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检索条件"机构=Graduate Program in Biochemistry and Structural Biology"
42 条 记 录,以下是1-10 订阅
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Variations in kinase and effector signaling logic in a bacterial two component signaling network
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Journal of Biological Chemistry 2025年 第6期301卷 108534页
作者: Swingle, Danielle Epstein, Leah Aymon, Ramisha Isiorho, Eta A. Abzalimov, Rinat R. Favaro, Denize C. Gardner, Kevin H. Structural Biology Initiative CUNY Advanced Science Research Center New YorkNY United States PhD. Program in Biochemistry The Graduate Center – City University of New York New YorkNY United States Department of Chemistry and Biochemistry City College of New York New YorkNY United States PhD. Programs in Biochemistry Biology and Chemistry The Graduate Center – City University of New York New YorkNY United States
The general stress response (GSR) protects bacteria from a wide range of stressors. In Alphaproteobacteria, GSR activation is coordinated by HWE/HisKA2 family histidine kinases (HKs), which can exhibit noncanonical st... 详细信息
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Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: insights into Parkinson’s disease
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Neural Regeneration Research 2021年 第6期16卷 1198-1199页
作者: Susan M.L.Banks Audrey T.Medeiros Rui Sousa Eileen M.Lafer Jennifer R.Morgan Department of Biology Florida Southern CollegeLakelandFLUSA Neuroscience Graduate Program Brown UniversityProvidenceRIUSA Department of Biochemistry and Structural Biology and Center for Biomedical Neuroscience The University of Texas Health Science Center at San AntonioSan AntonioTXUSA The Eugene Bell Center for Regenerative Biology&Tissue Engineering Marine Biological LaboratoryWoods HoleMAUSA
α-Synuclein accumulation causes synaptic vesicle trafficking defects and may underlie neurodegenerative disorders:Neurodegenerative disorders,such as Parkinson’s disease(PD)and other synucleinopathies,impact the liv... 详细信息
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Single-image example-based superresolution of hyperpolarized 13C images
arXiv
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arXiv 2023年
作者: Deh, Kofi Coffee, Elizabeth Zhang, Guannan Kim, Nathaniel Miloushev, Vesselin Keshari, Kayvan R. Department of Radiology Memorial Sloan Kettering Cancer Center New York CityNY United States Department of Neurology Memorial Sloan Kettering Cancer Center New York CityNY United States Department of Physiology & Biophysics Weill Cornell Graduate School New York CityNY United States Department of Biochemistry & Structural Biology Weill Cornell Graduate School NYCNY United States Molecular Pharmacology Program Memorial Sloan Kettering Cancer Center NYCNY United States
The transient signal available for hyperpolarized (HP) 13C imaging limits the image spatial resolution. This paper demonstrates a method of increasing spatial resolution by post-processing the HP 13C metabolic map usi... 详细信息
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Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks  25
Graph-based information diffusion method for prioritizing fu...
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25th Pacific Symposium on Biocomputing, PSB 2020
作者: Pham, Minh Lichtarge, Olivier Integrative Molecular and Biomedical Sciences Graduate Program Department of Molecular and Human Genetics Baylor College of Medicine One Baylor Plaza HoustonTX77030 United States Departments of Molecular and Human Genetics Structural and Computational Biology and Molecular Biophysics Biochemistry and Molecular Biology and Pharmacology One Baylor Plaza HoustonTX77030 United States
Shortest path length methods are routinely used to validate whether genes of interest are functionally related to each other based on biological network information. However, the methods are computationally intensive,... 详细信息
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Virtual Flavonoids Screening Identifies Potent Compounds Against Enterovirus A71 and Coxsackievirus A16
SSRN
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SSRN 2023年
