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SARS-CoV-2 identified through crystallographic screening and computational docking

science Advances 2021年第16期7卷

作者： Schuller, Marion Correy, Galen J. Gahbauer, Stefan Fearon, Daren Wu, Taiasean Díaz, Roberto Efraín Young, Iris D. Martins, Luan Carvalho Smith, Dominique H. Schulze-Gahmen, Ursula Owens, Tristan W. Deshpande, Ishan Merz, Gregory E. Thwin, Aye C. Biel, Justin T. Peters, Jessica K. Moritz, Michelle Herrera, Nadia Kratochvil, Huong T. Aimon, Anthony Bennett, James M. Neto, Jose Brandao Cohen, Aina E. Dias, Alexandre Douangamath, Alice Dunnett, Louise Fedorov, Oleg Ferla, Matteo P. Fuchs, Martin R. Gorrie-Stone, Tyler J. Holton, James M. Johnson, Michael G. Krojer, Tobias Meigs, George Powell, Ailsa J. Rack, Johannes Gregor Matthias Rangel, Victor L. Russi, Silvia Skyner, Rachael E. Smith, Clyde A. Soares, Alexei S. Wierman, Jennifer L. Zhu, Kang O Brien, Peter Jura, Natalia Ashworth, Alan Irwin, John J. Thompson, Michael C. Gestwicki, Jason E. Von Delft, Frank Shoichet, Brian K. Fraser, James S. Ahel, Ivan Sir William Dunn School of Pathology University of Oxford South Parks Road OxfordOX1 3RE United Kingdom Department of Bioengineering and Therapeutic Sciences University of California San Francisco San FranciscoCA94158 United States Department of Pharmaceutical Chemistry University of California San Francisco San FranciscoCA94158 United States Diamond Light Source Ltd. Harwell Science and Innovation Campus DidcotOX11 0DE United Kingdom Institute for Neurodegenerative Disease University of California San Francisco San FranciscoCA94158 United States Chemistry and Chemical Biology Graduate Program University of California San Francisco San FranciscoCA94158 United States Tetrad Graduate Program University of California San Francisco San FranciscoCA94158 United States Coronavirus Research Group Structural Biology Consortium University of California San Francisco San FranciscoCA94158 United States Biochemistry Department Institute for Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil Helen Diller Family Comprehensive Cancer University of California San Francisco San FranciscoCA94158 United States Centre for Medicines Discovery University of Oxford South Parks Road HeadingtonOX3 7DQ United Kingdom Stanford Synchrotron Radiation Lightsource Slac National Accelerator Center Menlo ParkCA94025 United States Wellcome Centre for Human Genetics University of Oxford Old Road Campus OxfordOX3 7BN United Kingdom National Synchrotron Light Source Ii Brookhaven National Laboratory UptonNY11973 United States Department of Biochemistry and Biophysics University of California San Francisco San FranciscoCA94158 United States Department of Molecular Biophysics and Integrated Bioimaging Lawrence Berkeley National Laboratory BerkeleyCA94720 United States ChemPartner Corporation South San FranciscoCA94080 United States Structural Genomics Consortium University of Oxford Old Road Campus HeadingtonOX3 7DQ United Kingdom School of

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate ribosylation signaling. This enzyme is a promising antiviral target because catalytic mutations render viruses nonpathogenic. Here, we report a massive crystallographic screening and computational docking effort, identifying new chemical matter primarily targeting the active site of the macrodomain. Crystallographic screening of 2533 diverse fragments resulted in 214 unique macrodomain-binders. An additional 60 molecules were selected from docking more than 20 million fragments, of which 20 were crystallographically confirmed. X-ray data collection to ultra-high resolution and at physiological temperature enabled assessment of the conformational heterogeneity around the active site. Several fragment hits were confirmed by solution binding using three biophysical techniques (differential scanning fluorimetry, homogeneous time-resolved fluorescence, and isothermal titration calorimetry). The 234 fragment structures explore a wide range of chemotypes and provide starting points for development of potent SARS-CoV-2 macrodomain inhibitors. © 2021 American Association for the Advancement of science. All rights reserved.

