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Nanoscale molecular dams and traps for low-abundance protein analysis

Nanoscale molecular dams and traps for low-abundance protein...

第八届全国微全分析系统学术会议、第三届全国微纳尺度生物分离分析学术会议暨第五届国际微化学与微系统学术会议

作者： Chia-Fu Chou Kuo-Tang Liao Leonardo Lesser-Rojas K. K. Sriram Yii-Lih Lin Academia Sinica Taiwan Department of Chemistry National Taiwan UniversityTaiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica Taiwan Research Center for Applied Sciences Institute of Physics Institute of Physics Department of Engineering and System Science National Tsing Hua UniversityTaiwan Institute of Physics Institute of Physics Genomics Research Center

Miniaturized biosensors and bioanalytical systems promise to revolutionize the field of health care and personalized medicine,in light of sample reduction,speed,and ***,mass transport has generally been recognized as a major limiting factor in the sensitivity and performance of miniaturized sensor platforms in that miniaturization poses penalties on passive transport of biomolecules to the sensor surface due to prolonged diffusion length from the bulk liquid or in the direction of the fluidic ***,for low-abundance protein analysis,sample enrichment is often regarded as the first prerequisite for high-resolution analysis,since chemical amplification methods are not readily available for *** factors pose major challenges for early or acute disease diagnostics and biomarker discovery using micro- or nanoscale sensor *** tackle these challenges,we developed nanofluidic and nanoelectronic platforms for the active transport of target analytes to the sensing *** example,nanoscale molecular dam,using nanoconstriction as field-focusing lens to enhance mass transport,may be used for ultrafast protein enrichment in nanofluidic channels by electrodeless dielectrophoresis [1] under physiological buffer conditions [2-4].On the other hand,sub-10 nm electrode nanogap may be used as an active molecular trap for SERS and tunneling current measurements for low-copy number protein analysis,potentially down to single-molecule *** platforms may open up a simple way for heterogeneous protein analysis.

关键词： Protein analysis nanogap electrode dielectrophoresis surface enhanced Raman spectroscopy (SERS) tunneling current

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Solution-processed zinc oxide nanoparticles as interlayer materials for inverted organic solar cells

Solution-processed zinc oxide nanoparticles as interlayer ma...

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作者： Ibrahem, Mohammed Aziz Wei, Hung-Yu Tsai, Meng-Hung Ho, Kuo-Chuan Shyue, Jing-Jong Chu, Chih Wie Department of Physics National Taiwan University Taipei 106 Taiwan Research Center of Applied Science Academia Sinica Taipei 115 Taiwan Nanoscience and Technology Program Taiwan International Graduate Program Academia Sinica Taipei 115 Taiwan Institute of Polymer Science and Engineering National Taiwan University Taipei 10617 Taiwan Department of Material Science and Engineering National Taiwan University Taipei 106 Taiwan Department of Photonics National Chiao Tung University Hsinchu 300 Taiwan

This paper describes inverted bulk heterojunction organic solar cells featuring solution-processed zinc oxide nanoparticles (ZnO NPs) as an electron extraction layer, prepared at relatively low annealing temperatures (≤150°C). A solution of ZnO NPs (average size: 25 nm) was prepared using a wet grinding method. When the ZnO interlayer was present in the solar cell, the vertical phase separation of the active layers prepared with and without solvent annealing exhibited similar gradient concentrations and, therefore, similar photocurrent generation, both of which were superior to those of conventional devices incorporating a poly(3,4-ethylenedioxythiophene): poly(styrene sulfonic acid) (PEDOT:PSS) hole extraction layer. We attribute this vertical phase separation to the similar surface energies of the fullerene derivative and the ZnO interlayer. Under simulated air mass (AM) 1.5 G illumination at 100 mW cm-2, the power conversion efficiency of the optimized device was approximately 4%. © 2012 Elsevier B.V.

