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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

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The Lancet HIV 2021年第10期8卷 e633-e651页

作者： Jahagirdar, Deepa Walters, Magdalene K. Novotney, Amanda Brewer, Edmond D. Frank, Tahvi D. Carter, Austin Biehl, Molly H. Abbastabar, Hedayat Abhilash, E.S. Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Adekanmbi, Victor Adeyinka, Daniel Adedayo Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Aghababaei, Soodabeh Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmadi, Keivan Ahmadi, Sepideh Ahmadpour, Ehsan Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akram, Tayyaba Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alanezi, Fahad Mashhour Aleksandrova, Ekaterina A. Alene, Kefyalew Addis Ali, Liaqat Alipour, Vahid Almustanyir, Sami Alvis-Guzman, Nelson Ameyaw, Edward Kwabena Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Anvari, Davood Arabloo, Jalal Aremu, Olatunde Arulappan, Judie Atnafu, Desta Debalkie Quintanilla, Beatriz Paulina Ayala Ayza, Muluken Altaye Azari, Samad Darshan, B.B. Banach, Maciej Bärnighausen, Till Winfried Barra, Fabio Barrow, Amadou Basu, Sanjay Bazargan-Hejazi, Shahrzad Belay, Habtamu Gebrehana Berheto, Tezera Moshago Bezabhe, Woldesellassie Mequanint Bezabih, Yihienew Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Bisignano, Catherine Bolarinwa, Obasanjo Afolabi Boloor, Archith Boltaev, Azizbek A. Briko, Nikolay Ivanovich Buonsenso, Danilo Burkart, Katrin Butt, Zahid A. Cao, Chao Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Cowden, Richard G. Dachew, Berihun Assefa Dadras, Omid Dagnew, Amare Belachew Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi das Neves, José Degenhardt, Louisa Demeke, Feleke Mekonnen Desta, Abebaw Alemayehu Deuba, Keshab Dhamnetiya, Deepak Dhungana, Govinda Prasad Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Doan, Linh Phuong Dorostkar, Fariba Edinur, Hisham Atan Effiong, Andem Eftekharzadeh, Sahar El Sayed Zaki, Maysaa Elayedath, Rajesh Elhadi, Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States School of Social Work University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Vagelos College of Physicians and Surgeones Columbia University Medical Center New York NY United States Division of Data Analytics and Delivery for Impact WHO Geneva Switzerland Advanced Diagnostic and Interventional Radiology Research Centre Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Centre Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Paediatric Chronic Kidney Disease Research Centre Tehran University of Medical Sciences Tehran Iran Department of Psychiatry Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Centre Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Centre Tehran University of Medical Sciences Tehran Iran Research Centre for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Centre Tehran University of Medical Sciences Tehran Iran Department of Botany Sree Narayana Guru College Chelannur Kozhikode India Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Mass Communication Department University of Sharjah Sharjah United Arab Emirates Department of Health-Care Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Department of Population Medicine Ca

Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was

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Calibrated Langevin-dynamics simulations of intrinsically disordered proteins

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Physical Review E 2014年第4期90卷 042709-042709页

作者： W. Wendell Smith Po-Yi Ho Corey S. O'Hern Department of Physics Yale University New Haven Connecticut 06520-8120 USA Integrated Graduate Program in Physical and Engineering Biology Yale University New Haven Connecticut 06520-8114 USA Department of Mechanical Engineering and Materials Science Yale University New Haven Connecticut 06520-8286 USA Department of Applied Physics Yale University New Haven Connecticut 06520-8267 USA Program in Computational Biology and Bioinformatics Yale University New Haven Connecticut 06520 USA

We perform extensive coarse-grained (CG) Langevin dynamics simulations of intrinsically disordered proteins (IDPs), which possess fluctuating conformational statistics between that for excluded volume random walks and collapsed globules. Our CG model includes repulsive steric, attractive hydrophobic, and electrostatic interactions between residues and is calibrated to a large collection of single-molecule fluorescence resonance energy transfer data on the interresidue separations for 36 pairs of residues in five IDPs: α−, β−, and γ-synuclein, the microtubule-associated protein τ, and prothymosin α. We find that our CG model is able to recapitulate the average interresidue separations regardless of the choice of the hydrophobicity scale, which shows that our calibrated model can robustly capture the conformational dynamics of IDPs. We then employ our model to study the scaling of the radius of gyration with chemical distance in 11 known IDPs. We identify a strong correlation between the distance to the dividing line between folded proteins and IDPs in the mean charge and hydrophobicity space and the scaling exponent of the radius of gyration with chemical distance along the protein.

