences Leuven Belgium National Institute of Public Health University of Southern Denmark Denmark BioPsyC - Biopsychosocial Corporation Non-profit association for Research Funding Ltd. Vienna Austria University of California San Diego California United States University of Basel Universitä

International studies measuring wellbeing/multidimensional mental health before/ during the COVID-19 pandemic, including representative samples for >2 years, identifying risk groups and coping strategies are lacking. COH-FIT is an online, international, anonymous survey measuring changes in well-being (WHO-5) and a composite psychopathology P-score, and their associations with COVID-19 deaths/restrictions, 12 a-priori defined risk individual/cumulative factors, and coping strategies during COVID-19 pandemic (26/04/2020-26/06/2022) in 30 languages (representative, weighted non-representative, adults). T-test, χ², penalized cubic splines, linear regression, correlation analyses were conducted. Analyzing 121,066/142,364 initiated surveys, WHO-5/P-score worsened intra-pandemic by 11.1±21.1/13.2±17.9 points (effect size d=0.50/0.60) (comparable results in representative/weighted non-probability samples). Persons with WHO-5 scores indicative of depression screening (<50, 13% to 32%) and major depression (<29, 3% to 12%) significantly increased. WHO-5 worsened from those with mental disorders, female sex, COVID-19-related loss, low-income country location, physical disorders, healthcare worker occupations, large city location, COVID-19 infection, unemployment, first-generation immigration, to age=18-29 with a cumulative effect. Similar findings emerged for P-score. Changes were significantly but minimally related to COVID-19 deaths, returning to near-pre-pandemic values after >2 years. The most subjectively effective coping strategies were exercise and walking, internet use, social contacts. Identified risk groups, coping strategies and outcome trajectories can inform global public health strategies. © 2024 The Authors

关键词： Covid-19 Mental health P-factor Pandemic Psychiatry Psychopathology Survey Well-being WHO-5

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Unpackaging the link between economic inequality and self-construal

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Self and Identity 2023年第5期22卷 713-739页

作者： Ángel Sánchez-Rodríguez Ayse K. Uskul Rosa Rodríguez-Bailón Guillermo B. Willis Vivian L. Vignoles Kuba Krys Mladen Adamovic Charity S. Akotia Isabelle Albert Lily Appoh Arno Baltin Pablo Eduardo Barrientos Michael Harris Bond Patrick Denoux Alejandra Domínguez-Espinosa Carla Sofia Esteves Márta Fülöp Vladimer Gamsakhurdia Ragna B. Garðarsdóttir Alin Gavreliuc Diana Hanke-Boer Brian W. Haas David O. Igbokwe İdil Işık Natalia Kascakova Lucie Klůzová Kračmárová Agata Kocimska-Zych Aleksandra Kosiarczyk Olga Kostoula Nicole Kronberger Anna Kwiatkowska J. Hannah Lee Xinhui Liu Magdalena Łużniak-Piecha Arina Malyonova Fridanna Maricchiolo Arévalo Mira Tamara Mohorić Oriana Mosca Elke Murdock Nur Fariza Mustaffa Vivian Miu-Chi Lun Martin Nader Azar Nadi Ayu Okvitawanli Yvette van Osch Joonha Park Vassilis Pavlopoulos Zoran Pavlović Iva Poláčková Šolcová Eric Raymond Igou Muhammad Rizwan Vladyslav Romashov Espen Røysamb Ruta Sargautyte Beate Schwarz Heyla A. Selim Ursula Serdarevich David Sirlopú Maria Stogianni Stanislava Stoyanova Chien-Ru Sun Julien Teyssier Wijnand A. P. van Tilburg Claudio Torres Yukiko Uchida Christin-Melanie Vauclair Cai Xing John M. Zelenski a Social Psychology and Anthropology University of Salamanca Salamanca Spainb University of Granada Spain c Social Psychology and Anthropology University of Kent Salamanca UKd School of Psychology University of Sussex Brighton UK b University of Granada Spain d School of Psychology University of Sussex Brighton UK e Institute of Psychology Polish Academy of Sciences Warsaw Polandf Kokoro Research Center Kyoto University Kyoto Japan g King’s Business School King’s College London United Kingdom h School of Social Sciences University of Ghana Acra Ghana i Faculty of Nursing and Health Sciences Nord University Acra Norway j School of Natural Sciences and Health Tallinn University Tallinn Estonia k Psychology Department Centro Integral de Psicología Aplicada Universidad del Valle de Guatemala Ciudad de Guatemala Guatemala l Department of Management and Marketing Faculty of Business Hong Kong Polytechnic University Hong Kong Hong Kong m University of Essex Colchester UK n Psychology Department Iberoamerican University Mexico City Mexico o CIS-IUL Instituto Universitário de Lisboa (ISCTE-IUL) Lisboa Portugal p Social and Cultural Psychology Research Group Institute of Cognitive Neuroscience and Psychology Resarch Centre of Natural Sciences Budapest Hungaryq Institute of Psychology Károli Gáspár University of the Reformed Church Budapest Hungary r Ivane Javakhishvili Tbilisi State University Tiflis Georgia s Faculty of Psychology University of Iceland Reykjavík Iceland t Department of Psychology West University of Timisoara Timisoara Romania u Department of Social and Organizational Psychology University of Koblenz-Landau Koblenz Germany v Department of Psychology University of Georgia Athens GA USA q Institute of Psychology Károli Gáspár University of the Reformed Church Budapest Hungaryw Baze University Abuja Federal Capital Territory Nigeria x Organizational Psychology Master’s Program Istanbul Bilgi University Istanbul Turkey y Psychiatric C