关键词： Zinc oxide

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All-optical tunable comb filters using ytterbium doped fibers and an LPG pair

All-optical tunable comb filters using ytterbium doped fiber...

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2013 18th OptoElectronics and Communications Conference Held Jointly with 2013 International Conference on Photonics in Switching, OECC/PS 2013

作者： Kim, Yune Hyoun Kim, Bok Hyeon Hann, Swook Im, Young-Eun Lim, Jung Woon Kim, Jong-Sup Kim, Jeong Ho Lim, Ju Young Han, Won-Taek Laser-IT Research Center KOPTI 971-35 Wolchul-dong Buk-gu Gwangju 500-430 Korea Republic of Advanced Photonics Research Institute GIST 1 Oryong-dong Buk-gu Gwangju 500-712 Korea Republic of Graduate Program of Photonics and Applied Physics School of Information and Communications GIST 1 Oryong-dong Buk-gu Gwangju 500-712 Korea Republic of

ISBN: (纸本)9784885522710

We have demonstrated a new type all-optical tunable comb filter by using a long-period fiber gratings(LPG) pair spliced with an ytterbium doped fiber. When the 25.5cm long ytterbium doped fiber was used with the ytterbium doping concentration of ∼0.82at%, the wavelength channel spacing and the isolation between channels were 0.7nm and 16-21dB, respectively, between 1545nm and 1555nm. Also, the optical comb filter was tuned up to '1.53π' phase shift at the launched pump power of 56mW with the LD at 976nm. © 2013 IEICE.

关键词： Comb filters

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All-optical tunable comb filters using ytterbium doped fibers and an LPG pair

All-optical tunable comb filters using ytterbium doped fiber...

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International Conference on Photonics in Switching (PS)

作者： Yune Hyoun Kim Bok Hyeon Kim Swook Hann Young-Eun Im Jung Woon Lim Jong-Sup Kim Jeong Ho Kim Ju Young Lim Won-Taek Han Laser-IT Research Center KOPTI Gwangju South Korea Advanced Photonics Research Institute GIST Gwangju South Korea Graduate Program of Photonics and Applied Physics School of Information and Communications GIST Gwangju South Korea

ISBN: (纸本)9784885522710

We have demonstrated a new type all-optical tunable comb filter by using a long-period fiber gratings(LPG) pair spliced with an ytterbium doped fiber. When the 25.5cm long ytterbium doped fiber was used with the ytterbium doping concentration of ~0.82at%, the wavelength channel spacing and the isolation between channels were 0.7nm and 16-21dB, respectively, between 1545nm and 1555nm. Also, the optical comb filter was tuned up to `1.53π' phase shift at the launched pump power of 56mW with the LD at 976nm.

关键词： Optical fiber polarization Optical fiber communication Optical fiber devices Optical fiber filters Ytterbium Optical pumping

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Electrodes: Lithium Intercalation Behavior in Multilayer Silicon Electrodes (Adv. Energy Mater. 7/2014)

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Advanced Energy Materials 2014年第7期4卷

作者： Tim T. Fister Jennifer Esbenshade Xiao Chen Brandon R. Long Bing Shi Christian M. Schlepütz Andrew A. Gewirth Michael J. Bedzyk Paul Fenter Chemical Sciences and Engineering Division Argonne National Laboratory Argonne IL 60439 USA Department of Chemistry University of Illinois Urbana‐Champaign Urbana IL 61801 USA Graduate Program in Applied Physics Northwestern University Evanston IL USA Advanced Photon Source Argonne National Laboratory Argonne IL 60439 USA Departments of Materials Science & Engineering and Physics & Astronomy Northwestern University Evanston IL 60208 USA

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Nanofluidics-enabled statistical physics in biosystems: nanoscale electrokinetics, single molecule tug-of-war, and bacterial protein oscillators

Nanofluidics-enabled statistical physics in biosystems: nano...