关键词： Coronavirus

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Depth Dependence of the Photoelectron Emission Profile for Cathode Lens Microscopy

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Microscopy and Microanalysis 2018年第S2期24卷 154-155页

作者： Huang, Yen Chuang, Tzu-Hung Lu, Chun-I Huang, Chih-Heng Lin, Deng-Sung Kuo, Chien-Chen Wei, Der-Hsin Graduate Program of Science and Technology of Synchrotron Light Source National Tsing Hua University Hsinchu Taiwan National Synchrotron Radiation Research Center Hsinchu Taiwan Program of Synchrotron Radiation and Neutron Beam Applications National Sun Yat-sen University Kaohsiung Taiwan Department of Physics National Tsing Hua University Hsinchu Taiwan

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Kramers nodal lines in intercalated TaS2 superconductors

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Nature communications 2025年第1期16卷 4984页

作者： Yichen Zhang Yuxiang Gao Aki Pulkkinen Xingyao Guo Jianwei Huang Yucheng Guo Ziqin Yue Ji Seop Oh Alex Moon Mohamed Oudah Xue-Jian Gao Alberto Marmodoro Alexei Fedorov Sung-Kwan Mo Makoto Hashimoto Donghui Lu Anil Rajapitamahuni Elio Vescovo Junichiro Kono Alannah M Hallas Robert J Birgeneau Luis Balicas Ján Minár Pavan Hosur Kam Tuen Law Emilia Morosan Ming Yi Department of Physics and Astronomy Rice University Houston TX 77005 USA. New Technologies Research Center University of West Bohemia Plzen 301 00 Czech Republic. Department of Physics Hong Kong University of Science and Technology Clear Water Bay Hong Kong China. Applied Physics Graduate Program Smalley-Curl Institute Rice University Houston TX 77005 USA. Department of Physics University of California Berkeley Berkeley CA 94720 USA. National High Magnetic Field Laboratory Tallahassee Tallahassee FL 32310 USA. Physics Department Florida State University Tallahassee FL 32306 USA. Stewart Blusson Quantum Matter Institute University of British Columbia Vancouver Vancouver BC V6T 1Z4 Canada. Advanced Light Source Lawrence Berkeley National Laboratory Berkeley Berkeley CA 94720 USA. Stanford Synchrotron Radiation Lightsource SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA. National Synchrotron Light Source II Brookhaven National Lab Upton NY 11973 USA. Rice Center for Quantum Materials Rice University Houston TX 77005 USA. Department of Electrical and Computer Engineering Rice University Houston TX 77005 USA. Department of Materials Science and NanoEngineering Rice University Houston TX 77005 USA. Smalley-Curl Institute Rice University Houston TX 77005 USA. Department of Physics & Astronomy University of British Columbia Vancouver Vancouver BC V6T 1Z1 Canada. Canadian Institute for Advanced Research Toronto Toronto ON M5G 1M1 Canada. Materials Science Division Lawrence Berkeley National Laboratory Berkeley Berkeley CA 94720 USA. Department of Physics and Texas Center for Superconductivity University of Houston Houston TX 77204 USA. Department of Physics and Astronomy Rice University Houston TX 77005 USA. emorosan@rice.edu. Rice Center for Quantum Materials Rice University Houston TX 77005 USA. emorosan@rice.edu. Smalley-Curl Institute Rice University Houston TX 77005 USA.

Kramers degeneracy is one fundamental embodiment of the quantum mechanical nature of particles with half-integer spin under time reversal symmetry. Under the chiral and noncentrosymmetric achiral crystalline symmetries, Kramers degeneracy emerges respectively as topological quasiparticles of Weyl fermions and Kramers nodal lines (KNLs), anchoring the Berry phase-related physics of electrons. However, an experimental demonstration for ideal KNLs well isolated at the Fermi level is lacking. Here, we establish a class of noncentrosymmetric achiral intercalated transition metal dichalcogenide superconductors with large Ising-type spin-orbit coupling, represented by InTaS, to host an ideal KNL phase. We provide evidence from angle-resolved photoemission spectroscopy with spin resolution, angle-dependent quantum oscillation measurements, and ab-initio calculations. Our work not only provides a realistic platform for realizing and tuning KNLs in layered materials, but also paves the way for exploring the interplay between KNLs and superconductivity, as well as applications pertaining to spintronics, valleytronics, and nonlinear transport.