关键词： LANGEVIN equations SIMULATION methods & models CONFORMATIONAL analysis MICROTUBULE-associated proteins HYDROPHOBIC compounds

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Flexible Metallic Nanowires with Self-Adaptive Contacts to Semiconducting Transition-Metal Dichalcogenide Monolayers

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Microscopy and Microanalysis 2014年第S3期20卷 1760-1761页

作者： Junhao Lin Ovidiu Cretu Wu Zhou Kazu Suenaga Dhiraj Prasai Kirill I. Bolotin Nguyen Thanh Cuong Minoru Otani Susumu Okada Andrew R. Lupini Department of Physics and Astronomy Vanderbilt University Nashville TN 37235 USA Materials Science & Technology Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba 305-8565 Japan Interdisciplinary Graduate Program in Materials Science Vanderbilt University Nashville TN 37235 USA Graduate School of Pure and Applied Sciences University of Tsukuba Tsukuba 305-8571 Japan

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Relic neutrinos: Physically consistent treatment of effective number of neutrinos and neutrino mass

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Physical Review D 2014年第2期89卷 023008-023008页

作者： Jeremiah Birrell Cheng-Tao Yang Pisin Chen Johann Rafelski Program in Applied Mathematics The University of Arizona Tucson Arizona 85721 USA Department of Physics and Graduate Institute of Astrophysics National Taiwan University Taipei Taiwan 10617 Leung Center for Cosmology and Particle Astrophysics (LeCosPA) National Taiwan University Taipei Taiwan 10617 Kavli Institute for Particle Astrophysics and Cosmology SLAC National Accelerator Laboratory Menlo Park California 94025 USA Department of Physics The University of Arizona Tucson Arizona 85721 USA

We perform a model independent study of the neutrino momentum distribution at freeze-out, treating the freeze-out temperature as a free parameter. Our results imply that measurement of neutrino reheating, as characterized by the measurement of the effective number of neutrinos Nν, amounts to the determination of the neutrino kinetic freeze-out temperature within the context of the standard model of particle physics where the number of neutrino flavors is fixed and no other massless (fractional) particles arise. At temperatures on the order of the neutrino mass, we show how cosmic background neutrino properties, i.e., energy density, pressure, and particle density, are modified in a physically consistent way as a function of neutrino mass and Nν.

关键词： Relic mass neutrinos neutrino mass Momentum distribution Particle physics Neutrinos standard model (particle physics)

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Nonlocal correlations in a proximity-coupled normal-metal

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Physical Review B 2013年第2期88卷 024502-024502页

作者： Taewan Noh Sam Davis Venkat Chandrasekhar Department of Physics and Astronomy Northwestern University Evanston Illinois 60208 USA Graduate Program in Applied Physics Northwestern University Evanston Illinois 60208 USA

We report evidence of large, nonlocal correlations between two spatially separated normal-metals in superconductor/normal-metal (SN) heterostructures, which manifest themselves as nonlocal voltage generated in response to a driving current. Unlike prior experiments in SN heterostructures, the nonlocal correlations are mediated not by a superconductor, but by a proximity-coupled normal-metal. The nonlocal correlations extend over relatively long length scales in comparison to the superconducting case. At very low temperatures, we find a reduction in the nonlocal voltage for small applied currents that cannot be explained by the quasiclassical theory of superconductivity, which we believe is a signature of new long-range quantum correlations in the system.