ABSTRACTPast research has shown that economic inequality shapes individuals’ self-construals. However, it has been unclear which dimensions of self-construal are associated with and affected by economic inequality. A correlational (Study 1:N= 264) and an experimental study (Study 2:N= 532) provided converging evidence linking perceived economic inequality with two forms of independent (vs. interdependent) self-construal: Difference from Others and Self-Reliance. In Study 3 (N= 12,634) societal differences in objective economic inequality across 48 nations predicted feelings of Difference from Others, but not Self-Reliance. Importantly, we found no significant associations of economic inequality with the other six dimensions of self-construal. Our findings help extend previous results linking economic inequality to forms of “social distance.”

关键词： Economic inequality multidimensional self-construal independence interdependence

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Self-construals predict personal life satisfaction with different strengths across societal contexts differing in national wealth and religious heritage

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Self and Identity 2023年第5期22卷 689-712页

作者： Ángel Sánchez-Rodríguez Vivian L. Vignoles Michael Harris Bond Mladen Adamovic Charity S. Akotia Isabelle Albert Lily Appoh Arno Baltin Pablo Eduardo Barrientos Patrick Denoux Alejandra Domínguez-Espinosa Carla Sofia Esteves Márta Fülöp Vladimer Gamsakhurdia Ragna B. Garðarsdóttir Alin Gavreliuc Diana Hanke-Boer Brian W. Haas David O. Igbokwe İ̇dil Işık Natalia Kascakova Lucie Klůzová Kračmárová Agata Kocimska-Zych Aleksandra Kosiarczyk Olga Kostoula Nicole Kronberger Kuba Krys Anna Kwiatkowska J. Hannah Lee Xinhui Liu Magdalena Łużniak-Piecha Arina Malyonova Fridanna Maricchiolo Arévalo Mira Tamara Mohorić Oriana Mosca Elke Murdock Nur Fariza Mustaffa Vivian Miu-Chi Lun Martin Nader Azar Nadi Ayu Okvitawanli Yvette van Osch Joonha Park Vassilis Pavlopoulos Zoran Pavlović Iva Poláčková Šolcová Eric Raymond Igou Muhammad Rizwan Vladyslav Romashov Espen Røysamb Ruta Sargautyte Beate Schwarz Heyla A. Selim Ursula Serdarevich David Sirlopú Maria Stogianni Stanislava Stoyanova Chien-Ru Sun Julien Teyssier Wijnand A. P. van Tilburg Claudio Torres Yukiko Uchida Christin-Melanie Vauclair Cai Xing John M. Zelenski a Social Psychology and Anthropology University of Salamanca Salamanca Spain b School of Psychology University of Sussex Brighton UK c Department of Management and Marketing Faculty of Business Hong Kong Polytechnic University Hong Kong China d King’s Bussiness School King’s College London UK e School of Social Sciences University of Ghana Acra Ghana f Department of Culture Studies Tilburg University Tilburg The Netherlands g Faculty of Nursing and Health Sciences Nord University Acra Norway h School of Natural Sciences and Health Tallinn University Tallinn Estonia i Psychology Department Centro Integral de Psicología Aplicada Universidad del Valle de Guatemala Ciudad de Guatemala Guatemala j University of Essex Colchester UK k Department of Psychology Iberoamerican University Mexico City Mexico l CIS-IUL Instituto Universitário de Lisboa (ISCTE-IUL) Lisboa Portugal m Institute of Cognitive Neuroscience and Psychology Research Centre of Natural Sciencesn Institute of Psychology Károli Gáspár University of the Reformed Chuch o Social Psychology and Anthropology Ivane Javakhishvili Tbilisi State University Salamanca Georgia p Faculty of Psychology University of Iceland Reykjavík Iceland q Department of Psychology West University of Timisoara Timisoara Romania r Department of Social and Organizational Psychology University of Koblenz-Landau Koblenz Germany s Department of Psychology University of Georgia Athens GA USA t Baze University Abuja Federal Capital Territory Nigeria u Organizational Psychology Master’s Program Istanbul Bilgi University Istanbul Turkey v Psychiatric Clinic Pro Mente Sana Bratislava Slovakiaw Olomouc University Social Health Institute Palacky University Olomouc Czech Republic x Czech Academy of Sciences Prague Czech Republic y Wroclaw Faculty of Psychology SWPS University of Social Sciences and Humanities Warsaw Poland z Institute for Education and Psychology Johannes Kepler University Linz Linz Austria aa Kokoro Researc