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Presolar stardust in asteroid Ryugu

arXiv

引用

arXiv 2022年

作者： Barosch, Jens Nittler, Larry R. Wang, Jianhua O'D. Alexander, Conel M. De Gregorio, Bradley T. Engrand, Cécile Kebukawa, Yoko Nagashima, Kazuhide Stroud, Rhonda M. Yabuta, Hikaru Abe, Yoshinari Aléon, Jérôme Amari, Sachiko Amelin, Yuri Bajo, Ken-Ichi Bejach, Laure Bizzarro, Martin Bonal, Lydie Bouvier, Audrey Carlson, Richard W. Chaussidon, Marc Choi, Byeon-Gak Cody, George D. Dartois, Emmanuel Dauphas, Nicolas Davis, Andrew M. Dazzi, Alexandre Deniset-Besseau, Ariane Rocco, Tommaso Di Duprat, Jean Fujiya, Wataru Fukai, Ryota Gautam, Ikshu Haba, Makiko K. Hashiguchi, Minako Hibiya, Yuki Hidaka, Hiroshi Homma, Hisashi Hoppe, Peter Huss, Gary R. Ichida, Kiyohiro Iizuka, Tsuyoshi Ireland, Trevor R. Ishikawa, Akira Ito, Motoo Itoh, Shoichi Kamide, Kanami Kawasaki, Noriyuki Kilcoyne, David A.L. Kita, Noriko T. Kitajima, Kouki Kleine, Thorsten Komatani, Shintaro Komatsu, Mutsumi Krot, Alexander N. Liu, Ming-Chang Martins, Zita Masuda, Yuki Mathurin, Jérémie McKeegan, Kevin D. Montagnac, Gilles Morita, Mayu Mostefaoui, Smail Motomura, Kazuko Moynier, Frédéric Nakai, Izumi Nguyen, Ann N. Ohigashi, Takuji Okumura, Taiga Onose, Morihiko Pack, Andreas Park, Changkun Piani, Laurette Qin, Liping Quirico, Eric Remusat, Laurent Russell, Sara S. Sakamoto, Naoya Sandford, Scott A. Schönbächler, Maria Shigenaka, Miho Suga, Hiroki Tafla, Lauren Takahashi, Yoshio Takeichi, Yasuo Tamenori, Yusuke Tang, Haolan Terada, Kentaro Terada, Yasuko Usui, Tomohiro Verdier-Paoletti, Maximilien Wada, Sohei Wadhwa, Meenakshi Wakabayashi, Daisuke Walker, Richard J. Yamashita, Katsuyuki Yamashita, Shohei Yin, Qing-Zhu Yokoyama, Tetsuya Yoneda, Shigekazu Young, Edward D. Yui, Hiroharu Zhang, Ai-Cheng Abe, Masanao Miyazaki, Akiko Nakato, Aiko Nakazawa, Satoru Nishimura, Masahiro Okada, Tatsuaki Saiki, Takanao Tanaka, Satoshi Terui, Fuyuto Tsuda, Yuichi Watanabe, Seiichiro Yada, Toru Yogata, Kasumi Yoshikawa, Makoto Nakamura, Tomoki Naraoka, Hiroshi Noguchi, Takaaki Okazaki, Ryuji Sakamoto, Kanako Tachibana, Shogo Yurimoto, Hisayoshi Earth and Planets Laboratory Carnegie Institution of Washington 5241 Broad Branch Rd. NW WashingtonDC20015 United States Materials Science and Technology Division US Naval Research Laboratory WashingtonDC20375 United States IJCLab UMR 9012 Université Paris-Saclay CNRS Orsay91405 France Faculty of Engineering Yokohama National University Kanagawa Yokohama240-8501 Japan Hawai‘i Institute of Geophysics and Planetology University of Hawai‘i at Mānoa HonoluluHI96822 United States Department of Earth and Planetary Systems Science Hiroshima University Higashi-Hiroshima Hiroshima739-8526 Japan Graduate School of Engineering Materials Science and Engineering Tokyo Denki University Tokyo120-8551 Japan Institut de Mineralogie Physique des Materiaux et de Cosmochimie Museum National d'Histoire Naturelle CNRS Sorbonne Université Paris75231 France McDonnell Center for the Space Sciences and Physics Department Washington University St. LouisMO63130 United States Geochemical Research Center The University of Tokyo Bunkyo-ku Tokyo113-0033 Japan Guangzhou Institute of Geochemistry Chinese Academy of Sciences GD Guangzhou510640 China Department of Natural History Sciences Hokkaido University Sapporo060-0810 Japan Centre for Star and Planet Formation Globe Institute University of Copenhagen Copenhagen1350 Denmark Institut de Planétologie et d'Astrophysique Université Grenoble Alpes Grenoble38000 France Bayerisches Geoinstitut Universität Bayreuth Bayreuth95447 Germany Institut de Physique du Globe de Paris Université de Paris CNRS Paris75005 France Department of Physics and Astronomy Seoul National University Seoul08826 Korea Republic of UMR 8214 Université Paris-Saclay CNRS Orsay91405 France Department of the Geophysical Sciences Enrico Fermi Institute The University of Chicago ChicagoIL60637 United States UMR 8000 Université Paris-Saclay CNRS Orsay91405 France Faculty of Geosciences and Geography University of Göttingen Götti