关键词： HETEROSTRUCTURES SUPERCONDUCTORS NONMETALS SUPERCONDUCTIVITY QUANTUM correlations LOW temperatures QUASI-classical trajectory method

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A Questionnaire on Materialisms

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OCTOBER 2016年第155期 3-110页

作者： [Anonymous] EMILY APTER is Chair of the Department of Comparative Literature at NYU and coeditor of the Dictionary of Untranslatables: A Philosophical Lexicon (Princeton 2014). ED ATKINS is an artist who lives in Berlin. ARMEN AVANESSIAN is a philosopher and the editor-in-chief at Merve Verlag Berlin founder of . BILL BROWN author of “Thing Theory” (Critical Inquiry 28 Autumn 2001) and Other Things (Chicago 2015) teaches at the University of Chicago. GIULIANA BRUNO is Emmet Blakeney Gleason Professor of Visual and Environmental Studies at Harvard University. JULIA Bryan-Wilson is Associate Professor of Contemporary Art at UC Berkeley. D. GRAHAM BURNETT writes and makes things. He teaches at Princeton and is an editor at Cabinet. MEL Y. CHEN is Associate Professor of Gender and Women's Studies at UC Berkeley and the author of Animacies (Duke 2012). ANDREW COLE is professor of English and director of the Gauss Seminars at Princeton University. His most recent book is The Birth of Theory (Chicago 2014). CHRISTOPH COX is Professor of Philosophy at Hampshire College. SUHAIL MALIK is co-director of MFA Fine Art Goldsmiths London and author of On the Necessity of Art's Exit from Contemporary Art (Urbanomic 2016). T. J. DEMOS is Professor in the Department of the History of Art and Visual Culture University of California Santa Cruz and Director of its Center for Creative Ecologies. JEFF DOLVEN teaches English at Princeton University and is an editor-at-large at Cabinet magazine. DAVID T. DORIS is Associate Professor at the University of Michigan directly above the center of the Earth. He wrote Vigilant Things (Washington 2011). HELMUT DRAXLER is professor for Art Theory at the University of Applied Arts in Vienna. PATRICIA FALGUIÈRES is a professor at the École des Hautes Études en Sciences Sociales (EHESS) Paris. PETER GALISON is the Joseph Pellegrino University Professor in History of Science and Physics at Harvard University. ALEXANDER R. GALLOWAY teaches media theory at New York University. RACHEL HAIDU is Asso

Recent philosophical tendencies of Actor-Network Theory, Object-Oriented Ontology, and Speculative Realism have profoundly challenged the centrality of subjectivity in the humanities, and many artists and curators, particularly in the UK, Germany, and the United States, appear deeply influenced by this shift from epistemology to ontology. October editors asked artists, historians, and philosophers invested in these projectsfrom Graham Harman and Alexander R. Galloway to Armen Avanessian and Patricia Falguieres to Ed Atkins and Amie Siegelto explore what the rewards and risks of assigning agency to objects may be, and how, or if, such new materialisms can be productive for making and thinking about art today.

关键词： Objectivity in art Materialism Art & society

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Computer program for analysis and design of nanostructured semiconductor devices

Computer program for analysis and design of nanostructured s...

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2013 15th SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference, IMOC 2013

作者： Tanaka, Roberto Yuji Passaro, Angelo Abe, Nancy Mieko Sperotto, Lucas Kriesel De Moura Pedroso, Diogo Vieira, Gustavo Soares Applied Physics Division Instituto de Estudos Avançados - IEAv São José dos Campos Brazil Space Science and Technology Graduate Program Instituto Tecnologico de Aeromiutica - ITA Sao Jose dos Campos Brazil Faculty of Engineering Universidade Estadual Paulista - UNESP Guaratingueta Brazil

ISBN: (纸本)9781479913978

This work presents the recent improvements in a computer program created to assist the design and analysis of quantum well, wire, and dot nanostructured semiconductor-based devices. The list of added features includes the calculation of heavy hole, light hole and split-off energy bands, dark current, photocurrent, and absorption spectrum. Additionally, the computer program allows self-consistent computation and can take into account the energy band non-parabolic effects in the effective mass approximation. © 2013 IEEE.