ABSTRACTWe explore to what extent previously observed pan-cultural association between dimensions of self-construal and personal life satisfaction (PLS) may be moderated by three national-contextual variables: national wealth, economic inequality, and religious heritage. The results showed that Self-reliance (vs. dependence on others) predicted PLS positively in poorer countries but negatively in richer countries. Connectedness to others (vs. self-containment) predicted PLS more strongly in Protestant-heritage countries. Self-expression (vs. harmony) predicted PLS more weakly (and non-significantly) in Muslim-heritage countries. In contrast, previously reported associations of self-direction (vs. reception-to-influence), consistency (vs. variability), and decontextualized (vs. contextualized) self-understanding with personal life satisfaction were not significantly moderated by these aspects of societal context. These results show the importance of considering the impact of national religious and economic context.

关键词： Multicomponentself-construal religious heritage national wealth economic inequality personal life satisfaction

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Emerging contaminants:A One health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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Author Correction: Towards symbiotic approaches between universities, sustainable development, and cities

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Scientific reports 2023年第1期13卷 552页

作者： Walter Leal Filho Liliana Caughman Maria Alzira Pimenta Dinis Fernanda Frankenberger Anabela Marisa Azul Amanda Lange Salvia Department of Natural Sciences Manchester Metropolitan University Chester Street Manchester M115GD UK. Research and Transfer Centre "Sustainable Development and Climate Change Management" Hamburg University of Applied Sciences Ulmenliet 20 21033 Hamburg Germany. Postdoctoral Research Scholar Earth Systems Science for the Anthropocene Arizona State University Tempe USA. UFP Energy Environment and Health Research Unit (FP-ENAS) University Fernando Pessoa (UFP) Praça 9 de Abril 349 4249-004 Porto Portugal. Business School PUCPR Pontifical Catholic University of Paraná Rua Imaculada Conceição Curitiba 1155 Brazil. Brazil Business School Universidade Positivo Rua Pedro Viriato Parigot de Souza Curitiba 5300 Brazil. CNC-Center for Neuroscience and Cell Biology University of Coimbra 3004-504 Coimbra Portugal. CIBB-Center for Innovative Biomedicine and Biotechnology University of Coimbra Coimbra Portugal. IIIUC-Institute for Interdisciplinary Research University of Coimbra 3030-789 Coimbra Portugal. Graduate Program in Civil and Environmental Engineering University of Passo Fundo Campus I - BR285 São José Passo Fundo RS 99052-900 Brazil. amandasalvia@***. European School of Sustainability Science and Research Hamburg University of Applied Sciences Ulmenliet 20 21033 Hamburg Germany. amandasalvia@***.

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PATH-04. OPTIMIZING CELL-FREE DNA ASSAYS FOR LOW INPUT LIQUID BIOPSY SAMPLES FROM PEDIATRIC BRAIN TUMOR PATIENTS

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Neuro-Oncology 2024年第SUPPLEMENT_4期26卷 0–0页