We have conducted a NanoSIMS-based search for presolar material in samples recently returned from C-type asteroid Ryugu as part of JAXA’s Hayabusa2 mission. We report the detection of all major presolar grain types with O- and C-anomalous isotopic compositions typically identified in carbonaceous chondrite meteorites: 1 silicate, 1 oxide, 1 O-anomalous supernova grain of ambiguous phase, 38 SiC, and 16 carbonaceous grains. At least two of the carbonaceous grains are presolar graphites, whereas several grains with moderate C isotopic anomalies are probably organics. The presolar silicate was located in a clast with a less altered lithology than the typical extensively aqueously altered Ryugu matrix. The matrix-normalized presolar grain abundances in Ryugu are 4.8 !".$%&.' ppm for O-anomalous grains, 25 !(%$ ppm for SiC grains and 11 !)%(ppm for carbonaceous grains. Ryugu is isotopically and petrologically similar to carbonaceous Ivuna-type (CI) chondrites. To compare the in situ presolar grain abundances of Ryugu with CI chondrites, we also mapped Ivuna and Orgueil samples and found a total of 15 SiC grains and 6 carbonaceous grains. No O-anomalous grains were detected. The matrix-normalized presolar grain abundances in the CI chondrites are similar to those in Ryugu: 23 !$%' ppm SiC and 9.0 !).$%(.& ppm carbonaceous grains. Thus, our results provide further evidence in support of the Ryugu-CI connection. They also reveal intriguing hints of small-scale heterogeneities in the Ryugu samples, such as locally distinct degrees of alteration that allowed the preservation of delicate presolar material. Copyright © 2022, The Authors. All rights reserved.

关键词： Silicon carbide

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Analysis of the synchrotron radiation from segmented undulator in double-mini beta function 8

Analysis of the synchrotron radiation from segmented undulat...

引用

8th International Particle accelerator Conference, IPAC 2017

作者： Luo, H.W. Chung, T.Y. Hwang, C.S. Lee, C.H. Graduate Program in Science and Technology of Synchrotron Light Source National Tsing Hua University Hsinchu Taiwan National Synchrotron Radiation Research Center Hsinchu Taiwan Department of Electrophysics National Chiao Tung University Hsinchu Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu Taiwan

ISBN: (纸本)9783954501823

Three long straight sections with double-mini beta-y lattice were created in the Taiwan Photon source (TPS) for which the effects of focusing elements and phase shifters between the collinear undulators result in incorrect calculations of the brilliance while assuming a Gaussian-approximation. Therefore, an on-axis Wigner distribution function (WDF), which includes effects of wave phenomena, is a natural way to measure the intensity of synchrotron radiation and is used in this article as the definition of brilliance. © 2017 CC-BY-3.0 and by the respective authors