作者: Sripattarphan, Amita Sanachai, Kamonpan Chavasiri, Warinthorn Wolschann, Peter Langer, Thierry Boonyasuppayakorn, Siwaporn Rungrotmongkol, Thanyada Center of Excellence in Structural and Computational Biology Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok10330 Thailand Department of Biochemistry Faculty of Science Khon Kaen University Khon Kaen40002 Thailand Center of Excellence in Natural Products Chemistry Department of Chemistry Faculty of Science Chulalongkorn University Bangkok10330 Thailand Department of Pharmaceutical Chemistry Faculty of Life Sciences University of Vienna Althanstraße 14 ViennaA-1090 Austria Institute of Theoretical Chemistry University of Vienna Vienna1090 Austria Center of Excellence in Applied Medical Virology Department of Microbiology Faculty of Medicine Chulalongkorn University Bangkok10330 Thailand Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Bangkok10330 Thailand
Worldwide outbreaks of hand, foot, and mouth disease (HFMD) are caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Since no anti-HFMD drugs are currently available, it is interesting to study potentia... 详细信息
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Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance
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Biomedicine and Pharmacotherapy 2024年 180卷 117569-117569页
作者: Kaewlert, Waleeporn Sakonsinsiri, Chadamas Lert-itthiporn, Worachart Mahalapbutr, Panupong Ali, Saba Rungrotmongkol, Thanyada Jusakul, Apinya Armartmuntree, Napat Pairojkul, Chawalit Feng, Guofei Ma, Ning Pinlaor, Somchai Murata, Mariko Thanan, Raynoo Department of Biochemistry Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Cholangiocarcinoma Research Institute Khon Kaen University Khon Kaen 40002 Thailand Center of Excellence in Structural and Computational Biology Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand Program in Bioinformatics and Computational Biology Graduated School Chulalongkorn University Bangkok 10330 Thailand The Center for Research and Development of Medical Diagnostic Laboratories Faculty of Associated Medical Sciences Khon Kaen University Khon Kaen 40002 Thailand Department of Medical Science Amnatcharoen Campus Mahidol University Amnat Charoen 37000 Thailand Department of Pathology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Department of Environmental and Molecular Medicine Mie University Graduate School of Medicine Mie 514-8507 Japan Graduate School of Health Science Suzuka University of Medical Science Suzuka Mie 510-0226 Japan Department of Parasitology Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand
Cholangiocarcinoma (CCA) is an oxidative stress-driven liver cancer with bile duct epithelial cell phenotypes and currently lacks effective treatments, making targeted drug therapy urgently needed. Oxidative stress pl... 详细信息
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Mapping the interaction surface between CaVβ and actin and its role in calcium channel clearance
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Nature Communications 2025年 第1期16卷 1-21页
作者: Castilla, Francisco Lugo, Victor Miranda-Laferte, Erick Jordan, Nadine Huesgen, Pitter F. Santiago-Schübel, Beatrix Alfonso-Prieto, Mercedes Hidalgo, Patricia Institute of Biological Information Processing (IBI-1)—Molecular and Cellular Physiology Forschungszentrum Jülich Jülich Germany Graduate Program Faculty of Mathematics and Natural Sciences Heinrich-Heine University Düsseldorf Germany Central Institute of Engineering Electronics and Analytics (ZEA-3) Forschungszentrum Jülich Jülich Germany Institute of Biological Information Processing (IBI-7)—Structural Biochemistry Forschungszentrum Jülich Jülich Germany Institute of Neuroscience and Medicine (INM-9)—Computational Biomedicine Forschungszentrum Jülich Jülich Germany Cécile and Vogt Institute for Brain Research Medical Faculty Heinrich-Heine University Düsseldorf Germany Institute of Biochemistry Heinrich-Heine University Düsseldorf Germany Biologics Analytical Research and Development AbbVie Deutschland GmbH & Co. KG Ludwigshafen Germany Institute of Biology II University of Freiburg Freiburg Germany
Defective ion channel turnover and clearance of damaged proteins are associated with aging and neurodegeneration. The L-type CaV1.2 voltage-gated calcium channel mediates depolarization-induced calcium signals in hear...