作者： Tom T Fischer Kendra K Maaß Pitithat Puranachot Markus Mieskolainen Martin Sill Agnes M E Finster Paulina S Schad Fabian Rosing Tatjana Wedig Nathalie Schwarz Florian Iser Jochen Meyer Felix Sahm Benedikt Brors Hannu Haapasalo Stefan M Pfister Joonas Haapasalo Kristian W Pajtler Kristiina Nordfors Hopp Children’s Cancer Center (KiTZ) and Division of Pediatric Neurooncology National Center for Tumor Diseases (NCT) German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Department of Pediatric Oncology Hematology Immunology and Pulmonology Heidelberg University Hospital Heidelberg Germany Princess Srisavangavadhana College of Medicine Chulabhorn Royal Academy Bangkok Thailand Unit of Neurosurgery Tampere University Hospital Tampere Finland Department of Pathology Tampere University Hospital Tampere Finland Clinic for Children and Adolescent Medicine Karlsruhe Hospital Karlsruhe Germany Clinical Cooperation Unit Neurooncology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Neurology and Neurooncology Program National Center for Tumor Diseases (NCT) Heidelberg University Hospital Heidelberg Germany Clinical Cooperation Unit Neuropathology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Department of Neuropathology Heidelberg University Hospital Heidelberg Germany Division of Applied Bioinformatics National Center for Tumor Diseases (NCT) German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Medical Faculty Heidelberg and Faculty of Biosciences Heidelberg University Heidelberg Germany Tampere Center for Child Health Research TU and Department of Pediatric Hematology and Oncology Tampere University Hospital Tampere Finland

BACKGROUND Genetic and epigenetic profiling have transformed biological understanding, diagnostics, and therapeutic approaches for pediatric central nervous system (CNS) tumors. Obtaining tumor tissue may be associated with neurosurgical risk, may not be feasible in some cases, and is not routinely performed during follow-up or at relapse. Liquid biopsies (LBs) have emerged as a minimally invasive, serially collectable source of tumor-derived DNA. Here, we collected cerebrospinal fluid (CSF) and serum LBs from a large, unselected, cross-entity pediatric CNS tumor cohort ( n=55 patients) for method optimization.

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK/Akt-mTOR signaling axis

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Phytomedicine : international journal of phytotherapy and phytopharmacology 2023年 108卷 154478页

作者： Ming-Yao Chen Chia-Hung Hsu Syahru Agung Setiawan David T W Tzeng Hon-Ping Ma Jiann Ruey Ong Yi Cheng Chu Ming-Shou Hsieh Alexander T H Wu Yew-Min Tzeng Chi-Tai Yeh Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan. Department of Emergency Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei City 110 Taiwan Department of Emergency Medicine School of Medicine Taipei Medical University Taipei City 110 Taiwan. International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan. School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR 999077 China Lifebit Mindspace Shoreditch London England EC2A 2AP UK. Department of Medicine St. George's University School of Medicine St. George Grenada. Department of Applied Science National Taitung University Taitung 95092 Taiwan. Electronic address: ymtzeng@nttu.edu.tw. Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan Continuing Education Program of Food Biotechnology Applications College of Science and Engineering National Taitung University Taitung 95092 Taiwan. Electronic address: ctyeh@s.tmu.edu.tw.

Activation of mitogen-activated protein kinase (MAPK) and PI3K signaling confers resistance against sorafenib, a mainstay treatment for advanced hepatocellular carcinoma (HCC). Antrocin and ovatodiolide constitute as the most potent secondary metabolites isolated from Antrodia camphorata and Anisomeles indica, respectively. Both natural compounds have recently gained a lot of attention due to their putative inhibition of MAPK and PI3K signaling in various solid cancers. However, whether their combination is effective in HCC remains unknown. Here, we investigated their effect, alone or in various combinations, on MAPK and PI3K signaling pathways in HCC cells. An array of in vitro study were used to investigate anticancer and stemness effects to treat HCC, such as cytotoxicity, drug combination index, migration, invasion, colony formation, and tumor sphere formation. Drug effect in vivo was evaluated using mouse xenograft models. In this study, antrocin and ovatodiolide synergistically inhibited the SNU387, Hep3B, Mahlavu, and Huh7 cell lines. Sequential combination treatment of Huh7 and Mahlavu with ovatodiolide followed by antrocin resulted stronger cytotoxic effect than did treatment with antrocin followed by ovatodiolide, their simultaneous administration, antrocin alone, or ovatodiolide alone. In the Huh7 and Mahlavu cell lines, ovatodiolide→antrocin significantly suppressed colony formation and proliferation as well as markedly downregulated ERK1/2, Akt, and mTOR expression. Inhibition of ERK1/2 and Akt/mTOR signaling by ovatodiolide→antrocin suppressed ribosomal biogenesis, autophagy, and cancer stem cell-like phenotypes and promoted apoptosis in Huh7 and Mahlavu cells. The sorafenib-resistant clone of Huh7 was effectively inhibited by synergistic combination of both compound in vitro. Eventually, the ovatodiolide→antrocin combination synergistically suppressed the growth of HCC xenografts. Taken together, our findings suggested that ovatodiolide→antrocin combi

关键词： Advanced HCC Antrocin (ANC) MAPK Ovatodiolide (OVA) PI3K

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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