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第二届全国统计物理与复杂系统学术会议暨第七届海峡两岸统计物理研讨会

作者： Chia-Fu Chou Kuo-Tang Liao Jia-Wei Yeh Alessandro Taloni Jie-Pan Shen Yi-Ren Chang Li-Ling Yang Department of Engineering and System Sciences National Tsing Hua UniversityHsinchu 30013Taiwan Department of Applied Physics Cornell UniversityIthacaNY 14853USA Institute of Physics Research Center for Applied Sciences Academia SinicaTaipei 11529Taiwan Institute of Physics Institute of Physics CNR-IENI Via R.Cozzi 5320125 MilanoItaly Institute of Physics Nanoscience and Technology/Taiwan International Graduate Program Academia SinicaTaipei 11529Taiwan Institute of Physics Genomics Research Center

Given its simplicity in geometry, nanofluidic confinement, in the forms of nanoslits and nanoconstrictions, nevertheless offers unique platforms for the study of molecular biophysics and biosensing applications [1-4].We recently demonstrated a new approach, molecular dam, to enhance mass transport for protein enrichment in nanofluidic channels by nanoscale electrodeless dielectrophoresis [5] under physiological buffer conditions [6, 7].

关键词： Electrokinetics DNA Protein Microfluidics Nanofluidics Dielectrophoresis Entropic recoiling Single molecules

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Computer program for analysis and design of nanostructured semiconductor devices

Computer program for analysis and design of nanostructured s...

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SBMO/IEEE MTT-S International Conference on Microwave and Optoelectronics (IMOC)

作者： Roberto Yuji Tanaka Angelo Passaro Nancy Mieko Abe Lucas Kriesel Sperotto Diogo de Moura Pedroso Gustavo Soares Vieira Space Science and Technology Graduate Program Instituto Tecnológico de Aeronáutica – ITA São José dos Campos Brazil Applied Physics Division Instituto de Estudos Avançados – IEAv São José dos Campos Brazil Applied Physics Division Instituto de Estudos Avançados Sao Jose dos Campos Brazil Applied Physics Division Instituto de Estudos Avançados - IEAv São José dos Campos Brazil

ISBN: (纸本)9781479913961

This work presents the recent improvements in a computer program created to assist the design and analysis of quantum well, wire, and dot nanostructured semiconductor-based devices. The list of added features includes the calculation of heavy hole, light hole and split-off energy bands, dark current, photocurrent, and absorption spectrum. Additionally, the computer program allows self-consistent computation and can take into account the energy band non-parabolic effects in the effective mass approximation.

关键词： Convergence

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Unwinding and rewinding the nucleosome inner turn: Force dependence of the kinetic rate constants

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Physical Review E 2013年第1期87卷 012710-012710页

作者： S. G. J. Mochrie A. H. Mack D. J. Schlingman R. Collins M. Kamenetska L. Regan Integrated Graduate Program in Physical and Engineering Biology Yale University New Haven Connecticut 06520 USA Department of Applied Physics Yale University New Haven Connecticut 06520 USA Department of Physics Yale University New Haven Connecticut 06520 USA Department of Molecular Biophysics and Biochemistry Yale University New Haven Connecticut 06520 USA Department of Chemistry Yale University New Haven Connecticut 06520 USA

A simple model for the force-dependent unwinding and rewinding rates of the nucleosome inner turn is constructed and quantitatively compared to the results of recent measurements [A. H. Mack et al., J. Mol. Biol. 423, 687 (2012)]. First, a coarse-grained model for the histone-DNA free-energy landscape that incorporates both an elastic free-energy barrier and specific histone-DNA bonds is developed. Next, a theoretical expression for the rate of transitions across a piecewise linear free-energy landscape with multiple minima and maxima is presented. Then, the model free-energy landscape, approximated as a piecewise linear function, and the theoretical expression for the transition rates are combined to construct a model for the force-dependent unwinding and rewinding rates of the nucleosome inner turn. Least-mean-squares fitting of the model rates to the rates observed in recent experiments rates demonstrates that this model is able to well describe the force-dependent unwinding and rewinding rates of the nucleosome inner turn, observed in the recent experiments, except at the highest forces studied, where an additional ad hoc term is required to describe the data, which may be interpreted as an indication of an alternate high-force nucleosome disassembly pathway, that bypasses simple unwinding. The good agreement between the measurements and the model at lower forces demonstrates that both specific histone-DNA contacts and an elastic free-energy barrier play essential roles for nucleosome winding and unwinding, and quantifies their relative contributions.