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OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials
arXiv
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arXiv 2023年
作者: Eastman, Peter Galvelis, Raimondas Peláez, Raúl P. Abreu, Charlles R.A. Farr, Stephen E. Gallicchio, Emilio Gorenko, Anton Henry, Michael M. Hu, Frank Huang, Jing Krämer, Andreas Michel, Julien Mitchell, Joshua A. Pande, Vijay S. Rodrigues, João P.G.L.M. Rodriguez-Guerra, Jaime Simmonett, Andrew C. Singh, Sukrit Swails, Jason Turner, Philip Wang, Yuanqing Zhang, Ivy Chodera, John D. De Fabritiis, Gianni Markland, Thomas E. Department of Chemistry Stanford University StanfordCA94305 United States Acellera Labs C Dr Trueta 183 Barcelona08005 Spain C Dr. Aiguader 88 Barcelona08003 Spain Chemical Engineering Department School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro68542 Brazil Redesign Science Inc. 180 Varick St. New YorkNY10014 United States EaStCHEM School of Chemistry University of Edinburgh EH9 3FJ United Kingdom Department of Chemistry and Biochemistry Brooklyn College The City University of New York NY United States Ph.D. Program in Chemistry Ph.D. Program in Biochemistry The Graduate Center of the City University of New York New YorkNY United States Stream HPC Koningin Wilhelminaplein 1 - 40601 Amsterdam1062 HG Netherlands Computational and Systems Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New YorkNY10065 United States Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University 18 Shilongshan Road Zhejiang Hangzhou310024 China Department of Mathematics and Computer Science Freie Universität Berlin Arnimallee 12 Berlin14195 Germany The Open Force Field Initiative Open Molecular Software Foundation DavisCA95616 United States Andreessen Horowitz 2865 Sand Hill Rd Menlo ParkCA94025 United States Department of Structural Biology Stanford University StanfordCA94305 United States Charité Universitätsmedizin Berlin In silico Toxicology and Structural Bioinformatics Virchowweg 6 Berlin10117 Germany Laboratory of Computational Biology National Heart Lung and Blood Institute National Institutes of Health BethesdaMD20892 United States Entos Inc. 9310 Athena Circle La Jolla CA92037 United States College of Engineering Virginia Polytechnic Institute State University BlacksburgVA24061 United States Simons Center for Computational Physical Chemistry Center for Data Science New York University 24 Waverly Place New YorkNY10004 United States T
Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbi... 详细信息
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structural basis and synergism of ATP and Na+ activation in bacterial K+ uptake system KtrAB
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Nature Communications 2024年 第1期15卷 3850页
作者: Chiang, Wesley Tien Chang, Yao-Kai Hui, Wei-Han Chang, Shu-Wei Liao, Chen-Yi Chang, Yi-Chuan Chen, Chun-Jung Wang, Wei-Chen Lai, Chien-Chen Wang, Chun-Hsiung Luo, Siou-Ying Huang, Ya-Ping Chou, Shan-Ho Horng, Tzyy-Leng Hou, Ming-Hon Muench, Stephen P. Chen, Ren-Shiang Tsai, Ming-Daw Hu, Nien-Jen Graduate Institute of Biochemistry National Chung Hsing University Taichung 402202 Taiwan Institute of Biological Chemistry Academia Sinica Taipei 115201 Taiwan Department of Civil Engineering National Taiwan University Taipei 106319 Taiwan Department of Biomedical Engineering National Taiwan University Taipei 10663 Taiwan Life Science Group Scientific Research Division National Synchrotron Radiation Research Center Hsinchu 30092 Taiwan Institute of Molecular Biology National Chung Hsing University Taichung 402202 Taiwan Graduate Institute of Chinese Medical Science China Medical University Taichung 406040 Taiwan Department of Applied Mathematics Feng Chia University Taichung 407102 Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung 402202 Taiwan School of Biomedical Sciences Faculty of Biological Sciences and the Astbury Centre for Structural Molecular Biology University of Leeds Leeds LS2 9JT United Kingdom Department of Life Science Tunghai University Taichung 407224 Taiwan Institute of Biochemical Sciences National Taiwan University Taipei 106319 Taiwan Ph.D Program in Translational Medicine National Chung Hsing University Taichung 402202 Taiwan
The K+ uptake system KtrAB is essential for bacterial survival in low K+ environments. The activity of KtrAB is regulated by nucleotides and Na+. Previous studies proposed a putative gating mechanism of KtrB regulated...
来源: 评论
Inhibition of topoisomerase IIα and induction of DNA damage in cholangiocarcinoma cells by altholactone and its halogenated benzoate derivatives
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Biomedicine and Pharmacotherapy 2020年 127卷 110149-110149页
作者: Kitdumrongthum, Sarunya Reabroi, Somrudee Suksen, Kanoknetr Tuchinda, Patoomratana Munyoo, Bamroong Mahalapbutr, Panupong Rungrotmongkol, Thanyada Ounjai, Puey Chairoungdua, Arthit Toxicology Graduate Program Faculty of Science Mahidol University Bangkok Thailand Excellent Center for Drug Discovery (ECDD) Mahidol University Bangkok Thailand Department of Pharmacology Faculty of Science Mahidol University Bangkok Thailand Department of Physiology Faculty of Science Mahidol University Bangkok Thailand Department of Chemistry Faculty of Science Mahidol University Bangkok Thailand Structural and Computational Biology Research Unit Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok Thailand Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Bangkok Thailand Department of Biology Faculty of Science Mahidol University Bangkok Thailand
Topoisomerase IIα enzyme (Topo IIα) plays a critical function in DNA replication process and is considered to be a promising target of anti-cancer drugs. In the present study, we reported that the altholactone deriv... 详细信息
来源: 评论