关键词： Finite element method

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Nanoscale molecular dams and traps for low-abundance protein analysis

Nanoscale molecular dams and traps for low-abundance protein...

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第八届全国微全分析系统学术会议、第三届全国微纳尺度生物分离分析学术会议暨第五届国际微化学与微系统学术会议

作者： Chia-Fu Chou Kuo-Tang Liao Leonardo Lesser-Rojas K. K. Sriram Yii-Lih Lin Academia Sinica Taiwan Department of Chemistry National Taiwan UniversityTaiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan Research Center for Applied Sciences Institute of Physics Institute of Physics Department of Engineering and System Science National Tsing Hua UniversityTaiwan Institute of Physics Institute of Physics Genomics Research Center

Miniaturized biosensors and bioanalytical systems promise to revolutionize the field of health care and personalized medicine,in light of sample reduction,speed,and ***,mass transport has generally been recognized as a major limiting factor in the sensitivity and performance of miniaturized sensor platforms in that miniaturization poses penalties on passive transport of biomolecules to the sensor surface due to prolonged diffusion length from the bulk liquid or in the direction of the fluidic ***,for low-abundance protein analysis,sample enrichment is often regarded as the first prerequisite for high-resolution analysis,since chemical amplification methods are not readily available for *** factors pose major challenges for early or acute disease diagnostics and biomarker discovery using micro- or nanoscale sensor *** tackle these challenges,we developed nanofluidic and nanoelectronic platforms for the active transport of target analytes to the sensing *** example,nanoscale molecular dam,using nanoconstriction as field-focusing lens to enhance mass transport,may be used for ultrafast protein enrichment in nanofluidic channels by electrodeless dielectrophoresis [1] under physiological buffer conditions [2-4].On the other hand,sub-10 nm electrode nanogap may be used as an active molecular trap for SERS and tunneling current measurements for low-copy number protein analysis,potentially down to single-molecule *** platforms may open up a simple way for heterogeneous protein analysis.

关键词： Protein analysis nanogap electrode dielectrophoresis surface enhanced Raman spectroscopy (SERS) tunneling current

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Solution-processed zinc oxide nanoparticles as interlayer materials for inverted organic solar cells

Solution-processed zinc oxide nanoparticles as interlayer ma...

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作者： Ibrahem, Mohammed Aziz Wei, Hung-Yu Tsai, Meng-Hung Ho, Kuo-Chuan Shyue, Jing-Jong Chu, Chih Wie Department of Physics National Taiwan University Taipei 106 Taiwan Research Center of Applied Science Academia Sinica Taipei 115 Taiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Institute of Polymer Science and Engineering National Taiwan University Taipei 10617 Taiwan Department of Material Science and Engineering National Taiwan University Taipei 106 Taiwan Department of Photonics National Chiao Tung University Hsinchu 300 Taiwan

This paper describes inverted bulk heterojunction organic solar cells featuring solution-processed zinc oxide nanoparticles (ZnO NPs) as an electron extraction layer, prepared at relatively low annealing temperatures (≤150°C). A solution of ZnO NPs (average size: 25 nm) was prepared using a wet grinding method. When the ZnO interlayer was present in the solar cell, the vertical phase separation of the active layers prepared with and without solvent annealing exhibited similar gradient concentrations and, therefore, similar photocurrent generation, both of which were superior to those of conventional devices incorporating a poly(3,4-ethylenedioxythiophene): poly(styrene sulfonic acid) (PEDOT:PSS) hole extraction layer. We attribute this vertical phase separation to the similar surface energies of the fullerene derivative and the ZnO interlayer. Under simulated air mass (AM) 1.5 G illumination at 100 mW cm-2, the power conversion efficiency of the optimized device was approximately 4%. © 2012 Elsevier B.V.

关键词： Zinc oxide

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