关键词： CHROMATIN HISTONES LEAST squares CHEMICAL bonds ANALYSIS of DNA

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Lineage structure of the human antibody repertoire in response to influenza vaccination

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医用生物力学 2013年第S1期28卷 36-37页

作者： Ning Jiang Jiankui He Joshua A.Weinstein Lolita Penland Sanae Sasaki Xiao-Song He Patrick C.Wilson Harry B.Greenberg Mark M.Davis Daniel S.Fisher Stephen R.Quake Department of Biomedical Engineering the University of Texas at AustinAustinTXUSA Department of Bioengineering Stanford University School of MedicineStanfordCaliforniaUSA Biophysics Graduate Program Stanford UniversityStanfordCaliforniaUSA Department of Immunology and Microbiology Stanford University School of MedicineStanfordCaliforniaUSA VA Palo Alto Health Care System Palo AltoCaliforniaUSA Department of Medicine Stanford University School of MedicineStanfordCaliforniaUSA Department of Medicine University of Chicago Pritzker School of MedicineChicagoIllinoisUSA Howard Hughes Medical Institute Department of Applied Physics Stanford UniversityStanfordCaliforniaUSA Department of Biology Stanford UniversityStanfordCaliforniaUSA

The adaptive immune system produces a large and diverse set of antibodies,each with an individual evolutionary and clonal *** so called"antibody repertoire"protects each individual against insults such as infection and cancer,and responds to vaccination with B cell proliferation in response to the antigenic *** and antigen-specific FACSbased analysis have given us much insight on how the immune system generates the complex and diverse immune response required to protect the body from the wide variety of potential ***,these methods have not been sufficient to make global and unbiased characterizations of the clonal structure of the immune system of a particular individual。

关键词： vaccination clonal antigenic diverse insight stimulation evolutionary immunized protect vaccine

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Phase-controlled switching between incoherent optical images in a double-Λ system

Phase-controlled switching between incoherent optical images...

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Quantum Information and Measurement, QIM 2012

作者： Kim, Bongjune Park, Young Ho Sohn, Byoung Uk Ko, Do-Keyung Oh, Cha-Hwan Kang, Hoonsoo Quantum Optics Lab Advanced Photonics Research Institute GIST Gwangju 500-712 Korea Republic of Department of Physics Hanyang University Seoul 133-791 Korea Republic of Graduate program of Photonics and Applied Physics GIST Gwangju 500-712 Korea Republic of

ISBN: (纸本)9781557529398

The coherent control of optical images has garnered attention because the range of information embedded in optical images is expected to be controlled in high efficiency. Recently, the storage of optical images using coherent control techniques opened a method for multiple information storage. Image control in coherent medium might move up new era of quantum information technology since the generation of entangled image pairs was realized with parametric process in coherent medium. One of the most important optical controls is switch for information distribution. Here, phase-controlled optical image switching with low light intensity was demonstrated in a double-Λ system. Switching by interference in a double-Λ system was observed as having a 90 % switching depth between incoherent image pixels. Two independent laser sources were adopted for a double-Λ system such that images inscribed in two weak probe lights were incoherent with each other.

关键词： Diode lasers Image storage Laser sources Light intensity Phase shift Quantum information Atom optics (020.1335) Coherence (030.1640) Coherent optical effects (030.1670)

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