关键词： Synchrotron radiation

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Transition-Metal Dichalcogenides: Anisotropic Collective Charge Excitations in Quasimetallic 2D Transition-Metal Dichalcogenides (Adv. Sci. 10/2020)

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Advanced science 2020年第10期7卷 2070055-2070055页

作者： Chi Sin Tang Xinmao Yin Ming Yang Di Wu Jing Wu Lai Mun Wong Changjian Li Shi Wun Tong Yung-Huang Chang Fangping Ouyang Yuan Ping Feng Shi Jie Wang Dongzhi Chi Mark B. H. Breese Wenjing Zhang Andrivo Rusydi Andrew T. S. Wee Department of Physics Faculty of Science National University of Singapore S12 Science Drive 3 Singapore 117551 Singapore NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 21 Lower Kent Ridge Singapore 119077 Singapore Singapore Synchrotron Light Source (SSLS) National University of Singapore 5 Research Link Singapore 117603 Singapore Institute of Materials Research and Engineering (IMRE) A*STAR (Agency for Science Technology and Research) 2 Fusionopolis Way Innovis Singapore 138634 Singapore International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Shenzhen University Shenzhen 518060 China School of Physics and Electronics Central South University No. 932 South Lushan Road Changsha Hunan 410083 China Department of Materials Science & Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117575 Singapore Bachelor Program in Interdisciplinary Studies National Yunlin University of Science and Technology 123 University Road Section 3 Douliou Yunlin 64002 Taiwan

In article number https://***/10.1002/advs.201902726 , Xinmao Yin, Andrew T. S. Wee, and co‐workers observe 1D mid‐IR range anisotropic plasmons in quasi‐metallic WSe 2 and MoS 2 monolayers. In‐depth analysis reveals that the long‐range inter‐chain coupling is responsible for the 1D‐charge dynamics and the plasmon energy is dictated by the effects of spin–orbit coupling. Detailed investigation into these collective modes in 2D‐chained systems opens new opportunities for novel device applications and holds significant implications to the underlying mechanism that governs superconductivity in 2D‐transition‐metal dichalcogenide systems.

关键词： anisotropic charge dynamics phase transitions plasmons spectroscopic ellipsometry transition-metal dichalcogenides

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A low temperature inkjet printing and filling process for low resistive silver TSV fabrication in a SU-8 substrate

A low temperature inkjet printing and filling process for lo...

引用

IEEE International Conference on Micro Electro Mechanical Systems

作者： Tsung-Han Yang Zi-Li Guo Yu-Min Fu Yu-Ting Cheng Yen-Fang Song Pu-Wei Wu Department of Electronics Engineering National Chiao Tung University Hsinchu Taiwan Program of Science and Technology of Accelerator Light Source National Chiao Tung University and National Synchrotron Radiation Research Center Hsinchu Taiwan

ISBN: (纸本)9781509050796

The paper presents a low temperature (with 60 °C) inkjet printing and filling process to realize low resistive Ag TSV (Through Substrate Vias) with the aspect ratio of via depth vs. diameter from 2 to 5 in a SU-8 substrate potential for flexible microsystem packaging applications. Combining humidity control and layer-by-layer Ag mirror reaction, the proposed process technology can accomplish a fully filled TSV with the lowest electrical resistivity of ~450 μΩ·cm in comparison with the prior printing and filling technologies.

关键词： Through-silicon vias Filling Substrates Printing Mirrors Resistance Ink

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Orbital-dependent spin textures in Bi2Se3 quantum well states

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Physical Review B 2018年第7期98卷 075149-075149页

作者： Chiu-Yun Lin Kenneth Gotlieb Chris Jozwiak Jonathan A. Sobota Zhi-Xun Shen James G. Analytis Zahid Hussain Alessandra Lanzara Department of Physics University of California Berkeley California 94720 USA Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA Graduate Group in Applied Science & Technology University of California Berkeley California 94720 USA Advanced Light Source Lawrence Berkeley National Laboratory Berkeley California 94720 USA Stanford Institute for Materials and Energy Sciences SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park California 94025 USA Geballe Laboratory for Advanced Materials Departments of Physics and Applied Physics Stanford University Stanford California 94305 USA

Understanding the fine interplay between spin and orbital degrees of freedom in the surface states of topological insulators is the key to the development of next-generation spintronics devices. So far, the majority of studies have focused on the helical spin texture of the topologically protected surface state (TSS) and little attention has been devoted to the spin texture of the other surface states: the bulk-originated quantum well states (QWSs). This paper presents such study in a prototypical topological insulator, Bi2Se3. By using spin- and angle-resolved photoemission spectroscopy, we reveal a full momentum-dependent spin texture of the QWSs and their response to light polarization. We find that these states share a similar spin-orbital texture with the TSS. This paper shows an intimate correlation between the surface and bulk states, which was overseen before, and provides relevant information to understand how the surface states evolve with the bulk states.

关键词： Rashba coupling Spin-orbit coupling Surface states Topological materials Quantum wells Angle-resolved photoemission spectroscopy Spin-resolved photoemission spectroscopy

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Lithium‐Ion Batteries: Cooling Induced Surface Reconstruction during Synthesis of High‐Ni Layered Oxides (Adv. Energy Mater. 43/2019)

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Advanced Energy Materials 2019年第43期9卷

作者： Ming‐Jian Zhang Xiaobing Hu Maofan Li Yandong Duan Luyi Yang Chong Yin Mingyuan Ge Xianghui Xiao Wah‐Keat Lee Jun Young Peter Ko Khalil Amine Zonghai Chen Yimei Zhu Eric Dooryhee Jianming Bai Feng Pan Feng Wang School of Advanced Materials Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China Sustainable Energy Technologies Department Brookhaven National Laboratory Upton NY 11973 USA Condensed Matter Physics and Materials Science Department Brookhaven National Laboratory Upton NY 11973 USA School of Science Hebei University of Science and Technology Shijiazhuang 050018 P. R. China Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo 315201 P. R. China National Synchrotron Light Source II Brookhaven National Laboratory Upton NY 11973 USA The Cornell High Energy Synchrotron Source Cornell University Ithaca NY 14853 USA Electrochemical Technology Program Chemical Sciences and Engineering Division Argonne National Laboratory 9700 South Cass Avenue Lemont IL 60439 USA Materials Science and Engineering Stanford University Stanford CA 94305 USA Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University (IAU) Dammam 34212 Saudi Arabia

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2D Transition Metal Dichalcogenide: Unraveling High-Yield Phase-Transition Dynamics in Transition Metal Dichalcogenides on Metallic Substrates (Adv. Sci. 7/2019)

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Advanced science 2019年第7期6卷 1970042-1970042页

作者： Xinmao Yin Chi Sin Tang Di Wu Weilong Kong Changjian Li Qixing Wang Liang Cao Ming Yang Yung-Huang Chang Dianyu Qi Fangping Ouyang Stephen J. Pennycook Yuan Ping Feng Mark B. H. Breese Shi Jie Wang Wenjing Zhang Andrivo Rusydi Andrew T. S. Wee Department of Physics Faculty of Science National University of Singapore Singapore 117542 Singapore Singapore Synchrotron Light Source (SSLS) National University of Singapore Singapore 117603 Singapore NUS Graduate School for Integrative Sciences and Engineering National University of Singapore Singapore 117456 Singapore International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Shenzhen University Shenzhen 518060 China Hunan Key Laboratory of Super-microstructure and Ultrafast Process School of Physics and Electronics Central South University No. 932 South Lushan Road Changsha Hunan Province 410083 China Department of Materials Science and Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117575 Singapore Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of Sciences Hefei 230031 China Institute of Materials Research and Engineering A∗STAR (Agency for Science Technology and Research) 2 Fusionopolis Way Singapore 138634 Singapore Bachelor Program in Interdisciplinary Studies National Yunlin University of Science and Technology Yunlin 640 Taiwan

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